JP6966428B2 - 副溝結合テイルを有するｄｎａ結合物質 - Google Patents

副溝結合テイルを有するｄｎａ結合物質 Download PDF

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JP6966428B2
JP6966428B2 JP2018513780A JP2018513780A JP6966428B2 JP 6966428 B2 JP6966428 B2 JP 6966428B2 JP 2018513780 A JP2018513780 A JP 2018513780A JP 2018513780 A JP2018513780 A JP 2018513780A JP 6966428 B2 JP6966428 B2 JP 6966428B2
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substituted
methyl
compound
pyrrole
alkoxy
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JP2018527372A (ja
JP2018527372A5 (https=
Inventor
ワルデマー プリーベ
リウェイ グオ
アルカディウシュ カジミエスキ
イザベラ フォクト
チャールズ コンラッド
ティモシー マッデン
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University of Texas System
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University of Texas System
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C13/00—Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
    • C07C13/28—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
    • C07C13/32—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings
    • C07C13/62—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with more than three condensed rings
    • C07C13/66—Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof with condensed rings with more than three condensed rings the condensed ring system contains only four rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/244—Anthraquinone radicals, e.g. sennosides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
JP2018513780A 2015-09-16 2016-09-16 副溝結合テイルを有するｄｎａ結合物質 Active JP6966428B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562219380P 2015-09-16 2015-09-16
US62/219,380 2015-09-16
PCT/US2016/052144 WO2017049091A1 (en) 2015-09-16 2016-09-16 Dna binding agents with a minor groove binding tail

Publications (3)

Publication Number Publication Date
JP2018527372A JP2018527372A (ja) 2018-09-20
JP2018527372A5 JP2018527372A5 (https=) 2019-10-24
JP6966428B2 true JP6966428B2 (ja) 2021-11-17

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ID=58289623

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JP2018513780A Active JP6966428B2 (ja) 2015-09-16 2016-09-16 副溝結合テイルを有するｄｎａ結合物質

Country Status (7)

Country Link
US (1) US10358439B2 (https=)
EP (1) EP3350145B1 (https=)
JP (1) JP6966428B2 (https=)
CN (1) CN108368006B (https=)
AU (1) AU2016323777B2 (https=)
PL (1) PL3350145T3 (https=)
WO (1) WO2017049091A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20250009727A1 (en) * 2021-11-17 2025-01-09 Board Of Regents, The University Of Texas System Water-soluble salts of dna binding agents

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4288608A (en) 1978-06-01 1981-09-08 Research Corporation Synthesis of anthracyclines
US4196127A (en) 1978-06-01 1980-04-01 Research Corporation Anthracyclines
CA1174669A (en) 1980-07-18 1984-09-18 Michael J. Broadhurst Anthracycline glycosides
ZA814722B (en) * 1980-07-18 1982-07-28 Hoffmann La Roche Novel anthracycline glycosides
US5874412A (en) * 1996-03-22 1999-02-23 Priebe; Waldemar Bis-anthracyclines with high activity against doxorubicin resistant tumors
GB9812937D0 (en) * 1998-06-16 1998-08-12 Btg Int Ltd Compounds
ATE546457T1 (de) * 1999-03-19 2012-03-15 Waldemar Priebe Verfahren und zusammensetzungen zur herstellung von c-3' und c-4' -anthracyclin antibiotika
AU2003217782A1 (en) * 2002-02-27 2003-09-09 The Government Of The United States Of America, Representated By The Secretary, Deparment Of Health Dna-binding polyamide drug conjugates
CN101284136A (zh) * 2002-12-03 2008-10-15 布朗歇特洛克菲勒神经科学研究所 传输物质穿过血脑屏障的人工低密度脂蛋白载体
SE0401066D0 (sv) * 2004-04-22 2004-04-22 Stefan Sjoeberg Chemical Derivatives
PL380561A1 (pl) 2006-09-05 2008-03-17 Szeja Wiesław Prochem Szeja Sposób otrzymywania pochodnych antracyklin
WO2010104585A1 (en) * 2009-03-12 2010-09-16 Luitpold Pharmaceuticals, Inc. Gaba-linked anthracycline-lipid conjugates

Also Published As

Publication number Publication date
CN108368006B (zh) 2023-03-07
AU2016323777A1 (en) 2018-04-12
EP3350145A1 (en) 2018-07-25
EP3350145A4 (en) 2019-03-27
AU2016323777B2 (en) 2021-05-13
EP3350145B1 (en) 2020-09-16
US20180251454A1 (en) 2018-09-06
JP2018527372A (ja) 2018-09-20
US10358439B2 (en) 2019-07-23
WO2017049091A1 (en) 2017-03-23
PL3350145T3 (pl) 2021-05-04
CA2998867A1 (en) 2017-03-23
CN108368006A (zh) 2018-08-03

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