JP6882269B2 - 免疫応答を調節するための、炭水化物で修飾された粒子および粒子製剤 - Google Patents

免疫応答を調節するための、炭水化物で修飾された粒子および粒子製剤 Download PDF

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JP6882269B2
JP6882269B2 JP2018514933A JP2018514933A JP6882269B2 JP 6882269 B2 JP6882269 B2 JP 6882269B2 JP 2018514933 A JP2018514933 A JP 2018514933A JP 2018514933 A JP2018514933 A JP 2018514933A JP 6882269 B2 JP6882269 B2 JP 6882269B2
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disaccharide
particles
antigen
carbohydrate
tolerance
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JP2018515627A (ja
JP2018515627A5 (enExample
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ポール ジェイ. ブライス
ポール ジェイ. ブライス
カレン ビー. シーン
カレン ビー. シーン
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Northwestern University
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    • AHUMAN NECESSITIES
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    • A61K39/385Haptens or antigens, bound to carriers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • AHUMAN NECESSITIES
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    • A61K31/7016Disaccharides, e.g. lactose, lactulose
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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JP2018514933A 2015-05-27 2016-05-27 免疫応答を調節するための、炭水化物で修飾された粒子および粒子製剤 Active JP6882269B2 (ja)

Priority Applications (2)

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JP2021078275A JP7369734B2 (ja) 2015-05-27 2021-05-06 免疫応答を調節するための、炭水化物で修飾された粒子および粒子製剤
JP2023109210A JP2023130428A (ja) 2015-05-27 2023-07-03 免疫応答を調節するための、炭水化物で修飾された粒子および粒子製剤

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US201562167054P 2015-05-27 2015-05-27
US62/167,054 2015-05-27
PCT/US2016/034765 WO2016191723A1 (en) 2015-05-27 2016-05-27 Carbohydrate-modified particles and particulate formulations for modulating an immune response

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JP2021078275A Division JP7369734B2 (ja) 2015-05-27 2021-05-06 免疫応答を調節するための、炭水化物で修飾された粒子および粒子製剤

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JP2018515627A JP2018515627A (ja) 2018-06-14
JP2018515627A5 JP2018515627A5 (enExample) 2019-06-27
JP6882269B2 true JP6882269B2 (ja) 2021-06-02

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JP2021078275A Active JP7369734B2 (ja) 2015-05-27 2021-05-06 免疫応答を調節するための、炭水化物で修飾された粒子および粒子製剤
JP2023109210A Pending JP2023130428A (ja) 2015-05-27 2023-07-03 免疫応答を調節するための、炭水化物で修飾された粒子および粒子製剤

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JP2023109210A Pending JP2023130428A (ja) 2015-05-27 2023-07-03 免疫応答を調節するための、炭水化物で修飾された粒子および粒子製剤

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US (3) US20160346382A1 (enExample)
EP (1) EP3302446A4 (enExample)
JP (3) JP6882269B2 (enExample)
KR (1) KR102808155B1 (enExample)
CN (2) CN108024969A (enExample)
AU (1) AU2016267671B2 (enExample)
BR (1) BR112017025422A2 (enExample)
IL (2) IL293655B2 (enExample)
MX (1) MX2017015127A (enExample)
RU (1) RU2752620C2 (enExample)
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Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9597385B2 (en) 2012-04-23 2017-03-21 Allertein Therapeutics, Llc Nanoparticles for treatment of allergy
EP3760223A1 (en) 2013-04-03 2021-01-06 N-Fold Llc Nanoparticle composition for desensitizing a subject to peanut allergens
JP7653696B2 (ja) 2016-12-09 2025-03-31 ノースウエスタン ユニバーシティ 骨形成促進温度応答性巨大分子
WO2018209259A1 (en) * 2017-05-11 2018-11-15 Northwestern University Intravascular retrievable cell delivery system
WO2019023060A2 (en) 2017-07-28 2019-01-31 Kimberly-Clark Worldwide, Inc. NANOPOROUS SUPERABSORBENT PARTICLES
BR112021004081A2 (pt) * 2018-09-04 2021-05-25 Ecole Polytechnique Federale De Lausanne (Epfl) nanopartículas virucidas, composição farmacêutica, composição virucida, método de desinfecção e/ou esterilização, dispositivo e uso das nanopartículas virucidas
GB201819759D0 (en) * 2018-12-04 2019-01-23 Phytoquest Ltd Bioactive phytochemicals in zizphus and guarana
CN115212198A (zh) * 2021-04-15 2022-10-21 北京大学第三医院(北京大学第三临床医学院) 一种组合物在制备预防、缓解、治疗泪腺功能低下的药物方面的应用
CN113143939A (zh) * 2021-06-07 2021-07-23 长春中医药大学 贝母素甲在制备预防和/或治疗溃疡性结肠炎药物中的应用
CN114042441B (zh) * 2021-12-09 2024-05-03 云南师范大学 在血液灌流树脂微球表面修饰并固载肝素的方法及其制备的吸附剂

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20020387A2 (en) * 1999-11-12 2005-10-31 Maxygen Holdings Ltd. Interferon gamma conjugates
RU2268749C2 (ru) * 1999-11-12 2006-01-27 Максиджен Холдингз Лтд КОНЪЮГАТЫ γ-ИНТЕРФЕРОНА
US20040047866A1 (en) * 2002-09-09 2004-03-11 President And Fellows Of Harvard College Immunomodulatory methods using carbohydrate antigens
US9267937B2 (en) * 2005-12-15 2016-02-23 Massachusetts Institute Of Technology System for screening particles
US8343497B2 (en) * 2008-10-12 2013-01-01 The Brigham And Women's Hospital, Inc. Targeting of antigen presenting cells with immunonanotherapeutics
CN103665170A (zh) * 2008-12-05 2014-03-26 安吉奥开米公司 肽治疗剂轭合物及其应用
US10988516B2 (en) * 2012-03-26 2021-04-27 Uti Limited Partnership Methods and compositions for treating inflammation
EP3939572B1 (en) * 2012-04-12 2024-03-27 Yale University Vehicles for controlled delivery of different pharmaceutical agents
CN105848649B (zh) * 2013-11-01 2019-08-02 耶鲁大学 用于免疫疗法的模块化粒子

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KR102808155B1 (ko) 2025-05-16
IL293655B1 (en) 2024-12-01
KR20180012796A (ko) 2018-02-06
AU2016267671A1 (en) 2018-01-18
CN108024969A (zh) 2018-05-11
BR112017025422A2 (pt) 2018-08-07
IL255944A (en) 2018-01-31
JP7369734B2 (ja) 2023-10-26
MX2017015127A (es) 2018-06-22
JP2018515627A (ja) 2018-06-14
IL255944B (en) 2022-07-01
US20210205443A1 (en) 2021-07-08
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WO2016191723A1 (en) 2016-12-01
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