JP6929867B2 - がんに対する免疫療法で使用するための形質移入ｔ細胞およびｔ細胞受容体 - Google Patents

がんに対する免疫療法で使用するための形質移入ｔ細胞およびｔ細胞受容体 Download PDF

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JP6929867B2
JP6929867B2 JP2018548050A JP2018548050A JP6929867B2 JP 6929867 B2 JP6929867 B2 JP 6929867B2 JP 2018548050 A JP2018548050 A JP 2018548050A JP 2018548050 A JP2018548050 A JP 2018548050A JP 6929867 B2 JP6929867 B2 JP 6929867B2
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tcr
cancer
chain
seq
cells
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JP2019512242A5 (https=
JP2019512242A (ja
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マウラー，ドミニク
アルテン，レオニー
バンク，ゼバスティアン
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イマティクス バイオテクノロジーズ ゲーエムベーハー
イマティクス バイオテクノロジーズ ゲーエムベーハー
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
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    • A61K40/00—Cellular immunotherapy
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
    • A61K40/4269—NY-ESO
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]

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JP2018548050A 2016-03-16 2017-03-16 がんに対する免疫療法で使用するための形質移入ｔ細胞およびｔ細胞受容体 Expired - Fee Related JP6929867B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662308970P 2016-03-16 2016-03-16
US62/308,970 2016-03-16
GB1604494.3 2016-03-16
GBGB1604494.3A GB201604494D0 (en) 2016-03-16 2016-03-16 Transfected T-Cells and T-Cell receptors for use in immunotherapy against cancers
PCT/EP2017/056289 WO2017158116A1 (en) 2016-03-16 2017-03-16 Transfected t-cells and t-cell receptors for use in immunotherapy against cancers

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JP2019512242A JP2019512242A (ja) 2019-05-16
JP2019512242A5 JP2019512242A5 (https=) 2019-06-20
JP6929867B2 true JP6929867B2 (ja) 2021-09-01

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US (1) US10537624B2 (https=)
EP (1) EP3430037B1 (https=)
JP (1) JP6929867B2 (https=)
KR (1) KR102266721B1 (https=)
CN (1) CN108884143A (https=)
AU (1) AU2017235069B2 (https=)
BR (1) BR112018067989A2 (https=)
CA (1) CA3017419A1 (https=)
CR (1) CR20180490A (https=)
EA (1) EA201891759A1 (https=)
GB (1) GB201604494D0 (https=)
MA (2) MA45309B1 (https=)
MX (1) MX2018011223A (https=)
PE (1) PE20190124A1 (https=)
SG (1) SG11201807590SA (https=)
TW (1) TWI788284B (https=)
UA (1) UA124532C2 (https=)
WO (1) WO2017158116A1 (https=)

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JP2020537515A (ja) 2017-10-03 2020-12-24 ジュノー セラピューティクス インコーポレイテッド Ｈｐｖ特異的結合分子
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US12331095B2 (en) 2018-03-14 2025-06-17 Medigene Immunotherapies Gmbh Inducible T cell receptors and uses thereof
DE102018108612A1 (de) 2018-03-21 2019-09-26 Immatics US, Inc. Verfahren zur erhöhung der persistenz von adoptiv infundierten t-zellen
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WO2020127827A1 (de) * 2018-12-20 2020-06-25 Ava Lifescience Gmbh Verfahren zur selektion biologischer bindemoleküle
DE102019108125B4 (de) 2019-03-28 2022-02-03 Immatics US, Inc. Cd28 t-zellkulturen, zusammensetzungen und verfahren zu deren verwendung
US20200297768A1 (en) 2019-03-19 2020-09-24 Immatics US, Inc. Cd28 t cell cultures, compositions, and methods of using thereof
WO2020243134A1 (en) 2019-05-27 2020-12-03 Immatics US, Inc. Viral vectors and their use in adoptive cellular therapy
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US20210032370A1 (en) 2019-08-02 2021-02-04 Immatics Biotechnologies Gmbh Recruiting agent further binding an mhc molecule
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US20230226181A1 (en) * 2020-06-22 2023-07-20 Nanjing Legend Biotech Co., Ltd. GENETIC ENGINEERING OF gamma delta T CELLS FOR IMMUNOTHERAPY
US20220056411A1 (en) 2020-08-21 2022-02-24 Immatics US, Inc. Methods for isolating cd8+ selected t cells
TW202241938A (zh) 2020-12-31 2022-11-01 美商英麥提克斯股份有限公司 Ｃｄ８多肽、組合物及其使用方法
DE102021100038A1 (de) 2020-12-31 2022-06-30 Immatics US, Inc. Modifizierte cd8-polypeptide, zusammensetzungen und verfahren zu deren verwendung
IL308258A (en) 2021-05-05 2024-01-01 Immatics Biotechnologies Gmbh Bma031 antigen binding polypeptides
TW202332765A (zh) 2021-09-20 2023-08-16 美商英麥提克斯股份有限公司 用於ｔ細胞療法之ｔ細胞群體的單核球耗盡
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EP3430037B1 (en) 2022-08-31
UA124532C2 (uk) 2021-10-05
TW201742873A (zh) 2017-12-16
PE20190124A1 (es) 2019-01-17
CN108884143A (zh) 2018-11-23
WO2017158116A1 (en) 2017-09-21
MA45309A (fr) 2019-01-23
KR20180122430A (ko) 2018-11-12
MX2018011223A (es) 2018-11-22
EP3430037A1 (en) 2019-01-23
CA3017419A1 (en) 2017-09-21
JP2019512242A (ja) 2019-05-16
US10537624B2 (en) 2020-01-21
GB201604494D0 (en) 2016-04-27
US20170312350A1 (en) 2017-11-02
MA43328B2 (fr) 2022-02-28
MA45309B1 (fr) 2023-01-31
AU2017235069A1 (en) 2018-10-04
AU2017235069B2 (en) 2020-05-07
EA201891759A1 (ru) 2019-02-28
MA43328A1 (fr) 2019-05-31
BR112018067989A2 (pt) 2019-02-05
KR102266721B1 (ko) 2021-06-17
SG11201807590SA (en) 2018-10-30
TWI788284B (zh) 2023-01-01
CR20180490A (es) 2019-01-10

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