JP2019112332A - Skin cleansing composition - Google Patents

Abstract

To provide a skin cleansing composition having an improved antibacterial activity by containing miconazole and/or a salt thereof and having an antibacterial activity.SOLUTION: There is provided a skin cleansing composition comprising miconazole and/or a salt thereof, isopropylmethylphenol and salicylic acid, which can improve an antibacterial activity by providing an excellent antibacterial activity in addition to an antifungal activity by miconazole nitrate although isopropylmethylphenol and salicylic acid do not have a sufficient antifungal activity either singly or in combination thereof.SELECTED DRAWING: None

Description

  The present invention relates to a skin cleansing composition. More specifically, the present invention relates to a skin cleansing composition comprising miconazole and / or a salt thereof and having improved antibacterial activity.

  There are usually a large number of indigenous bacteria and bacteria passing through on human skin, and one of the fungi Malassezia is a cause of dandruff, oily dermatitis and folliculitis of the head, and acne bacteria which is one of bacteria. Various skin infections can be caused by bacteria, such as causing acne.

  Miconazole nitrate is a kind of imidazole antifungal agent, and is widely used as an active ingredient of medicines, quasi-drugs or cosmetics. For example, Patent Document 1 discloses a cleaning composition having antimycotic activity, which contains miconazole nitrate.

  Furthermore, a formulation formulation for improving the antibacterial activity of a cleaning composition containing miconazole nitrate is being studied, for example, Patent Document 1 contains an azole antifungal agent such as miconazole nitrate and an antibacterial agent. The cleaning composition is disclosed, and preferably, the antibacterial agent is at least one selected from triclosan, triclocarban and isopropylmethylphenol. Patent Document 2 discloses a cleaning composition containing miconazole nitrate, an antifungal activity-enhancing component, a predetermined amount of surfactant and a predetermined amount of water, and preferably, the antifungal activity is enhanced. It is disclosed that the component is menthol and / or camphor, or one or more compounds selected from the group consisting of geraniol, eugenol, thymol, carvacrol, borneol and carveol.

JP 2007-277227 A Unexamined-Japanese-Patent No. 2006-335768 JP, 2014-088373, A

  Although the pharmaceutical formulation described in Patent Document 2 contains an antibacterial agent, the antibacterial agents actually showing an antibacterial effect are triclosan and triclocarban, and the antibacterial agent by blending isopropyl methyl phenol The effect has not been confirmed. Although it is assumed that the pharmaceutical preparation described in Patent Document 3 enhances the anti-acne effect among the effects of miconazole nitrate by enhancing the antifungal activity, it is effective against acne caused by the bacteria Acne bacteria. Absent.

  The inventor examined a formulation for improving the antibacterial activity of the composition for skin cleansing from both the antifungal activity and the antibacterial activity by the new formulation design, and it was found that the composition for cleansing the skin comprising miconazole nitrate is generally used. Even when it contains isopropylmethylphenol, which is known as an anti-bacterial agent, it faces the problem that sufficient anti-bacterial activity can not be obtained. Then, an object of this invention is to provide the composition for skin washing | cleaning which antifungal activity improved by containing mimiconazole and / or its salt, and also having antibacterial activity.

  The inventors of the present invention conducted intensive studies to solve the above problems, and found that isopropylmethylphenol and salicylic acid, which are generally known as antibacterial agents, were individually incorporated into a skin cleansing composition containing miconazole nitrate. In addition to antifungal activity by miconazole nitrate, the composition for cleansing the skin containing miconazole nitrate is superior by combining both of them even though sufficient antibacterial activity can not be obtained. It has been found that anti-bacterial activity can also be provided. The present invention has been completed by further studies based on such findings.

That is, the present invention provides the invention of the aspects listed below.
Item 1. A skin cleansing composition comprising (A) miconazole and / or a salt thereof, (B) isopropylmethylphenol, and (C) salicylic acid.
Item 2. The skin cleansing composition according to Item 1, further comprising (D) a surfactant.
Item 3. The skin cleansing composition according to item 1, wherein the component (D) is at least one selected from the group consisting of anionic surfactants, nonionic surfactants, and amphoteric surfactants.
Item 4. (A) A method for improving the antimicrobial activity of a skin cleansing composition containing miconazole and / or a salt thereof, comprising: (B) isopropylmethylphenol and (C) together with the component (A) in the composition for skin cleansing 2.) A method for improving antibacterial activity, which contains salicylic acid.

