JP6956174B2 - 発酵における感染に対する脂肪酸エステル - Google Patents
発酵における感染に対する脂肪酸エステル Download PDFInfo
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- JP6956174B2 JP6956174B2 JP2019511364A JP2019511364A JP6956174B2 JP 6956174 B2 JP6956174 B2 JP 6956174B2 JP 2019511364 A JP2019511364 A JP 2019511364A JP 2019511364 A JP2019511364 A JP 2019511364A JP 6956174 B2 JP6956174 B2 JP 6956174B2
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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Description
微生物増殖用の基質;並びに
外因性の添加成分として、
i)下記の式1に従うラクチレート
(R-(O-CH(CH3)-CO)aO)bM (式1);
ii)下記の式2に従うグリセロールエステル
CH2OR1-CHOR2-CH2OR3 (式2);及び
iii)そのような化合物の混合物
から選択される抗菌剤を含み、
ここで、
RはC4〜C18のアシル基を表し、該アシル基は、分岐されていてもよく又は分岐されていなくてもよいアルキル又はアルケニル鎖を有し;
R1、R2及びR3はそれぞれ独立して、H又はC4〜C18のアシル基を表し、該アシル基は、分岐されていてもよく又は分岐されていなくてもよいアルキル又はアルケニル鎖を有し、但し、R1、R2及びR3の少なくとも1つはHであり且つR1、R2及びR3の少なくとも1つはアシル基であり;
Mは、プロトン(H+)、又はLi、Na、K、Ca、Mg、Zn、Fe(II)、Cu、Mn、Ag、アンモニウム、若しくは1以上のヒドロキシで任意的に置換されていてもよい1以上の(C1〜4)アルキルを有する置換アンモニウムの群から選択される対カチオンを表し;
aは、1〜3の整数であり;及び
bは、Mの原子価に等しい1又は2である。
グラム陰性菌、カビ又は酵母の培養物;及び
i)下記の式1に従うラクチレート
(R-(O-CH(CH3)-CO)aO)bM (式1);
ii)下記の式2に従うグリセロールエステル
CH2OR1-CHOR2-CH2OR3 (式2);及び
iii)そのような化合物の混合物
から選択される抗菌剤を含み、
ここで、
RはC4〜C18のアシル基を表し、該アシル基は、分岐されていてもよく又は分岐されていなくてもよいアルキル又はアルケニル鎖を有し;
R1、R2及びR3はそれぞれ独立して、H又はC4〜C18のアシル基を表し、該アシル基は、分岐されていてもよく又は分岐されていなくてもよいアルキル又はアルケニル鎖を有し、但し、R1、R2及びR3の少なくとも1つはHであり且つR1、R2及びR3の少なくとも1つはアシル基であり;
Mは、プロトン(H+)、又はLi、Na、K、Ca、Mg、Zn、Fe(II)、Cu、Mn、Ag、アンモニウム、若しくは1以上のヒドロキシで任意的に置換されていてもよい1以上の(C1〜4)アルキルを有する置換アンモニウムの群から選択される対カチオンを表し;
aは、1〜3の整数であり;及び
bは、Mの原子価に等しい1又は2である。
(R-(O-CH(CH3)-CO)aO)bM (式1);
CH2OR1-CHOR2-CH2OR3 (式2)
i)発酵槽1:大腸菌TG128 純粋培養発酵;
ii)発酵槽2:大腸菌TG128 クロストリジウム・パストゥリアヌムJEG2と混合された;
iii)発酵槽3:大腸菌TG128 0.05%(w/v)のテトラデカノイル-ラクチレート(C14-ラクチレート:Corbion Caravan,Lenexa,Kansas,米国)を添加して、クロストリジウム・パストゥリアヌムJEG2と混合された。
大腸菌 serotype O157:H7 (ATCC 700728);
大腸菌 (ATCC 8739);
スタフィロコッカス・アウレウス (ATCC 6538P);
リステリア・モノサイトゲネス (F2399);
リステリア・モノサイトゲネス (ATCC 7644);
リステリア・モノサイトゲネス NFPA 83 (Seman,D.L.,A.C.Borger等,(2002年) Journal of Food Protection 65(4):651-658);
リステリア・モノサイトゲネス LCDC 861 (Seman,D.L.,A.C.Borger等,(2002年) Journal of Food Protection 65(4):651-658);
