JP6987638B2 - クレブシエラ・ニューモニエのガラクタンベースのｏ抗原をターゲティングする抗体 - Google Patents

クレブシエラ・ニューモニエのガラクタンベースのｏ抗原をターゲティングする抗体 Download PDF

Info

Publication number
JP6987638B2
JP6987638B2 JP2017543737A JP2017543737A JP6987638B2 JP 6987638 B2 JP6987638 B2 JP 6987638B2 JP 2017543737 A JP2017543737 A JP 2017543737A JP 2017543737 A JP2017543737 A JP 2017543737A JP 6987638 B2 JP6987638 B2 JP 6987638B2
Authority
JP
Japan
Prior art keywords
antibody
seq
sequence
amino acid
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2017543737A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018508208A5 (https=
JP2018508208A (ja
Inventor
スジャルト，ヴァレリア
ナギー，ガボール
グアシャラ，ルイ
ビスラム，ゼフラ
ナギー，エスター
ルカシェヴィッチ，ヨランタ・カタジーナ
Original Assignee
エックスフォー・ファーマシューティカルズ（オーストリア）ゲーエムべーハー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by エックスフォー・ファーマシューティカルズ（オーストリア）ゲーエムべーハー filed Critical エックスフォー・ファーマシューティカルズ（オーストリア）ゲーエムべーハー
Publication of JP2018508208A publication Critical patent/JP2018508208A/ja
Publication of JP2018508208A5 publication Critical patent/JP2018508208A5/ja
Priority to JP2021194395A priority Critical patent/JP2022058341A/ja
Application granted granted Critical
Publication of JP6987638B2 publication Critical patent/JP6987638B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Gram-negative bacteria
    • C07K16/1228—Enterobacterales (O), e.g. Citrobacter (G), Serratia (G), Proteus (G), Providencia (G), Morganella (G) or Yersinia (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56916—Enterobacteria, e.g. shigella, salmonella, klebsiella, serratia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/24—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • G01N2333/26—Klebsiella (G)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/26—Infectious diseases, e.g. generalised sepsis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2017543737A 2015-02-17 2015-11-03 クレブシエラ・ニューモニエのガラクタンベースのｏ抗原をターゲティングする抗体 Expired - Fee Related JP6987638B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021194395A JP2022058341A (ja) 2015-02-17 2021-11-30 クレブシエラ・ニューモニエのガラクタンベースのｏ抗原をターゲティングする抗体

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15155448.2 2015-02-17
EP15155448 2015-02-17
PCT/EP2015/075583 WO2016131503A1 (en) 2015-02-17 2015-11-03 Antibodies targeting a galactan-based o-antigen of k. pneumoniae

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021194395A Division JP2022058341A (ja) 2015-02-17 2021-11-30 クレブシエラ・ニューモニエのガラクタンベースのｏ抗原をターゲティングする抗体

Publications (3)

Publication Number Publication Date
JP2018508208A JP2018508208A (ja) 2018-03-29
JP2018508208A5 JP2018508208A5 (https=) 2019-04-18
JP6987638B2 true JP6987638B2 (ja) 2022-01-05

Family

ID=52469764

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2017543737A Expired - Fee Related JP6987638B2 (ja) 2015-02-17 2015-11-03 クレブシエラ・ニューモニエのガラクタンベースのｏ抗原をターゲティングする抗体
JP2021194395A Withdrawn JP2022058341A (ja) 2015-02-17 2021-11-30 クレブシエラ・ニューモニエのガラクタンベースのｏ抗原をターゲティングする抗体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2021194395A Withdrawn JP2022058341A (ja) 2015-02-17 2021-11-30 クレブシエラ・ニューモニエのガラクタンベースのｏ抗原をターゲティングする抗体

Country Status (12)

Country Link
US (2) US11466074B2 (https=)
EP (1) EP3259287A1 (https=)
JP (2) JP6987638B2 (https=)
KR (1) KR20170122726A (https=)
CN (1) CN107371365B (https=)
AU (1) AU2015383632B2 (https=)
BR (1) BR112017017553A2 (https=)
CA (1) CA2973134A1 (https=)
IL (1) IL253920B2 (https=)
MX (1) MX2017009955A (https=)
RU (2) RU2021131224A (https=)
WO (1) WO2016131503A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022058341A (ja) * 2015-02-17 2022-04-12 エックスフォー・ファーマシューティカルズ（オーストリア）ゲーエムべーハー クレブシエラ・ニューモニエのガラクタンベースのｏ抗原をターゲティングする抗体