  In addition to the antifungal activity by miconazole nitrate, the skin cleanser composition of this invention can be equipped with the outstanding antibacterial activity, Therefore An antimicrobial activity can be improved.

1. Skin cleansing composition The skin cleansing composition of the present invention comprises (A) miconazole and / or a salt thereof (hereinafter sometimes referred to as component (A)), (B) isopropylmethylphenol (hereinafter referred to as It is characterized in that it includes B) component, and (C) salicylic acid (hereinafter, sometimes referred to as component (C)). Hereinafter, the skin cleansing composition of the present invention will be described in detail.

(A) Miconazole and / or a salt thereof The composition for cleansing a skin of the present invention contains miconazole and / or a salt thereof as the component (A). Miconazole and / or a salt thereof is an agent known as an imidazole antifungal agent having a bactericidal effect against fungi.

  Miconazole is a compound also referred to as 1- [2,4-dichloro-β-[(2,4-dichlorobenzyl) oxy] phenethyl] imidazole. The salt of miconazole is not particularly limited as long as it is pharmaceutically acceptable, and specifically, salts of inorganic acids such as hydrochloric acid, hydrobromic acid, sulfuric acid, nitric acid, phosphoric acid and the like can be mentioned. These salts may be used singly or in combination of two or more.

  In the skin cleansing composition of the present invention, as the component (A), one of miconazole and a salt of miconazole may be selected and used, or two or more may be used in combination. Among these (A) components, preferably a salt of miconazole is mentioned, and more preferably miconazole nitrate is mentioned.

  In the skin cleansing composition of the present invention, the content of the component (A) is not particularly limited and may be appropriately set depending on the medicinal effect etc. to be imparted. For example, the total amount of the component (A) is 0. 1-20 weight% is mentioned. From the viewpoint of obtaining better efficacy and solubility, the content of the component (A) is preferably 0.2 to 5% by weight, more preferably 0.5 to 2% by weight in total of the component (A). It can be mentioned.

(B) Isopropylmethylphenol The skin cleansing composition of the present invention contains isopropylmethylphenol as the component (B). Isopropylmethylphenol is a compound also referred to as 4-isopropyl-3-methylphenol, and is a known drug known to have an antibacterial effect.

  The content of the component (B) in the composition for cleansing the skin according to the present invention is not particularly limited and may be appropriately set depending on the medicinal effect etc. to be imparted, but, for example, 0.01 to 10% by weight . The content of the component (B) is preferably 0.05 to 2% by weight, more preferably 0.05 to 1% from the viewpoint of obtaining antibacterial properties more efficiently in the composition for cleansing the skin of the present invention. %, More preferably 0.05 to 0.5% by weight, particularly preferably 0.05 to 0.2% by weight.

  In the skin cleansing composition of the present invention, the ratio of component (B) to component (A) is not particularly limited, but from the viewpoint of obtaining antibacterial properties more efficiently, per part by weight of component (A) The component B) is, for example, 0.01 to 1 part by weight, preferably 0.05 to 0.5 part by weight, and more preferably 0.1 to 0.2 part by weight.

(C) Salicylic acid The skin cleansing composition of the present invention contains salicylic acid as the component (C). Salicylic acid is a known drug that is known to have antifungal and antibacterial effects.

  In the skin cleansing composition of the present invention, the content of the component (C) is not particularly limited and may be appropriately set according to the medicinal effect to be imparted, but for example, the total amount of the component (A) 0.01-10 weight% is mentioned. The content of the component (C) is preferably 0.05 to 5% by weight, more preferably 0.05 to 1% from the viewpoint of obtaining the antibacterial effect in the composition for cleansing the skin of the present invention more efficiently. % Is listed.

  In the skin cleansing composition of the present invention, the ratio of the component (C) to the component (A) is not particularly limited, but from the viewpoint of obtaining the antibacterial effect more efficiently, per part by weight of the component (A) The component C) is, for example, 0.01 to 1 part by weight, preferably 0.05 to 0.5 parts by weight, and more preferably 0.1 to 0.3 parts by weight.

Skin cleansing compositions of the water present invention may contain water as a base. The content of water in the composition for cleansing the skin of the present invention is appropriately set according to the solubility of the component (A), the form of the preparation, etc., but it is, for example, 30 to 98% by weight, preferably 40 to 95%. %, More preferably 50 to 90% by weight.

