JP6998211B2 - 腫瘍抗原ny-eso-1のmhc iおよびmhc ii拘束性エピトープに対する、癌の併用t細胞受容体遺伝子療法 - Google Patents
腫瘍抗原ny-eso-1のmhc iおよびmhc ii拘束性エピトープに対する、癌の併用t細胞受容体遺伝子療法 Download PDFInfo
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EP15159001.5A EP3067366A1 (en) | 2015-03-13 | 2015-03-13 | Combined T cell receptor gene therapy of cancer against MHC I and MHC II-restricted epitopes of the tumor antigen NY-ESO-1 |
PCT/EP2016/055242 WO2016146505A1 (en) | 2015-03-13 | 2016-03-11 | Combined t cell receptor gene therapy of cancer against mhc i and mhc ii-restricted epitopes of the tumor antigen ny-eso-1 |
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US9511151B2 (en) | 2010-11-12 | 2016-12-06 | Uti Limited Partnership | Compositions and methods for the prevention and treatment of cancer |
US10988516B2 (en) | 2012-03-26 | 2021-04-27 | Uti Limited Partnership | Methods and compositions for treating inflammation |
US9603948B2 (en) | 2012-10-11 | 2017-03-28 | Uti Limited Partnership | Methods and compositions for treating multiple sclerosis and related disorders |
EP3065771B1 (en) | 2013-11-04 | 2019-03-20 | UTI Limited Partnership | Methods and compositions for sustained immunotherapy |
US12011480B2 (en) | 2015-05-06 | 2024-06-18 | Uti Limited Partnership | Nanoparticle compositions for sustained therapy |
DE102016123893A1 (de) | 2016-12-08 | 2018-06-14 | Immatics Biotechnologies Gmbh | T-Zellrezeptoren mit verbesserter Bindung |
EP3354658A1 (en) * | 2017-01-25 | 2018-08-01 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft | Novel t cell receptors and immune therapy using the same for the treatment of cancer and infectious diseases |
US11236145B2 (en) | 2017-03-23 | 2022-02-01 | Immatics Biotechnologies Gmbh | T cell receptors and immune therapy using the same against PRAME positive cancers |
SG11201909290TA (en) * | 2017-04-07 | 2019-11-28 | Uti Lp | Assay to measure the potency of receptor-ligand interactions in nanomedicines |
CN109837245A (zh) * | 2017-11-25 | 2019-06-04 | 深圳宾德生物技术有限公司 | 一种tcr敲除的靶向ny-eso-1的t细胞受体基因修饰t细胞及其制备方法和应用 |
CN111819194B (zh) * | 2018-02-26 | 2024-06-04 | 基因医疗免疫疗法有限责任公司 | Nyeso t细胞受体(tcr) |
CN110856751A (zh) | 2018-08-24 | 2020-03-03 | 合成免疫股份有限公司 | 包含核酸及tcr修饰的免疫细胞的治疗剂及其应用 |
EP3760217A1 (en) * | 2019-07-01 | 2021-01-06 | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft | Cd5 specific t cell receptor cell or gene therapy |
US20220273714A1 (en) * | 2019-07-19 | 2022-09-01 | The Regents Of The University Of California | T-cell receptors and methods of use thereof |
CN112390875B (zh) * | 2019-08-16 | 2023-01-24 | 香雪生命科学技术(广东)有限公司 | 一种识别afp的高亲和力t细胞受体 |
CN113512124A (zh) * | 2020-04-10 | 2021-10-19 | 香雪生命科学技术(广东)有限公司 | 一种识别hpv16的高亲和力tcr |
CN112501269B (zh) * | 2020-12-15 | 2022-02-18 | 清华大学 | 一种快速鉴定高亲和力tcr抗原交叉反应活性的方法 |
CN114121142B (zh) * | 2021-09-02 | 2023-10-31 | 四川大学华西医院 | 一种新型基因修饰增强型ny-eso-1特异型tcr-t模型构建方法及应用 |
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JP2013541332A (ja) | 2010-09-20 | 2013-11-14 | ビオエンテッヒ・アクチェンゲゼルシャフト | 抗原特異的t細胞受容体およびt細胞エピトープ |
