JP7054694B2 - 誘導性カスパーゼおよび使用方法 - Google Patents

誘導性カスパーゼおよび使用方法 Download PDF

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JP7054694B2
JP7054694B2 JP2019518451A JP2019518451A JP7054694B2 JP 7054694 B2 JP7054694 B2 JP 7054694B2 JP 2019518451 A JP2019518451 A JP 2019518451A JP 2019518451 A JP2019518451 A JP 2019518451A JP 7054694 B2 JP7054694 B2 JP 7054694B2
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エリック オスタータグ，
デボン シェドロック，
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ポセイダ セラピューティクス， インコーポレイテッド
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    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C12N9/10—Transferases (2.)
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    • C12Y304/22—Cysteine endopeptidases (3.4.22)
    • C12Y304/22062—Caspase-9 (3.4.22.62)
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    • C12Y304/22—Cysteine endopeptidases (3.4.22)
    • C12Y304/22036—Caspase-1 (3.4.22.36), i.e. interleukin-1-beta-convertase

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JP2019518451A 2016-10-06 2017-10-06 誘導性カスパーゼおよび使用方法 Active JP7054694B2 (ja)

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Application Number Priority Date Filing Date Title
US201662405184P 2016-10-06 2016-10-06
US62/405,184 2016-10-06
PCT/US2017/055661 WO2018068022A1 (en) 2016-10-06 2017-10-06 Inducible caspases and methods for use

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JP2019528774A JP2019528774A (ja) 2019-10-17
JP2019528774A5 JP2019528774A5 (cg-RX-API-DMAC7.html) 2020-10-08
JP7054694B2 true JP7054694B2 (ja) 2022-04-14

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EP (2) EP3523325B1 (cg-RX-API-DMAC7.html)
JP (1) JP7054694B2 (cg-RX-API-DMAC7.html)
KR (1) KR102447083B1 (cg-RX-API-DMAC7.html)
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AU (1) AU2017339511B2 (cg-RX-API-DMAC7.html)
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EP3523325B1 (en) 2016-10-06 2025-08-06 Poseida Therapeutics, Inc. Inducible caspases and methods for use
WO2020037142A1 (en) 2018-08-17 2020-02-20 Yale University Compositions and methods for high-throughput activation screening to boost t cell effector function
US20220042038A1 (en) 2018-12-20 2022-02-10 Poseida Therapeutics, Inc. Nanotransposon compositions and methods of use
JP2022547866A (ja) 2019-09-05 2022-11-16 ポセイダ セラピューティクス，インコーポレイティド 同種異系細胞組成物と使用方法
KR20220117915A (ko) 2019-12-20 2022-08-24 포세이다 테라퓨틱스, 인크. 항-muc1 조성물 및 사용 방법
US20230121433A1 (en) 2020-03-11 2023-04-20 Poseida Therapeutics, Inc. Chimeric stimulatory receptors and methods of use in t cell activation and differentiation
US20240060090A1 (en) 2021-02-23 2024-02-22 Poseida Therapeutics, Inc. Genetically modified induced pluripotent stem cells and methods of use thereof
CA3233506A1 (en) 2021-10-04 2023-04-13 Joseph S. LUCAS Transposon compositions and methods of use thereof
CN113999873B (zh) * 2021-12-31 2022-05-20 北京市疾病预防控制中心 一种基因修饰的非人动物的构建方法及其应用
CN114736306B (zh) * 2022-03-01 2024-04-19 中国科学院深圳先进技术研究院 一种受化学调控的蛋白酶工具及其配套底物
US20250228940A1 (en) * 2022-03-11 2025-07-17 Yale University Compositions and methods for efficient and stable genetic modification of eukaryotic cells
CN118185901B (zh) * 2022-12-12 2025-03-21 北京精缮生物科技有限责任公司 一种PBase蛋白、融合蛋白、核酸和基因整合系统及应用
IL322767A (en) 2023-02-21 2025-10-01 Poseida Therapeutics Inc Genome editing vehicles and methods
EP4669746A1 (en) 2023-02-21 2025-12-31 Poseida Therapeutics, Inc. COMPOSITIONS AND GENOMIC EDITING PROCESSES
CN121195065A (zh) 2023-04-05 2025-12-23 波西达治疗公司 转座酶多核苷酸及其用途
AU2024317892A1 (en) * 2023-07-29 2025-08-28 Limited Liability Company «Genetic Technologies» (Llc «Genetic Technologies») Adeno-associated virus-based expression vectors
WO2025038655A1 (en) 2023-08-14 2025-02-20 Ponce Therapeutics, Inc. Multimerizer pharmaceutical compositions of rimiducid

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