JP7015109B2 - 流体の分離および検出 - Google Patents

流体の分離および検出 Download PDF

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Publication number
JP7015109B2
JP7015109B2 JP2016530880A JP2016530880A JP7015109B2 JP 7015109 B2 JP7015109 B2 JP 7015109B2 JP 2016530880 A JP2016530880 A JP 2016530880A JP 2016530880 A JP2016530880 A JP 2016530880A JP 7015109 B2 JP7015109 B2 JP 7015109B2
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flow
fluid
components
channel
component
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Japanese (ja)
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JP2017502262A5 (enExample
JP2017502262A (ja
Inventor
イエーツ，エマ
ドブソン，クリストファー
ハーリング，テレーズ
ノウルズ，ツォーマス
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Cambridge Enterprise Ltd
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Cambridge Enterprise Ltd
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502753—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0266—Investigating particle size or size distribution with electrical classification
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0631—Purification arrangements, e.g. solid phase extraction [SPE]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0636—Focussing flows, e.g. to laminate flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0883—Serpentine channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0038—Investigating nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N2015/0288—Sorting the particles

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Electrochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2016530880A 2013-11-14 2014-11-14 流体の分離および検出 Expired - Fee Related JP7015109B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021031813A JP2021099359A (ja) 2013-11-14 2021-03-01 流体の分離および検出

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1320146.2A GB201320146D0 (en) 2013-11-14 2013-11-14 Fluidic separation and detection
GB1320146.2 2013-11-14
PCT/GB2014/053385 WO2015071683A1 (en) 2013-11-14 2014-11-14 Fluidic separation and detection

Related Child Applications (1)

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JP2021031813A Division JP2021099359A (ja) 2013-11-14 2021-03-01 流体の分離および検出

Publications (3)

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JP2017502262A JP2017502262A (ja) 2017-01-19
JP2017502262A5 JP2017502262A5 (enExample) 2020-09-10
JP7015109B2 true JP7015109B2 (ja) 2022-02-02

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JP2016530880A Expired - Fee Related JP7015109B2 (ja) 2013-11-14 2014-11-14 流体の分離および検出
JP2021031813A Pending JP2021099359A (ja) 2013-11-14 2021-03-01 流体の分離および検出

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US (4) US9952222B2 (enExample)
EP (1) EP3069136A1 (enExample)
JP (2) JP7015109B2 (enExample)
CN (1) CN105723218B (enExample)
AU (1) AU2014349851A1 (enExample)
CA (1) CA2929156A1 (enExample)
GB (1) GB201320146D0 (enExample)
WO (1) WO2015071683A1 (enExample)

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US20220219168A1 (en) * 2019-06-10 2022-07-14 University Of Massachusetts Microgradient-based microfluidic devices and high-throughput analytical methods
CN112354572B (zh) * 2019-07-11 2022-02-11 北京理工大学 一种多维微流控电泳芯片及检测装置，检测方法
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CN111617812B (zh) * 2019-10-17 2021-12-03 北京京东方健康科技有限公司 微流控基板及其流体驱动方法、微流控装置
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EP4341378A4 (en) * 2021-05-21 2024-09-18 Timo Rapakko HIGH CAPACITY CLINICAL TESTING
CN114471762B (zh) * 2022-02-22 2023-04-07 西北大学 一种可控超低流速的微流控芯片设计及实现方法
KR102593306B1 (ko) * 2023-03-21 2023-10-25 부경대학교 산학협력단 저투수성 매체 내 형광 추적자 농도분포 추정 장치 및 방법
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Title
Ｙｉｎｇｊｉｅ Ｌｉｕ， ｅｔ ａｌ．，「Ｅｌｅｃｔｒｏｐｈｏｒｅｔｉｃ Ｓｅｐａｒａｔｉｏｎ ｏｆ Ｐｒｏｔｅｉｎｓ ｏｎ ａ Ｍｉｃｒｏｃｈｉｐ ｗｉｔｈ Ｎｏｎｃｏｖａｌｅｎｔ， Ｐｏｓｔｃｏｌｕｍｎ Ｌａｂｅｌｉｎｇ」，Ａｎａｌｙｔｉｃａｌ Ｃｈｅｍｉｓｔｒｙ，２０００年，Ｖｏｌ．７２， Ｎｏ．１９，ｐ．４６０８－ｐ．４６１３

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US20160266138A1 (en) 2016-09-15
US20180267054A1 (en) 2018-09-20
GB201320146D0 (en) 2014-01-01
CA2929156A1 (en) 2015-05-21
US11959923B2 (en) 2024-04-16
US10295545B2 (en) 2019-05-21
AU2014349851A1 (en) 2016-05-19
US20190331692A1 (en) 2019-10-31
HK1225439A1 (zh) 2017-09-08
US9952222B2 (en) 2018-04-24
JP2021099359A (ja) 2021-07-01
JP2017502262A (ja) 2017-01-19
CN105723218A (zh) 2016-06-29
WO2015071683A1 (en) 2015-05-21
EP3069136A1 (en) 2016-09-21
CN105723218B (zh) 2020-02-14
US11029315B2 (en) 2021-06-08

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