BR112018008416A2 - antagonistas do receptor cgrp - Google Patents
antagonistas do receptor cgrpInfo
- Publication number
- BR112018008416A2 BR112018008416A2 BR112018008416A BR112018008416A BR112018008416A2 BR 112018008416 A2 BR112018008416 A2 BR 112018008416A2 BR 112018008416 A BR112018008416 A BR 112018008416A BR 112018008416 A BR112018008416 A BR 112018008416A BR 112018008416 A2 BR112018008416 A2 BR 112018008416A2
- Authority
- BR
- Brazil
- Prior art keywords
- receptor antagonists
- cgrp receptor
- cgrp
- antagonists
- calcitonin
- Prior art date
Links
- 108010078311 Calcitonin Gene-Related Peptide Receptors Proteins 0.000 title 1
- 102000008323 calcitonin gene-related peptide receptor activity proteins Human genes 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 102000055006 Calcitonin Human genes 0.000 abstract 1
- 108060001064 Calcitonin Proteins 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 abstract 1
- 229960004015 calcitonin Drugs 0.000 abstract 1
- 208000026106 cerebrovascular disease Diseases 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 208000019553 vascular disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1519194.3A GB201519194D0 (en) | 2015-10-30 | 2015-10-30 | CGRP receptor antagonists |
| PCT/IB2016/056519 WO2017072723A1 (en) | 2015-10-30 | 2016-10-28 | Cgrp receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018008416A2 true BR112018008416A2 (pt) | 2018-10-23 |
Family
ID=55130446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018008416A BR112018008416A2 (pt) | 2015-10-30 | 2016-10-28 | antagonistas do receptor cgrp |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US9688660B2 (https=) |
| EP (1) | EP3368526B1 (https=) |
| JP (1) | JP6874014B2 (https=) |
| CN (1) | CN108430991B (https=) |
| AR (1) | AR106487A1 (https=) |
| AU (1) | AU2016344689A1 (https=) |
| BR (1) | BR112018008416A2 (https=) |
| CA (1) | CA3002625A1 (https=) |
| GB (1) | GB201519194D0 (https=) |
| IL (1) | IL258894A (https=) |
| SG (1) | SG11201803382XA (https=) |
| TW (1) | TW201722936A (https=) |
| WO (1) | WO2017072723A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201519194D0 (en) * | 2015-10-30 | 2015-12-16 | Heptares Therapeutics Ltd | CGRP receptor antagonists |
| GB201519195D0 (en) | 2015-10-30 | 2015-12-16 | Heptares Therapeutics Ltd | CGRP Receptor Antagonists |
| GB201519196D0 (en) | 2015-10-30 | 2015-12-16 | Heptares Therapeutics Ltd | CGRP Receptor Antagonists |
| CA3164445A1 (en) * | 2019-12-17 | 2021-06-24 | Biohaven Pharmaceutical Holding Company Ltd. | Intranasal pharmaceutical compositions of cgrp inhibitors |
| WO2024046223A1 (zh) * | 2022-08-30 | 2024-03-07 | 熙源安健医药（上海）有限公司 | 吲唑甲酰胺类衍生物及其制备方法和用途 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2732221B1 (fr) | 1995-03-28 | 1997-04-25 | Oreal | Utilisation d'un antagoniste de cgrp pour traiter les rougeurs cutanees d'origine neurogene et composition obtenue |
| DE59711622D1 (de) | 1996-09-10 | 2004-06-17 | Boehringer Ingelheim Pharma | Abgewandelte aminosäuren, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| US20030069231A1 (en) | 1999-10-12 | 2003-04-10 | Klaus Rudolf | Modified aminoacids, pharmaceuticals containing these compounds and method for their production |
| US6294534B1 (en) | 1998-06-11 | 2001-09-25 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
| AU742425B2 (en) | 1998-06-11 | 2002-01-03 | Merck & Co., Inc. | Spiropiperidine derivatives as melanocortin receptor agonists |
| DE19952146A1 (de) * | 1999-10-29 | 2001-06-07 | Boehringer Ingelheim Pharma | Arylalkane, Arylalkene und Aryl-azaalkane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| US7220862B2 (en) | 2002-06-05 | 2007-05-22 | Bristol-Myers Squibb Company | Calcitonin gene related peptide receptor antagonists |
| US7842808B2 (en) | 2002-06-05 | 2010-11-30 | Bristol-Myers Squibb Company | Anti-migraine spirocycles |
| BRPI0311812B8 (pt) * | 2002-06-05 | 2021-05-25 | Bristol Myers Squibb Co | antagonistas de receptor de peptídeo relacionado com o gene de calcitonina, composição farmacêutica e seu uso |
| JO2355B1 (en) | 2003-04-15 | 2006-12-12 | ميرك شارب اند دوم كوربوريشن | Hereditary calcitonin polypeptide receptor antagonists |
