JP2019522285A5 - - Google Patents
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- JP2019522285A5 JP2019522285A5 JP2018566224A JP2018566224A JP2019522285A5 JP 2019522285 A5 JP2019522285 A5 JP 2019522285A5 JP 2018566224 A JP2018566224 A JP 2018566224A JP 2018566224 A JP2018566224 A JP 2018566224A JP 2019522285 A5 JP2019522285 A5 JP 2019522285A5
- Authority
- JP
- Japan
- Prior art keywords
- methylation
- pel
- genomic
- genome
- modeled
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 230000011987 methylation Effects 0.000 claims 29
- 238000007069 methylation reaction Methods 0.000 claims 29
- 238000000034 method Methods 0.000 claims 20
- 238000009826 distribution Methods 0.000 claims 8
- 238000012163 sequencing technique Methods 0.000 claims 8
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 3
- 230000001973 epigenetic effect Effects 0.000 claims 3
- 108091029523 CpG island Proteins 0.000 claims 2
- 238000001712 DNA sequencing Methods 0.000 claims 2
- 108700009124 Transcription Initiation Site Proteins 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 108010077544 Chromatin Proteins 0.000 claims 1
- 108700024394 Exon Proteins 0.000 claims 1
- 101000782147 Homo sapiens WD repeat-containing protein 20 Proteins 0.000 claims 1
- 108091092195 Intron Proteins 0.000 claims 1
- 102000006835 Lamins Human genes 0.000 claims 1
- 108010047294 Lamins Proteins 0.000 claims 1
- 238000007476 Maximum Likelihood Methods 0.000 claims 1
- 108091023040 Transcription factor Proteins 0.000 claims 1
- 102000040945 Transcription factor Human genes 0.000 claims 1
- 238000013459 approach Methods 0.000 claims 1
- 238000001369 bisulfite sequencing Methods 0.000 claims 1
- 210000003483 chromatin Anatomy 0.000 claims 1
- 238000004590 computer program Methods 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 210000005053 lamin Anatomy 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 238000005192 partition Methods 0.000 claims 1
- 238000005381 potential energy Methods 0.000 claims 1
- 238000012175 pyrosequencing Methods 0.000 claims 1
- 238000013179 statistical model Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662351056P | 2016-06-16 | 2016-06-16 | |
| US62/351,056 | 2016-06-16 | ||
| PCT/US2017/037900 WO2017218908A2 (en) | 2016-06-16 | 2017-06-16 | Methods and system for epigenetic analysis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019522285A JP2019522285A (ja) | 2019-08-08 |
| JP2019522285A5 true JP2019522285A5 (enExample) | 2020-06-25 |
| JP7066643B2 JP7066643B2 (ja) | 2022-05-13 |
Family
ID=60664277
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018566224A Active JP7066643B2 (ja) | 2016-06-16 | 2017-06-16 | エピジェネティクス解析の為の方法及びシステム |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20220076779A1 (enExample) |
| EP (1) | EP3472358B1 (enExample) |
| JP (1) | JP7066643B2 (enExample) |
| AU (1) | AU2017285496B2 (enExample) |
| ES (1) | ES2897550T3 (enExample) |
| WO (1) | WO2017218908A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11821027B2 (en) | 2017-01-10 | 2023-11-21 | Juno Therapeutics, Inc. | Epigenetic analysis of cell therapy and related methods |
| CN110853706B (zh) * | 2018-08-01 | 2022-07-22 | 中国科学院深圳先进技术研究院 | 一种整合表观遗传组学的肿瘤克隆组成构建方法及系统 |
| CN109213833A (zh) * | 2018-09-10 | 2019-01-15 | 成都四方伟业软件股份有限公司 | 二分类模型训练方法、数据分类方法及对应装置 |
| CN110428319B (zh) * | 2019-08-05 | 2021-04-27 | 深圳乐信软件技术有限公司 | 一种数据比对平台、方法、设备和存储介质 |
| US11795495B1 (en) * | 2019-10-02 | 2023-10-24 | FOXO Labs Inc. | Machine learned epigenetic status estimator |
| US11887698B2 (en) | 2020-01-08 | 2024-01-30 | Samsung Electronics Co., Ltd. | Method and electronic device for building comprehensive genome scale metabolic model |
| CN112102878B (zh) * | 2020-09-16 | 2024-01-26 | 张云鹏 | 一种LncRNA学习系统 |
| CN114480655B (zh) * | 2022-03-03 | 2024-07-16 | 北京起源聚禾生物科技有限公司 | Dna甲基化标志物组合及应用、卵巢癌早期检测引物探针及试剂盒 |
| EP4265738A4 (en) * | 2022-03-03 | 2025-05-07 | Beijing OriginPoly Bio-Tec Co., Ltd. | Combination of DNA methylation markers and their use, primers, probes and kit for the early detection of ovarian cancer |
| CN115831217A (zh) * | 2022-11-23 | 2023-03-21 | 四川大学 | 基于多模态融合的染色质拓扑关联结构域边界预测方法 |
| WO2024137407A1 (en) * | 2022-12-21 | 2024-06-27 | The Johns Hopkins University | Methods and targets of dna methylation entropy |
| WO2024173655A1 (en) * | 2023-02-16 | 2024-08-22 | Foundation Medicine, Inc. | Classification of samples based on methylation analysis of dna fragments |
| CN116642819B (zh) * | 2023-07-19 | 2023-10-10 | 江苏得康生物科技有限公司 | 细胞群的识别方法及其装置 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5695934A (en) | 1994-10-13 | 1997-12-09 | Lynx Therapeutics, Inc. | Massively parallel sequencing of sorted polynucleotides |
| US5888737A (en) | 1997-04-15 | 1999-03-30 | Lynx Therapeutics, Inc. | Adaptor-based sequence analysis |
| GB0507835D0 (en) | 2005-04-18 | 2005-05-25 | Solexa Ltd | Method and device for nucleic acid sequencing using a planar wave guide |
| US7514952B2 (en) | 2005-06-29 | 2009-04-07 | Altera Corporation | I/O circuitry for reducing ground bounce and VCC sag in integrated circuit devices |
| SG170802A1 (en) | 2006-03-31 | 2011-05-30 | Solexa Inc | Systems and devices for sequence by synthesis analysis |
| US8497066B2 (en) * | 2008-12-04 | 2013-07-30 | Rush University Medical Center | DNA methylation based test for monitoring efficacy of treatment |
| AU2012253414B2 (en) * | 2011-05-12 | 2016-03-17 | The Johns Hopkins University | Method of detecting cancer through generalized loss of stability of epigenetic domains, and compositions thereof |
| FI4056712T3 (fi) * | 2012-09-20 | 2024-08-29 | Univ Hong Kong Chinese | Kasvaimen metyloomin nonivasiivinen määrittäminen plasmasta |
-
2017
- 2017-06-16 WO PCT/US2017/037900 patent/WO2017218908A2/en not_active Ceased
- 2017-06-16 ES ES17814184T patent/ES2897550T3/es active Active
- 2017-06-16 EP EP17814184.2A patent/EP3472358B1/en active Active
- 2017-06-16 US US16/310,176 patent/US20220076779A1/en active Pending
- 2017-06-16 JP JP2018566224A patent/JP7066643B2/ja active Active
- 2017-06-16 AU AU2017285496A patent/AU2017285496B2/en active Active
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