JP7094226B2 - 医薬品有効成分用のタンパク質をベースにした添加物 - Google Patents

医薬品有効成分用のタンパク質をベースにした添加物 Download PDF

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JP7094226B2
JP7094226B2 JP2018556473A JP2018556473A JP7094226B2 JP 7094226 B2 JP7094226 B2 JP 7094226B2 JP 2018556473 A JP2018556473 A JP 2018556473A JP 2018556473 A JP2018556473 A JP 2018556473A JP 7094226 B2 JP7094226 B2 JP 7094226B2
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api
protein
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acid
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JP2019514932A5 (cg-RX-API-DMAC10.html
JP2019514932A (ja
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ビョルン・ヴェルグエン
ヒー・ファン・デ・ムーター
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ルスロ・ベー・フェー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
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    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
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    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Psychiatry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2018556473A 2016-04-29 2017-04-28 医薬品有効成分用のタンパク質をベースにした添加物 Active JP7094226B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
BE2016/5302 2016-04-29
BE2016/5302A BE1023653B1 (nl) 2016-04-29 2016-04-29 Eiwit gebaseerd excipient voor actieve farmaceutische stoffen
BE2016/5977 2016-12-26
BE201605977 2016-12-26
PCT/EP2017/060143 WO2017186889A1 (en) 2016-04-29 2017-04-28 Protein based excipient for active pharmaceutical ingredients

Publications (3)

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JP2019514932A JP2019514932A (ja) 2019-06-06
JP2019514932A5 JP2019514932A5 (cg-RX-API-DMAC10.html) 2020-04-23
JP7094226B2 true JP7094226B2 (ja) 2022-07-01

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US (2) US20190083629A1 (cg-RX-API-DMAC10.html)
EP (2) EP4062941A1 (cg-RX-API-DMAC10.html)
JP (1) JP7094226B2 (cg-RX-API-DMAC10.html)
CN (1) CN109152842B (cg-RX-API-DMAC10.html)
AU (2) AU2017256767B2 (cg-RX-API-DMAC10.html)
BR (1) BR112018072113A2 (cg-RX-API-DMAC10.html)
CA (1) CA3018812A1 (cg-RX-API-DMAC10.html)
ES (1) ES2925656T3 (cg-RX-API-DMAC10.html)
IL (1) IL262568A (cg-RX-API-DMAC10.html)
MX (1) MX394644B (cg-RX-API-DMAC10.html)
PT (1) PT3448435T (cg-RX-API-DMAC10.html)
WO (1) WO2017186889A1 (cg-RX-API-DMAC10.html)
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US20190307886A1 (en) * 2016-12-23 2019-10-10 University Of Copenhagen A co-amorphous form of a substance and a protein
EP4069200A1 (en) * 2019-12-04 2022-10-12 Albumedix Ltd Methods and compositions produced thereby
CN111821309B (zh) * 2020-04-30 2021-08-24 深圳市新阳唯康科技有限公司 一种具有改良溶出速度的达芦那韦组合物
CN111840255B (zh) * 2020-07-31 2022-03-01 北京丰帆生物医药科技有限公司 一种维拉帕米温敏缓释制剂及其制备方法和应用
CN112176002B (zh) * 2020-11-10 2022-09-02 四川大学 胶原基酒精发酵促进剂、及其制备方法和应用
WO2022258759A1 (en) 2021-06-10 2022-12-15 Bend Research, Inc. Spray drying of api in supersaturated solutions with formic acid
US20250025420A1 (en) * 2021-11-24 2025-01-23 Zerion Pharma ApS Ternary co-amorphous forms of drugs, proteins, and water-soluble polymers
WO2024011185A1 (en) * 2022-07-07 2024-01-11 Serán BioScience, LLC Methods and systems for use of low-volatility solvents for spray drying
WO2026082944A1 (en) 2024-10-17 2026-04-23 Hovione Farmaciência S.A. High-density composite active particles comprising beta-lactoglobulin and api, compositions comprising same, and methods for the manufacture thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003508482A (ja) 1999-09-03 2003-03-04 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 標的動物に対する水分布システムを通す水−不溶性薬品の投与のための獣医学的調合物
JP2007501219A (ja) 2003-08-04 2007-01-25 ファイザー・プロダクツ・インク 薬物及び重合体の固体無定形分散を形成するための噴霧乾燥（スプレードライ）方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5993805A (en) 1991-04-10 1999-11-30 Quadrant Healthcare (Uk) Limited Spray-dried microparticles and their use as therapeutic vehicles
DE4201173C2 (de) 1992-01-17 1998-10-29 Alfatec Pharma Gmbh Akutarzneimittel in Form von Dihydropyridinderivaten enthaltenden Pellets und ihre Herstellung
DE4221880A1 (de) 1992-07-03 1994-01-05 Alfatec Pharma Gmbh Feste und flüssige Lösungen von schwer wasserlöslichen Arzneistoffen
US5916596A (en) * 1993-02-22 1999-06-29 Vivorx Pharmaceuticals, Inc. Protein stabilized pharmacologically active agents, methods for the preparation thereof and methods for the use thereof
US20070092563A1 (en) * 1996-10-01 2007-04-26 Abraxis Bioscience, Inc. Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
JPH11189548A (ja) 1997-12-25 1999-07-13 Toshio Sato 無晶性医薬組成物及びその製造方法
DE10000792A1 (de) 2000-01-11 2001-07-19 Bernhard C Lippold Formulierungen von Wirkstoffen in Form einer festen Dispersion
IL134701A0 (en) 2000-02-23 2001-04-30 J P M E D Ltd Homogeneous solid matrix containing vegetable proteins
CN1235587C (zh) * 2002-12-12 2006-01-11 复旦大学 9－硝基喜树碱固体分散体及其制备方法
WO2008066899A2 (en) * 2006-11-28 2008-06-05 Marinus Pharmaceuticals Nanoparticulate formulations and methods for the making and use thereof
US20100233272A1 (en) * 2007-11-15 2010-09-16 Leah Elizabeth Appel Dosage forms comprising celecoxib providing both rapid and sustained pain relief
WO2011017835A1 (en) * 2009-08-11 2011-02-17 Nanjing University Preparation method of protein or peptide nanoparticles for in vivo drug delivery by unfolding and refolding
WO2011025771A1 (en) * 2009-08-25 2011-03-03 Biogen Idec Ma Inc. Compositions for delivery of insoluble agents
CN103732216A (zh) * 2011-08-16 2014-04-16 默沙东公司 无机基质和有机聚合物组合用于制备稳定的无定形分散体的用途
CN102327230B (zh) * 2011-09-30 2014-05-21 中国药科大学 一种包裹紫杉烷类药物的蛋白纳米颗粒及其制备方法
WO2015140736A1 (en) * 2014-03-18 2015-09-24 Izun Pharmaceuticals Corp. Protein-bound cannabinoid compositions
GB201416293D0 (en) 2014-09-15 2014-10-29 Solvotrin Therapeutics Ltd Methods and preparations

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003508482A (ja) 1999-09-03 2003-03-04 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 標的動物に対する水分布システムを通す水−不溶性薬品の投与のための獣医学的調合物
JP2007501219A (ja) 2003-08-04 2007-01-25 ファイザー・プロダクツ・インク 薬物及び重合体の固体無定形分散を形成するための噴霧乾燥（スプレードライ）方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Enhanced Dispersibility and Bioactivity of Curcumin by Encapsulation in Casein Nanocapsules，J. Agric. Food Chem.，2013年，Vol.61(25)，p.6036-6043

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