JP6922092B2 - 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法 - Google Patents

片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法 Download PDF

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JP6922092B2
JP6922092B2 JP2020530455A JP2020530455A JP6922092B2 JP 6922092 B2 JP6922092 B2 JP 6922092B2 JP 2020530455 A JP2020530455 A JP 2020530455A JP 2020530455 A JP2020530455 A JP 2020530455A JP 6922092 B2 JP6922092 B2 JP 6922092B2
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dose
headaches
migraine
pharmaceutical composition
rasumijitan
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JP2020530861A (ja
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シーナ・オーロラ
カーク・ウィリス・ジョンソン
ジョン・ヘンリー・クリージ
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イーライ リリー アンド カンパニー
イーライ リリー アンド カンパニー
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Priority to JP2025115518A priority patent/JP2025165940A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2020530455A 2017-09-06 2018-08-30 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法 Active JP6922092B2 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2021122905A JP7183355B2 (ja) 2017-09-06 2021-07-28 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法
JP2022186221A JP7480261B2 (ja) 2017-09-06 2022-11-22 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法
JP2024070372A JP7711255B2 (ja) 2017-09-06 2024-04-24 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法
JP2025115518A JP2025165940A (ja) 2017-09-06 2025-07-09 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762554726P 2017-09-06 2017-09-06
US62/554,726 2017-09-06
PCT/US2018/048730 WO2019050759A1 (en) 2017-09-06 2018-08-30 POLYTHERAPY OF LASMIDITAN AND CGRP ANTAGONIST FOR USE IN THE TREATMENT OF MIGRAINE

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JP2021122905A Division JP7183355B2 (ja) 2017-09-06 2021-07-28 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法

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JP2020530861A JP2020530861A (ja) 2020-10-29
JP6922092B2 true JP6922092B2 (ja) 2021-08-18

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JP2020530455A Active JP6922092B2 (ja) 2017-09-06 2018-08-30 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法
JP2021122905A Active JP7183355B2 (ja) 2017-09-06 2021-07-28 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法
JP2022186221A Active JP7480261B2 (ja) 2017-09-06 2022-11-22 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法
JP2024070372A Active JP7711255B2 (ja) 2017-09-06 2024-04-24 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法
JP2025115518A Withdrawn JP2025165940A (ja) 2017-09-06 2025-07-09 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法

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JP2021122905A Active JP7183355B2 (ja) 2017-09-06 2021-07-28 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法
JP2022186221A Active JP7480261B2 (ja) 2017-09-06 2022-11-22 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法
JP2024070372A Active JP7711255B2 (ja) 2017-09-06 2024-04-24 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法
JP2025115518A Withdrawn JP2025165940A (ja) 2017-09-06 2025-07-09 片頭痛の処置における使用のためのラスミジタンとｃｇｒｐアンタゴニストとの併用療法

Country Status (17)

Country Link
US (1) US20200268735A1 (enExample)
EP (2) EP3678665A1 (enExample)
JP (5) JP6922092B2 (enExample)
KR (2) KR20230025945A (enExample)
CN (3) CN111032044A (enExample)
AU (1) AU2018329568B2 (enExample)
BR (1) BR112020002077A2 (enExample)
CA (1) CA3073996C (enExample)
EA (1) EA202090457A1 (enExample)
IL (2) IL314347A (enExample)
MA (2) MA71474A (enExample)
MX (2) MX2020002554A (enExample)
MY (1) MY205182A (enExample)
SG (1) SG11202001387WA (enExample)
TW (1) TWI754772B (enExample)
WO (1) WO2019050759A1 (enExample)
ZA (1) ZA202000443B (enExample)