リステリア・イノキュア (ATCC 33090);
リステリア・イノキュア TNO strain (TNO,Zeist,オランダ);
サルモネラ・エンテリカ(Salmonella enterica) (ATCC 13076,S.Enteritidis);
サルモネラ・エンテリカ (ATCC 13311,S.Typhimurium);
サルモネラ・エンテリカ JAVA (NCTC 8458,NCTC: National Collection of Type Cultures,Porton Down,Salisbury,英国);
ラクトバチルス・サケイ(Lactobacillus sakei) (DSMZ 20017,DSMZ:Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH,Braunschweig,ドイツ);
ラクトバチルス・プランタルム(Lactobacillus plantarum) (DSMZ 20174);
ラクトバチルス・カルバタス(Lactobacillus curvatus) (DSMZ 20019);
バチルス・セレウス (ATCC 11778);
シュードモナス・ルンデンシス(Pseudomonas lundensis) (LMG 13517,LMG:Belgian Coordinated Collections of Microorganisms/LMG Bacteria Collection,Gent,ベルギー);及び
シュードモナス・フラギ(Pseudomonas fragi) (LMG 2191)。
Claims (24)
- 発酵培地であって、
グラム陰性菌、カビ又は酵母の培養物を含む接種物、ここで、該酵母がブレタノマイセス属(Brettanomyces)、カンジダ属(Candida)、デッケラ属(Dekkera)及びピキア属(Pichia)から選択される、
微生物増殖用の基質;並びに
外因性の添加成分として、
i) 下記の式1に従う少なくとも1つのラクチレート
(R-(O-CH(CH3)-CO)aO)bM (式1);
ii) 下記の式2に従う少なくとも1つのグリセロールエステル
CH2OR1-CHOR2-CH2OR3 (式2);及び
iii) 上記のi)及びii)の混合物
から選択される抗菌剤
を含み、
ここで、
RはC4〜C18のアシル基を表し、該アシル基は、分岐されていてもよく又は分岐されていなくてもよいアルキル又はアルケニル鎖を有し;
R1、R2及びR3はそれぞれ独立して、H又はC4〜C18のアシル基を表し、該アシル基は、分岐されていてもよく又は分岐されていなくてもよいアルキル又はアルケニル鎖を有し、但し、R1、R2及びR3の少なくとも1つはHであり且つR1、R2及びR3の少なくとも1つはアシル基であり;
Mは、プロトン(H+)、又はLi、Na、K、Ca、Mg、Zn、Fe(II)、Cu、Mn、Ag、アンモニウム、若しくは1以上のヒドロキシで任意的に置換されていてもよい1以上の(C1〜4)アルキルを有する置換アンモニウムの群から選択される対カチオンを表し;
aは、1〜3の整数であり;及び
bは、Mの原子価に等しい1又は2である、
上記発酵培地。 - 該抗菌剤が、式1に従うラクチレート又はその塩である、請求項1に記載の発酵培地。
- Rが、4〜18の炭素原子からなる直鎖又は分岐鎖を有するアシル基を表す、請求項2に記載の発酵培地。
- Rが、12〜14の炭素原子からなる直鎖又は分岐鎖を有するアシル基を表す、請求項3に記載の発酵培地。
- 式1におけるaが1である、請求項4に記載の発酵培地。
- 該抗菌剤が、式2に従うグリセロールエステルである、請求項1に記載の発酵培地。
- R1、R2及びR3のうちの1つ又は2つが8の炭素原子を有するアシル基であり、且つ他がHである、請求項6に記載の発酵培地。
- 該抗菌剤の量が、該培地の全重量に基づいて0.001〜0.5重量%である、請求項1〜7のいずれか1項に記載の発酵培地。
- 該抗菌剤の量が、該培地の全重量に基づいて0.025〜0.5重量%である、請求項8に記載の発酵培地。
- エタノール;1,3-プロパンジオール;グリセロール;ブタノール;1,4-ブタンジオール;アラビトール;キシリトール;ソルビトール;マンニトール;酢酸;プロピオン酸;3-ヒドロキシプロピオン酸;乳酸;コハク酸;2,5-フランジカルボン酸;フマル酸;リンゴ酸;アジピン酸;クエン酸;アコニット酸;グルタミン酸;イタコン酸;レブリン酸;グルタル酸;アスパラギン酸;マロン酸;及びそれらの混合物の生産の為の、請求項1〜7のいずれか1項に記載の発酵培地。
- 1,4-ブタンジオール;プロピオン酸;3-ヒドロキシプロピオン酸;乳酸;コハク酸;2,5-フランジカルボン酸;フマル酸;リンゴ酸;又はイタコン酸の生産の為の、請求項1〜7のいずれか1項に記載の発酵培地。
- 発酵培地用の接種物であって、