WO2013177247A1 (en) | 2012-05-22 | 2013-11-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Murine anti-ny-eso-1 t cell receptors |
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WO2000060055A1 (en) * | 1999-04-01 | 2000-10-12 | The Brigham And Women's Hospital, Inc. | Modified dendritic cells and uses therefor |
EP1252309A2 (en) * | 2000-01-28 | 2002-10-30 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by the Secretary, Department of Health and Human Services | Mhc class ii restricted t cell epitopes from the cancer antigen ny-eso-1 |
EP1409646B1 (en) * | 2000-12-19 | 2012-06-13 | Altor BioScience Corporation | Transgenic animals comprising a humanized immune system |
AU2003217384A1 (en) * | 2002-02-13 | 2003-09-04 | Ludwig Institute For Cancer Research | Isolated peptides which bind to hla molecules and uses thereof |
GB0411123D0 (en) * | 2004-05-19 | 2004-06-23 | Avidex Ltd | High-affinity NY-ESO T cell receptors |
WO2006031221A1 (en) * | 2004-09-13 | 2006-03-23 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Compositions comprising t cell receptors and methods of use thereof |
MX343633B (es) * | 2007-03-05 | 2016-11-11 | Int Inst Cancer Immunology Inc | Gen receptor de celulas t especificas de antigeno cancerigeno, peptido codificado por el gen, y uso de los mismos. |
CN101381402B (zh) * | 2008-10-20 | 2011-06-01 | 中国人民解放军第三军医大学 | Ny-eso-1肿瘤抗原模拟表位及其应用 |
PT2951202T (pt) | 2013-01-29 | 2020-07-07 | Max Delbruck Centrum Fur Molekulare Medizin Mdc Berlin Buch | Moléculas de ligação de alta avidez que reconhecem mage-a1 |
RU2578009C2 (ru) * | 2013-05-08 | 2016-03-20 | Закрытое акционерное общество "ЕВРОГЕН" | Способ идентификации нативных пар фрагментов днк или рнк, присутствующих в одних и тех же живых клетках |
EP3572510B1 (en) * | 2013-11-21 | 2022-09-21 | Repertoire Genesis Incorporation | T cell receptor and b cell receptor repertoire analysis system, and use of same in treatment and diagnosis |
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WO2013177247A1 (en) | 2012-05-22 | 2013-11-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Murine anti-ny-eso-1 t cell receptors |
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AU2016232441A1 (en) | 2017-08-10 |
HK1247212A1 (zh) | 2018-09-21 |
JP2018509163A (ja) | 2018-04-05 |
EP3067366A1 (en) | 2016-09-14 |
EP3268385A1 (en) | 2018-01-17 |
US20180057560A1 (en) | 2018-03-01 |
ES2784315T3 (es) | 2020-09-24 |
WO2016146505A1 (en) | 2016-09-22 |
DK3268385T3 (da) | 2020-04-06 |
US10781243B2 (en) | 2020-09-22 |
CN107428816A (zh) | 2017-12-01 |
EP3268385B1 (en) | 2020-01-08 |
CN107428816B (zh) | 2022-01-14 |
PT3268385T (pt) | 2020-04-08 |
CN114195883A (zh) | 2022-03-18 |
JP2021151249A (ja) | 2021-09-30 |
EP3666793A3 (en) | 2020-07-29 |
AU2016232441B2 (en) | 2020-08-27 |
CA2974955A1 (en) | 2016-09-22 |
HUE049444T2 (hu) | 2020-09-28 |
PL3268385T3 (pl) | 2020-06-29 |
EP3666793A2 (en) | 2020-06-17 |
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