JP7041961B2 - ヒト嚢胞性線維症肺上皮における気道表面の生理機能の小分子介在性回復 - Google Patents

ヒト嚢胞性線維症肺上皮における気道表面の生理機能の小分子介在性回復 Download PDF

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JP7041961B2
JP7041961B2 JP2018552659A JP2018552659A JP7041961B2 JP 7041961 B2 JP7041961 B2 JP 7041961B2 JP 2018552659 A JP2018552659 A JP 2018552659A JP 2018552659 A JP2018552659 A JP 2018552659A JP 7041961 B2 JP7041961 B2 JP 7041961B2
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certain embodiments
molar ratio
amb
cholesterol
composition
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JP2019510788A (ja
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ディー バーク，マーティン
エー ムラリア，カトリーナ
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University of Illinois System
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2018552659A 2016-04-08 2017-04-10 ヒト嚢胞性線維症肺上皮における気道表面の生理機能の小分子介在性回復 Active JP7041961B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662320111P 2016-04-08 2016-04-08
US62/320,111 2016-04-08
US201662320795P 2016-04-11 2016-04-11
US62/320,795 2016-04-11
PCT/US2017/026806 WO2017177228A1 (en) 2016-04-08 2017-04-10 Small molecule-mediated restoration of airway surface physiology in human cystic fibrosis lung epithelia

Publications (3)

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JP2019510788A JP2019510788A (ja) 2019-04-18
JP2019510788A5 JP2019510788A5 (https=) 2020-04-30
JP7041961B2 true JP7041961B2 (ja) 2022-03-25

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JP2018552659A Active JP7041961B2 (ja) 2016-04-08 2017-04-10 ヒト嚢胞性線維症肺上皮における気道表面の生理機能の小分子介在性回復

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US (2) US20190083517A1 (https=)
EP (1) EP3439668B1 (https=)
JP (1) JP7041961B2 (https=)
AU (1) AU2017248394B2 (https=)
DK (1) DK3439668T3 (https=)
ES (1) ES2983639T3 (https=)
FI (1) FI3439668T3 (https=)
PT (1) PT3439668T (https=)
WO (1) WO2017177228A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020536859A (ja) * 2017-10-11 2020-12-17 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ 小分子重炭酸イオンチャネルを用いた嚢胞性線維症の遺伝子型非依存性救済
US12419899B2 (en) 2022-03-21 2025-09-23 The Board Of Trustees Of The University Of Illinois Ion channel prosthetic compositions comprising lipid-coated crystals of amphotericin B

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3439668T (pt) 2016-04-08 2024-08-12 Univ Illinois Restauração da fisiologia da superfície das vias aéreas mediada por pequenas moléculas no epitélio pulmonar da fibrose quística humana

Citations (3)

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US20090220599A1 (en) 2003-12-10 2009-09-03 Industrial Technology Research Institute Antifungal formulation and manufacturing method thereof
JP2010505965A (ja) 2006-10-10 2010-02-25 ジャイナ ファーマシューティカルズ，インコーポレーテッド 脂質ベースの医薬化合物の製造のための水性系、その組成物、方法、および使用
WO2015054148A1 (en) 2013-10-07 2015-04-16 The Board Of Trustees Of The University Of Illinois Amphotericin b derivatives with improved therapeutic index

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US4906476A (en) * 1988-12-14 1990-03-06 Liposome Technology, Inc. Novel liposome composition for sustained release of steroidal drugs in lungs
AU643141B2 (en) 1991-03-15 1993-11-04 Amgen, Inc. Pulmonary administration of granulocyte colony stimulating factor
US5451569A (en) 1994-04-19 1995-09-19 Hong Kong University Of Science And Technology R & D Corporation Limited Pulmonary drug delivery system
EP0771205A2 (de) * 1994-06-28 1997-05-07 Dr. Zerle Gmbh Neue klinische anwendungen von polyen-makroliden
CA2569402A1 (en) * 2004-06-04 2005-12-22 The Regents Of The University Of California Compounds having activity in increasing ion transport by mutant-cftr and uses thereof
WO2009006311A2 (en) * 2007-06-29 2009-01-08 Wisconsin Alumni Research Foundation Structuring effect of cholesterol in peg-phospholipid micelles, drug delivery of amphotericin b, and combination antifungals
BRPI1003990B1 (pt) * 2009-10-16 2021-09-14 Lifecare Innovations Pvt. Ltd Formulação para o tratamento de infecções fúngicas
WO2016073462A1 (en) * 2014-11-04 2016-05-12 The Board Of Trustees Of The University Of Illinois Restoring physiology with small molecule mimics of missing proteins
PT3439668T (pt) 2016-04-08 2024-08-12 Univ Illinois Restauração da fisiologia da superfície das vias aéreas mediada por pequenas moléculas no epitélio pulmonar da fibrose quística humana

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090220599A1 (en) 2003-12-10 2009-09-03 Industrial Technology Research Institute Antifungal formulation and manufacturing method thereof
JP2010505965A (ja) 2006-10-10 2010-02-25 ジャイナ ファーマシューティカルズ，インコーポレーテッド 脂質ベースの医薬化合物の製造のための水性系、その組成物、方法、および使用
WO2015054148A1 (en) 2013-10-07 2015-04-16 The Board Of Trustees Of The University Of Illinois Amphotericin b derivatives with improved therapeutic index

Non-Patent Citations (3)

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J. Am. Chem. Soc.，2015年，Vol. 137，pp. 10096-10099
NATURE CHEMICAL BIOLOGY，2014年，Vol. 10，pp. 400-406, ONLINE METHODS
PNAS，2012年，Vol. 109, No. 7，pp. 2234-2239

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020536859A (ja) * 2017-10-11 2020-12-17 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイＴｈｅ Ｂｏａｒｄ Ｏｆ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｔｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｉｌｌｉｎｏｉｓ 小分子重炭酸イオンチャネルを用いた嚢胞性線維症の遺伝子型非依存性救済
JP2023126932A (ja) * 2017-10-11 2023-09-12 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ 小分子重炭酸イオンチャネルを用いた嚢胞性線維症の遺伝子型非依存性救済
JP7355335B2 (ja) 2017-10-11 2023-10-03 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ 小分子重炭酸イオンチャネルを用いた嚢胞性線維症の遺伝子型非依存性救済
US12090164B2 (en) 2017-10-11 2024-09-17 The Board Of Trustees Of The University Of Illinois Genotype-agnostic rescue of cystic fibrosis with small molecule bicarbonate channels
US12419899B2 (en) 2022-03-21 2025-09-23 The Board Of Trustees Of The University Of Illinois Ion channel prosthetic compositions comprising lipid-coated crystals of amphotericin B

Also Published As

Publication number Publication date
DK3439668T3 (da) 2024-09-02
EP3439668A1 (en) 2019-02-13
US20190083517A1 (en) 2019-03-21
AU2017248394B2 (en) 2023-02-23
ES2983639T3 (es) 2024-10-24
US11850256B2 (en) 2023-12-26
WO2017177228A1 (en) 2017-10-12
AU2017248394A1 (en) 2018-11-22
EP3439668B1 (en) 2024-06-19
PT3439668T (pt) 2024-08-12
FI3439668T3 (fi) 2024-09-05
US20210393661A1 (en) 2021-12-23
EP3439668A4 (en) 2019-12-18
JP2019510788A (ja) 2019-04-18

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