JP6898848B2 - 脳転移を治療するための方法 - Google Patents

脳転移を治療するための方法 Download PDF

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JP6898848B2
JP6898848B2 JP2017515756A JP2017515756A JP6898848B2 JP 6898848 B2 JP6898848 B2 JP 6898848B2 JP 2017515756 A JP2017515756 A JP 2017515756A JP 2017515756 A JP2017515756 A JP 2017515756A JP 6898848 B2 JP6898848 B2 JP 6898848B2
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inhibitor
cancer
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gap junction
composition according
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JP2017534583A (ja
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ジョアン マッサーグ,
ジョアン マッサーグ,
エイドリアン ボワール,
エイドリアン ボワール,
チン チェン,
チン チェン,
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メモリアル スローン ケタリング キャンサー センター
メモリアル スローン ケタリング キャンサー センター
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • AHUMAN NECESSITIES
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    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
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    • G01N33/5011Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants

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  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2017515756A 2014-09-19 2015-09-18 脳転移を治療するための方法 Active JP6898848B2 (ja)

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Application Number Priority Date Filing Date Title
US201462052966P 2014-09-19 2014-09-19
US62/052,966 2014-09-19
PCT/US2015/051057 WO2016044790A1 (en) 2014-09-19 2015-09-18 Methods for treating brain metastasis

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JP2017534583A JP2017534583A (ja) 2017-11-24
JP2017534583A5 JP2017534583A5 (OSRAM) 2018-10-25
JP6898848B2 true JP6898848B2 (ja) 2021-07-07

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US (3) US10413522B2 (OSRAM)
EP (2) EP3685832B1 (OSRAM)
JP (1) JP6898848B2 (OSRAM)
CN (1) CN107106544B (OSRAM)
AU (3) AU2015317330B2 (OSRAM)
CA (1) CA2961894C (OSRAM)
WO (1) WO2016044790A1 (OSRAM)

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CN107290438B (zh) * 2016-03-31 2020-10-16 深圳翰宇药业股份有限公司 一种多肽有关物质的高效液相色谱分析方法
KR20200037796A (ko) * 2017-07-10 2020-04-09 코넬 유니버시티 암 치료를 위한 염색체 불안정성 및 다운스트림 사이토졸 dna 시그널링의 표적화
CA3072087A1 (en) * 2017-08-11 2019-02-14 Board Of Regents, The University Of Texas System Targeting kinases for the treatment of cancer metastasis
US11717506B2 (en) 2019-05-07 2023-08-08 The Johns Hopkins University Neuroprotective compounds for amyotrophic lateral sclerosis
US20220401408A1 (en) * 2019-09-13 2022-12-22 Auckland Uniservices Limited Compositions and methods for rescuing retinal and choroidal structure and function
CN111420025B (zh) * 2020-04-28 2021-06-11 中国药科大学 茜草科类型环肽化合物在制备cGAS-STING信号通路激活剂的药物中的应用
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WO2024020491A1 (en) * 2022-07-20 2024-01-25 The University Of North Carolina At Chapel Hill Methods of treating cancer of the central nervous system comprising 5-ethynyl-2'-deoxyuridine
WO2025024284A1 (en) * 2023-07-21 2025-01-30 The Board Of Regents Of The University Of Texas System Monoclonal antibodies against pcdh7 for lung cancer therapy
CN117298143A (zh) * 2023-10-11 2023-12-29 广州医科大学附属第一医院(广州呼吸中心) β葡聚糖在制备治疗肺癌脑转移瘤药物中的应用

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US11058665B2 (en) 2021-07-13
AU2015317330A1 (en) 2017-04-13
US20220105069A1 (en) 2022-04-07
AU2023219864A1 (en) 2023-09-14
CN107106544B (zh) 2021-09-24
EP3685832A1 (en) 2020-07-29
US20200085781A1 (en) 2020-03-19
EP3193865A1 (en) 2017-07-26
EP3685832B1 (en) 2023-08-30
US12029717B2 (en) 2024-07-09
CA2961894C (en) 2023-12-12
JP2017534583A (ja) 2017-11-24
WO2016044790A1 (en) 2016-03-24
EP3193865B1 (en) 2019-11-06
EP3193865A4 (en) 2018-04-11
AU2021202257A1 (en) 2021-05-06
US10413522B2 (en) 2019-09-17
US20170258758A1 (en) 2017-09-14
AU2015317330B2 (en) 2021-01-14
AU2021202257B2 (en) 2023-05-25
CA2961894A1 (en) 2016-03-24
CN107106544A (zh) 2017-08-29
NZ730319A (en) 2024-03-22

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