(D) Surfactant The skin cleansing composition of the present invention can contain a surfactant as the component (D). Although it does not specifically limit as surfactant, From a viewpoint of suppressing the irritation | stimulation to skin, Preferably anionic surfactant, nonionic surfactant, and amphoteric surfactant are mentioned. Among surfactants, anionic surfactants, nonionic surfactants and amphoteric surfactants may be used alone or in any combination of two or more. . Further, as the surfactant, from the viewpoint of facilitating the dissolution of the component (A), it is preferable to include at least an anionic surfactant and an amphoteric surfactant, or at least a nonionic surfactant, and an anion It is more preferable to include an ionic surfactant, a nonionic surfactant and a double-sided surfactant.

  Specific examples of the anionic surfactant include a base for soap, sodium laurate, sodium palmitate, fatty acid salt such as coconut carrageenan, etc .; sodium polyoxyethylene lauryl ether acetate, sodium polyoxyethylene tridecyl ether acetate, etc. Alkyl ether carboxylic acids and salts thereof; sulfuric acid ester salts of higher alcohols such as sodium lauryl sulfate, potassium lauryl sulfate and triethanolamine lauryl sulfate; sodium polyoxyethylene lauryl ether sulfate, polyoxyethylene lauryl sulfate triethanolamine, polyoxy acid Alkyl ether sulfates such as sodium ethylene lauryl sulfate; sodium lauroyl sarcosine; sodium lauroyl-N-methyl-β-alanine; N-lauroyl glucose N-Acylamine acid salts such as monosodium mynoate, disodium N-stearoylglutamate, monosodium N-myristoyl-L-glutamate, diethanolamine N-palmitoyl aspartate; N-myristoyl-N-methyltaurine sodium, coconut fatty acid methyltaurine Higher fatty acid amide sulfonates such as sodium (cocoyl methyl taurine sodium), sodium lauroyl methyl taurine, sodium polyoxyethylene lauryl amide ether sulfonate; polyoxyethylene oleyl ether sodium phosphate, polyoxyethylene stearyl ether phosphate, polyoxy acid Phosphate ester salts such as sodium ethylene lauryl amide ether phosphate; sodium di-2-ethylhexyl sulfosuccinate, monola Sulfosuccinates such as uroyl monoethanolamide polyoxyethylene sodium sulfosuccinate sodium, lauryl polypropylene glycol sodium sulfosuccinate sodium salt; linear sodium dodecyl benzene sulfonate sodium, linear dodecyl benzene sulfonic acid triethanolamine, linear dodecyl benzene sulfonic acid alkyl benzene sulfonic acid Salts; Cured coconut oil fatty acid glycerol sodium sulfate, sulfated oil such as funnel oil, α-olefin sulfonate, higher fatty acid ester sulfonate, higher alcohol ester sulfate such as secondary alcohol sulfate ester salt, lauroyl monoethanol Sodium amidosuccinate, and higher fatty acid alkylolamide sulfates such as sodium caseinate; alkyl sulfates, polyoxyethylenes Sulfate type or sulfonate type surfactant such as alkyl sulfate ester salt, fatty acid amide ether sulfate ester salt, acyl isethionate salt, sulfosuccinate salt; ether carboxylate, fatty acid amide ether carboxylate, N-acyliminodiacetic acid And carboxylic acid type surfactants such as N-acyl amino acid salts.

  Among these anionic surfactants, alkyl ether carboxylic acids and salts thereof, alkyl ether sulfuric acid ester salts, and N-acyl amine acid salts are preferably mentioned from the viewpoint of obtaining better solubility of the component (A).

  These anionic surfactants may be used alone or in combination of two or more.

