JP6893622B2 - 水溶液中のカルボン酸の分析法 - Google Patents
水溶液中のカルボン酸の分析法 Download PDFInfo
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- JP6893622B2 JP6893622B2 JP2017202331A JP2017202331A JP6893622B2 JP 6893622 B2 JP6893622 B2 JP 6893622B2 JP 2017202331 A JP2017202331 A JP 2017202331A JP 2017202331 A JP2017202331 A JP 2017202331A JP 6893622 B2 JP6893622 B2 JP 6893622B2
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- quaternary ammonium
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- 239000007864 aqueous solution Substances 0.000 title claims description 44
- 150000001732 carboxylic acid derivatives Chemical class 0.000 title claims description 39
- 238000004458 analytical method Methods 0.000 title claims description 6
- 238000000034 method Methods 0.000 claims description 32
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 29
- 239000003960 organic solvent Substances 0.000 claims description 28
- 230000002209 hydrophobic effect Effects 0.000 claims description 26
- 238000004817 gas chromatography Methods 0.000 claims description 21
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 claims description 21
- 238000004811 liquid chromatography Methods 0.000 claims description 12
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 10
- 150000001350 alkyl halides Chemical class 0.000 claims description 8
- 150000001735 carboxylic acids Chemical class 0.000 claims description 8
- 238000005259 measurement Methods 0.000 claims description 8
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims description 4
- 229930195734 saturated hydrocarbon Natural products 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 claims description 3
- 238000004949 mass spectrometry Methods 0.000 claims description 3
- VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 27
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 27
- 230000000052 comparative effect Effects 0.000 description 16
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 16
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 15
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 150000001875 compounds Chemical class 0.000 description 12
- 235000011054 acetic acid Nutrition 0.000 description 9
- 238000000605 extraction Methods 0.000 description 9
- 230000029936 alkylation Effects 0.000 description 8
- 238000005804 alkylation reaction Methods 0.000 description 8
- 235000019260 propionic acid Nutrition 0.000 description 8
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- SYZCZDCAEVUSPM-UHFFFAOYSA-M tetrahexylazanium;bromide Chemical compound [Br-].CCCCCC[N+](CCCCCC)(CCCCCC)CCCCCC SYZCZDCAEVUSPM-UHFFFAOYSA-M 0.000 description 8
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 7
- 239000007789 gas Substances 0.000 description 7
