JP7044540B2 - Skin cleansing composition - Google Patents

Description

The present invention relates to a skin cleansing composition. More specifically, the present invention relates to a skin cleansing composition containing miconazole and / or a salt thereof and water, in which the formation of precipitates is suppressed.

Miconazole nitrate is a kind of imidazole antifungal agent and is widely used as an active ingredient of pharmaceuticals, quasi-drugs or cosmetics. For example, Patent Document 1 discloses a cleaning composition having antifungal activity, which contains miconazole nitrate.

Miconazole nitrate is a crystalline powder and is sparingly soluble in various solvents such as water. Therefore, a pharmaceutical formulation that suppresses the precipitation of miconazole nitrate has been studied. For example, Patent Document 2 provides excellent pharmaceutical stability by blending acylated hydrolyzed collagen in hair cosmetics containing an azole antifungal agent such as miconazole nitrate and a cationic surfactant. Is disclosed. Further, Patent Document 3 describes excellent formulation stability of hair cosmetics containing an azole antifungal agent such as miconazole nitrate and a cationic surfactant by setting the pH to 3.0 to 5.5. Is disclosed to be equipped with.

Japanese Unexamined Patent Publication No. 2007-277227 Japanese Unexamined Patent Publication No. 2011-032212 Japanese Unexamined Patent Publication No. 2011-032213

The pharmaceutical formulations described in Patent Document 2 and Patent Document 3 are specialized for hair cosmetics containing a cationic surfactant. However, since the cationic surfactant has strong skin irritation, it is not preferable to apply the formulation to the skin cleansing composition. Therefore, it is required to develop a technique for improving the formulation stability of the skin cleansing composition by a new formulation design.

Therefore, an object of the present invention is to provide a skin cleansing composition containing mimiconazole and / or a salt thereof but in which the formation of precipitates is suppressed.

The present inventor has made diligent studies to solve the above problems, and when isopropylmethylphenol and dipotassium glycyrrhizinate are mixed alone, a precipitate of a skin cleansing composition containing miconazole nitrate is likely to be formed. Nevertheless, it has been found that the combination of both of them suppresses the formation of precipitates in the skin cleansing composition containing miconazole nitrate. The present invention has been completed by further studies based on such findings.

That is, the present invention provides the inventions of the following aspects.
Item 1. A skin cleansing composition comprising (A) miconazole and / or a salt thereof, (B) isopropylmethylphenol, (C) glycyrrhizic acid, a derivative thereof, and / or a salt thereof, and (D) water.
Item 2. Item 2. The skin cleansing composition according to Item 1, further comprising (E) a surfactant.
Item 3. Item 2. The skin cleansing composition according to Item 1, wherein the component (E) is at least one selected from the group consisting of an anionic surfactant, a nonionic surfactant, and an amphoteric surfactant.
Item 4. A method for suppressing the formation of precipitates in a skin cleansing composition containing (A) miconazole and / or a salt thereof and (D) water.
Precipitate formation in which (B) isopropylmethylphenol and (C) glycyrrhizic acid, a derivative thereof, and / or a salt thereof are blended with the component (A) and the component (D) for skin cleansing. How to suppress.

The skin cleansing composition of the present invention can suppress the formation of precipitates while containing miconazole and / or a salt thereof.

1. 1. Skin cleansing composition The skin cleansing composition of the present invention comprises (A) myconazole and / or a salt thereof (hereinafter, may be referred to as (A) component) and (B) isopropylmethylphenol (hereinafter, (hereinafter, (). (B) component), (C) glycyrrhizinic acid, derivatives thereof, and / or salts thereof (hereinafter, may be referred to as (C) component), and (D) water (hereinafter, referred to as component). (D) It may be referred to as a component). Hereinafter, the skin cleansing composition of the present invention will be described in detail.