グラム陰性菌、カビ又は酵母の培養物、ここで、該酵母がブレタノマイセス属(Brettanomyces)、カンジダ属(Candida)、デッケラ属(Dekkera)及びピキア属(Pichia)から選択される;並びに
i) 下記の式1に従う少なくとも1つのラクチレート
(R-(O-CH(CH3)-CO)aO)bM (式1);
ii) 下記の式2に従う少なくとも1つのグリセロールエステル
CH2OR1-CHOR2-CH2OR3 (式2);及び
iii) 上記のi)及びii)の混合物
から選択される抗菌剤
を含み、
ここで、
RはC4〜C18のアシル基を表し、該アシル基は、分岐されていてもよく又は分岐されていなくてもよいアルキル又はアルケニル鎖を有し;
R1、R2及びR3はそれぞれ独立して、H又はC4〜C18のアシル基を表し、該アシル基は、分岐されていてもよく又は分岐されていなくてもよいアルキル又はアルケニル鎖を有し、但し、R1、R2及びR3の少なくとも1つはHであり且つR1、R2及びR3の少なくとも1つはアシル基であり;
Mは、プロトン(H+)、又はLi、Na、K、Ca、Mg、Zn、Fe(II)、Cu、Mn、Ag、アンモニウム、若しくは1以上のヒドロキシで任意的に置換されていてもよい1以上の(C1〜4)アルキルを有する置換アンモニウムの群から選択される対カチオンを表し;
aは、1〜3の整数であり;及び
bは、Mの原子価に等しい1又は2である、
上記接種物。 - グラム陰性菌の発酵培養におけるグラム陽性菌によって引き起こされる微生物感染を防ぐ又は低減する為の方法であって、
i) 式1に従う少なくとも1つのラクチレート
(R-(O-CH(CH3)-CO)aO)bM (式1);
ii) 式2に従う少なくとも1つのグリセロールエステル
CH2OR1-CHOR2-CH2OR3 (式2);及び
iii) 上記のi)及びii)の混合物
から選択される抗菌剤の有効量を培養物に添加することを含み、
ここで、
RはC4〜C18のアシル基を表し、該アシル基は、分岐されていてもよく又は分岐されていなくてもよいアルキル又はアルケニル鎖を有し;
R1、R2及びR3はそれぞれ独立して、H又はC4〜C18のアシル基を表し、該アシル基は、分岐されていてもよく又は分岐されていなくてもよいアルキル又はアルケニル鎖を有し、但し、R1、R2及びR3の少なくとも1つはHであり且つR1、R2及びR3の少なくとも1つはアシル基であり;
Mは、プロトン(H+)、又はLi、Na、K、Ca、Mg、Zn、Fe(II)、Cu、Mn、Ag、アンモニウム、若しくは1以上のヒドロキシで任意的に置換されていてもよい1以上の(C1〜4)アルキルを有する置換アンモニウムの群から選択される対カチオンを表し;
aは、1〜3の整数であり;及び
bは、Mの原子価に等しい1又は2である、
上記方法。 - 発酵生産物を得る為の方法であって、
微生物増殖用の基質を含有する発酵培地を用意すること、
グラム陰性菌、カビ又は酵母の培養物を含む接種物を培地内に導入して、発酵生産物を得ること、そして、
前記発酵生産物を清澄化し、精製し及び/又は濃縮すること
を含み、
該方法は、該発酵培地が、
外因性の添加成分として、
i) 式1に従う少なくとも1つのラクチレート
(R-(O-CH(CH3)-CO)aO)bM (式1);
ii) 式2に従う少なくとも1つのグリセロールエステル
CH2OR1-CHOR2-CH2OR3 (式2);及び
iii) 上記のi)及びii)の混合物
から選択される抗菌剤
を含むことを特徴とし、
ここで、
RはC4〜C18のアシル基を表し、該アシル基は、分岐されていてもよく又は分岐されていなくてもよいアルキル又はアルケニル鎖を有し;
R1、R2及びR3はそれぞれ独立して、H又はC4〜C18のアシル基を表し、該アシル基は、分岐されていてもよく又は分岐されていなくてもよいアルキル又はアルケニル鎖を有し、但し、R1、R2及びR3の少なくとも1つはHであり且つR1、R2及びR3の少なくとも1つはアシル基であり;
Mは、プロトン(H+)、又はLi、Na、K、Ca、Mg、Zn、Fe(II)、Cu、Mn、Ag、アンモニウム、若しくは1以上のヒドロキシで任意的に置換されていてもよい1以上の(C1〜4)アルキルを有する置換アンモニウムの群から選択される対カチオンを表し;
aは、1〜3の整数であり;及び
bは、Mの原子価に等しい1又は2である、
