JP6912387B2 - 吸着透析を実行するためのカートリッジ、方法、および、装置 - Google Patents
吸着透析を実行するためのカートリッジ、方法、および、装置 Download PDFInfo
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- JP6912387B2 JP6912387B2 JP2017558450A JP2017558450A JP6912387B2 JP 6912387 B2 JP6912387 B2 JP 6912387B2 JP 2017558450 A JP2017558450 A JP 2017558450A JP 2017558450 A JP2017558450 A JP 2017558450A JP 6912387 B2 JP6912387 B2 JP 6912387B2
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
- B01J2220/62—In a cartridge
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Description
例I.
3つのフラスコに5グラムの活性炭が計量された。濃度18mmol/Lの尿素水溶液50mLが各フラスコに加えられた。各フラスコは様々の温度に保たれ、1つは2°Cの氷水浴に、1つは室温に、1つは37°Cの加熱キャビネットに保たれた。上記のフラスコは2.5時間、磁気撹拌機によって撹拌された。上記のフラスコからの、そして、元の尿素溶液からのサンプルの尿素濃度が2回分析された。そして、活性炭に結合した尿素の量を計算するために尿素濃度の減少が用いられた。下の表を参照。
300グラムの活性炭Xおよび活性炭Yを800mLの円筒形のプレキシガラスのフローカラム(複数)に充填した。腹膜透析患者からの使用済み透析液は、臑動ポンプによって16ml/分の流速で上記カラムを通してポンプで送られた。流体のサンプルは、3時間の間の様々の時点で上記カラムの出口で採取された。上記出口からンのサンプルと上記カラムにポンプで注入された透析液のサンプルとにおける尿素濃度が分析された。そして、カラムの出口における尿素濃度の時間変化がプロットされた。上記カラムにポンプで注入された透析液の尿素濃度は点線で描写されている。活性炭に結合した尿素の総量は、上記尿素濃度の時間変化のグラフと上記点線との間の面積を、流体の流速を考慮して積分することによって計算された。総尿素結合は、それぞれ、活性炭Xにおいては31.2mmol、活性炭Yにおいては28.5mmolであり、それぞれの活性炭の単位当たり尿素結合は、0.104mmol/gおよび0.095mmol/gとなった。
高リン酸塩血症は、腎不全を有する患者の間においては一般的な状況である。従来の透析によるリン酸塩の除去はしばしば十分でない。食事摂取量を制限し、経口リン吸着剤を使用することによって、リン酸塩レベルは更に制御されなければならない。透析液が再生され再循環させられるシステムにおいては、透析膜を越えてのリン酸塩の濃度勾配を高く維持し、患者の血液からのできるだけ効率的なリン酸塩の除去に寄与するために、リン酸塩は透析液から連続的に除去される必要がある。
Claims (15)
- 吸着透析の際に使用するための吸着カートリッジであって、
容積可変の内部空間、及び、少なくとも、フレキシブルな材料で作られた部分を有するコンテナと、
前記内部空間の全てを占めるように前記内部空間に充填される非溶性の吸着剤粉末材料であって、活性炭を含む吸着剤粉末材料と、
前記コンテナの前記内部空間内へ、及び、前記コンテナの前記内部空間内外へと流体を流して前記非溶性の吸着剤粉末材料を通過させるための入口管及び出口管と、
前記非溶性の吸着剤粉末材料が前記内部空間から流出することを防止するための前記出口管に備えられた粒子フィルタを有し、
前記内部空間内の前記吸着剤粉末材料は周囲圧力に対する前記内部空間内の陰圧によって固定され、それにより、前記フレキシブルな材料が前記吸着剤粉末材料に対して吸引される、カートリッジ。 - 前記吸着剤粉末材料は、リン酸塩吸着剤およびカリウム吸着剤をさらに含む請求項1に記載のカートリッジ。
- 前記カートリッジの前記入口管における圧力を下げるために、前記カートリッジの前記入口管に減圧弁が設けられる請求項1または2に記載のカートリッジ。
- 前記減圧弁は前記カートリッジと一体に設けられる請求項3に記載のカートリッジ。
- 前記減圧弁が少なくとも50mbarだけ減圧するように構成される請求項3に記載のカートリッジ。
- 前記減圧弁が、流体が該減圧弁を通過する際に50mbar、100mbar、150mbar、200mbar、または、500mbarだけ減圧するために調節可能である請求項3に記載のカートリッジ。
- 前記入口管から殆ど前記出口管まで延びて、少なくとも2つのチャネルを形成する少なくとも1つの隔壁をさらに有し、
前記各チャネルは入口管及び弁を有し、
前記弁は、対応する弁が開いたときに、浄化液をそれぞれの前記チャネルへ供給する請求項1に記載のカートリッジ。 - 前記内部空間は直列に連結された4つの実質的に円筒形の空間を有する請求項1に記載のカートリッジ。
- 前記円筒形の空間は、端部に沿ったシールされた2つのプラスチックシートにより形成され、ミアンダ状の空間を形成する3つの漏れ止め部を有する請求項1に記載のカートリッジ。
- 前記吸着剤粉末材料が、固定された金属イオン(M)を有するポリスチレン系樹脂を含むリン酸塩結着樹脂であり、そのリン酸塩は、リン酸イオンを捕捉するために低い溶解度を有する請求項1に記載のカートリッジ。
- 前記金属イオンは金属キレートリガンドによって固定される請求項10に記載のカートリッジ。
- 前記金属キレートリガンドは、前記金属イオン(M)と錯体を形成したイミノ二酢酸(IDA)を含む請求項11に記載のカートリッジ。
- 前記金属イオン(M)は、ランタンイオンまたは鉄イオン(Fe−III(Fe3+)またはFe−II(Fe2+))である請求項12に記載のカートリッジ。
- 前記イミノ二酢酸(IDA)リガンドを有する前記ポリスチレン系樹脂は、キレート部位に結合された水素イオンを有する第1の形態、および、キレート部位に結合されたナトリウムイオンを有する第2の形態で提供され、前記第1の形態および第2の形態は、炭素粉末材料に接触するときに透析液のpHの上昇に対して逆に作用するような比率で組み合わされる請求項12又は13に記載のカートリッジ。
- 固定された金属イオンを有さないイミノ二酢酸(IDA)リガンドを有する第2のポリスチレン樹脂を更に有し、
前記第2のポリスチレン樹脂は、前記第1のイミノ二酢酸(IDA)金属錯体から漏れ出る任意の金属イオンを吸着するために、前記第1のポリスチレン樹脂イミノ二酢酸(IDA)金属錯体の下流側に設けられる請求項12〜14のいずれか一項に記載のカートリッジ。
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US10463776B2 (en) * | 2015-12-31 | 2019-11-05 | Baxter International Inc. | Methods and apparatuses using urea permselective diffusion through charged membranes |
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FR3075649A1 (fr) * | 2017-12-22 | 2019-06-28 | Mexbrain | Dispositif pour le maintien de l'homeostasie metallique, et ses utilisations |
EP4106834A1 (en) | 2020-02-18 | 2022-12-28 | ICinnovation BV | Wearable and portable device for recirculating flow dialysis |
EP3868417A1 (en) | 2020-02-18 | 2021-08-25 | ICinnovation BV | Wearable and portable device for recirculating flow dialysis |
US11690940B2 (en) * | 2020-11-02 | 2023-07-04 | Fresenius Medical Care Holdings, Inc. | Preserving sorbent devices in dialysis systems |
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