(A) Miconazole and / or a salt thereof The composition for skin cleansing of the present invention contains miconazole and / or a salt thereof as a component (A). Miconazole and / or a salt thereof is a known agent as an imidazole antifungal agent having a bactericidal effect against fungi.

Miconazole is a compound also called 1- [2,4-dichloro-β-[(2,4-dichlorobenzyl) oxy] phenethyl] imidazole. The salt of myconazole is not particularly limited as long as it is pharmaceutically acceptable, and specific examples thereof include salts of inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, and phosphoric acid. These salts may be used alone or in combination of two or more.

In the skin cleansing composition of the present invention, as the component (A), one of miconazole and the salt of miconazole may be selected and used, or two or more thereof may be used in combination. Among these components (A), a salt of miconazole is preferable, and a salt of miconazole nitrate is more preferable.

In the skin cleansing composition of the present invention, the content of the component (A) is not particularly limited and may be appropriately set according to the medicinal effect to be imparted. For example, the total amount of the component (A) is 0. 1 to 20% by weight is mentioned. From the viewpoint of better obtaining medicinal properties and inhibitory properties of precipitates, the content of the component (A) is preferably 0.2 to 15% by weight, more preferably 0.5 to the total amount of the component (A). 10% by weight is mentioned.

(B) Isopropylmethylphenol The skin cleansing composition of the present invention contains isopropylmethylphenol as a component (B). By blending the component (B) together with the component (C), the solubility of the component (A) can be enhanced and the formation of precipitates in the skin cleansing composition can be suppressed.

Isopropylmethylphenol is a compound also called 4-isopropyl-3-methylphenol, which is a known drug known to have a bactericidal action.

In the skin cleansing composition of the present invention, the content of the component (B) is not particularly limited and may be appropriately set according to the medicinal effect to be imparted, and examples thereof include 0.01 to 10% by weight. .. From the viewpoint of better obtaining the inhibitory property of precipitate formation in the skin cleansing composition of the present invention, the content of the component (B) is preferably 0.05 to 8% by weight, more preferably 0.05 to. 5% by weight is mentioned.

In the skin cleansing composition of the present invention, the ratio of the component (B) to the component (A) is not particularly limited, but from the viewpoint of better obtaining the inhibitory property of precipitate formation, per part by weight of the component (A). , (B) component is, for example, 0.01 to 1 part by weight, preferably 0.05 to 0.5 part by weight, and more preferably 0.1 to 0.2 part by weight.

(C) Glycyrrhizic acid, a derivative thereof, and / or a salt thereof The composition for skin cleansing of the present invention contains glycyrrhizic acid, a derivative thereof, and / or a salt thereof as a component (C).

Glycyrrhizic acid is a known drug known to have anti-inflammatory action, antiallergic action and the like.

The derivative of glycyrrhizic acid is not particularly limited as long as it is pharmaceutically acceptable, and specific examples thereof include methyl glycyrrhizinate and stearyl glycyrrhizinate. These derivatives of glycyrrhizic acid may be used alone or in combination of two or more.

The salt of glycyrrhizinic acid and / or a derivative thereof is not particularly limited as long as it is pharmaceutically acceptable, and specific examples thereof include alkali metal salts such as sodium salt and potassium salt; ammonium salts and the like. .. These salts may be used alone or in combination of two or more.

In the skin cleaning composition of the present invention, one of glycyrrhizic acid, a salt of glycyrrhizic acid, a derivative of glycyrrhizic acid, and a salt of a derivative of glycyrrhizic acid may be selected and used as the component (C). Two or more kinds may be used in combination.

Among these components (C), glycyrrhizic acid and a salt of glycyrrhizic acid are preferable; a salt of glycyrrhizic acid is more preferable; and dipotassium glycyrrhizinate is even more preferable.

