JP6996844B2 - 体細胞可動要素の分析のための方法、およびその使用 - Google Patents

体細胞可動要素の分析のための方法、およびその使用 Download PDF

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JP6996844B2
JP6996844B2 JP2016572365A JP2016572365A JP6996844B2 JP 6996844 B2 JP6996844 B2 JP 6996844B2 JP 2016572365 A JP2016572365 A JP 2016572365A JP 2016572365 A JP2016572365 A JP 2016572365A JP 6996844 B2 JP6996844 B2 JP 6996844B2
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Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2853829C (en) 2011-07-22 2023-09-26 President And Fellows Of Harvard College Evaluation and improvement of nuclease cleavage specificity
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10584381B2 (en) 2012-08-14 2020-03-10 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
BR112015003354A8 (pt) 2012-08-14 2018-01-16 10X Genomics Inc métodos e composições de microcápsula
EP3567116A1 (en) 2012-12-14 2019-11-13 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
CA2900481A1 (en) 2013-02-08 2014-08-14 10X Genomics, Inc. Polynucleotide barcode generation
EP3828285B1 (en) 2013-05-23 2023-12-13 The Board of Trustees of the Leland Stanford Junior University Transposition into native chromatin for personal epigenomics
US20180113137A1 (en) * 2013-10-18 2018-04-26 Tcm Biotech International Corp. Method for detecting the quantity of biomarker and identifying disease status
PL3102722T3 (pl) 2014-02-04 2021-03-08 Jumpcode Genomics, Inc. Frakcjonowanie genomu
KR102596508B1 (ko) 2014-04-10 2023-10-30 10엑스 제노믹스, 인크. 시약을 캡슐화 및 구획화하기 위한 유체 디바이스, 시스템, 및 방법, 및 이의 응용
KR20170026383A (ko) 2014-06-26 2017-03-08 10엑스 제노믹스, 인크. 핵산 서열의 분석
EP4574974A3 (en) 2014-06-26 2025-10-08 10x Genomics, Inc. Methods of analyzing nucleic acids from individual cells or cell populations
US12312640B2 (en) 2014-06-26 2025-05-27 10X Genomics, Inc. Analysis of nucleic acid sequences
US20160122817A1 (en) 2014-10-29 2016-05-05 10X Genomics, Inc. Methods and compositions for targeted nucleic acid sequencing
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
SG11201705615UA (en) 2015-01-12 2017-08-30 10X Genomics Inc Processes and systems for preparing nucleic acid sequencing libraries and libraries prepared using same
CN107532202A (zh) 2015-02-24 2018-01-02 10X 基因组学有限公司 用于靶向核酸序列覆盖的方法
US10697000B2 (en) 2015-02-24 2020-06-30 10X Genomics, Inc. Partition processing methods and systems
WO2016138292A1 (en) 2015-02-25 2016-09-01 Igenomx International Genomics Corporation Methods and compositions for in silico long read sequencing
EP4144861B1 (en) 2015-12-04 2024-09-11 10X Genomics, Inc. Methods and compositions for nucleic acid analysis
US11339427B2 (en) 2016-02-12 2022-05-24 Jumpcode Genomics, Inc. Method for target specific RNA transcription of DNA sequences
WO2017197343A2 (en) 2016-05-12 2017-11-16 10X Genomics, Inc. Microfluidic on-chip filters
WO2017197338A1 (en) 2016-05-13 2017-11-16 10X Genomics, Inc. Microfluidic systems and methods of use
CN105886645A (zh) * 2016-05-27 2016-08-24 福建爱我健康生物科技有限公司 一种用于评估皮肤抗皱情况的引物和探针及试剂盒
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US12264411B2 (en) 2017-01-30 2025-04-01 10X Genomics, Inc. Methods and systems for analysis
EP4310183B1 (en) 2017-01-30 2025-07-09 10X Genomics, Inc. Methods and systems for droplet-based single cell barcoding
US20180340169A1 (en) 2017-05-26 2018-11-29 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
CN109526228B (zh) 2017-05-26 2022-11-25 10X基因组学有限公司 转座酶可接近性染色质的单细胞分析
CN107245529A (zh) * 2017-08-08 2017-10-13 杭州千麦医学检验所有限公司 血液病融合基因筛查方法
WO2019099751A1 (en) 2017-11-15 2019-05-23 10X Genomics, Inc. Functionalized gel beads
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
DK3746564T3 (da) 2018-01-29 2023-01-30 St Jude Childrens Res Hospital Inc Fremgangsmåde til nukleinsyreamplifikation
EP4299755A3 (en) 2018-02-05 2024-04-10 The Board of Trustees of the Leland Stanford Junior University Systems and methods for multiplexed measurements in single and ensemble cells
CN108384846B (zh) * 2018-02-28 2020-06-16 固安博健生物技术有限公司 C11orf95基因及其表达产物在诊治类风湿性关节炎和骨关节炎方面的应用
SG11202009889VA (en) 2018-04-06 2020-11-27 10X Genomics Inc Systems and methods for quality control in single cell processing
CN112941155B (zh) * 2018-05-14 2023-07-14 北京艾克伦医疗科技有限公司 具有茎环结构的dna引物对及其应用
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
KR102102107B1 (ko) * 2019-05-30 2020-04-20 단국대학교 천안캠퍼스 산학협력단 이동성 유전인자 SINE 선택적 발굴을 위한 HiSeq 시퀀서 기반의 DNA 라이브러리 제작 방법
CA3146298A1 (en) * 2019-07-30 2021-02-04 University Health Network T cell receptors and methods of use thereof
EP4021581A4 (en) * 2019-08-30 2023-08-30 Foundation Medicine, Inc. KMT2A-MAML2 FUSION MOLECULES AND USES THEREOF
CN118891374A (zh) * 2022-03-24 2024-11-01 南京传奇生物科技有限公司 制备dna文库和检测逆转录病毒整合位点的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003508082A (ja) 1999-09-07 2003-03-04 デコード ジェネティクス イーエッチエフ. ヒト可動性因子を使用する長領域pcrによる遺伝子における変更の検出