  Specific examples of the nonionic surfactant include glyceryl monostearate, glyceryl monostearate, glyceryl monoisostearate, and glycerin fatty acid esters such as glyceryl monoisostearate; polyoxyethylene glyceryl monostearate, polyoxy monooleate Polyoxyethylene glycerine fatty acid esters such as ethylene glyceryl; polyglycerin fatty acid esters such as diglyceryl monostearate, tetraglyceryl tristearate, decaglyceryl pentastearate; sorbitan monolaurate, sorbitan sesquistearate, sorbitan monooleate Sorbitan fatty acid ester; polyoxyethylene sorbitan monolaurate, monocobalt fatty acid polyoxyethylene sorbitan, polyoxyethylene tristearate Polyoxyethylene sorbitan fatty acid esters such as rubitan and trioleate polyoxyethylene sorbitan; polyoxyethylene sorbit fatty acid esters such as polyoxyethylene sorbit monolaurate and polyoxyethylene sorbit tetraoleate; polyethylene glycol monolaurate and polyethylene monostearate Polyethylene glycol fatty acid esters such as glycol, monooleic acid polyethylene glycol, distearic acid polyethylene glycol; alkylene glycol mono fatty acid esters such as propylene glycol monolaurate and propylene glycol monomyristate; glycerin monododecyl ether, glycerin monocetyl ether, Glycerin monostearyl ether, pen Alkyl monohydric alcohol ethers such as erythritol monododecyl ether; polyoxyethylene alkyl ethers (for example, polyoxyethylene lauryl ether, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether etc.), polyoxyethylene polyoxypropylene alkyl ether (for example, , Polyoxyalkylene alkyl ethers such as polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / polyoxypropylene decyl tetradecyl ether, etc .; polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / polyoxypropylene decyl Polyoxyethylene polyoxypropylene alkyl ether such as tetradecyl ether; Polyoxyethylene alkylphenyl ethers such as polyether ether, polyoxyethylene octyl phenyl ether, polyoxyethylene branched chain octyl phenyl ether, etc .; polyoxyethylene alkyl amines such as polyoxyethylene stearyl amine, polyoxyethylene oleyl amine, etc .; coconut fatty acid diethanolamide, laurin Fatty acid alkanolamides such as acid diethanolamide, palm kernel oil fatty acid diethanolamide; acyl methyl glucamides such as methyl glucamide laurate and methyl cothyl coconut acid; other acetylene glycols, polyoxyethylene acetylene glycol, polyoxyethylene lanolin, poly Oxyethylene lanolin alcohol, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polycarbonate Ethylene phytosterol, polyoxyethylene cholestanol, polyoxyethylene nonylphenyl formaldehyde condensate, an alkyl polyglucoside, and the like.

  Among these nonionic surfactants, polyoxyethylene sorbitan fatty acid ester, polyoxyalkylene alkyl ether and fatty acid alkanolamide are preferably mentioned from the viewpoint of obtaining the solubility of the component (A) better.

  These non-ionic surfactants may be used alone or in combination of two or more.

  Specific examples of amphoteric surfactants include coconut oil fatty acid amidopropyl dimethylaminoacetic acid betaine, lauryl dimethylaminoacetic acid betaine, lauric amidopropyl betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium Betaine-type amphoteric surfactants such as betaine and lauryl hydroxysulfobetaine; amino acid-type amphoteric surfactants such as sodium β-laurylaminopropionate and sodium lauryldiaminoethylglycine; and amine oxides such as decyldimethylamine oxide and lauryldimethylamine oxide And amphoteric surfactants.

  Among these amphoteric surfactants, from the viewpoint of obtaining better solubility of the component (A), betaine-type amphoteric surfactants are preferably mentioned.

  These amphoteric surfactants may be used alone or in combination of two or more.

  The content of the component (D) in the skin cleansing composition of the present invention may be appropriately set according to the form of the composition for cleansing the skin, etc., but from the viewpoint of better dissolving the component (A), The total amount of the component (D) is, for example, 0.1 to 60% by weight, preferably 0.5 to 50% by weight, and more preferably 1 to 40% by weight. More preferably, the total amount of the anionic surfactant and the amphoteric surfactant is 10 to 25% by weight, and the total amount of the nonionic surfactant is 1 to 10% by weight.

  In the skin cleansing composition of the present invention, the ratio of the component (D) to the component (A) is not particularly limited, but from the viewpoint of better dissolving the component (A), per part by weight of the component (A) The total amount of the component (D) is, for example, 1 to 60 parts by weight, preferably 3 to 50 parts by weight. More preferably, the total amount of the anionic surfactant and the amphoteric surfactant is 10 to 30 parts by weight per 1 part by weight of the component (A), and the total amount of nonionic surfactants is (A) 1-10 weight parts are mentioned per 1 weight part of ingredients.

Other Components The composition for cleansing the skin of the present invention, in addition to the components (A) to (C) described above, may be selected according to the form of the composition for cleansing the skin as long as the effects of the present invention are not impaired. You may contain the addition component normally used in the technical field. Such additives include, for example, whitening agents, cell activators, anti-inflammatory agents, antibacterial agents (other than the above components (A) to (C)), moisturizers, refreshing agents, inorganic powders, fragrances, coloring agents And deodorants, thickeners, pH adjusters, bases, solvents, antioxidants, pearlescent agents, chelating agents and the like.