上記方法。 - 該接種物が、大腸菌(Escherichia coli);アシネトバクター(Acinetobacter);ボルデテラ(Bordetella);ブルセラ(Brucella);カンピロバクター(Campylobacter);シアノバクテリア(Cyanobacteria);エンテロバクター(Enterobacter);エルウィニア(Erwinia);フランシセラ(Franciscella);ヘリコバクター(Helicobacter);クレブシエラ(Klebsiella);レジオネラ(Legionella);モラクセラ(Moraxella);ナイセリア(Neisseria);パンテア(Pantooea);パスツレラ科(Pasteurellaceae);シュードモナス(Pseudomonas);プロテウス(Proteus);サルモネラ菌(Salmonella);セレノモナス属(Selenomonadales);セラチア(Serratia);赤痢菌(Shigella);トレポネーマ(Treponema);ビブリオ(Vibrio);エルシニア(Yersinia);ザイノモナス(Zynomonas);及びそれらの混合物から成る群から選択されるグラム陰性菌を含む、請求項14に記載の方法。
- 該接種物が、大腸菌、シュードモナス種、及びパスツレラ科の種から成る群から選択される1以上のグラム陰性菌を含む、請求項15に記載の方法。
- 該接種物が、アクチノバチルス(Actinobacillus)属、ヘモフィルス(Hemophilus)属及びパスツレラ(Pasteurella)属の種から成る群から選択される1以上のグラム陰性菌を含む、請求項15に記載の方法。
- 該接種物が、アスペルギルス(Aspergillus)及びクモノスカビ(Rhizopus)の属から選択される1以上のカビを含む、請求項14に記載の方法。
- 該接種物が、アスペルギルス・オリゼ(Aspergillus oryzae)、アスペルギルス・テレウス(Aspergillus terreus)、アスペルギルス・ニガー(Aspergillus niger);リゾプス・オリゴスポラス(Rhizopus oligosporus)及びリゾプス・オリゼ(Rhizopus oryzae)から選択される1以上のカビを含む、請求項18に記載の方法。
- 該接種物が、ブレタノマイセス属(Brettanomyces);カンジダ属(Candida);デッケラ属(Dekkera);ピキア属(Pichia);及びサッカロミセス属(Saccharomyces)の属から選択される1以上の酵母を含む、請求項14に記載の方法。
- エタノール;1,3-プロパンジオール;グリセロール;ブタノール;1,4-ブタンジオール;アラビトール;キシリトール;ソルビトール;マンニトール;アセトイン;酢酸;プロピオン酸;3-ヒドロキシプロピオン酸;乳酸;コハク酸;フランジカルボン酸;フマル酸;リンゴ酸;アジピン酸;クエン酸;アコニット酸;グルタミン酸;イタコン酸;レブリン酸;グルタル酸;アスパラギン酸;マロン酸;グリシン;セリン;スレオニン;リジン;イソプレン;及び、ポリヒドロキシブチレート;及びそれらの混合物から成る群から選択される発酵生産物を得る為の、請求項14〜20のいずれか1項に記載の方法。
- エタノール;1,3-プロパンジオール;グリセロール;ブタノール;1,4-ブタンジオール;アラビトール;キシリトール;ソルビトール;マンニトール;酢酸;プロピオン酸;3-ヒドロキシプロピオン酸;乳酸;コハク酸;2,5-フランジカルボン酸;フマル酸;リンゴ酸;アジピン酸;クエン酸;アコニット酸;グルタミン酸;イタコン酸;レブリン酸;グルタル酸;アスパラギン酸;マロン酸;及びそれらの混合物から成る群から選択される発酵生産物を得る為の、請求項14〜20のいずれか1項に記載の方法。
- プロピオン酸;乳酸;コハク酸;1,4-ブタンジオール;及び2,5-フランジカルボン酸から選択される発酵生産物を得る為の、請求項14〜20のいずれか1項に記載の方法。
- グラム陰性菌又はカビ又は酵母の培養においてグラム陽性汚染菌の増殖を抑制する抗菌剤であって、
i) 式1に従う少なくとも1つのラクチレート
(R-(O-CH(CH3)-CO)aO)bM (式1);
ii) 式2に従う少なくとも1つのグリセロールエステル
CH2OR1-CHOR2-CH2OR3 (式2);及び
iii) 上記のi)及びii)の混合物
から選択され、
ここで、
RはC4〜C18のアシル基を表し、該アシル基は、分岐されていてもよく又は分岐されていなくてもよいアルキル又はアルケニル鎖を有し;
R1、R2及びR3はそれぞれ独立して、H又はC4〜C18のアシル基を表し、該アシル基は、分岐されていてもよく又は分岐されていなくてもよいアルキル又はアルケニル鎖を有し、但し、R1、R2及びR3の少なくとも1つはHであり且つR1、R2及びR3の少なくとも1つはアシル基であり;
Mは、プロトン(H+)、又はLi、Na、K、Ca、Mg、Zn、Fe(II)、Cu、Mn、Ag、アンモニウム、若しくは1以上のヒドロキシで任意的に置換されていてもよい1以上の(C1〜4)アルキルを有する置換アンモニウムの群から選択される対カチオンを表し;
aは、1〜3の整数であり;及び
bは、Mの原子価に等しい1又は2である、
上記抗菌剤。
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