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU9596098A (en) * 1997-09-29 1999-04-23 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Display technique for identifying line-1 insertion site polymorphisms
HUP0201423A3 (en) * 1999-04-01 2004-12-28 Dna Landmarks Inc St Jean Rich A novel type of transposon-based genetic marker
AU2003209453A1 (en) * 2002-03-05 2003-09-16 Arrow Therapeutics Limited Transposon
US20060035245A1 (en) * 2004-04-20 2006-02-16 Ason Brandon L Modulators of enzymatic nucleic acid elements mobilization
US8071310B2 (en) * 2005-11-14 2011-12-06 Keygene Nv Method for the high throughput screening of transposon tagging populations and massive parallel sequence identification of insertion sites
AU2008245546A1 (en) * 2007-04-25 2008-11-06 John Wayne Cancer Institute Use of methylated or unmethylated LINE-I DNA as a cancer marker
US20120252015A1 (en) * 2011-02-18 2012-10-04 Bio-Rad Laboratories Methods and compositions for detecting genetic material
EP2789694A1 (en) * 2009-04-02 2014-10-15 Fluidigm Corporation Microfluidic device with reaction product recovery system
US9028561B2 (en) * 2009-05-05 2015-05-12 Milliken & Company Bluing composition and method for treating textile articles using the same
WO2011017404A2 (en) * 2009-08-05 2011-02-10 The Salk Institute For Biological Studies Retroelements and mental disorders and methods of measuring l1 retrotransposition
CN103517990A (zh) * 2010-10-07 2014-01-15 通用医疗公司 癌症生物标志物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003508082A (ja) 1999-09-07 2003-03-04 デコード ジェネティクス イーエッチエフ. ヒト可動性因子を使用する長領域pcrによる遺伝子における変更の検出

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Cell, 2010, Vol. 141, pp. 1253-1261
Cell, 2013, Vol. 153, pp. 101-111

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