  For example, as a humectant, polyhydric alcohols such as propylene glycol, dipyropyrene glycol, 1,3-butylene glycol, glycerin, diglycerin, 1,2-pentanediol, polyethylene glycol, polypropylene glycol, polyglycerin, etc .; sorbitol, Besides sugar alcohols such as xylitol, maltitol, lactitol, erythritol, pentaerythritol, mannitol, trehalose, etc., heparinoids (heparin analogues), chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronate, atelocollagen, cholesteryl-12-hydroxystearate Sodium lactate, bile salt, dl-pyrrolidone carboxylate, short chain soluble collagen, diglycerin (EO) PO adduct, extract of Izayoibara, se Iodide yarrow extract, sweet clover extract, aloe extract, royal jelly extract, soybean extract, seaweed extract, and the like. These humectants may be used alone or in combination of two or more.

  Among the above-described humectants, polyhydric alcohols and sugar alcohols are preferable from the viewpoint of obtaining better solubility of the component (A). In the skin cleansing composition of the present invention, the total amount of polyhydric alcohol and sugar alcohol is, for example, 1 to 20% by weight, preferably 5 to 15% by weight. The ratio of the total amount of polyhydric alcohol and sugar alcohol to the component (A) is, for example, 1 to 25 parts by weight, preferably 5 to 20 parts by weight, per part by weight of the component (A).

Form The form of the skin cleanser composition of the present invention is not particularly limited, and examples thereof include liquid, emulsion, and cream. The form of the composition for cleansing the skin according to the present invention preferably includes liquid and emulsion, more preferably emulsion.

Applications The skin cleansing composition of the present invention is mixed with a suitable amount of water and foamed to be used for cleansing a body part. The body part to be cleaned of the skin cleansing composition of the present invention is not particularly limited, and can be used as a cleansing agent for all body parts, but it is suitably used as a cleanser, body soap, hand soap and the like. In addition, the composition for cleansing the skin according to the present invention is excellent in both antifungal and antibacterial properties, so that the acne and bacterial properties of the fungal (as specific example Malassezia furfur) are specific (as specific example) It is particularly suitably used as a body soap for cleansing the back and the central part of the chest, etc. which both occur with acne of Propionibacterium acnes.

Production method The skin cleanser composition of the present invention is produced by mixing the above-mentioned components (A) to (C) and other components, which are optionally blended, and preparing them into the predetermined properties. .

2. Method for Improving Antibacterial Activity As described above, isopropylmethylphenol and salicylic acid have good antibacterial properties in addition to the antifungal properties of miconazole and / or a salt thereof in a skin cleansing composition containing miconazole and / or a salt thereof. By imparting, the antimicrobial activity can be improved. Therefore, the present invention is further a method of improving the antimicrobial activity of a composition for cleansing the skin comprising miconazole, which is the component (A), and / or a salt thereof, comprising the composition for cleansing the skin according to the component (A). Further, the present invention provides a method for improving antibacterial activity, which comprises blending isopropylmethylphenol as component (B) and salicylic acid as component (C).

  In the present invention, the term "improved antibacterial activity" refers to a composition for cleansing the skin containing miconazole and / or a salt thereof, which exhibits antifungal activity due to miconazole and / or a salt thereof, isopropylphenol and salicylic acid, or salicylic acid. It exhibits superior antibacterial properties compared to the case where it does not contain.

  The method for improving the antibacterial activity is a composition for cleansing the skin comprising miconazole (A) component and / or a salt thereof by using isopropylmethylphenol (B) component and salicylic acid (C) component. It is a method of improving the antibacterial activity.

  In the method for improving the antibacterial activity, the types and amounts of the components to be used, the form of the composition for cleansing the skin, etc. are as described in the section "1. Composition for cleansing the skin".

  EXAMPLES The present invention will be more specifically described below by way of Examples, but the present invention is not limited thereto.

Test Example <Preparation of composition for skin cleansing>
The components of the composition shown in Table 1 were weighed, and the necessary amount of purified water was added, and the mixture was stirred while keeping warm at about 80 ° C., and then cooled while stirring to obtain a uniform composition for skin cleansing. In Table 1, the unit of the numerical value indicating the amount of each component is% by weight.

