JP6961879B2 - 変異体イソクエン酸デヒドロゲナーゼを包含する腫瘍の処置 - Google Patents

変異体イソクエン酸デヒドロゲナーゼを包含する腫瘍の処置 Download PDF

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JP6961879B2
JP6961879B2 JP2018534683A JP2018534683A JP6961879B2 JP 6961879 B2 JP6961879 B2 JP 6961879B2 JP 2018534683 A JP2018534683 A JP 2018534683A JP 2018534683 A JP2018534683 A JP 2018534683A JP 6961879 B2 JP6961879 B2 JP 6961879B2
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protein
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cancer
idh
idh2
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JP2019506380A (ja
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シ，ヤガン
キーナン，マリー・シー
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レ ラボラトワール セルヴィエ ソシエテ・パール・アクシオンス・サンプリフィエ
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
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JP2018534683A 2015-12-30 2016-12-29 変異体イソクエン酸デヒドロゲナーゼを包含する腫瘍の処置 Expired - Fee Related JP6961879B2 (ja)

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US201562273135P 2015-12-30 2015-12-30
US62/273,135 2015-12-30
PCT/US2016/069161 WO2017117372A1 (en) 2015-12-30 2016-12-29 Treatment of tumors incorporating mutant isocitrate dehydrogenase

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JP2019506380A JP2019506380A (ja) 2019-03-07
JP2019506380A5 JP2019506380A5 (https=) 2020-02-06
JP6961879B2 true JP6961879B2 (ja) 2021-11-05

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US (2) US20190025313A1 (https=)
EP (1) EP3397625A4 (https=)
JP (1) JP6961879B2 (https=)
KR (1) KR20180102105A (https=)
CN (1) CN108699023A (https=)
AU (1) AU2016380280B2 (https=)
CA (1) CA3009826A1 (https=)
IL (1) IL260326A (https=)
MX (1) MX2018008169A (https=)
WO (1) WO2017117372A1 (https=)

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PL3139914T3 (pl) 2014-05-08 2023-11-27 Kiora Pharmaceuticals Gmbh Związki stosowane w leczeniu chorób i schorzeń okulistycznych
US20180369206A1 (en) 2017-04-24 2018-12-27 Aurigene Discovery Technologies Limited Methods of Use for Trisubstituted Benzotriazole Derivatives as Dihydroorotate Oxygenase Inhibitors
MA48459B1 (fr) 2017-04-24 2021-09-30 Aurigene Discovery Tech Ltd Méthodes d'utilisation de dérivés de benzotriazole trisubstitués en tant qu'inhibiteurs de dihydroorotate oxygénase
KR102861339B1 (ko) 2018-02-20 2025-09-19 르 라보레또레 쎄르비에르 삼치환 벤조트리아졸 유도체의 사용 방법
ES2972099T3 (es) 2018-03-09 2024-06-11 Kiora Pharmaceuticals Gmbh Formulación oftálmica
WO2019175396A1 (en) * 2018-03-16 2019-09-19 Immunic Ag Novel calcium salt polymorphs as anti-inflammatory, immunomodulatory and anti-proliferatory agents
EP3773579A4 (en) 2018-03-26 2022-03-09 Clear Creek Bio, Inc. COMPOSITIONS AND METHODS FOR INHIBITING DIHYDROOROTATE DEHYDROGENASE
JP7126556B2 (ja) * 2018-09-28 2022-08-26 富士フイルム株式会社 シタラビンを含む抗腫瘍剤、シタラビンと併用される抗腫瘍効果増強剤、抗腫瘍用キット、およびシタラビンと併用される抗腫瘍剤
CA3133376A1 (en) * 2018-11-30 2020-06-04 Aptose Biosciences Inc. Combination therapy with 2,3-dihydro-isoindole-1-one compounds and methods for treating patients with various mutations
PE20212197A1 (es) 2018-12-21 2021-11-16 Les Laboratoires Servier Sas Formas de sal y cristalinas de un compuesto organico y composiciones farmaceuticas del mismo
EP3750892A1 (en) 2019-06-14 2020-12-16 Yerevan State University Novel 5-cyclopropyl-furo[3,4-c]pyridine-3,4(1h,5h)-dione 1,1' substituted derivatives and their uses
US11228361B2 (en) 2019-10-25 2022-01-18 Atlas Space Operations, Inc. System and method for configuring a communications device for space-terrestrial communications
WO2021134045A1 (en) * 2019-12-26 2021-07-01 Ohio State Innovation Foundation Methods and compositions for inhibition of dihydroorotate dehydrogenase in combination with an anti-cd38 therapeutic agent
US20210300873A1 (en) 2020-03-20 2021-09-30 Clear Creek Bio, Inc. Stable polymorphic compositions of brequinar sodium and methods of use and manufacture thereof
WO2022167402A1 (en) * 2021-02-02 2022-08-11 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of therapy comprising administering a therapeutically effective combination comprising a dhodh inhibitor and an idh inhibitor
US12600721B2 (en) 2021-02-19 2026-04-14 Sudo Biosciences Limited TYK2 inhibitors and uses thereof
IL305165A (en) 2021-02-19 2023-10-01 Sudo Biosciences Ltd Tyk2 inhibitors and uses thereof
CA3207819A1 (en) 2021-02-19 2022-08-25 Anjali Pandey Tyk2 inhibitors and uses thereof
EP4319766A4 (en) * 2021-04-08 2025-05-28 Memorial Sloan Kettering Cancer Center NADK2 INHIBITION IN CANCER AND FIBROTIC DISEASES
IL315335A (en) * 2022-03-01 2024-10-01 Kiora Pharmaceuticals Gmbh salts of dehydrogenase inhibitor (DHOD)
WO2023172818A1 (en) * 2022-03-09 2023-09-14 Kiora Pharmaceuticals Gmbh Polymorphs of a dihydroorotate dehydrogenase (dhod) inhibitor

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MXPA04000224A (es) * 2001-07-10 2005-07-25 4Sc Ag Novedosos compuestos como agentes antiinflamatorios, inmunomoduladores y antiproliferativos.
US9316632B2 (en) * 2009-03-17 2016-04-19 Marshall University Research Corporation Methods of screening chemotherapeutic agents and treating cancer
JP5967827B2 (ja) * 2009-12-09 2016-08-10 アジオス ファーマシューティカルズ， インコーポレイテッド Ｉｄｈ変異体をもつことを特徴とする癌治療用の治療的活性化合物
WO2013049112A1 (en) * 2011-09-27 2013-04-04 Emory University Detection of biomarkers using magnetic resonance
PL3139914T3 (pl) * 2014-05-08 2023-11-27 Kiora Pharmaceuticals Gmbh Związki stosowane w leczeniu chorób i schorzeń okulistycznych
WO2017037022A1 (en) * 2015-09-01 2017-03-09 Bayer Pharma Aktiengesellschaft Compounds and methods useful for treating or preventing hematological cancers

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CA3009826A1 (en) 2017-07-06
AU2016380280B2 (en) 2021-09-23
IL260326A (en) 2018-08-30
MX2018008169A (es) 2019-02-20
AU2016380280A1 (en) 2018-07-12
WO2017117372A1 (en) 2017-07-06
KR20180102105A (ko) 2018-09-14
JP2019506380A (ja) 2019-03-07
US20210088520A1 (en) 2021-03-25
EP3397625A4 (en) 2019-12-25
US20190025313A1 (en) 2019-01-24
EP3397625A1 (en) 2018-11-07
CN108699023A (zh) 2018-10-23

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