In the skin cleansing composition of the present invention, the content of the component (C) is not particularly limited and may be appropriately set according to the medicinal effect to be imparted. For example, the total amount of the component (A) may be used. 0.01 to 10% by weight is mentioned. From the viewpoint of better obtaining the inhibitory property of precipitate formation in the skin cleansing composition of the present invention, the content of the component (C) is preferably 0.05 to 8% by weight, more preferably 0.05 to. 5% by weight is mentioned.

In the skin cleansing composition of the present invention, the ratio of the component (C) to the component (A) is not particularly limited, but from the viewpoint of better obtaining the inhibitory property of precipitate formation, per part by weight of the component (A). , (C) component is, for example, 0.01 to 1 part by weight, preferably 0.05 to 0.5 part by weight, and more preferably 0.1 to 0.4 part by weight.

(D) Water The skin cleansing composition of the present invention contains water as a base. The component (A) is sparingly soluble in water and causes precipitation formation in the aqueous composition, but according to the skin cleansing composition of the present invention, such precipitation formation can be suppressed.

In the skin cleansing composition of the present invention, the content of the component (D) is appropriately set according to the formulation form and the like, and is, for example, 30 to 98% by weight, preferably 40 to 95% by weight, more preferably. Is 50 to 93% by weight.

(E) Surfactant The skin cleansing composition of the present invention contains a surfactant as a component (E). The surfactant is not particularly limited, but preferably an anionic surfactant, a nonionic surfactant, and an amphoteric surfactant are mentioned from the viewpoint of suppressing irritation to the skin. As the surfactant, one of anionic surfactant, nonionic surfactant, and amphoteric surfactant may be used alone, or two or more thereof may be used in any combination. .. In addition, examples of the surfactant include anionic surfactants and amphoteric surfactants from the viewpoint of more preferably suppressing the formation of precipitates in the skin cleaning composition of the present invention. Further, from the viewpoint of more preferably obtaining the inhibitory property of precipitate formation (formulation stability) with time in the skin cleaning composition of the present invention, anionic surfactants and nonionic surfactants are more preferable. Particularly preferably, anionic surfactant is mentioned.

Specific examples of the anionic surfactant include a substrate for sequent, a fatty acid salt such as sodium laurate, sodium palmitate, and coconut sulphate; sodium polyoxyethylene lauryl ether acetate, sodium polyoxyethylene tridecyl ether acetate, and the like. Alkyl ether carboxylic acid and its salts; sodium sulfate ester salts of higher alcohols such as sodium lauryl sulfate, potassium lauryl sulfate, triethanolamine lauryl sulfate; sodium polyoxyethylene lauryl ether sulfate, triethanolamine polyoxyethylene lauryl sulfate, polyoxy Alkyl ether sulfate ester salts such as sodium ethylene lauryl sulfate; sodium lauroyl sarcosin, sodium lauroyl-N-methyl-β-alanine, monosodium N-lauroyl glutamate, disodium N-stearoyl glutamate, monosodium N-myristoyl-L-monosodium glutamate. , N-acyl sulphate such as N-palmitoyl aspartate diethanolamine; N-myristoyl-N-methyl taurine sodium, coconut fatty acid methyl taurine sodium (cocoyl methyl taurine sodium), lauroyl methyl taurine sodium, polyoxyethylene lauryl amide ether sulfonic acid. Higher fatty acid amide sulfonates such as sodium; Phosphate ester salts such as polyoxyethylene oleyl ether phosphate sodium, polyoxyethylene stearyl ether phosphate, polyoxyethylene lauryl amide ether sodium phosphate; di-2-ethylhexyl sulfosuccinic acid Sodium, monolauroyl monoethanolamide polyoxyethylene sulfosuccinate sodium, lauryl polypropylene glycol sodium sulfosuccinate and other sulfosuccinates; Sulfonate; Sodium glycyl sulfate of hardened coconut oil, sulfated oil such as funnel oil, α-olefin sulfonate, higher fatty acid ester sulfonate, higher fatty acid ester sulfate such as secondary alcohol sulfate, lauroyl Higher fatty acids such as monoethanolamide sodium succinate and sodium caseinate Alkyrrole amide sulfate ester salt; Alkyl sulfate ester salt, polyoxyethyle Sulfate-type or sulfonate-type surfactants such as alkyl sulphate, fatty acid amide ether sulphate, acyl isethionate, sulfosuccinate; ether carboxylate, fatty acid amide ether carboxylate, N-acyliminodiacetic acid. , N-Carboxylic acid type surfactants such as acyl amino acid salts and the like.

