JP6874014B2 - Ｃｇｒｐ受容体アンタゴニスト - Google Patents
Ｃｇｒｐ受容体アンタゴニスト Download PDFInfo
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- JP6874014B2 JP6874014B2 JP2018541593A JP2018541593A JP6874014B2 JP 6874014 B2 JP6874014 B2 JP 6874014B2 JP 2018541593 A JP2018541593 A JP 2018541593A JP 2018541593 A JP2018541593 A JP 2018541593A JP 6874014 B2 JP6874014 B2 JP 6874014B2
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- UTUVUXYKFFKIKP-UHFFFAOYSA-N tert-butyl 4-(1h-imidazol-2-yl)piperidine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCC1C1=NC=CN1 UTUVUXYKFFKIKP-UHFFFAOYSA-N 0.000 description 1
- JAXXBKHEMJKLOI-UHFFFAOYSA-N tert-butyl 4-[4-(1H-1,2,4-triazol-5-yl)piperidin-1-yl]piperidine-1-carboxylate Chemical compound N=1N=C(NC=1)C1CCN(CC1)C1CCN(CC1)C(=O)OC(C)(C)C JAXXBKHEMJKLOI-UHFFFAOYSA-N 0.000 description 1
- TWNFMKCGRHDKBY-UHFFFAOYSA-N tert-butyl 4-[4-[1-[(2-methylpropan-2-yl)oxycarbonyl]imidazol-2-yl]piperidin-1-yl]piperidine-1-carboxylate Chemical compound C(C)(C)(C)OC(=O)N1C(=NC=C1)C1CCN(CC1)C1CCN(CC1)C(=O)OC(C)(C)C TWNFMKCGRHDKBY-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000012096 transfection reagent Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- BDTOTMBOHYUNSQ-UHFFFAOYSA-N triazole-1-carboxylic acid Chemical compound OC(=O)N1C=CN=N1 BDTOTMBOHYUNSQ-UHFFFAOYSA-N 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical class CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 229940005605 valeric acid Drugs 0.000 description 1
- 230000025033 vasoconstriction Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 238000002424 x-ray crystallography Methods 0.000 description 1
- 229960004175 xylazine hydrochloride Drugs 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1519194.3 | 2015-10-30 | ||
| GBGB1519194.3A GB201519194D0 (en) | 2015-10-30 | 2015-10-30 | CGRP receptor antagonists |
| PCT/IB2016/056519 WO2017072723A1 (en) | 2015-10-30 | 2016-10-28 | Cgrp receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018532790A JP2018532790A (ja) | 2018-11-08 |
| JP2018532790A5 JP2018532790A5 (https=) | 2019-12-05 |
| JP6874014B2 true JP6874014B2 (ja) | 2021-05-19 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| JP2018541593A Active JP6874014B2 (ja) | 2015-10-30 | 2016-10-28 | Ｃｇｒｐ受容体アンタゴニスト |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9688660B2 (https=) |
| EP (1) | EP3368526B1 (https=) |
| JP (1) | JP6874014B2 (https=) |
| CN (1) | CN108430991B (https=) |
| AR (1) | AR106487A1 (https=) |
| AU (1) | AU2016344689A1 (https=) |
| BR (1) | BR112018008416A2 (https=) |
| CA (1) | CA3002625A1 (https=) |
| GB (1) | GB201519194D0 (https=) |
| IL (1) | IL258894A (https=) |
| SG (1) | SG11201803382XA (https=) |
| TW (1) | TW201722936A (https=) |
| WO (1) | WO2017072723A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201519196D0 (en) | 2015-10-30 | 2015-12-16 | Heptares Therapeutics Ltd | CGRP Receptor Antagonists |
| GB201519194D0 (en) * | 2015-10-30 | 2015-12-16 | Heptares Therapeutics Ltd | CGRP receptor antagonists |
| GB201519195D0 (en) | 2015-10-30 | 2015-12-16 | Heptares Therapeutics Ltd | CGRP Receptor Antagonists |
| CN114980862A (zh) * | 2019-12-17 | 2022-08-30 | 拜尔哈文制药股份有限公司 | Cgrp抑制剂的鼻内药物组合物 |
| WO2024046223A1 (zh) * | 2022-08-30 | 2024-03-07 | 熙源安健医药（上海）有限公司 | 吲唑甲酰胺类衍生物及其制备方法和用途 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2732221B1 (fr) | 1995-03-28 | 1997-04-25 | Oreal | Utilisation d'un antagoniste de cgrp pour traiter les rougeurs cutanees d'origine neurogene et composition obtenue |
| SK285631B6 (sk) | 1996-09-10 | 2007-05-03 | Dr. Karl Thomae Gmbh | Modifikované aminokyseliny, farmaceutický prostriedok s ich obsahom a ich použitie |
| US20030069231A1 (en) | 1999-10-12 | 2003-04-10 | Klaus Rudolf | Modified aminoacids, pharmaceuticals containing these compounds and method for their production |
| WO1999064002A1 (en) | 1998-06-11 | 1999-12-16 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
| US6294534B1 (en) | 1998-06-11 | 2001-09-25 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
| DE19952146A1 (de) * | 1999-10-29 | 2001-06-07 | Boehringer Ingelheim Pharma | Arylalkane, Arylalkene und Aryl-azaalkane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US7220862B2 (en) | 2002-06-05 | 2007-05-22 | Bristol-Myers Squibb Company | Calcitonin gene related peptide receptor antagonists |
| RS52552B (sr) * | 2002-06-05 | 2013-04-30 | Bristol-Myers Squibb Company | Antagonisti, peptidnog receptora koji je u vezi sa kalcitoninskim genom |
| US7842808B2 (en) | 2002-06-05 | 2010-11-30 | Bristol-Myers Squibb Company | Anti-migraine spirocycles |
| JO2355B1 (en) | 2003-04-15 | 2006-12-12 | ميرك شارب اند دوم كوربوريشن | Hereditary calcitonin polypeptide receptor antagonists |
| TW200524601A (en) | 2003-12-05 | 2005-08-01 | Bristol Myers Squibb Co | Heterocyclic anti-migraine agents |
| RS20060382A (sr) | 2003-12-05 | 2008-09-29 | Bristol-Myers Squibb Company, | Antagonisti receptora za peptid povezan sa genom za kalcitonin |
| TW200533398A (en) | 2004-03-29 | 2005-10-16 | Bristol Myers Squibb Co | Novel therapeutic agents for the treatment of migraine |
| DE102004015723A1 (de) | 2004-03-29 | 2005-10-20 | Boehringer Ingelheim Pharma | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| US20050233980A1 (en) * | 2004-04-20 | 2005-10-20 | Boehringer Ingelheim International Gmbh | CGRP-antagonist in combination with a serotonin-reuptake inhibitor for the treatment of migraine |
| DE102004019492A1 (de) | 2004-04-22 | 2005-11-10 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| BRPI0517418A (pt) | 2004-10-13 | 2008-10-07 | Merck & Co Inc | composto, composição farmacêutica, e, métodos para antagonismo de atividade do receptor de cgrp em um mamìfero, para tratar, controlar, melhorar ou reduzir o risco de dor de cabeça, enxaqueca ou cefalgia, e de tratamento ou prevenção de dores de cabeça de enxaqueca, cefalgias, e dores de cabeça |
| WO2006044449A2 (en) | 2004-10-14 | 2006-04-27 | Merck & Co., Inc. | Cgrp receptor antagonists |
| DE602005027230D1 (de) | 2004-10-22 | 2011-05-12 | Merck Sharp & Dohme | Cgrp-rezeptorantagonisten |
| EP1770091A1 (de) | 2005-09-29 | 2007-04-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| US7834007B2 (en) | 2005-08-25 | 2010-11-16 | Bristol-Myers Squibb Company | CGRP antagonists |
| KR20090021214A (ko) | 2006-06-08 | 2009-02-27 | 베링거 인겔하임 인터내셔날 게엠베하 | Ｃｇｒｐ-길항제에 의한 위장 장애의 치료 |
| US8044043B2 (en) | 2008-04-11 | 2011-10-25 | Bristol-Myers Squibb Company | CGRP receptor antagonists |
| CN102256963B (zh) * | 2008-12-19 | 2014-06-11 | 贝林格尔.英格海姆国际有限公司 | 作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺 |
| US8314117B2 (en) | 2009-10-14 | 2012-11-20 | Bristol-Myers Squibb Company | CGRP receptor antagonists |
| US8481546B2 (en) * | 2010-03-30 | 2013-07-09 | Bristol-Myers Squibb Company | CGRP receptor antagonist |
| US9174989B2 (en) | 2012-05-09 | 2015-11-03 | Merck Sharp & Dohme Corp. | Process for making CGRP receptor antagonists |
| GB201519194D0 (en) * | 2015-10-30 | 2015-12-16 | Heptares Therapeutics Ltd | CGRP receptor antagonists |
-
2015
- 2015-10-30 GB GBGB1519194.3A patent/GB201519194D0/en not_active Ceased
-
2016
- 2016-10-28 JP JP2018541593A patent/JP6874014B2/ja active Active
- 2016-10-28 AR ARP160103294A patent/AR106487A1/es unknown
- 2016-10-28 AU AU2016344689A patent/AU2016344689A1/en not_active Abandoned
- 2016-10-28 BR BR112018008416A patent/BR112018008416A2/pt not_active Application Discontinuation
- 2016-10-28 EP EP16808804.5A patent/EP3368526B1/en active Active
- 2016-10-28 CA CA3002625A patent/CA3002625A1/en not_active Abandoned
- 2016-10-28 TW TW105135025A patent/TW201722936A/zh unknown
- 2016-10-28 WO PCT/IB2016/056519 patent/WO2017072723A1/en not_active Ceased
- 2016-10-28 CN CN201680063940.2A patent/CN108430991B/zh active Active
- 2016-10-28 US US15/336,893 patent/US9688660B2/en active Active
- 2016-10-28 SG SG11201803382XA patent/SG11201803382XA/en unknown
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2017
- 2017-05-05 US US15/588,051 patent/US9925178B2/en active Active
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2018
- 2018-01-29 US US15/882,038 patent/US10166226B2/en active Active
- 2018-04-24 IL IL258894A patent/IL258894A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN108430991A (zh) | 2018-08-21 |
| GB201519194D0 (en) | 2015-12-16 |
| SG11201803382XA (en) | 2018-05-30 |
| JP2018532790A (ja) | 2018-11-08 |
| US20180153876A1 (en) | 2018-06-07 |
| US20170121311A1 (en) | 2017-05-04 |
| CN108430991B (zh) | 2021-01-05 |
| EP3368526A1 (en) | 2018-09-05 |
| IL258894A (en) | 2018-06-28 |
| WO2017072723A1 (en) | 2017-05-04 |
| TW201722936A (zh) | 2017-07-01 |
| AR106487A1 (es) | 2018-01-17 |
| CA3002625A1 (en) | 2017-05-04 |
| US9688660B2 (en) | 2017-06-27 |
| BR112018008416A2 (pt) | 2018-10-23 |
| US9925178B2 (en) | 2018-03-27 |
| AU2016344689A1 (en) | 2018-05-17 |
| US20170239236A1 (en) | 2017-08-24 |
| EP3368526B1 (en) | 2019-12-25 |
| US10166226B2 (en) | 2019-01-01 |
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