JP7062673B2 - 前立腺がんの治療 - Google Patents

前立腺がんの治療 Download PDF

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Publication number
JP7062673B2
JP7062673B2 JP2019538720A JP2019538720A JP7062673B2 JP 7062673 B2 JP7062673 B2 JP 7062673B2 JP 2019538720 A JP2019538720 A JP 2019538720A JP 2019538720 A JP2019538720 A JP 2019538720A JP 7062673 B2 JP7062673 B2 JP 7062673B2
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administration
oral
weeks
present disclosure
once
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JP2019538720A
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Japanese (ja)
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JP2019529574A (ja
JP2019529574A5 (cg-RX-API-DMAC7.html
Inventor
ラジャセクアール、ヴィジェイクマール、レディ
マーク ジョンソン、ブレンダン
ビー. マクリーン、デイヴィッド
シーリ、リン
エヌ. マッド、ジュニア、ポール
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Takeda Pharmaceutical Co Ltd
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Takeda Pharmaceutical Co Ltd
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Publication of JP2019529574A5 publication Critical patent/JP2019529574A5/ja
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41661,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2019538720A 2016-09-30 2017-09-29 前立腺がんの治療 Active JP7062673B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662402150P 2016-09-30 2016-09-30
US201662402004P 2016-09-30 2016-09-30
US62/402,150 2016-09-30
US62/402,004 2016-09-30
PCT/EP2017/074849 WO2018060463A2 (en) 2016-09-30 2017-09-29 Treatment of prostate cancer

Publications (3)

Publication Number Publication Date
JP2019529574A JP2019529574A (ja) 2019-10-17
JP2019529574A5 JP2019529574A5 (cg-RX-API-DMAC7.html) 2020-11-12
JP7062673B2 true JP7062673B2 (ja) 2022-05-06

Family

ID=60915459

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019538720A Active JP7062673B2 (ja) 2016-09-30 2017-09-29 前立腺がんの治療

Country Status (21)

Country Link
US (8) US10449191B2 (cg-RX-API-DMAC7.html)
EP (2) EP4520398A3 (cg-RX-API-DMAC7.html)
JP (1) JP7062673B2 (cg-RX-API-DMAC7.html)
CN (1) CN110248661A (cg-RX-API-DMAC7.html)
AU (2) AU2017334035B2 (cg-RX-API-DMAC7.html)
BR (1) BR112019006228A2 (cg-RX-API-DMAC7.html)
CA (1) CA3038875A1 (cg-RX-API-DMAC7.html)
DK (1) DK3518932T3 (cg-RX-API-DMAC7.html)
ES (1) ES3002857T3 (cg-RX-API-DMAC7.html)
FI (1) FI3518932T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20241740T1 (cg-RX-API-DMAC7.html)
HU (1) HUE070578T2 (cg-RX-API-DMAC7.html)
IL (3) IL308528A (cg-RX-API-DMAC7.html)
LT (1) LT3518932T (cg-RX-API-DMAC7.html)
MA (1) MA46361A (cg-RX-API-DMAC7.html)
MX (2) MX2019003733A (cg-RX-API-DMAC7.html)
NZ (1) NZ752918A (cg-RX-API-DMAC7.html)
PL (1) PL3518932T3 (cg-RX-API-DMAC7.html)
PT (1) PT3518932T (cg-RX-API-DMAC7.html)
SI (1) SI3518932T1 (cg-RX-API-DMAC7.html)
WO (1) WO2018060463A2 (cg-RX-API-DMAC7.html)

Families Citing this family (11)

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Publication number Priority date Publication date Assignee Title
LT3415517T (lt) 2012-09-28 2022-06-10 Takeda Pharmaceutical Company Limited Kristalinė 1-(4-(1-(2,6-difluorbenzil)-5-dimetilaminometil-3-(6-metoksipiridazin-3-il)-2,4-diokso-1,2,3,4- tetrahidrotieno(2,3-d)pirimidin-6-il)fenil)-3-metoksikarbamido forma
FI3518932T3 (fi) 2016-09-30 2025-02-03 Sumitomo Pharma Switzerland Gmbh Eturauhassyövän hoito
DK3518933T4 (da) 2016-09-30 2025-04-22 Takeda Pharmaceuticals Co Fremgangsmåder til behandling af uterusfibromer og endometriose
CN110194776B (zh) * 2019-06-27 2021-05-28 四川伊诺达博医药科技有限公司 一种瑞卢戈利的合成方法
CN115175912B (zh) * 2019-10-10 2025-04-11 住友制药瑞士有限公司 N-(4-(1-(2,6-二氟苄基)-5-((二甲基氨基)甲基)-3-(6-甲氧基-3-哒嗪基)-2,4-二氧代-1,2,3,4-四氢噻吩并[2,3-d]嘧啶-6-基)苯基)-n′-甲氧基脲的结晶溶剂化形式
CN115279769A (zh) * 2019-10-10 2022-11-01 梦欧文科学有限责任公司 N-(4-(1-(2,6-二氟苄基)-5-((二甲基氨基)甲基)-3-(6-甲氧基-3-哒嗪基)-2,4-二氧代-1,2,3,4-四氢噻吩并[2,3-d]嘧啶-6-基)苯基)-n’-甲氧基脲的结晶形式
BR112022023937A2 (pt) 2020-05-29 2022-12-27 Myovant Sciences Gmbh Formas de dosagem oral sólidas de combinação de antagonistas do hormônio liberador de gonadotropina
US20230384316A1 (en) * 2020-10-20 2023-11-30 Baylor College Of Medicine Multiplex metabolic markers in plasma for early detection of african american prostate cancer
WO2022101303A1 (en) 2020-11-11 2022-05-19 Myovant Sciences Gmbh Methods of administering relugolix
JP2024540922A (ja) 2021-10-18 2024-11-06 スミトモ ファーマ スウィッツァーランド ゲーエムベーハー N-(4-(1-(2,6-ジフルオロベンジル)-5-((ジメチルアミノ)メチル)-3-(6-メトキシ-3-ピリダジニル)-2,4-ジオキソ-1,2,3,4-テトラヒドロチエノ[2,3-d]ピリミジン-6-イル)フェニル)-N’-メトキシ尿素のエタノール溶媒和物の結晶形
WO2023152611A1 (en) * 2022-02-11 2023-08-17 Aragon Pharmaceuticals, Inc. Apalutamide and relugolix for the treatment of prostate cancer