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DK2413933T4 (da) 2009-04-02 2021-08-23 Colucid Pharmaceuticals Inc 2,4,6-trifluor-N-[6-(1-methyl-piperidin-4-carbonyl)-pyridin-2-yl]-benzamid til behandling af migræne via oral eller intravenøs indgivelse
TWI692485B (zh) * 2011-05-20 2020-05-01 美商艾爾德生物控股有限責任公司 抗降血鈣素基因相關胜肽（ａｎｔｉ-ｃｇｒｐ）組成物及其用途
CN112022818A (zh) 2014-02-05 2020-12-04 默沙东公司 Cgrp-活性化合物的片剂制剂
US12168004B2 (en) 2014-02-05 2024-12-17 Merck Sharp & Dohme Llc Treatment of migraine
US11717515B2 (en) 2020-12-22 2023-08-08 Allergan Pharmaceuticals International Limited Treatment of migraine
CA3043772C (en) 2016-12-06 2022-06-07 Colucid Pharmaceuticals, Inc. Hydrates of 2,4,6-trifluoro-n-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide hemisuccinate, and uses thereof as a 5-ht1f agonist
TWI754772B (zh) * 2017-09-06 2022-02-11 美商美國禮來大藥廠 用於治療偏頭痛之拉米迪坦(lasmiditan)與cgrp拮抗劑之組合療法
US20190374518A1 (en) * 2018-06-08 2019-12-12 Allergan Pharmaceuticals International Limited Treatment of migraine
US12383545B1 (en) 2018-06-08 2025-08-12 Allergan Pharmaceuticals International Limited Treatment of migraine
TWI826514B (zh) 2018-09-04 2023-12-21 美商美國禮來大藥廠 用於預防偏頭痛之拉米迪坦(lasmiditan)長期夜間投藥
PH12021551689A1 (en) * 2019-01-20 2022-05-11 Pfizer Ireland Pharmaceuticals Cgrp antagonists for treating migraine breakthrough
TWI776175B (zh) 2019-07-09 2022-09-01 美商美國禮來大藥廠 大規模製備2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺半琥珀酸鹽的方法及中間體，以及2,4,6-三氟-n-[6-(1-甲基-哌啶-4-羰基)-吡啶-2-基]-苯甲醯胺醋酸鹽之製備
EP4188375A4 (en) 2020-07-29 2024-07-24 Allergan Pharmaceuticals International Limited MIGRAINE TREATMENT
MX2024003952A (es) 2021-09-27 2024-05-27 Allergan Pharmaceuticals Int Ltd Combinación que comprende atogepant para tratar la migraña.
CN116270505A (zh) * 2021-12-20 2023-06-23 南京科默生物医药有限公司 含半琥珀酸拉司米地坦的口服固体制剂及其3d打印制备技术
JP7499538B1 (ja) 2023-03-29 2024-06-14 ロゴスサイエンス株式会社 慢性疼痛の治療、改善およびセルフケアシステム

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TWI263497B (en) 2002-03-29 2006-10-11 Lilly Co Eli Pyridinoylpiperidines as 5-HT1F agonists
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AR081434A1 (es) * 2010-06-10 2012-08-29 Lilly Co Eli Anticuerpo del peptido relacionado con el gen calcitonina (cgrp), composicion farmaceutica que lo comprende, uso de dicho anticuerpo para preparar un medicamento util para tratar dolor de osteoartritis o migranas y fragmento de union a antigeno de dicho anticuerpo
AR104847A1 (es) * 2015-06-17 2017-08-16 Lilly Co Eli Formulación de anticuerpo anti-cgrp
AU2017331593B2 (en) * 2016-09-23 2022-04-28 Teva Pharmaceuticals International Gmbh Treating refractory migraine
RU2770066C2 (ru) * 2017-03-02 2022-04-14 Бет Изрейэл Диконисс Медикал Сентер, Инк. Отбор пациентов с головной болью, восприимчивых к антителам, направленным против кальцитонин ген-родственного пептида
TWI754772B (zh) * 2017-09-06 2022-02-11 美商美國禮來大藥廠 用於治療偏頭痛之拉米迪坦(lasmiditan)與cgrp拮抗劑之組合療法

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MX2023008760A (es) 2023-08-02
KR20200036919A (ko) 2020-04-07
ZA202000443B (en) 2022-07-27
JP2023029872A (ja) 2023-03-07
CA3073996A1 (en) 2019-03-14
AU2018329568A1 (en) 2020-02-06
NZ761634A (en) 2024-05-31
EA202090457A1 (ru) 2020-06-10
EP4397317A3 (en) 2024-10-16
IL314347A (en) 2024-09-01
CA3073996C (en) 2022-05-31
CN116059204A (zh) 2023-05-05
JP2020530861A (ja) 2020-10-29
TW201919624A (zh) 2019-06-01
JP2021176884A (ja) 2021-11-11
BR112020002077A2 (pt) 2020-07-28
SG11202001387WA (en) 2020-03-30
JP7711255B2 (ja) 2025-07-22
MX2020002554A (es) 2020-07-13
US20200268735A1 (en) 2020-08-27
TWI754772B (zh) 2022-02-11
MA50073A (fr) 2020-07-15
KR20230025945A (ko) 2023-02-23
CN116509861A (zh) 2023-08-01
EP4397317A2 (en) 2024-07-10
WO2019050759A1 (en) 2019-03-14
JP2024109585A (ja) 2024-08-14
JP7480261B2 (ja) 2024-05-09
EP3678665A1 (en) 2020-07-15
MY205182A (en) 2024-10-04
AU2018329568B2 (en) 2021-09-23
MA71474A (fr) 2025-04-30
IL273031A (en) 2020-04-30
JP7183355B2 (ja) 2022-12-05
CN111032044A (zh) 2020-04-17
JP2025165940A (ja) 2025-11-05

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