JP7008688B2 - アッセイ - Google Patents

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Publication number
JP7008688B2
JP7008688B2 JP2019508836A JP2019508836A JP7008688B2 JP 7008688 B2 JP7008688 B2 JP 7008688B2 JP 2019508836 A JP2019508836 A JP 2019508836A JP 2019508836 A JP2019508836 A JP 2019508836A JP 7008688 B2 JP7008688 B2 JP 7008688B2
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Japan
Prior art keywords
thiol
ligand
target molecule
reaction mixture
reaction
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JP2019508836A
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English (en)
Japanese (ja)
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JP2019526792A5 (enExample
JP2019526792A (ja
Inventor
マン，デイビッド・ジュリアン
クラベン，グレゴリー・ベネディクト
マチス，ステファン
アームストロング，アラン
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Ip2ipo Innovations Ltd
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Imperial College Innovations Ltd
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/557—Immunoassay; Biospecific binding assay; Materials therefor using kinetic measurement, i.e. time rate of progress of an antigen-antibody interaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2019508836A 2016-08-18 2017-08-18 アッセイ Active JP7008688B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1614152.5A GB201614152D0 (en) 2016-08-18 2016-08-18 Assay
GB1614152.5 2016-08-18
PCT/GB2017/052456 WO2018033753A2 (en) 2016-08-18 2017-08-18 Assay

Publications (3)

Publication Number Publication Date
JP2019526792A JP2019526792A (ja) 2019-09-19
JP2019526792A5 JP2019526792A5 (enExample) 2020-09-24
JP7008688B2 true JP7008688B2 (ja) 2022-02-10

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ID=57045465

Family Applications (1)

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JP2019508836A Active JP7008688B2 (ja) 2016-08-18 2017-08-18 アッセイ

Country Status (6)

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US (1) US11415579B2 (enExample)
EP (1) EP3500858B1 (enExample)
JP (1) JP7008688B2 (enExample)
ES (1) ES2972584T3 (enExample)
GB (1) GB201614152D0 (enExample)
WO (1) WO2018033753A2 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112121052B (zh) * 2019-06-25 2024-10-22 复旦大学 丙烯酰基苯并氮杂䓬类化合物在制备防治血液肿瘤药物中的用途
CN113387831A (zh) * 2020-03-11 2021-09-14 苏州大学 酰胺类化合物及其在制备神经炎症抑制剂中的应用
JP2023548079A (ja) * 2020-10-28 2023-11-15 ジェネンテック， インコーポレイテッド 遊離チオール検出のための蛍光エルマンアッセイ
JP7667684B2 (ja) * 2021-04-06 2025-04-23 株式会社日立製作所 検体の分析前処理方法および検体前処理装置

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004514891A (ja) 2000-11-21 2004-05-20 サネシス　ファーマシューティカルズ，　インコーポレイテッド リガンドの迅速な同定のための拡張されたテザー化アプローチ

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6335155B1 (en) 1998-06-26 2002-01-01 Sunesis Pharmaceuticals, Inc. Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
US6887667B2 (en) * 2000-12-28 2005-05-03 Alfred E. Mann Institute For Biomedical Engineering At The University Of Southern California Method and apparatus to identify small variations of biomolecules
US7672786B2 (en) * 2003-07-02 2010-03-02 Sergey Krylov Non-equilibrium capillary electrophoresis of equilibrium mixtures (NECEEM)—based methods for drug and diagnostic development
WO2005034840A2 (en) 2003-09-17 2005-04-21 Sunesis Pharmaceuticals, Inc. Identification of kinase inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004514891A (ja) 2000-11-21 2004-05-20 サネシス　ファーマシューティカルズ，　インコーポレイテッド リガンドの迅速な同定のための拡張されたテザー化アプローチ

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Christian K. Riener et al.，Quick measurement of protein sulfhydryls with Ellman's reagent and with 4,4'-dithiodipyridine，Anal Bioanal Chem，2002年06月06日，373，266-276
Stefan G. Kathman et al.，Covalent tethering of fragments for covalent probe discovery，MedChemComm，2016年01月28日，vol17, no4，576-585

Also Published As

Publication number Publication date
US11415579B2 (en) 2022-08-16
GB201614152D0 (en) 2016-10-05
WO2018033753A3 (en) 2018-05-24
ES2972584T3 (es) 2024-06-13
JP2019526792A (ja) 2019-09-19
US20190293641A1 (en) 2019-09-26
WO2018033753A2 (en) 2018-02-22
EP3500858B1 (en) 2023-12-27
EP3500858A2 (en) 2019-06-26

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