Among these anionic surfactants, an alkyl ether carboxylic acid and a salt thereof, an alkyl ether sulfate ester salt, and an N-acylamine salt are preferable from the viewpoint of more preferably obtaining the formulation stability of the skin cleaning composition of the present invention. N-acylamine salt is more preferably mentioned.

These anionic surfactants may be used alone or in combination of two or more.

Specific examples of the nonionic surfactant include glycerin fatty acid esters such as glyceryl monostearate, self-emulsifying glyceryl monostearate, and glyceryl monoisostearate; polyoxyethylene glyceryl monostearate and polyoxy monooleate. Polyoxyethylene glycerin fatty acid esters such as ethylene glyceryl; polyglycerin fatty acid esters such as diglyceryl monostearate, tetraglyceryl tristearate, and decaglyceryl pentastearate; sorbitan monolaurate, sorbitan sesquistearate, sorbitan monooleate, etc. Solbitan fatty acid ester; polyoxyethylene sorbitan fatty acid ester such as monolauric acid polyoxyethylene sorbitan, monococoyl fatty acid polyoxyethylene sorbitan, tristearate polyoxyethylene sorbitan, trioleate polyoxyethylene sorbitan; monolaurate polyoxyethylene sorbit, tetra Polyoxyethylene sorbit fatty acid ester such as polyoxyethylene sorbit oleate; polyethylene glycol fatty acid ester such as polyethylene glycol monolaurate, polyethylene glycol monostearate, polyethylene glycol monooleate, polyethylene glycol distearate; propylene glycol monolauric acid ester, propylene Alkylene glycol monofatty acid esters such as glycol monomyristinate; alkyl polyhydric alcohol ethers such as glycerin monododecyl ether, glycerin monocetyl ether, glycerin monostearyl ether, pentaerythritol monododecyl ether; polyoxyethylene alkyl ethers (eg, polyoxyethylene alkyl ethers). Polyoxyethylene lauryl ether, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, etc.), polyoxyethylene polyoxypropylene alkyl ether (for example, polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / polyoxypropylene decyltetra) Polyoxyalkylene alkyl ether such as decyl ether); polyoxyethylene polyoxypropylene alkyl ether such as polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / polyoxypropylene decyltetradecyl ether; polyoxyethylene nonylf Polyoxyethylene alkylphenyl ethers such as enyl ethers, polyoxyethylene octylphenyl ethers and polyoxyethylene branched octylphenyl ethers; polyoxyethylene alkyl amines such as polyoxyethylene stearylamines and polyoxyethylene oleylamines; palm fatty acid diethanolamides, Fatty acid alkanolamides such as lauric acid diethanolamide and palm kernel oil fatty acid diethanolamide; acylmethylglucamides such as lauric acid methylglucamide and coconut fatty acid methylglucamide; other acetylene glycols, polyoxyethylene acetylene glycols, polyoxyethylene lanolin, Examples thereof include polyoxyethylene lanolin alcohol, polyoxyethylene castor oil, polyoxyethylene cured castor oil, polyoxyethylene phytosterol, polyoxyethylene chorestanol, polyoxyethylene nonylphenylformaldehyde condensate, alkyl polyglucoside and the like.

Among these nonionic surfactants, fatty acid alkanolamide is preferably mentioned from the viewpoint of more preferably obtaining the pharmaceutical stability of the skin cleansing composition of the present invention.

