JP7078641B2 - 自己免疫疾患の治療のためのｒｎａ - Google Patents

自己免疫疾患の治療のためのｒｎａ Download PDF

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JP7078641B2
JP7078641B2 JP2019555957A JP2019555957A JP7078641B2 JP 7078641 B2 JP7078641 B2 JP 7078641B2 JP 2019555957 A JP2019555957 A JP 2019555957A JP 2019555957 A JP2019555957 A JP 2019555957A JP 7078641 B2 JP7078641 B2 JP 7078641B2
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cells
immunogenic
uridine
mrna
antigen
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JP2020516658A5 (https=
JP2020516658A (ja
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ウグル サヒン，
ゼバスティアン クライター，
クリスティーナ クリエンケ，
ユッタ ペチェンカ，
レナ マレーン クランツ，
ムスタファ ディケン，
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TRON Translationale Onkologie an der Universitaetsmedizin der Johannes Gutenberg Universitaet Mainz gGmbH
Biontech SE
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TRON Translationale Onkologie an der Universitaetsmedizin der Johannes Gutenberg Universitaet Mainz gGmbH
Biontech SE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0033—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being non-polymeric
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    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C12N15/101—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by chromatography, e.g. electrophoresis, ion-exchange, reverse phase
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/335—Modified T or U

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  • Chemical Kinetics & Catalysis (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2019555957A 2017-04-11 2018-04-10 自己免疫疾患の治療のためのｒｎａ Active JP7078641B2 (ja)

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JP2022082384A JP7444924B2 (ja) 2017-04-11 2022-05-19 自己免疫疾患の治療のためのｒｎａ
JP2024025246A JP2024059794A (ja) 2017-04-11 2024-02-22 自己免疫疾患の治療のためのｒｎａ

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EPPCT/EP2017/058651 2017-04-11
PCT/EP2017/058651 WO2018188730A1 (en) 2017-04-11 2017-04-11 Rna for treatment of autoimmune diseases
PCT/EP2018/059188 WO2018189193A1 (en) 2017-04-11 2018-04-10 Rna for treatment of autoimmune diseases

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JP2020516658A JP2020516658A (ja) 2020-06-11
JP2020516658A5 JP2020516658A5 (https=) 2021-09-09
JP7078641B2 true JP7078641B2 (ja) 2022-05-31

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JP2019555957A Active JP7078641B2 (ja) 2017-04-11 2018-04-10 自己免疫疾患の治療のためのｒｎａ
JP2022082384A Active JP7444924B2 (ja) 2017-04-11 2022-05-19 自己免疫疾患の治療のためのｒｎａ
JP2024025246A Pending JP2024059794A (ja) 2017-04-11 2024-02-22 自己免疫疾患の治療のためのｒｎａ

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JP2024025246A Pending JP2024059794A (ja) 2017-04-11 2024-02-22 自己免疫疾患の治療のためのｒｎａ

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US (2) US11701413B2 (https=)
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KR (2) KR20240042138A (https=)
CN (2) CN110719787B (https=)
AU (1) AU2018253352B2 (https=)
BR (1) BR112019020667A8 (https=)
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JP2024059794A (ja) * 2017-04-11 2024-05-01 バイオエヌテック エスエー 自己免疫疾患の治療のためのｒｎａ

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IL297419B2 (en) * 2020-04-22 2025-02-01 BioNTech SE Coronavirus vaccine
CN116710115A (zh) 2020-11-20 2023-09-05 思维疗法股份有限公司 用于优化的肽疫苗的组合物和方法
US11058751B1 (en) 2020-11-20 2021-07-13 Think Therapeutics, Inc. Compositions for optimized RAS peptide vaccines
US11161892B1 (en) 2020-12-07 2021-11-02 Think Therapeutics, Inc. Method of compact peptide vaccines using residue optimization
US11421015B2 (en) 2020-12-07 2022-08-23 Think Therapeutics, Inc. Method of compact peptide vaccines using residue optimization
CN115232825B (zh) * 2021-04-22 2023-09-26 中国人民解放军军事科学院军事医学研究院 一种基于1083骨架的新冠病毒疫苗
US11464842B1 (en) 2021-04-28 2022-10-11 Think Therapeutics, Inc. Compositions and method for optimized peptide vaccines using residue optimization
CN117750971A (zh) 2021-05-26 2024-03-22 易姆赛斯股份公司 治疗或预防自身免疫病的方法
AR126654A1 (es) 2021-06-29 2023-11-01 Imcyse Sa Péptidos y métodos para el tratamiento de neuromielitis óptica
CN113336862B (zh) * 2021-07-05 2022-03-01 广东省科学院动物研究所 一种抗多发性硬化的重组蛋白及其制备方法和用途
WO2023030635A1 (en) * 2021-09-02 2023-03-09 BioNTech SE Potency assay for therapeutic potential of coding nucleic acid
CN118369335A (zh) * 2022-01-06 2024-07-19 上海吉量医药工程有限公司 N1位修饰假尿嘧啶核苷及其在mRNA合成中的应用

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WO2016176330A1 (en) 2015-04-27 2016-11-03 The Trustees Of The University Of Pennsylvania Nucleoside-modified rna for inducing an adaptive immune response
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JP2024059794A (ja) * 2017-04-11 2024-05-01 バイオエヌテック エスエー 自己免疫疾患の治療のためのｒｎａ

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US20200061166A1 (en) 2020-02-27
DK3609529T3 (da) 2021-10-11
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WO2018188730A1 (en) 2018-10-18
US20230330198A1 (en) 2023-10-19
LT3609529T (lt) 2021-10-25
KR102824942B1 (ko) 2025-06-25
CN110719787B (zh) 2024-03-15
IL269793A (en) 2019-11-28
SI3609529T1 (sl) 2021-11-30
MX2019012144A (es) 2019-11-21
IL290980A (en) 2022-05-01
EP3981424A1 (en) 2022-04-13
CN118161602A (zh) 2024-06-11
RU2019135808A3 (https=) 2021-08-10
SMT202100572T1 (it) 2021-11-12
HRP20211559T1 (hr) 2022-01-21
SG11201909520VA (en) 2019-11-28
KR20240042138A (ko) 2024-04-01
EP3609529B1 (en) 2021-09-08
CN110719787A (zh) 2020-01-21
JP2020516658A (ja) 2020-06-11
AU2018253352B2 (en) 2025-04-10
IL269793B (en) 2022-04-01
PL3609529T3 (pl) 2021-12-13
KR20190134765A (ko) 2019-12-04
US11701413B2 (en) 2023-07-18
RS62582B1 (sr) 2021-12-31
JP7444924B2 (ja) 2024-03-06
PT3609529T (pt) 2021-10-14
RU2019135808A (ru) 2021-05-11
CA3059505A1 (en) 2018-10-18
HUE056871T2 (hu) 2022-04-28
EP3609529A1 (en) 2020-02-19
ES2893451T3 (es) 2022-02-09
JP2022110127A (ja) 2022-07-28
BR112019020667A8 (pt) 2022-08-16
WO2018189193A1 (en) 2018-10-18
JP2024059794A (ja) 2024-05-01
BR112019020667A2 (pt) 2020-05-05
SG10202111163VA (en) 2021-11-29
AU2018253352A1 (en) 2019-10-17

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