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 6
- 235000019253 formic acid Nutrition 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 125000005599 alkyl carboxylate group Chemical group 0.000 description 5
- 125000000217 alkyl group Chemical group 0.000 description 5
- -1 carboxylic acid methyl ester Chemical class 0.000 description 5
- 238000001514 detection method Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 5
- XDEPVFFKOVDUNO-UHFFFAOYSA-N pentafluorobenzyl bromide Chemical compound FC1=C(F)C(F)=C(CBr)C(F)=C1F XDEPVFFKOVDUNO-UHFFFAOYSA-N 0.000 description 5
- 239000003054 catalyst Substances 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 229910017053 inorganic salt Inorganic materials 0.000 description 4
- 239000008363 phosphate buffer Substances 0.000 description 4
- YPNVIBVEFVRZPJ-UHFFFAOYSA-L silver sulfate Chemical compound [Ag+].[Ag+].[O-]S([O-])(=O)=O YPNVIBVEFVRZPJ-UHFFFAOYSA-L 0.000 description 4
- 229910000367 silver sulfate Inorganic materials 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 229940005605 valeric acid Drugs 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- 150000001347 alkyl bromides Chemical class 0.000 description 3
- 238000004587 chromatography analysis Methods 0.000 description 3
- 238000001212 derivatisation Methods 0.000 description 3
- 230000005264 electron capture Effects 0.000 description 3
- AFAXGSQYZLGZPG-UHFFFAOYSA-N ethanedisulfonic acid Chemical compound OS(=O)(=O)CCS(O)(=O)=O AFAXGSQYZLGZPG-UHFFFAOYSA-N 0.000 description 3
- 229910052736 halogen Inorganic materials 0.000 description 3
- 150000002367 halogens Chemical class 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 150000002894 organic compounds Chemical class 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 125000005270 trialkylamine group Chemical group 0.000 description 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 230000032050 esterification Effects 0.000 description 2
- 238000005886 esterification reaction Methods 0.000 description 2
- 238000006266 etherification reaction Methods 0.000 description 2
- 238000004255 ion exchange chromatography Methods 0.000 description 2
- 238000000622 liquid--liquid extraction Methods 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 238000002414 normal-phase solid-phase extraction Methods 0.000 description 2
- XNGIFLGASWRNHJ-UHFFFAOYSA-N phthalic acid Chemical compound OC(=O)C1=CC=CC=C1C(O)=O XNGIFLGASWRNHJ-UHFFFAOYSA-N 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- NHGXDBSUJJNIRV-UHFFFAOYSA-M tetrabutylammonium chloride Chemical compound [Cl-].CCCC[N+](CCCC)(CCCC)CCCC NHGXDBSUJJNIRV-UHFFFAOYSA-M 0.000 description 2
- VDZOOKBUILJEDG-UHFFFAOYSA-M tetrabutylammonium hydroxide Chemical compound [OH-].CCCC[N+](CCCC)(CCCC)CCCC VDZOOKBUILJEDG-UHFFFAOYSA-M 0.000 description 2
