JP6887954B2 - 水媒体中の抽出アジュバントとしての非イオン性両親媒性化合物を用いた植物性由来マトリックス抽出物の製造方法 - Google Patents
水媒体中の抽出アジュバントとしての非イオン性両親媒性化合物を用いた植物性由来マトリックス抽出物の製造方法 Download PDFInfo
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-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2300/00—Processes
- A23V2300/14—Extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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Description
[式中、
・Alkは、3〜7個の炭素原子を有する、飽和または不飽和、直鎖状または分岐状の疎水性脂肪族炭化水素フラグメントを示し、かつ、
・Zは、グルコース、キシロース、アラビノース等の疎水性グリコシド基を表し、かつ、
・1<p<5である。]
のアルキルポリグリコシドである。
−濾液をそのまま保存または凍結乾燥した場合、広範囲の極性で分子および非イオン性両親媒性化合物を含有する完全抽出物の製造によって最終製品中における抽出物のより良い可溶化が可能になる。
−親油性化合物を沈殿によって精製した場合、水性抽出物および農業由来の物質を用いて得た親油性化合物が濃縮した抽出物の製造は、ヘキサン、酢酸エチルまたはアセトン等の毒性かつ石油化学系溶媒の代替である。
100gの乾燥し製粉したホオズキ(Physalis)の果実を700mLの1.5Mのヘプチルグルコシド水溶液(SEPICLEAR G7(商標),SEPPIC)で40℃にて2時間撹拌した。濾過後、濾液をpH2に酸性化し、次いで15容量の水で希釈した。遠心分離後、ペレットを取り出し乾燥させた。濃縮抽出物を2.1重量%の収率で得た。
20gの乾燥し製粉したホオズキ(Physalis)の果実を140mLの0.75Mのヘプチルグルコシド水溶液で40℃にて2時間撹拌した。濾過後、濾液を6.6容量の水で希釈した。遠心分離後、ペレットを取り出し乾燥させた。濃縮抽出物を0.64重量%の収率で得た。
20gの乾燥し製粉したホオズキ(Physalis)の果実を140mLの3Mのヘプチルグルコシド水溶液で40℃にて2時間撹拌した。濾過後、濾液を22容量の水で希釈した。遠心分離後、ペレットを取り出し乾燥させた。濃縮抽出物を0.98重量%の収率で得た。
5kgの乾燥し製粉したバニラの鞘を50Lの1.5Mのヘプチルグルコシド水溶液で50℃にて3時間抽出した。加圧濾過後、絞りかす25Lの同一の溶液で洗浄した。濾液を濃縮して赤褐色シロップ状溶液の形態でバニラ抽出物を得た。
100kgの乾燥し製粉したマンゴスチン(Garcinia mangostana)の果皮を1000Lの1.5Mのヘプチルグルコシド水溶液で40℃にて2時間撹拌した。濾過後、濾液をpH=2に酸性化し、次いでpH=2に酸性化した11容量の水で希釈した。遠心分離後、ペレットを取り出し乾燥させた。キサントンが豊富な抽出物(α−マンゴスチンで表すと21.3%)を7.3重量%の収率で得た。得られた抽出物はタンニンを含まない。
1kgの乾燥し製粉したカヴァ(Piper methysticum)の地下部を700mLの1.5mol/Lのアミルキシロシド水溶液(APXC5)で40℃下にて撹拌しながら1.5時間抽出した。濾過後、濾液を4容量の水で希釈した。遠心分離後、カヴァ(Kava)の濃縮抽出物に相当するペレットを6.2%の収率で得た。抽出物は3.0%のカヴァラクトンを含有する。
−1.5mol/Lのアミルグリコシド水溶液での抽出によって得られた抽出物は、酢酸エチル抽出より高い含有量の低極性カヴァラクトン(ヤンゴニン、デメトキシヤンゴニン、フラヴォカヴァインA、フラヴォカヴァインBおよびフラヴォカヴァインC)を有する(総カヴァラクトンは35.3%と比べて44.8%)。
−反対に、1.5mol/Lのアミルグリコシド水溶液での抽出によって得られた抽出物は、酢酸エチル抽出より低い含有量の最も極性なカヴァラクトン(メチスチシン、ジヒドロメチスチシン、カヴァインおよびマリンジニン(marindinine))を有する(総カヴァラクトンは55.2%と比べて64.7%)。
−水性抽出によって得られた抽出物は、1.66%のカヴァラクトンを含有し、低極性カヴァラクトン(ヤンゴニン、デメトキシヤンゴニン、フラヴォカヴァインA、フラヴォカヴァインBおよびフラヴォカヴァインC)を含有しない。
例5によるマンゴスチン抽出物 200mg
デンプン 45mg
ステアリン酸マグネシウム 2mg
例4によるバニラ抽出物 0.5〜3%
トリベヘニンPEG−20エステル 2〜7%
ネオペンタン酸イソデシル 2〜9%
グリセリン 0.5〜10%
パルミチン酸グリコール 1〜6%
セチルアルコール 0.5〜3%
2ナトリウムEDTA 0.05〜0.25%
