JP7046016B2 - Herv-e反応性t細胞受容体および使用方法 - Google Patents
Herv-e反応性t細胞受容体および使用方法 Download PDFInfo
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- JP7046016B2 JP7046016B2 JP2018567933A JP2018567933A JP7046016B2 JP 7046016 B2 JP7046016 B2 JP 7046016B2 JP 2018567933 A JP2018567933 A JP 2018567933A JP 2018567933 A JP2018567933 A JP 2018567933A JP 7046016 B2 JP7046016 B2 JP 7046016B2
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- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/32—T-cell receptors [TCR]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/46—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/56—Kidney
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/51—B7 molecules, e.g. CD80, CD86, CD28 (ligand), CD152 (ligand)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/10041—Use of virus, viral particle or viral elements as a vector
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Developmental Biology & Embryology (AREA)
- Peptides Or Proteins (AREA)
- Prostheses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662357265P | 2016-06-30 | 2016-06-30 | |
| US62/357,265 | 2016-06-30 | ||
| PCT/US2017/040448 WO2018006054A1 (en) | 2016-06-30 | 2017-06-30 | Herv-e reactive t cell receptors and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019522984A JP2019522984A (ja) | 2019-08-22 |
| JP2019522984A5 JP2019522984A5 (enExample) | 2020-08-06 |
| JP7046016B2 true JP7046016B2 (ja) | 2022-04-01 |
Family
ID=59381696
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018567933A Active JP7046016B2 (ja) | 2016-06-30 | 2017-06-30 | Herv-e反応性t細胞受容体および使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US11779603B2 (enExample) |
| EP (1) | EP3478711B1 (enExample) |
| JP (1) | JP7046016B2 (enExample) |
| KR (1) | KR102461926B1 (enExample) |
| CN (1) | CN109415429B (enExample) |
| AU (1) | AU2017286982B2 (enExample) |
| DK (1) | DK3478711T3 (enExample) |
| NZ (1) | NZ749585A (enExample) |
| WO (1) | WO2018006054A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111100185A (zh) * | 2018-10-26 | 2020-05-05 | 上海锐赛生物技术有限公司 | Ct-rcc herv-e来源的ctl表位肽、肽库及其应用 |
| CN113710697A (zh) | 2019-03-15 | 2021-11-26 | 美国政府(由卫生和人类服务部的部长所代表) | 嵌合衔接子和激酶信号传导蛋白及其在免疫疗法中的用途 |
| WO2021194495A1 (en) | 2020-03-26 | 2021-09-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Cd28h domain-containing chimeric antigen receptors and methods of use |
| WO2023044304A1 (en) | 2021-09-15 | 2023-03-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Chimeric adaptor and kinase signaling proteins and their use in immunotherapy |
| WO2025064539A1 (en) * | 2023-09-19 | 2025-03-27 | The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services | Herv-e antibodies and methods of their use |
| CN118620059B (zh) * | 2024-02-21 | 2025-08-15 | 北京永泰瑞科生物科技有限公司 | 一种t细胞抗原受体及其制备方法和其应用 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012038055A1 (en) | 2010-09-20 | 2012-03-29 | Unicell Gmbh | Antigen-specific t cell receptors and t cell epitopes |
| JP2013176373A (ja) | 2007-03-23 | 2013-09-09 | Shizuoka Prefecture | T細胞レセプターβ鎖遺伝子及びα鎖遺伝子 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| EP1224291A1 (en) * | 1999-10-28 | 2002-07-24 | Universite De Geneve | Multiple sclerosis-related superantigen |