These nonionic surfactants may be used alone or in combination of two or more.

Specific examples of the amphoteric tenside include coconut oil fatty acid amide propyl dimethylaminoacetic acid betaine, lauryl dimethylamino acetate betaine, lauric acid amide propyl betaine, and 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium. Betain-type amphoteric tenside agents such as betaine and lauryl hydroxysulfobetaine; amino acid-type amphoteric tenside agents such as β-lauryl aminopropionate sodium and lauryl diaminoethylglycine sodium; amine oxides such as decyldimethylamine oxide and lauryldimethylamine oxide. Examples include amphoteric tenside agents.

Among these amphoteric tenside agents, betaine-type amphoteric tenside agents are preferably mentioned from the viewpoint of more preferably suppressing the formation of precipitates in the skin cleaning composition of the present invention.

These amphoteric surfactants may be used alone or in combination of two or more.

The content of the component (E) in the skin cleansing composition of the present invention may be appropriately set according to the form of the skin cleansing composition and the like. For example, the total amount of the component (E) is 0.1. 60% by weight, preferably 0.5 to 50% by weight, more preferably 1 to 40% by weight.

In the skin cleaning composition of the present invention, the ratio of the component (E) to the component (A) is not particularly limited, but from the viewpoint of better obtaining the inhibitory property of precipitate formation, per part by weight of the component (A). , (E) The total amount of the component is, for example, 1 to 60 parts by weight, preferably 3 to 50 parts by weight, more preferably 5 to 40 parts by weight, and particularly preferably 8 to 35 parts by weight.

Other Ingredients In addition to the above-mentioned components (A) to (E), the skin cleansing composition of the present invention may be used according to the form of the skin cleansing composition as long as the effects of the present invention are not impaired. It may contain additive components commonly used in the art. Examples of such additive components include whitening agents, cell activators, anti-inflammatory agents (other than the above (C) component), antibacterial agents (other than the above (A) and (B) components), moisturizers, and refreshing agents. , Inorganic powder, fragrance, colorant, deodorant, thickener, pH adjuster, base, solvent, antioxidant, pearling agent, chelating agent and the like.

Form The form of the skin cleansing composition of the present invention is not particularly limited, and examples thereof include liquid, milky liquid, and cream. The form of the skin cleansing composition of the present invention preferably includes liquid and milky liquids, and more preferably milky liquids.

Uses The skin cleansing composition of the present invention is used for washing body parts by mixing with an appropriate amount of water and whipping. The body part to be cleaned of the skin cleansing composition of the present invention is not particularly limited and can be used as a cleansing agent for any body part. Because of its excellent properties, it is suitably used as a face wash, body soap, hand soap and the like. Further, in the skin cleansing composition of the present invention, the precipitation of the component (A), which is an antibacterial agent, is stably suppressed, so that the diminished efficacy due to the precipitation of the active component is suppressed, so that sebum secretion is large and acne. It is particularly preferably used as a body soap for cleaning the back and the center of the chest where it is easy to get rid of.

Production Method The skin cleansing composition of the present invention is produced by mixing the above-mentioned components (A) to (D) and other components to be blended as necessary to prepare them into predetermined properties. ..

2. 2. Method for Inhibiting Precipitate Formation As described above, isopropylmethylphenol and glycyrrhizinic acids (glycyrrhizinic acid, derivatives thereof, and / or salts thereof) are a skin cleaning composition containing miconazole and / or a salt thereof and water. It is possible to suppress the formation of precipitates in. Therefore, the present invention is a method for further suppressing the formation of precipitates in a skin cleansing composition containing myconazole and / or a salt thereof as a component (A) and water as a component (D), and is used for skin cleansing. Provided is a method for suppressing the formation of a precipitate by blending the component (A) and the component (D) together with the component (B) isopropylmethylphenol and the component (C) glycyrrhizinic acid. do.