保存料 0.5〜3%
香料 0.2〜0.5%
キサンタンガム 0.1〜0.4%
水 適量
異なる濃度での種々の非イオン性両親媒性化合物の水溶液中のスーダン・レッドの可溶化曲線を作成した。スーダン・レッドとの溶液の飽和および濾過後、各溶液に可溶化したスーダン・レッド含有量を、476nmでのUV分光測光法による希釈後に測定した。可溶化曲線は、添付の図1に記載されている。y軸は、希釈で乗じたOD値を表し、これら値は濃度に比例するものである(ランベルト・ベールの法則による)。
−乾燥していないオリーブかす(grignon)の抽出
製粉したオリーブ果肉を、油状物(76%の水を含有)を回収するために圧搾した後、10g計量し、12gのAPXC4(乾燥物質)および当量の水を添加して50%の最終APXC4濃度とした(植物の水分含有量を考慮する)。50℃で3時間加熱して濾過し、透明な褐色濾液を87.5%の収率で回収した。
・固定相:シリカゲル60でコーティングしたTLCプレート
・移動相:酢酸エチル/シクロヘキサン(1:1)
・現像液:硫酸バニリン+120℃への加熱
Claims (16)
- 少なくとも1種の非イオン性両親媒性化合物を少なくともその最小ハイドロトロープ濃度と同等の濃度で含有する水溶液を用いた固体−液体抽出を含む、植物性マトリックス抽出物の製造方法であって、
前記非イオン性両親媒性化合物が、一般式Alk−O−Zp
[式中、
・Alkは、3〜6個の炭素原子を有する、飽和または不飽和、直鎖状または分岐状の疎水性脂肪族炭化水素フラグメントを示し、かつ、
・Zは、グルコース、キシロース、アラビノース等の疎水性グリコシド基を表し、かつ、・1<p<5である]
のアルキルポリグリコシドである、方法。 - 前記植物性マトリックス抽出物が植物抽出物である、請求項1に記載の方法。
- 前記非イオン性両親媒性化合物を含有する水溶液が、使用される唯一の抽出溶媒を構成する、請求項1または2に記載の方法。
- 前記固体−液体抽出が、撹拌下で維持された、少なくとも1種の非イオン性両親媒性化合物を含有する前記水溶液中での植物のマセレーションによって行われる、請求項1〜3のいずれか一項に記載の方法。
- 前記固体−液体抽出が、マイクロ波下、超音波下あるいは向流法で行われる、請求項1〜3のいずれか一項に記載の方法。
- 前記水溶液中の非イオン性両親媒性化合物の濃度が、最小ハイドロトロープ濃度の1〜10倍である、請求項5に記載の方法。
- 前記水溶液中の非イオン性両親媒性化合物の濃度が、最小ハイドロトロープ濃度の1〜2倍である、請求項5に記載の方法。
- 前記非イオン性両親媒性化合物が、前記水溶液中に、該溶液の重量に対して60重量%未満の濃度で存在している、請求項1〜7のいずれか一項に記載の方法。
- 前記非イオン性両親媒性化合物が、前記水溶液中に、該溶液の重量に対して40重量%未満の濃度で存在している、請求項1〜7のいずれか一項に記載の方法。
- 前記水溶液が、抽出継続時間、20℃〜還流の温度で加熱される、請求項1〜9のいずれか一項に記載の方法。
- キログラムでの植物とリットルでの前記水溶液との比が、1:5〜1:50である、請求項1〜10のいずれか一項に記載の方法。
- 前記抽出後に、濾過または遠心分離による固体−液体分離が行われる、請求項1〜11のいずれか一項に記載の方法。
- 前記非イオン性両親媒性化合物が、アミルグリコシドであり、ここで、
アミルグリコシドの疎水性アミルフラグメントがビートまたはジャガイモの粉の発酵により得られたC5アルコールに相当し、かつ
アミルグリコシドのグリコシドフラグメントが穀類に由来する、請求項1〜12のいずれか一項に記載の方法。 - 使用される植物が、ブドウホオズキ(Physalis peruviana)の果実、エンベリア・リブス(Embelia ribes)の果実、ギンバイカ(Myrtus communis)の葉、コショウ属(Piper spp.)の地下部および葉、 サザンブルーガム(Eucalyptus globulus)の葉、マンゴスチン(Garcinia mangostana)の果皮、ホップ(Humulus lupulus)の雌花序、キナ属(Cinchona sp. )の樹皮、イラクサ(Urtica dioica)の地上部、ムギワラギク属(Helichrysum sp.)の地上部、バニラ属(Vanilla sp.)の果実、ウコン属(Curcuma spp.)の根茎、ショウガ(Zingiber officinale)の根茎、オリーブ(Olea europaea)の果実および葉から選択される、請求項1〜13のいずれか一項に記載の方法。
- 固体−液体分離後に得られた溶液が、そのまま保存されるかまたは凍結乾燥され、目的の分子および非イオン性両親媒性化合物を含有し、該非イオン性両親媒性化合物が最終製品中での抽出物のより良い可溶化を可能とする、請求項12〜14のいずれか一項に記載の方法。
- 前記得られた抽出物において、親油性化合物が沈殿によって精製される、請求項1〜15のいずれか一項に記載の方法。
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