| DE10019075B4 (de) * | 2000-04-18 | 2007-01-18 | Vision 7 Gmbh | Verwendung von CD34 oder einem davon abgeleiteten Polypeptid als Zell-Oberflächen- bzw. Gentransfer-Marker |
| US7820174B2 (en) * | 2006-02-24 | 2010-10-26 | The United States Of America As Represented By The Department Of Health And Human Services | T cell receptors and related materials and methods of use |
| WO2007109583A2 (en) * | 2006-03-17 | 2007-09-27 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Compositions and methods for prevention or treatment of neoplastic disease in a mammalian subject |
| SG173997A1 (en) * | 2006-07-21 | 2011-09-29 | Univ California | Human endogenous retrovirus polypeptide compositions and methods of use thereof |
| CN101528926A (zh) | 2006-08-18 | 2009-09-09 | 肿瘤疗法科学股份有限公司 | 过表达reg4或kiaa0101的癌症的治疗或预防 |
| JO3257B1 (ar) * | 2009-09-02 | 2018-09-16 | Novartis Ag | مركبات وتركيبات كمعدلات لفاعلية tlr |
-
2017
- 2017-06-30 DK DK17742333.2T patent/DK3478711T3/da active
- 2017-06-30 NZ NZ749585A patent/NZ749585A/en unknown
- 2017-06-30 WO PCT/US2017/040448 patent/WO2018006054A1/en not_active Ceased
- 2017-06-30 AU AU2017286982A patent/AU2017286982B2/en active Active
- 2017-06-30 CN CN201780040513.7A patent/CN109415429B/zh active Active
- 2017-06-30 EP EP17742333.2A patent/EP3478711B1/en active Active
- 2017-06-30 US US16/313,712 patent/US11779603B2/en active Active
- 2017-06-30 JP JP2018567933A patent/JP7046016B2/ja active Active
- 2017-06-30 KR KR1020187037984A patent/KR102461926B1/ko active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013176373A (ja) | 2007-03-23 | 2013-09-09 | Shizuoka Prefecture | T細胞レセプターβ鎖遺伝子及びα鎖遺伝子 |
| WO2012038055A1 (en) | 2010-09-20 | 2012-03-29 | Unicell Gmbh | Antigen-specific t cell receptors and t cell epitopes |
Non-Patent Citations (3)
| Title |
|---|
| DEBETS RENO,TCR-ENGINEERED T CELLS TO TREAT TUMORS: SEEING BUT NOT TOUCHING?,SEMINARS IN IMMUNOLOGY,2016年03月17日,VOL:28, NR:1,PAGE(S):10 - 21,http://dx.doi.org/10.1016/j.smim.2016.03.002 |
| KIRSCH ILAN,T-CELL RECEPTOR PROFILING IN CANCER,MOLECULAR ONCOLOGY,2015年09月15日,VOL:9, NR:10,PAGE(S):2063 - 2070,https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528728/pdf/MOL2-9-2063.pdf |
| YOSHIYUKI TAKAHASHI,REGRESSION OF HUMAN KIDNEY CANCER FOLLOWING ALLOGENEIC STEM CELL TRANSPLANTATION IS ASSOCIATED WITH RECOGNITION OF AN HERV-E ANTIGEN BY T CELLS,JOURNAL OF CLINICAL INVESTIGATION,米国,2008年03月03日,VOL:118,NR:3,PAGE(S):1099-1109,https://www.jci.org/articles/view/34409/pdf |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2019522984A (ja) | 2019-08-22 |
| KR20190058389A (ko) | 2019-05-29 |
| US20190231821A1 (en) | 2019-08-01 |
| DK3478711T3 (da) | 2022-12-12 |
| US11779603B2 (en) | 2023-10-10 |
| KR102461926B1 (ko) | 2022-11-02 |
| AU2017286982B2 (en) | 2022-10-13 |
| NZ749585A (en) | 2023-02-24 |
| CN109415429A (zh) | 2019-03-01 |
| CN109415429B (zh) | 2023-04-28 |
| WO2018006054A1 (en) | 2018-01-04 |
| EP3478711B1 (en) | 2022-10-12 |
| AU2017286982A1 (en) | 2019-01-17 |
| EP3478711A1 (en) | 2019-05-08 |
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