JP7045985B2 - Ｅｚｈ２阻害剤を用いた髄芽腫の処置方法 - Google Patents

Ｅｚｈ２阻害剤を用いた髄芽腫の処置方法 Download PDF

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JP7045985B2
JP7045985B2 JP2018517399A JP2018517399A JP7045985B2 JP 7045985 B2 JP7045985 B2 JP 7045985B2 JP 2018517399 A JP2018517399 A JP 2018517399A JP 2018517399 A JP2018517399 A JP 2018517399A JP 7045985 B2 JP7045985 B2 JP 7045985B2
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ezh2
medulloblastoma
cells
pharmaceutical composition
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JP2018529742A5 (enExample
JP2018529742A (ja
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キールハック ハイク
ジェイ． ウォーターズ ナイジェル
ヴィブハカール ラジーバ
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エピザイム，インコーポレイティド
ザ・レジェンツ・オブ・ザ・ユニバーシティー・オブ・コロラド，ア・ボディー・コーポレイト
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
JP2018517399A 2015-10-06 2016-10-05 Ｅｚｈ２阻害剤を用いた髄芽腫の処置方法 Expired - Fee Related JP7045985B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562238074P 2015-10-06 2015-10-06
US62/238,074 2015-10-06
US201662299312P 2016-02-24 2016-02-24
US62/299,312 2016-02-24
PCT/US2016/055554 WO2017062495A2 (en) 2015-10-06 2016-10-05 Method of treating medulloblastoma with an ezh2 inhibitor

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JP2018529742A JP2018529742A (ja) 2018-10-11
JP2018529742A5 JP2018529742A5 (enExample) 2019-11-07
JP7045985B2 true JP7045985B2 (ja) 2022-04-01

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US (2) US20190083504A1 (enExample)
EP (2) EP3371175A4 (enExample)
JP (1) JP7045985B2 (enExample)
KR (1) KR20180058829A (enExample)
CN (1) CN108699046A (enExample)
AU (3) AU2016333982A1 (enExample)
CA (1) CA3000983A1 (enExample)
EA (1) EA201890878A1 (enExample)
IL (2) IL258510A (enExample)
MX (1) MX394355B (enExample)
SG (1) SG10201909413SA (enExample)
WO (1) WO2017062495A2 (enExample)

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BR112015008447A2 (pt) 2012-10-15 2017-07-04 Epizyme Inc métodos para tratar câncer
KR20180042356A (ko) 2015-08-24 2018-04-25 에피자임, 인코포레이티드 암 치료 방법
WO2017132518A1 (en) 2016-01-29 2017-08-03 Epizyme, Inc. Combination therapy for treating cancer
JP7121660B2 (ja) 2016-06-01 2022-08-18 エピザイム，インコーポレイティド 癌を処置するためのｅｚｈ２阻害剤の使用
WO2017218953A1 (en) 2016-06-17 2017-12-21 Epizyme, Inc. Ezh2 inhibitors for treating cancer
WO2018183885A1 (en) 2017-03-31 2018-10-04 Epizyme, Inc. Combination therapy for treating cancer
AU2018275123A1 (en) 2017-06-02 2020-01-30 Epizyme, Inc. Use of EZH2 inhibitors for treating cancer
MA49651A (fr) 2017-07-19 2021-04-28 Childrens Medical Center Compositions et procédés pour traiter des maladies associées à un défaut d'empreinte
US11452727B2 (en) 2017-09-05 2022-09-27 Epizyme, Inc. Combination therapy for treating cancer
US20220298510A1 (en) * 2019-06-03 2022-09-22 Icahn School Of Medicine At Mount Sinai Compounds and methods for inhibiting cancers via rest inhibition
CN111905102A (zh) * 2020-09-04 2020-11-10 福建医科大学附属第一医院 Ezh2抑制剂在治疗胶质瘤中的应用
KR102821233B1 (ko) 2022-02-10 2025-06-17 서울대학교병원 Hsp70을 표적으로 하는 수모세포종 치료 및 전이 억제 방법

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WO2014062720A3 (en) 2012-10-15 2014-06-19 Epizyme, Inc. Methods of treating cancer

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US4236945A (en) * 1978-11-27 1980-12-02 Allegheny Ludlum Steel Corporation Phosphorus-iron powder and method of producing soft magnetic material therefrom
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
WO2011140325A1 (en) * 2010-05-07 2011-11-10 Glaxosmithkline Llc Indazoles
SG185431A1 (en) 2010-05-07 2012-12-28 Glaxosmithkline Llc Indoles
JO3438B1 (ar) 2011-04-13 2019-10-20 Epizyme Inc مركبات بنزين مستبدلة بأريل أو أريل غير متجانس
EP2953941B1 (en) 2013-02-11 2017-04-05 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
JP5989805B2 (ja) 2012-02-10 2016-09-07 コンステレーション・ファーマシューティカルズ・インコーポレイテッドＣｏｎｓｔｅｌｌａｔｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． メチル基変更酵素の調節物質、組成物及びその使用
KR102473113B1 (ko) * 2013-12-06 2022-12-01 에피자임, 인코포레이티드 암 치료를 위한 병용 요법
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Patent Citations (1)

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Non-Patent Citations (2)

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ACS Med Chem Lett，2015年03月04日，Vol.6，pp.491-495
Front Oncol，2014年，Vol.4, No.176，pp.1-8

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Publication number Publication date
EP4309738A3 (en) 2024-07-17
MX394355B (es) 2025-03-24
EP4309738A2 (en) 2024-01-24
AU2016333982A1 (en) 2018-04-26
MX2018004132A (es) 2018-09-26
EP3371175A2 (en) 2018-09-12
EA201890878A1 (ru) 2018-08-31
JP2018529742A (ja) 2018-10-11
SG10201909413SA (en) 2019-11-28
CN108699046A (zh) 2018-10-23
AU2021204331A1 (en) 2021-07-22
IL258510A (en) 2018-05-31
KR20180058829A (ko) 2018-06-01
US20200268765A1 (en) 2020-08-27
IL281318A (en) 2021-04-29
AU2023246384A1 (en) 2023-11-02
CA3000983A1 (en) 2017-04-13
EP3371175A4 (en) 2019-09-25
WO2017062495A2 (en) 2017-04-13
WO2017062495A3 (en) 2017-06-08
US20190083504A1 (en) 2019-03-21

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