<Evaluation of antibacterial activity>
1) Test bacteria Acne bacteria: Propionibacterium acnes (NBRC107605)
Malassezia: Malassezia furfur (NBRC101610)
2) Medium for determining the number of bacteria and culture conditions Acne bacteria:
GAM agar medium (manufactured by Nissui Pharmaceutical Chemical Co., Ltd.) was used.
The cells were cultured for 4 to 5 days at 37 ° C. ± 1 ° C. using agar plating method.
It was placed in an anelopack (manufactured by Mitsubishi Gas Chemical Co., Ltd.) and cultured in an anaerobic jar.
Malassezia:
The chromogar malacetia / Candida agar medium (Kanto Chemical Co., Ltd.) was used.
The cells were cultured at 32 ° C. ± 1 ° C. for 2 days using agar plating method.
3) Preparation of test bacterial solution The bacterial suspension was suspended in sterile physiological saline by platinum loop assay to prepare a bacterial solution.
4) Test procedure Each skin cleansing composition was diluted 10-fold with sterile purified water to prepare a test sample. For 9.9 mL of the test sample, 0.1 mL of the bacterial solution was taken, stirred rapidly, and allowed to stand at room temperature (25 ° C.) for 1 minute to obtain a bactericidal test solution. 0.1 mL of the bactericidal test solution was taken in a culture medium for measuring the number of bacteria and cultured. In the reference example, as a control, a 10-fold dilution of physiological saline was prepared instead of the 10-fold dilution of the skin washing composition, and the same culture procedure was performed.
5) Evaluation method The number of colonies (number of viable cells) on the culture medium for measuring the number of bacteria after culture was counted and evaluated based on the following criteria.
-: No growth of bacteria was observed.
+: Growth of bacteria was observed (log 10 (number of viable bacteria) is greater than 0 and less than 2.5)
++: Growth of bacteria was recognized (log 10 (number of viable bacteria) is more than 2.5)

  As shown in Comparative Example 6 and Comparative Example 7, a composition for cleansing the skin comprising (A) component miconazole nitrate, (B) component isopropylmethylphenol, and (C) component salicylic acid, and (D) component surfactant. The thing had no antibacterial activity. In addition, as shown in Comparative Example 2, among the components (A), (B) and (C), the composition for cleansing the skin comprising the component (A) miconazole nitrate alone is a good anti-malacetia microbe. Fungal activity was observed but no antibacterial activity against Acne bacteria was observed. Further, as shown in Comparative Example 4 and Comparative Example 5, among the component (A), the component (B) and the component (C), the component (B) component isopropylmethylphenol alone or the component (C) component salicylic acid alone In the composition for cleansing the skin, the antibacterial activity against acne bacteria was not recognized although the components (B) and (C) were antibacterial agents. As shown in Comparative Example 3, it is a composition for cleansing the skin comprising both the component (B) and the component (C) which are antibacterial agents among the components (A), (B) and (C), Also, no antibacterial activity was observed against acne bacteria. As shown in Comparative Example 1, among the (A) component, the (B) component and the (C) component, even when combining the (A) component miconazole nitrate and the (B) component isopropylmethylphenol, it is good against Malassezia bacteria. Antifungal activity was observed, but again, no antibacterial activity was observed against acne bacteria.

  On the other hand, as shown in Examples 1 to 4, in the skin cleansing composition of the present invention containing (A) component miconazole nitrate, (B) component isopropylmethylphenol, and (C) component salicylic acid, (B) In addition to the antifungal activity by (A) component miconazole nitrate, although the component isopropylmethylphenol and the component (C) salicylic acid alone showed no antifungal activity against acne bacteria, they are excellent antibacterial agents against acne. An action was also observed. Therefore, the antimicrobial activity could be improved by the composition for skin washing of the present invention shown in Examples 1-4.

Claims (4)

  A skin cleansing composition comprising (A) miconazole and / or a salt thereof, (B) isopropylmethylphenol, and (C) salicylic acid.   The skin cleansing composition according to claim 1, further comprising (D) a surfactant.   The composition for cleansing the skin according to claim 1, wherein the component (D) is at least one selected from the group consisting of anionic surfactants, nonionic surfactants, and amphoteric surfactants. (A) A method for improving the antimicrobial activity of a skin cleansing composition comprising miconazole and / or a salt thereof,
A method for improving antibacterial activity, comprising (B) isopropylmethylphenol and (C) salicylic acid together with the component (A) in a skin cleansing composition.