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- ONDSBJMLAHVLMI-UHFFFAOYSA-N trimethylsilyldiazomethane Chemical compound C[Si](C)(C)[CH-][N+]#N ONDSBJMLAHVLMI-UHFFFAOYSA-N 0.000 description 2
- SCYULBFZEHDVBN-UHFFFAOYSA-N 1,1-Dichloroethane Chemical compound CC(Cl)Cl SCYULBFZEHDVBN-UHFFFAOYSA-N 0.000 description 1
- OQZAQBGJENJMHT-UHFFFAOYSA-N 1,3-dibromo-5-methoxybenzene Chemical compound COC1=CC(Br)=CC(Br)=C1 OQZAQBGJENJMHT-UHFFFAOYSA-N 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- YXHKONLOYHBTNS-UHFFFAOYSA-N Diazomethane Chemical compound C=[N+]=[N-] YXHKONLOYHBTNS-UHFFFAOYSA-N 0.000 description 1
- 230000005526 G1 to G0 transition Effects 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- XCOBLONWWXQEBS-KPKJPENVSA-N N,O-bis(trimethylsilyl)trifluoroacetamide Chemical compound C[Si](C)(C)O\C(C(F)(F)F)=N\[Si](C)(C)C XCOBLONWWXQEBS-KPKJPENVSA-N 0.000 description 1
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- JKNZUZCGFROMAZ-UHFFFAOYSA-L [Ag+2].[O-]S([O-])(=O)=O Chemical class [Ag+2].[O-]S([O-])(=O)=O JKNZUZCGFROMAZ-UHFFFAOYSA-L 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- AGEZXYOZHKGVCM-UHFFFAOYSA-N benzyl bromide Chemical compound BrCC1=CC=CC=C1 AGEZXYOZHKGVCM-UHFFFAOYSA-N 0.000 description 1
- VERAMNDAEAQRGS-UHFFFAOYSA-N butane-1,4-disulfonic acid Chemical compound OS(=O)(=O)CCCCS(O)(=O)=O VERAMNDAEAQRGS-UHFFFAOYSA-N 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000012159 carrier gas Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000009795 derivation Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- UQEAIHBTYFGYIE-UHFFFAOYSA-N hexamethyldisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)C UQEAIHBTYFGYIE-UHFFFAOYSA-N 0.000 description 1
- 150000002430 hydrocarbons Chemical group 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- HVTICUPFWKNHNG-UHFFFAOYSA-N iodoethane Chemical compound CCI HVTICUPFWKNHNG-UHFFFAOYSA-N 0.000 description 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 1
- 238000004460 liquid liquid chromatography Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000004452 microanalysis Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N octane Chemical compound CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- MGNVWUDMMXZUDI-UHFFFAOYSA-N propane-1,3-disulfonic acid Chemical compound OS(=O)(=O)CCCS(O)(=O)=O MGNVWUDMMXZUDI-UHFFFAOYSA-N 0.000 description 1
- 238000004451 qualitative analysis Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 description 1
- ODTSDWCGLRVBHJ-UHFFFAOYSA-M tetrahexylazanium;chloride Chemical compound [Cl-].CCCCCC[N+](CCCCCC)(CCCCCC)CCCCCC ODTSDWCGLRVBHJ-UHFFFAOYSA-M 0.000 description 1
- QBVXKDJEZKEASM-UHFFFAOYSA-M tetraoctylammonium bromide Chemical compound [Br-].CCCCCCCC[N+](CCCCCCCC)(CCCCCCCC)CCCCCCCC QBVXKDJEZKEASM-UHFFFAOYSA-M 0.000 description 1