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20190077306A (ko) 2016-08-05 2019-07-03 메디뮨 엘엘씨 항-o2 항체 및 이의 용도
SG11201903063UA (en) * 2016-10-19 2019-05-30 Medimmune Llc Anti-o1 antibodies and uses thereof
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
US12537071B1 (en) 2020-07-22 2026-01-27 David Gordon Bermudes Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins
CN120775040A (zh) * 2021-08-25 2025-10-14 北京三诺佳邑生物技术有限责任公司 特异性识别肺炎克雷伯菌o1抗原的抗体及其应用
EP4445911A4 (en) 2021-12-06 2025-10-22 Beijing Solobio Genetechnology Co Ltd BISPECIFIC ANTIBODY THAT BINDS SPECIFICALLY TO KLEBSIELLA PNEUMONIAE O1 AND O2 ANTIGENS AND COMPOSITION
CN118620072A (zh) * 2023-12-27 2024-09-10 上海博钒生物科技有限公司 一种肺炎克雷伯菌多糖单克隆抗体、其杂交瘤细胞株及其应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US20050112141A1 (en) * 2000-08-30 2005-05-26 Terman David S. Compositions and methods for treatment of neoplastic disease
EA013564B1 (ru) * 2000-08-03 2010-06-30 Терапеутик Хьюман Поликлоналз Инк. Гуманизированный иммуноглобулин и содержащая его фармацевтическая композиция
US7117096B2 (en) 2001-04-17 2006-10-03 Abmaxis, Inc. Structure-based selection and affinity maturation of antibody library
AU2003217912A1 (en) 2002-03-01 2003-09-16 Xencor Antibody optimization
EP3124497B1 (en) 2007-09-14 2020-04-15 Adimab, LLC Rationally designed, synthetic antibody libraries and uses therefor
US8877688B2 (en) 2007-09-14 2014-11-04 Adimab, Llc Rationally designed, synthetic antibody libraries and uses therefor
KR102318383B1 (ko) 2010-07-16 2021-10-27 아디맵 엘엘씨 항체 라이브러리
BR112017017553A2 (pt) * 2015-02-17 2018-05-08 Arsanis Biosciences Gmbh ?anticorpos direcionados contra um antígeno o baseado em galactano de k. pneumoniae, método de produção, preparação farmacêutica ou diagnóstica, método de diagnóstico, método de identificação, ácido nucleico isolado, célula hospedeira e invólucro de expressão?

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022058341A (ja) * 2015-02-17 2022-04-12 エックスフォー・ファーマシューティカルズ（オーストリア）ゲーエムべーハー クレブシエラ・ニューモニエのガラクタンベースのｏ抗原をターゲティングする抗体

Also Published As

Publication number Publication date
KR20170122726A (ko) 2017-11-06
JP2018508208A (ja) 2018-03-29
BR112017017553A2 (pt) 2018-05-08
US20180066041A1 (en) 2018-03-08
CN107371365A (zh) 2017-11-21
CA2973134A1 (en) 2016-08-25
MX2017009955A (es) 2017-10-19
AU2015383632A1 (en) 2017-07-27
CN107371365B (zh) 2022-01-11
RU2021131224A (ru) 2021-11-03
IL253920B (en) 2022-10-01
IL253920B2 (en) 2023-02-01
US20230220055A1 (en) 2023-07-13
EP3259287A1 (en) 2017-12-27
AU2015383632B2 (en) 2021-10-21
RU2759950C2 (ru) 2021-11-19
WO2016131503A1 (en) 2016-08-25
IL253920A0 (en) 2017-10-31
US11466074B2 (en) 2022-10-11
RU2017132168A3 (https=) 2019-06-11
RU2017132168A (ru) 2019-03-18
JP2022058341A (ja) 2022-04-12

Similar Documents

Publication Publication Date Title
JP6987638B2 (ja) クレブシエラ・ニューモニエのガラクタンベースのｏ抗原をターゲティングする抗体
US11529405B2 (en) MDR E. coli immunogen
US12103962B2 (en) E. coli specific antibodies
US20180298084A1 (en) Bactericidal monoclonal antibody targeting klebsiella pneumoniae
US20180312576A1 (en) Antibodies targeting a mannan-based o-antigen of k. pneumoniae
RU2819254C1 (ru) Рекомбинантное антитело, плазмида, экспрессирующая кассета, клетка-хозяин, способ получения вышеназванного антитела (варианты), способ идентификации антитела-кандидата, композиция и иммуноген
RU2819254C9 (ru) Рекомбинантное антитело, плазмида, экспрессирующая кассета, клетка-хозяин, способ получения вышеназванного антитела (варианты), способ идентификации антитела-кандидата, композиция и иммуноген

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20181102

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20190307

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190927

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20191226

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200617

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20200917

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20201117

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20210507

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210702

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20211006

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20211102

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20211201

R150 Certificate of patent or registration of utility model

Ref document number: 6987638

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees