JP6878473B2 - ブリンシドフォビルの製剤 - Google Patents

ブリンシドフォビルの製剤 Download PDF

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JP6878473B2
JP6878473B2 JP2018568195A JP2018568195A JP6878473B2 JP 6878473 B2 JP6878473 B2 JP 6878473B2 JP 2018568195 A JP2018568195 A JP 2018568195A JP 2018568195 A JP2018568195 A JP 2018568195A JP 6878473 B2 JP6878473 B2 JP 6878473B2
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concentration
pharmaceutical composition
solution
mannitol
arginine
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JP2019519570A (ja
JP2019519570A5 (enExample
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ムハンマド アナウルル カビール
ムハンマド アナウルル カビール
オーディン ヨハン ナデレル
オーディン ヨハン ナデレル
イルマ マリサ グローシー
イルマ マリサ グローシー
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キメリックス インコーポレイテッド
キメリックス インコーポレイテッド
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Publication of JP2019519570A5 publication Critical patent/JP2019519570A5/ja
Priority to JP2021075612A priority Critical patent/JP7221485B2/ja
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Priority to JP2023005643A priority patent/JP7407984B2/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2018568195A 2016-06-28 2017-06-28 ブリンシドフォビルの製剤 Active JP6878473B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2021075612A JP7221485B2 (ja) 2016-06-28 2021-04-28 ブリンシドフォビルの製剤
JP2023005643A JP7407984B2 (ja) 2016-06-28 2023-01-18 ブリンシドフォビルの製剤

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US201662355844P 2016-06-28 2016-06-28
US62/355,844 2016-06-28
US201662394665P 2016-09-14 2016-09-14
US62/394,665 2016-09-14
US201762446213P 2017-01-13 2017-01-13
US62/446,213 2017-01-13
US201762465053P 2017-02-28 2017-02-28
US62/465,053 2017-02-28
US201762507397P 2017-05-17 2017-05-17
US62/507,397 2017-05-17
US201762512825P 2017-05-31 2017-05-31
US62/512,825 2017-05-31
PCT/US2017/039804 WO2018005676A1 (en) 2016-06-28 2017-06-28 Formulations of brincidofovir

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021075612A Division JP7221485B2 (ja) 2016-06-28 2021-04-28 ブリンシドフォビルの製剤

Publications (3)

Publication Number Publication Date
JP2019519570A JP2019519570A (ja) 2019-07-11
JP2019519570A5 JP2019519570A5 (enExample) 2020-02-20
JP6878473B2 true JP6878473B2 (ja) 2021-05-26

Family

ID=59313330

Family Applications (3)

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JP2018568195A Active JP6878473B2 (ja) 2016-06-28 2017-06-28 ブリンシドフォビルの製剤
JP2021075612A Active JP7221485B2 (ja) 2016-06-28 2021-04-28 ブリンシドフォビルの製剤
JP2023005643A Active JP7407984B2 (ja) 2016-06-28 2023-01-18 ブリンシドフォビルの製剤

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2021075612A Active JP7221485B2 (ja) 2016-06-28 2021-04-28 ブリンシドフォビルの製剤
JP2023005643A Active JP7407984B2 (ja) 2016-06-28 2023-01-18 ブリンシドフォビルの製剤

Country Status (11)

Country Link
US (4) US20170368082A1 (enExample)
EP (2) EP3474822B1 (enExample)
JP (3) JP6878473B2 (enExample)
CN (4) CN114569547A (enExample)
AU (2) AU2017290703B2 (enExample)
DK (1) DK3474822T3 (enExample)
ES (1) ES3037596T3 (enExample)
FI (1) FI3474822T3 (enExample)
PL (1) PL3474822T3 (enExample)
PT (1) PT3474822T (enExample)
WO (1) WO2018005676A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021143178A (ja) * 2016-06-28 2021-09-24 キメリックス インコーポレイテッド ブリンシドフォビルの製剤

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA116825C2 (uk) 2013-11-15 2018-05-10 Чимерикс Інк. Морфологічні форми гексадецилоксипропілових складних ефірів фосфонової кислоти і способи їх синтезу
CN111201030B (zh) 2017-07-25 2024-11-01 真和制药有限公司 通过阻断tim-3和其配体的相互作用治疗癌症
KR20210124308A (ko) 2019-01-30 2021-10-14 트루바인딩 아이엔씨. 항-gal3 항체 및 이의 용도
MX2022014786A (es) 2020-05-26 2023-01-16 Truebinding Inc Metodos para tratar enfermedades inflamatorias mediante el bloqueo de galectina-3.
CN114073772A (zh) * 2020-08-18 2022-02-22 上海市公共卫生临床中心 铁螯合剂在制备用于治疗或预防多瘤病毒感染的药物中的用途
CN114558022B (zh) * 2022-02-16 2023-11-17 华中农业大学 布林西多福韦在制备抗伪狂犬病毒药物中的应用
CN114732821A (zh) * 2022-04-24 2022-07-12 华中农业大学 西多福韦的前药在制备防治非洲猪瘟药物中的应用
JP7417339B1 (ja) 2023-08-07 2024-01-18 シンバイオ製薬株式会社 アデノウイルス感染又はアデノウイルス感染に伴う疾患の治療
AU2024353056A1 (en) * 2023-09-29 2026-04-23 Symbio Pharmaceuticals Limited Brincidofovir for treatment of multiple sclerosis