In the present invention, suppressing the formation of a precipitate means that miconazole and / or a skin cleaning composition containing a salt thereof and water does not contain at least one of isopropylmethylphenol and glycyrrhizinic acid. And / or the solubility of the salt thereof is improved, and the formation of a precipitate containing miconazole and / or the salt thereof is suppressed. In the present invention, it is more preferable to suppress the formation of precipitates over time (more excellent in pharmaceutical stability).

The method for suppressing the formation of precipitates utilizes isopropylmethylphenol as a component (B) and glycyrrhizic acids as a component (C), and miconazole and / or a salt thereof as a component (A) and (D). This is a method for suppressing the formation of precipitates in a skin cleansing composition containing water as a component.

The types and amounts of the components used in the method for suppressing the formation of precipitates, the form of the skin cleansing composition, and the like are as shown in the column of "1. Skin cleansing composition".

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.

Test Example 1
<Preparation of skin cleansing composition>
The components of the composition shown in Table 1 were weighed, a required amount of purified water was added, and the mixture was stirred while keeping the temperature at about 80 ° C. and then cooled while stirring to obtain a uniform skin cleansing composition. In Table 1, the unit of the numerical value indicating the amount of each component is% by weight.

<Evaluation of precipitate formation inhibitory>
Each of the obtained skin cleansing compositions was placed in a screw tube (Maruem, No. 5, diameter 27 mm, height 55 mm), stored at room temperature for 1 hour, and the properties were visually observed. Table 2 shows a representative example in a state where the precipitate is well suppressed (no precipitate) and a representative example in a state where the precipitate is not suppressed (precipitate floating and precipitate precipitation). In some cases, both precipitation floating and precipitation precipitation occur at the same time. In addition, it was also described that the separation occurred when the phase separation occurred regardless of the presence or absence of the precipitate. It is considered that the phase separation is caused by the separation of the phase containing miconazole nitrate and the phase not containing miconazole nitrate.

As shown in Reference Example 1, no precipitate was observed in the skin cleansing composition containing miconazole nitrate 1 hour after the preparation. As shown in Comparative Example 1 and Comparative Example 2, in the skin cleansing composition in which either isopropylmethylphenol or dipotassium glycyrrhizinate was blended with miconazole nitrate, a precipitate was observed 1 hour after the preparation, so that precipitation was suppressed. It has been shown that sex worsens. On the other hand, as shown in Example 1, in the skin cleansing composition of the present invention in which both isopropylmethylphenol and dipotassium glycyrrhizinate were added to miconazole nitrate, no precipitate was observed 1 hour after the preparation.

In the skin cleansing composition of Reference Example 1, precipitation of precipitates was observed after 2 hours, and a significantly large amount of precipitates were observed after 1 week. Therefore, in order to examine the formulation stability of the skin cleansing composition of the present invention for a longer period of time, Test Example 2 described later is shown.

Test Example 2
<Preparation of skin cleansing composition>
The components of the composition shown in Table 3 were weighed, a required amount of purified water was added, and the mixture was stirred while keeping the temperature at about 80 ° C. and then cooled while stirring to obtain a uniform skin cleansing composition. In Table 3, the unit of the numerical value indicating the amount of each component is% by weight.

<Evaluation of precipitate formation inhibitory>
Except that the storage condition was set to room temperature for 1 week, the inhibitory property of precipitation was evaluated in the same manner as in Test Example 1.

As shown in Comparative Example 3 and Comparative Example 4, in the skin cleansing composition in which either isopropylmethylphenol or dipotassium glycyrrhizinate was blended with miconazole nitrate, a precipitate was observed one week after the preparation, and therefore, a precipitate was observed. The production inhibitory property was poor. On the other hand, as shown in Example 2, in the skin washing composition of the present invention containing both isopropylmethylphenol and dipotassium glycyrrhizinate in miconazole nitrate, no precipitate was observed even one week after the preparation. Since the inhibitory property of precipitate formation was good, excellent pharmaceutical stability was obtained. The appearances of the skin cleansing compositions of Example 2, Comparative Example 3 and Comparative Example 4 after storage correspond to the no precipitate, the floating precipitate, and the precipitate precipitation in Table 2, respectively.