- 239000002351 wastewater Substances 0.000 description 1
- 239000008096 xylene Substances 0.000 description 1
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- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
1.カルボン酸を含む水溶液に、第四級アンモニウム塩、ハロゲン化アルキル、疎水性有機溶媒を加え、カルボン酸をアルキル化した後、そのカルボン酸アルキルである誘導体化物を含む疎水性有機溶媒から、第四級アンモニウム塩を除去した後に、疎水性有機溶媒の機器測定を行う水溶液中のカルボン酸の分析法であって、疎水性有機溶媒からの第四級アンモニウム塩除去剤が過塩素酸、その水溶液、硫酸、その水溶液、有機スルホン酸、その水溶液、及び、飽和炭化水素系溶剤、からなる群から選ばれる少なくとも一種である水溶液中のカルボン酸の分析法。
2.機器測定が、ガスクロマトグラフィー、ガスクロマトグラフィー・質量分析法、液体クロマトグラフィー、液体クロマトグラフィー・質量分析法、からなる群から選ばれる少なくとも一種である前記水溶液中のカルボン酸の分析法。
各々濃度約100μg/mLのギ酸、酢酸、プロピオン酸、酪酸、吉草酸の、濃度0.03mol/Lの水酸化ナトリウム水溶液1mL、濃度2mol/LのpH7リン酸緩衝液0.1mL、濃度0.1mol/Lの臭化テトラヘキシルアンモニウムのトルエン溶液1mL、及び、臭化ペンタフルオロベンジル0.25mmolをガラス容器に入れ、100℃で加熱撹拌した。相分離している水溶液を除去した後、濃度2mol/Lの過塩素酸水溶液1mLを加え、振盪した。相分離しているトルエン溶液を取り出し、ガスクロマトグラフィーで測定した。
装置本体:6890(アジレント・テクノロジー社製)
注入口:スプリット/スプリットレス注入口(アジレント・テクノロジー社製)
温度250℃、スプリットモード、スプリット比1/20、注入量1μL
カラム:DB−WAX(アジレント・テクノロジー社製)
内径0.25mm、長さ30m、膜厚0.25μm、流量2mL/分(一定)
検出器:水素炎イオン化検出器(FID)(アジレント・テクノロジー社製)
温度250℃
オーブン:初期温度50℃(1分保持)、昇温20℃/分、終期温度250℃(1分保持)
キャリアガス:ヘリウム。
実施例1における過塩素酸の代りに硫酸を用いた以外は、実施例1と同様の操作を行った。
実施例1における過塩素酸の代りに1,2‐エタンジスルホン酸を用いた以外は、実施例1と同様の操作を行った。
各々濃度約100μg/mLのギ酸、酢酸、プロピオン酸、酪酸、吉草酸の、濃度0.03mol/Lの水酸化ナトリウム水溶液1mL、濃度2mol/LのpH7リン酸緩衝液0.1mL、濃度0.2mol/Lの臭化テトラヘキシルアンモニウムのトルエン溶液0.5mL、及び、臭化ペンタフルオロベンジル0.25mmolをガラス容器に入れ、100℃で加熱撹拌した。ノルマルヘキサン0.5mLを加え、振盪した。相分離しているトルエン及びノルマルヘキサン混合溶液を取り出し、ガスクロマトグラフィーで測定した。ガスクロマトグラフィーの測定条件は実施例1と同様である。
各々濃度約100μg/mLのギ酸、酢酸、プロピオン酸、酪酸、吉草酸の、濃度0.03mol/Lの水酸化ナトリウム水溶液1mL、濃度2mol/LのpH7リン酸緩衝液0.1mL、濃度0.2mol/Lの臭化テトラヘキシルアンモニウムのトルエン溶液0.5mL、及び、臭化ペンタフルオロベンジル0.25mmolをガラス容器に入れ、加熱撹拌した。ノルマルヘキサン0.5mLを加え、振盪した。相分離している水溶液を除去した後、水1mLを加え、振盪した。相分離しているトルエン及びノルマルヘキサン混合溶液を取り出し、ガスクロマトグラフィーで測定した。ガスクロマトグラフィーの測定条件は実施例1と同様である。
実施例5における水の代りに濃度2mol/Lの過塩素酸水溶液を用いた以外は、実施例5と同様の操作を行った。
実施例6における過塩素酸の代りに硫酸を用いた以外は、実施例6と同様の操作を行った。
実施例6における過塩素酸の代りに1,2−エタンジスルホン酸を用いた以外は、実施例6と同様の操作を行った。
実施例5における水の代りに硫酸銀飽和水溶液を用いた以外は、実施例5と同様の操作を行った。
各々濃度約100μg/mLのギ酸、酢酸、プロピオン酸、酪酸、吉草酸の、濃度0.03mol/Lの水酸化ナトリウム水溶液1mL、濃度2mol/LのpH7リン酸緩衝液0.1mL、濃度0.1mol/Lの臭化テトラヘキシルアンモニウムのトルエン溶液1mL、及び、臭化ペンタフルオロベンジル0.25mmolをガラス容器に入れ、100℃で加熱撹拌した。相分離しているトルエン溶液を取り出し、ガスクロマトグラフィーで測定した。ガスクロマトグラフィーの測定条件は実施例1と同様である。
実施例1における濃度2mol/Lの過塩素酸水溶液の代りに水を用いた以外は、実施例1と同様の操作を行った。
実施例1における濃度2mol/Lの過塩素酸水溶液の代りに飽和硫酸銀水溶液を用いた以外は、実施例1と同様の操作を行った。
Claims (2)
- カルボン酸を含む水溶液に、第四級アンモニウム塩、ハロゲン化アルキル、疎水性有機溶媒を加え、カルボン酸をアルキル化した後、そのカルボン酸アルキルである誘導体化物を含む疎水性有機溶媒から、第四級アンモニウム塩を除去した後に、疎水性有機溶媒の機器測定を行う水溶液中のカルボン酸の分析法であって、
疎水性有機溶媒からの第四級アンモニウム塩除去剤が過塩素酸、その水溶液、硫酸、その水溶液、有機スルホン酸、その水溶液、からなる群から選ばれる少なくとも一種、及び、飽和炭化水素である水溶液中のカルボン酸の分析法。 - 機器測定が、ガスクロマトグラフィー、ガスクロマトグラフィー・質量分析法、液体クロマトグラフィー、液体クロマトグラフィー・質量分析法、からなる群から選ばれる少なくとも一種である請求項1に記載の水溶液中のカルボン酸の分析法。
Priority Applications (1)
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