JP7066643B2 - エピジェネティクス解析の為の方法及びシステム - Google Patents

エピジェネティクス解析の為の方法及びシステム Download PDF

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JP7066643B2
JP7066643B2 JP2018566224A JP2018566224A JP7066643B2 JP 7066643 B2 JP7066643 B2 JP 7066643B2 JP 2018566224 A JP2018566224 A JP 2018566224A JP 2018566224 A JP2018566224 A JP 2018566224A JP 7066643 B2 JP7066643 B2 JP 7066643B2
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methylation
genomic
genome
epigenetic
entropy
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ピー フェインバーグ アンドリュー
グッティアス ジョン
ジー ジェンキンソン ウィリアム
ピュジャダス エリザベート
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Johns Hopkins University
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    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/30—Detection of binding sites or motifs
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding

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JP2018566224A 2016-06-16 2017-06-16 エピジェネティクス解析の為の方法及びシステム Active JP7066643B2 (ja)

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US201662351056P 2016-06-16 2016-06-16
US62/351,056 2016-06-16
PCT/US2017/037900 WO2017218908A2 (en) 2016-06-16 2017-06-16 Methods and system for epigenetic analysis

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JP2019522285A JP2019522285A (ja) 2019-08-08
JP2019522285A5 JP2019522285A5 (enExample) 2020-06-25
JP7066643B2 true JP7066643B2 (ja) 2022-05-13

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US (1) US20220076779A1 (enExample)
EP (1) EP3472358B1 (enExample)
JP (1) JP7066643B2 (enExample)
AU (1) AU2017285496B2 (enExample)
ES (1) ES2897550T3 (enExample)
WO (1) WO2017218908A2 (enExample)

Families Citing this family (13)

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Publication number Priority date Publication date Assignee Title
US11821027B2 (en) 2017-01-10 2023-11-21 Juno Therapeutics, Inc. Epigenetic analysis of cell therapy and related methods
CN110853706B (zh) * 2018-08-01 2022-07-22 中国科学院深圳先进技术研究院 一种整合表观遗传组学的肿瘤克隆组成构建方法及系统
CN109213833A (zh) * 2018-09-10 2019-01-15 成都四方伟业软件股份有限公司 二分类模型训练方法、数据分类方法及对应装置
CN110428319B (zh) * 2019-08-05 2021-04-27 深圳乐信软件技术有限公司 一种数据比对平台、方法、设备和存储介质
US11795495B1 (en) * 2019-10-02 2023-10-24 FOXO Labs Inc. Machine learned epigenetic status estimator
US11887698B2 (en) 2020-01-08 2024-01-30 Samsung Electronics Co., Ltd. Method and electronic device for building comprehensive genome scale metabolic model
CN112102878B (zh) * 2020-09-16 2024-01-26 张云鹏 一种LncRNA学习系统
CN114480655B (zh) * 2022-03-03 2024-07-16 北京起源聚禾生物科技有限公司 Dna甲基化标志物组合及应用、卵巢癌早期检测引物探针及试剂盒
EP4265738A4 (en) * 2022-03-03 2025-05-07 Beijing OriginPoly Bio-Tec Co., Ltd. Combination of DNA methylation markers and their use, primers, probes and kit for the early detection of ovarian cancer
CN115831217A (zh) * 2022-11-23 2023-03-21 四川大学 基于多模态融合的染色质拓扑关联结构域边界预测方法
WO2024137407A1 (en) * 2022-12-21 2024-06-27 The Johns Hopkins University Methods and targets of dna methylation entropy
WO2024173655A1 (en) * 2023-02-16 2024-08-22 Foundation Medicine, Inc. Classification of samples based on methylation analysis of dna fragments
CN116642819B (zh) * 2023-07-19 2023-10-10 江苏得康生物科技有限公司 细胞群的识别方法及其装置

Citations (3)

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US20100143929A1 (en) 2008-12-04 2010-06-10 Rush University Medical Center Dna methylation based test for monitoring efficacy of treatment
JP2014519319A (ja) 2011-05-12 2014-08-14 ザ・ジョンズ・ホプキンス・ユニバーシティー エピジェネティックドメインの安定性の全般的な損失を通して癌を検出する方法およびその組成物
JP2015536639A (ja) 2012-09-20 2015-12-24 ザ チャイニーズ ユニバーシティ オブ ホンコン 血漿による胎児または腫瘍のメチロームの非侵襲的決定

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US5695934A (en) 1994-10-13 1997-12-09 Lynx Therapeutics, Inc. Massively parallel sequencing of sorted polynucleotides
US5888737A (en) 1997-04-15 1999-03-30 Lynx Therapeutics, Inc. Adaptor-based sequence analysis
GB0507835D0 (en) 2005-04-18 2005-05-25 Solexa Ltd Method and device for nucleic acid sequencing using a planar wave guide
US7514952B2 (en) 2005-06-29 2009-04-07 Altera Corporation I/O circuitry for reducing ground bounce and VCC sag in integrated circuit devices
SG170802A1 (en) 2006-03-31 2011-05-30 Solexa Inc Systems and devices for sequence by synthesis analysis

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
US20100143929A1 (en) 2008-12-04 2010-06-10 Rush University Medical Center Dna methylation based test for monitoring efficacy of treatment
JP2014519319A (ja) 2011-05-12 2014-08-14 ザ・ジョンズ・ホプキンス・ユニバーシティー エピジェネティックドメインの安定性の全般的な損失を通して癌を検出する方法およびその組成物
JP2015536639A (ja) 2012-09-20 2015-12-24 ザ チャイニーズ ユニバーシティ オブ ホンコン 血漿による胎児または腫瘍のメチロームの非侵襲的決定

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Michael Stevens、ほか１０名，Estimating absolute methylation levels at single-CpG resolution from methylation enrichment and restriction enzyme sequencing methods，Genome Res. [ONLINE]，第２３巻，Cold Spring Harbor Laboratory Press，2013年09月，ｐ．１５４１－１５５３，https://genome.cshlp.org/content/23/9/1541.full.pdf，[検索日:2021年5月18日]

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EP3472358A2 (en) 2019-04-24
WO2017218908A2 (en) 2017-12-21
JP2019522285A (ja) 2019-08-08
EP3472358A4 (en) 2020-02-26
AU2017285496A1 (en) 2019-01-24
EP3472358B1 (en) 2021-08-18
ES2897550T3 (es) 2022-03-01
US20220076779A1 (en) 2022-03-10
AU2017285496B2 (en) 2023-02-23
WO2017218908A3 (en) 2018-01-18

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