JP7086948B2 - ピリミド－ジアゼピノンキナーゼ骨格化合物およびｄｃｌｋ１／２媒介性障害の治療方法 - Google Patents

ピリミド－ジアゼピノンキナーゼ骨格化合物およびｄｃｌｋ１／２媒介性障害の治療方法 Download PDF

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JP7086948B2
JP7086948B2 JP2019520406A JP2019520406A JP7086948B2 JP 7086948 B2 JP7086948 B2 JP 7086948B2 JP 2019520406 A JP2019520406 A JP 2019520406A JP 2019520406 A JP2019520406 A JP 2019520406A JP 7086948 B2 JP7086948 B2 JP 7086948B2
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フルール エム． ファーガソン，
ナサナエル エス． グレイ，
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ダナ－ファーバー キャンサー インスティテュート，インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2019520406A 2016-10-18 2017-10-18 ピリミド－ジアゼピノンキナーゼ骨格化合物およびｄｃｌｋ１／２媒介性障害の治療方法 Active JP7086948B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662409457P 2016-10-18 2016-10-18
US62/409,457 2016-10-18
PCT/US2017/057126 WO2018075608A1 (en) 2016-10-18 2017-10-18 Pyrimido-diazepinone kinase scaffold compounds and methods of treating dclk1/2-mediated disorders

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JP2019530724A JP2019530724A (ja) 2019-10-24
JP2019530724A5 JP2019530724A5 (OSRAM) 2020-11-26
JP7086948B2 true JP7086948B2 (ja) 2022-06-20

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US (1) US11028089B2 (OSRAM)
EP (1) EP3528814B1 (OSRAM)
JP (1) JP7086948B2 (OSRAM)
AU (1) AU2017346845B2 (OSRAM)
CA (1) CA3040173A1 (OSRAM)
WO (1) WO2018075608A1 (OSRAM)

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US11155556B2 (en) * 2016-04-07 2021-10-26 Dana-Farber Cancer Institute, Inc. Pyrimido-diazepinone kinase scaffold compounds and methods for treating PI3K-mediated disorders
AU2018392805A1 (en) * 2017-12-22 2020-05-07 Dana-Farber Cancer Institute, Inc. NEK inhibitors and methods of use
WO2021024141A1 (en) * 2019-08-08 2021-02-11 Xiaoxiang Li Prevention or treatment of diseases and disorders associated with tissue damage
US20230135635A1 (en) * 2020-02-14 2023-05-04 Salk Institute For Biological Studies Inhibitors of ulk1/2 and methods of using same
CN116615429A (zh) * 2020-10-14 2023-08-18 珃诺生物医药科技(杭州)有限公司 用于靶向蛋白降解的方法和组合物
US20240254138A1 (en) * 2021-03-09 2024-08-01 Janssen Pharmaceutica Nv Tricyclic pyrimidines as cyclin-dependent kinase 7 (cdk7) inhibitors
CN115707469B (zh) * 2021-08-19 2024-07-02 首都医科大学附属北京朝阳医院 Dclk1抑制剂和tki在制备肺腺癌药物中的应用
CN114478539B (zh) * 2022-02-09 2024-02-02 中国人民解放军海军军医大学 一种新型dclk1抑制剂及其制备方法和应用
CN115969978A (zh) * 2022-10-27 2023-04-18 首都医科大学附属北京朝阳医院 Dclk1及il6/stat3通路抑制剂在治疗三阴性乳腺癌中的应用
CN115814094B (zh) * 2023-01-04 2024-04-02 暨南大学附属第一医院（广州华侨医院） Dclk抑制剂在制备治疗脊髓损伤的药物中的应用
CN116375713B (zh) * 2023-03-07 2024-11-19 中国人民解放军海军军医大学 一种dclk1蛋白降解靶向嵌合体及其应用

Citations (5)

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JP2012514601A (ja) 2009-01-06 2012-06-28 ダナ ファーバー キャンサー インスティテュート インコーポレイテッド ピリミド−ジアゼピノンキナーゼ骨格化合物及び疾患を治療する方法
US20140171422A1 (en) 2011-05-10 2014-06-19 Kyowa Hakko Kirin Co., Ltd. Pyrimidodiazepinone compound
WO2015117087A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
JP2016515537A (ja) 2013-03-15 2016-05-30 ダナ ファーバー キャンサー インスティテュート，インコーポレイテッド ピリミド−ジアゼピノン化合物および障害の治療方法
US20160176916A1 (en) 2014-12-23 2016-06-23 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules

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WO2014160430A1 (en) * 2013-03-13 2014-10-02 Georgetown University Small molecule lrrk2 and erk5 inhibitors
CN105940005A (zh) * 2014-01-31 2016-09-14 达纳-法伯癌症研究所股份有限公司 二氮杂环庚烷衍生物及其用途
MX2017001756A (es) * 2014-08-08 2017-05-30 Dana Farber Cancer Inst Inc Derivados de diazepano y sus usos.
JP6815318B2 (ja) * 2014-12-23 2021-01-20 ダナ−ファーバー キャンサー インスティテュート，インコーポレイテッド 二官能性分子によって標的化タンパク質分解を誘導する方法
MX387025B (es) * 2016-03-04 2025-03-19 Anhui New Star Pharmaceutical Dev Co Ltd Compuestos de anillo de siete miembros de pirimidina

Patent Citations (5)

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JP2012514601A (ja) 2009-01-06 2012-06-28 ダナ ファーバー キャンサー インスティテュート インコーポレイテッド ピリミド−ジアゼピノンキナーゼ骨格化合物及び疾患を治療する方法
US20140171422A1 (en) 2011-05-10 2014-06-19 Kyowa Hakko Kirin Co., Ltd. Pyrimidodiazepinone compound
JP2016515537A (ja) 2013-03-15 2016-05-30 ダナ ファーバー キャンサー インスティテュート，インコーポレイテッド ピリミド−ジアゼピノン化合物および障害の治療方法
WO2015117087A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Uses of diazepane derivatives
US20160176916A1 (en) 2014-12-23 2016-06-23 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules

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ACS Medicinal Chemistry Letters，2011年，Vol.2，p.195-200
Cancer Letters，2014年，Vol.351，p.151-161

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EP3528814B1 (en) 2024-08-14
CA3040173A1 (en) 2018-04-26
EP3528814A1 (en) 2019-08-28
AU2017346845A1 (en) 2019-04-04
JP2019530724A (ja) 2019-10-24
EP3528814A4 (en) 2020-07-29
AU2017346845B2 (en) 2021-12-02
WO2018075608A1 (en) 2018-04-26
US11028089B2 (en) 2021-06-08
US20190315753A1 (en) 2019-10-17

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