Family Cites Families (17)

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US6716825B2 (en) 1999-12-03 2004-04-06 The Regents Of The University Of California Phosphonate compounds
JP4136340B2 (ja) * 2000-08-18 2008-08-20 武田薬品工業株式会社 注射剤
JP2008538354A (ja) 2005-04-08 2008-10-23 キメリクス，インコーポレイテッド ウイルス感染症およびその他の内科疾患を治療するための化合物、組成物および方法
WO2006110655A2 (en) 2005-04-08 2006-10-19 Chimerix, Inc. Compounds, compositions and methods for the treatment of poxvirus infections
CN101678122A (zh) * 2007-04-27 2010-03-24 奇默里克斯公司 在核苷给药的受体中降低肾中毒性的方法
JP2011116658A (ja) * 2008-03-13 2011-06-16 Chemo-Sero-Therapeutic Research Inst 豚萎縮性鼻炎用薬剤の製造方法
US8614200B2 (en) 2009-07-21 2013-12-24 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
WO2011017253A1 (en) 2009-08-03 2011-02-10 Chimerix, Inc. Composition and methods of treating viral infections and viral induced tumors
AU2010313273B2 (en) 2009-10-30 2015-04-02 Emergent Biodefense Operations Lansing Llc Methods of treating viral associated diseases
PT2508170E (pt) 2009-12-03 2015-10-16 Shanghai Hengrui Pharm Co Ltd Lipossoma de irinotecano ou o seu cloridrato e seu método de preparação
US20110263536A1 (en) 2010-04-22 2011-10-27 Chimerix, Inc. Methods of Treating Orthopox Virus Infections and Associated Diseases
CN105998039A (zh) 2010-08-31 2016-10-12 奇默里克斯公司 膦酸酯衍生物及其合成方法
US20140303092A1 (en) * 2011-10-26 2014-10-09 Chimerix, Inc Hexadecyloxypropyl cidofovir for the treatment of double-stranded dna virus infection
WO2013163509A1 (en) 2012-04-27 2013-10-31 Chimerix, Inc. A method of mitigating virus associated end-organ damage
UA119324C2 (uk) * 2013-04-02 2019-06-10 Теміс Медікер Лімітед Композиції фармацевтично активних речовин, що містять моноетиловий ефір діетиленгліколю або інші алкільні похідні
UA116825C2 (uk) * 2013-11-15 2018-05-10 Чимерикс Інк. Морфологічні форми гексадецилоксипропілових складних ефірів фосфонової кислоти і способи їх синтезу
AU2017290703B2 (en) * 2016-06-28 2023-03-30 Emergent Biodefense Operations Lansing Llc Formulations of brincidofovir

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021143178A (ja) * 2016-06-28 2021-09-24 キメリックス インコーポレイテッド ブリンシドフォビルの製剤

Also Published As

Publication number Publication date
US20170368082A1 (en) 2017-12-28
US12485131B2 (en) 2025-12-02
AU2017290703B2 (en) 2023-03-30
WO2018005676A1 (en) 2018-01-04
EP3474822B1 (en) 2025-07-09
US20230210873A1 (en) 2023-07-06
JP2019519570A (ja) 2019-07-11
EP3474822A1 (en) 2019-05-01
FI3474822T3 (fi) 2025-08-15
JP7407984B2 (ja) 2024-01-04
PL3474822T3 (pl) 2025-11-03
PT3474822T (pt) 2025-08-21
JP7221485B2 (ja) 2023-02-14
ES3037596T3 (en) 2025-10-03
US20200138835A1 (en) 2020-05-07
CN114569547A (zh) 2022-06-03
JP2021143178A (ja) 2021-09-24
CN118416082A (zh) 2024-08-02
DK3474822T3 (da) 2025-08-18
AU2017290703A1 (en) 2018-12-13
EP4295853B1 (en) 2026-08-12
AU2023204117A1 (en) 2023-07-13
AU2023204117B2 (en) 2025-03-20
CA3024886A1 (en) 2018-01-04
CN109475497A (zh) 2019-03-15
US20260151411A1 (en) 2026-06-04
EP4295853A2 (en) 2023-12-27
EP4295853A3 (en) 2024-03-06
CN119139329A (zh) 2024-12-17
JP2023033538A (ja) 2023-03-10

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