Test Example 3
Tests were conducted with the use of other anionic surfactants. Specifically, preparation of a skin cleansing composition having the composition shown in Tables 4 and 5 (in both tables, the numerical unit indicating the amount of each component is% by weight) and formation of precipitates. The inhibitory property was evaluated in the same manner as in Test Example 2.

As shown in Comparative Examples 5 to 7, in the skin cleansing composition in which either isopropylmethylphenol or dipotassium glycyrrhizinate was blended with miconazole nitrate, a precipitate was observed one week after the preparation, and therefore, a precipitate was observed. The production inhibitory property was poor. On the other hand, as shown in Example 3, in the skin cleansing composition of the present invention containing both isopropylmethylphenol and dipotassium glycyrrhizinate in miconazole nitrate, a slight precipitate floats even one week after the preparation. The formation of precipitates was almost suppressed, and good pharmaceutical stability was obtained. Further, in the skin cleansing compositions of the present invention of Examples 4 to 8, no precipitate was observed even one week after the preparation, so that the precipitate formation inhibitory property was good and the preparation was excellent. Stability was obtained.

Test Example 4
Tests were conducted with the use of other surfactants (amphoteric or nonionic surfactants). Specifically, a skin cleansing composition having the composition shown in Table 6 (in the table, the unit of the numerical value indicating the amount of each component is weight%) is prepared in the same manner as in Test Example 2, and the storage period. The inhibitory property of precipitate formation was evaluated in the same manner as in Test Example 2 except that the setting was 30 minutes.

As shown in Comparative Example 8 and Comparative Example 9, a large amount of precipitates were observed in the skin cleansing composition in which either isopropylmethylphenol or dipotassium glycyrrhizinate was blended with miconazole nitrate, and therefore, the formation of precipitates. The inhibitory property was extremely poor. On the other hand, as shown in Example 9, no precipitate was observed in the skin cleansing composition of the present invention containing both isopropylmethylphenol and dipotassium glycyrrhizinate in miconazole nitrate, and therefore, the formation of precipitates was suppressed. The sex was good. Further, in the skin cleansing composition of the present invention of Example 10, the upper phase was slightly separated, and the precipitate was only slightly suspended in the lower layer which occupies most of the surface, and the formation of the precipitate was almost suppressed. .. Further, the skin cleansing composition of Example 10 was well maintained in a state in which the formation of precipitates was almost suppressed even 2 hours after the preparation.

Claims (4)

A composition for bark containing ( A) myconazole and / or a salt thereof, (B) isopropylmethylphenol, (C) glycyrrhizinic acid, a derivative thereof, and / or a salt thereof, and (D) water. However, this excludes cases where one or more species selected from the group consisting of hop extract, assenyaku extract, gambir bark extract, biwa leaf extract, salt extract, kumazasa extract and tannic acid are included). .. The skin cleansing composition according to claim 1, further comprising (E) a surfactant. The skin cleansing composition according to claim 1, wherein the component (E) is at least one selected from the group consisting of an anionic surfactant, a nonionic surfactant, and an amphoteric surfactant. A skin-cleaning composition containing (A) myconazole and / or a salt thereof and (D) water (however, hop extract, assenyaku extract, kiraya bark extract, biwa leaf extract, tannin extract, kumazasa extract). A method for suppressing the formation of precipitates in one or more selected from the group consisting of substances and tannins) .
Precipitate formation in which (B) isopropylmethylphenol and (C) glycyrrhizic acid, a derivative thereof, and / or a salt thereof are blended with the component (A) and the component (D) for skin cleansing. How to suppress.