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WO2016136849A1 (ja) 2015-02-26 2016-09-01 武田薬品工業株式会社 固形製剤

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FR2710637B1 (fr) 1993-09-28 1995-12-08 Roquette Freres Mannitol pulvérulent de friabilité modérée et son procédé de préparation.
TWI225863B (en) 1999-03-24 2005-01-01 Takeda Chemical Industries Ltd Thienopyrimidine compounds, their production and use
US6297379B1 (en) 1999-03-24 2001-10-02 Takeda Chemical Industries, Ltd. Thienopyrimidine compounds, their production and use
CN1539836A (zh) 2000-02-29 2004-10-27 武田药品工业株式会社 制备噻吩并嘧啶衍生物的方法
WO2003057689A1 (en) 2002-01-02 2003-07-17 Fujisawa Pharmaceutical Co., Ltd. Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them
EP1479684A4 (en) 2002-01-30 2006-01-04 Takeda Pharmaceutical THIENOPYRIMIDINES, METHODS OF MAKING AND USING SAME
EP1480679B1 (en) 2002-02-26 2007-05-23 Astrazeneca AB Pharmaceutical formulation of iressa comprising a water-soluble cellulose derivative
EP1591446B1 (en) 2003-01-29 2013-03-06 Takeda Pharmaceutical Company Limited Thienopyrimidine compounds and use thereof
ATE407679T1 (de) 2003-07-07 2008-09-15 Neurocrine Biosciences Inc Pyrimidin-2,4-dion-derivate als gonadotropin freisetzende hormon-rezeptor-antagonisten
JPWO2007011072A1 (ja) 2005-07-22 2009-02-05 武田薬品工業株式会社 早発排卵の防止剤
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FI3518932T3 (fi) 2016-09-30 2025-02-03 Sumitomo Pharma Switzerland Gmbh Eturauhassyövän hoito

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Also Published As

Publication number Publication date
IL300071A (en) 2023-03-01
CN110248661A (zh) 2019-09-17
US20200129507A1 (en) 2020-04-30
DK3518932T3 (da) 2025-01-27
JP2019529574A (ja) 2019-10-17
AU2017334035B2 (en) 2022-11-24
IL308528A (en) 2024-01-01
FI3518932T3 (fi) 2025-02-03
PT3518932T (pt) 2025-01-16
HRP20241740T1 (hr) 2025-02-28
SI3518932T1 (sl) 2025-03-31
ES3002857T3 (en) 2025-03-07
US12336990B2 (en) 2025-06-24
US12144809B1 (en) 2024-11-19
US20250332166A1 (en) 2025-10-30
IL265697B1 (en) 2023-03-01
AU2017334035A1 (en) 2019-05-16
LT3518932T (lt) 2025-02-10
EP3518932A2 (en) 2019-08-07
EP4520398A2 (en) 2025-03-12
US20210205303A1 (en) 2021-07-08
PL3518932T3 (pl) 2025-04-07
IL265697A (en) 2019-05-30
MA46361A (fr) 2021-03-31
US20220401443A1 (en) 2022-12-22
BR112019006228A2 (pt) 2019-06-18
US11583526B2 (en) 2023-02-21
EP4520398A3 (en) 2025-04-02
CA3038875A1 (en) 2018-04-05
AU2023201047A1 (en) 2023-03-23
NZ752918A (en) 2022-09-30
US10449191B2 (en) 2019-10-22
WO2018060463A3 (en) 2018-05-11
EP3518932B1 (en) 2024-11-13
HUE070578T2 (hu) 2025-06-28
US12097198B2 (en) 2024-09-24
WO2018060463A2 (en) 2018-04-05
US20190224196A1 (en) 2019-07-25
AU2023201047B2 (en) 2025-04-03
US20250082632A1 (en) 2025-03-13
US20240358700A1 (en) 2024-10-31
US10786501B2 (en) 2020-09-29
MX2023001468A (es) 2023-03-03
US20250057839A1 (en) 2025-02-20
IL265697B2 (en) 2023-07-01
MX2019003733A (es) 2019-09-26

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