JP6928385B2 - 神経変性疾患を治療および予防するための組成物および方法 - Google Patents
神経変性疾患を治療および予防するための組成物および方法 Download PDFInfo
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- JP6928385B2 JP6928385B2 JP2018506914A JP2018506914A JP6928385B2 JP 6928385 B2 JP6928385 B2 JP 6928385B2 JP 2018506914 A JP2018506914 A JP 2018506914A JP 2018506914 A JP2018506914 A JP 2018506914A JP 6928385 B2 JP6928385 B2 JP 6928385B2
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- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
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- C07C309/25—Sulfonic acids having sulfo groups bound to carbon atoms of rings other than six-membered aromatic rings of a carbon skeleton
- C07C309/26—Sulfonic acids having sulfo groups bound to carbon atoms of rings other than six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
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- C07D207/14—Nitrogen atoms not forming part of a nitro radical
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
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- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
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- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
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- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Hospice & Palliative Care (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562203256P | 2015-08-10 | 2015-08-10 | |
| US62/203,256 | 2015-08-10 | ||
| PCT/US2016/046336 WO2017027582A1 (en) | 2015-08-10 | 2016-08-10 | Compositions and methods for treating and preventing neurodegenerative disorders |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018529648A JP2018529648A (ja) | 2018-10-11 |
| JP2018529648A5 JP2018529648A5 (OSRAM) | 2019-09-26 |
| JP6928385B2 true JP6928385B2 (ja) | 2021-09-01 |
Family
ID=57983633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506914A Active JP6928385B2 (ja) | 2015-08-10 | 2016-08-10 | 神経変性疾患を治療および予防するための組成物および方法 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10590070B2 (OSRAM) |
| EP (1) | EP3334710B1 (OSRAM) |
| JP (1) | JP6928385B2 (OSRAM) |
| KR (1) | KR102657460B1 (OSRAM) |
| CN (1) | CN108026049B (OSRAM) |
| AU (1) | AU2016304862B2 (OSRAM) |
| CA (1) | CA2995093A1 (OSRAM) |
| EA (1) | EA035650B1 (OSRAM) |
| ES (1) | ES2965867T3 (OSRAM) |
| IL (1) | IL257332B (OSRAM) |
| MX (1) | MX380290B (OSRAM) |
| WO (1) | WO2017027582A1 (OSRAM) |
| ZA (1) | ZA201800831B (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX380290B (es) | 2015-08-10 | 2025-03-12 | Alzheon Inc | Composiciones y métodos para el tratamiento y la prevención de trastornos neurodegenerativos. |
| CN108623501B (zh) | 2017-03-21 | 2022-04-19 | 润佳(苏州)医药科技有限公司 | 同位素富集的3-氨基-1-丙磺酸衍生物及其用途 |
| MX2021011606A (es) | 2019-04-02 | 2021-12-10 | Aligos Therapeutics Inc | Compuestos dirigidos a prmt5. |
| CN114269949A (zh) * | 2019-06-17 | 2022-04-01 | 阿尔泽恩股份有限公司 | 用于治疗神经变性病症的方法 |
| CN116059192B (zh) | 2019-11-13 | 2024-10-29 | 润佳(苏州)医药科技有限公司 | 同位素富集的3-氨基-1-丙磺酸及其衍生物的用途 |
| WO2023212289A1 (en) | 2022-04-28 | 2023-11-02 | Alzheon, Inc. | Tramiprosate for treating apoe4-related diseases |
| IL321181A (en) | 2022-12-02 | 2025-07-01 | Alzheon Inc | Methods for treating neurodegenerative disorders with termiprost |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0407701A3 (en) * | 1989-05-15 | 1992-04-22 | Fujisawa Pharmaceutical Co., Ltd. | Antiretroviral pyrroline and pyrrolidine sulfonic acid derivatives |
| US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| AU2200199A (en) | 1997-12-17 | 1999-07-19 | Biocryst Pharmaceuticals, Inc. | Substituted cyclopentane and cyclopentene compounds useful as neuraminidase inhibitors |
| JP4726304B2 (ja) | 1999-04-28 | 2011-07-20 | ベルス ヘルス (インターナショナル) リミティッド | アミロイドーシスを治療するための組成物および方法 |
| EA012325B1 (ru) | 2002-12-24 | 2009-08-28 | Беллус Хелс (Интернэшнл) Лимитед | Терапевтические составы для лечения болезней, связанных с наличием бета-амилоида |
| CN100528840C (zh) * | 2003-06-23 | 2009-08-19 | 贝卢斯健康(国际)有限公司 | 改进的候选药物及其制备方法 |
| US20070010573A1 (en) * | 2003-06-23 | 2007-01-11 | Xianqi Kong | Methods and compositions for treating amyloid-related diseases |
| CA2529257C (en) * | 2003-06-23 | 2013-04-23 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| US7244764B2 (en) * | 2003-06-23 | 2007-07-17 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
| JP5607930B2 (ja) * | 2006-10-12 | 2014-10-15 | ビーエイチアイ リミテッド パートナーシップ | 3−アミノ−1−プロパンスルホン酸を送達するための方法、化合物、組成物および媒体 |
| US20090004140A1 (en) * | 2007-06-26 | 2009-01-01 | Yao-Ling Qiu | 4-substituted pyrrolidine as anti-infectives |
| KR101173677B1 (ko) * | 2009-12-11 | 2012-08-13 | 한국과학기술연구원 | Epps를 유효성분으로 함유하는 베타아밀로이드 집적 관련 질환의 예방 또는 치료용 약학적 조성물 |
| MX380290B (es) | 2015-08-10 | 2025-03-12 | Alzheon Inc | Composiciones y métodos para el tratamiento y la prevención de trastornos neurodegenerativos. |
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2016
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2018
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- 2018-02-08 ZA ZA2018/00831A patent/ZA201800831B/en unknown
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2020
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| US20200347012A1 (en) | 2020-11-05 |
| EP3334710B1 (en) | 2023-10-04 |
| MX380290B (es) | 2025-03-12 |
| ES2965867T3 (es) | 2024-04-17 |
| WO2017027582A1 (en) | 2017-02-16 |
| KR102657460B1 (ko) | 2024-04-12 |
| EP3334710A1 (en) | 2018-06-20 |
| MX2018001592A (es) | 2018-08-21 |
| IL257332A (en) | 2018-03-29 |
| EP3334710A4 (en) | 2019-04-03 |
| EP3334710C0 (en) | 2023-10-04 |
| IL257332B (en) | 2021-04-29 |
| EA201890460A1 (ru) | 2018-07-31 |
| NZ739621A (en) | 2024-08-30 |
| KR20180030709A (ko) | 2018-03-23 |
| US20180230091A1 (en) | 2018-08-16 |
| AU2016304862B2 (en) | 2021-02-18 |
| CN108026049B (zh) | 2021-08-31 |
| US10590070B2 (en) | 2020-03-17 |
| EA035650B1 (ru) | 2020-07-21 |
| JP2018529648A (ja) | 2018-10-11 |
| CN108026049A (zh) | 2018-05-11 |
| ZA201800831B (en) | 2022-07-27 |
| CA2995093A1 (en) | 2017-02-16 |
| HK1256298A1 (en) | 2019-09-20 |
| US11053192B2 (en) | 2021-07-06 |
| AU2016304862A1 (en) | 2018-02-22 |
| US12187668B2 (en) | 2025-01-07 |
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