| US7569578B2 (en) | 2003-12-05 | 2009-08-04 | Bristol-Meyers Squibb Company | Heterocyclic anti-migraine agents |
| CA2549330A1 (en) | 2003-12-05 | 2005-07-21 | Bristol-Myers Squibb Company | Calcitonin gene related peptide receptor antagonists |
| TW200533398A (en) | 2004-03-29 | 2005-10-16 | Bristol Myers Squibb Co | Novel therapeutic agents for the treatment of migraine |
| DE102004015723A1 (de) | 2004-03-29 | 2005-10-20 | Boehringer Ingelheim Pharma | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| US20050233980A1 (en) * | 2004-04-20 | 2005-10-20 | Boehringer Ingelheim International Gmbh | CGRP-antagonist in combination with a serotonin-reuptake inhibitor for the treatment of migraine |
| DE102004019492A1 (de) | 2004-04-22 | 2005-11-10 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| BRPI0517418A (pt) | 2004-10-13 | 2008-10-07 | Merck & Co Inc | composto, composição farmacêutica, e, métodos para antagonismo de atividade do receptor de cgrp em um mamìfero, para tratar, controlar, melhorar ou reduzir o risco de dor de cabeça, enxaqueca ou cefalgia, e de tratamento ou prevenção de dores de cabeça de enxaqueca, cefalgias, e dores de cabeça |
| AU2005295855B2 (en) | 2004-10-14 | 2011-08-18 | Merck Sharp & Dohme Corp. | CGRP receptor antagonists |
| AU2005299852B2 (en) | 2004-10-22 | 2011-08-04 | Merck Sharp & Dohme Corp. | CGRP receptor antagonists |
| EP1770091A1 (de) | 2005-09-29 | 2007-04-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| US7834007B2 (en) | 2005-08-25 | 2010-11-16 | Bristol-Myers Squibb Company | CGRP antagonists |
| PE20080370A1 (es) | 2006-06-08 | 2008-06-13 | Boehringer Ingelheim Int | Derivados de quinazolinona como antagonistas de cgrp |
| US8044043B2 (en) | 2008-04-11 | 2011-10-25 | Bristol-Myers Squibb Company | CGRP receptor antagonists |
| HUE025547T2 (en) * | 2008-12-19 | 2016-02-29 | Boehringer Ingelheim Int | Cyclic pyrimidine-4-carboxamides as CCR2 receptor antagonists for the treatment of inflammation, asthma and COPD |
| US8314117B2 (en) | 2009-10-14 | 2012-11-20 | Bristol-Myers Squibb Company | CGRP receptor antagonists |
| US8481546B2 (en) * | 2010-03-30 | 2013-07-09 | Bristol-Myers Squibb Company | CGRP receptor antagonist |
| US9174989B2 (en) | 2012-05-09 | 2015-11-03 | Merck Sharp & Dohme Corp. | Process for making CGRP receptor antagonists |
| GB201519194D0 (en) * | 2015-10-30 | 2015-12-16 | Heptares Therapeutics Ltd | CGRP receptor antagonists |
-
2015
- 2015-10-30 GB GBGB1519194.3A patent/GB201519194D0/en not_active Ceased
-
2016
- 2016-10-28 JP JP2018541593A patent/JP6874014B2/ja active Active
- 2016-10-28 WO PCT/IB2016/056519 patent/WO2017072723A1/en not_active Ceased
- 2016-10-28 CN CN201680063940.2A patent/CN108430991B/zh active Active
- 2016-10-28 CA CA3002625A patent/CA3002625A1/en not_active Abandoned
- 2016-10-28 AU AU2016344689A patent/AU2016344689A1/en not_active Abandoned
- 2016-10-28 BR BR112018008416A patent/BR112018008416A2/pt not_active Application Discontinuation
- 2016-10-28 SG SG11201803382XA patent/SG11201803382XA/en unknown
- 2016-10-28 US US15/336,893 patent/US9688660B2/en active Active
- 2016-10-28 TW TW105135025A patent/TW201722936A/zh unknown
- 2016-10-28 AR ARP160103294A patent/AR106487A1/es unknown
- 2016-10-28 EP EP16808804.5A patent/EP3368526B1/en active Active
-
2017
- 2017-05-05 US US15/588,051 patent/US9925178B2/en active Active
-
2018
- 2018-01-29 US US15/882,038 patent/US10166226B2/en active Active
- 2018-04-24 IL IL258894A patent/IL258894A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW201722936A (zh) | 2017-07-01 |
| US9688660B2 (en) | 2017-06-27 |
| WO2017072723A1 (en) | 2017-05-04 |
| AU2016344689A1 (en) | 2018-05-17 |
| US9925178B2 (en) | 2018-03-27 |
| JP6874014B2 (ja) | 2021-05-19 |
| CA3002625A1 (en) | 2017-05-04 |
| EP3368526B1 (en) | 2019-12-25 |
| JP2018532790A (ja) | 2018-11-08 |
| US20170121311A1 (en) | 2017-05-04 |
| AR106487A1 (es) | 2018-01-17 |
| SG11201803382XA (en) | 2018-05-30 |
| US10166226B2 (en) | 2019-01-01 |
| US20180153876A1 (en) | 2018-06-07 |
| CN108430991B (zh) | 2021-01-05 |
| IL258894A (en) | 2018-06-28 |
| CN108430991A (zh) | 2018-08-21 |
| EP3368526A1 (en) | 2018-09-05 |
| US20170239236A1 (en) | 2017-08-24 |
| GB201519194D0 (en) | 2015-12-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX383140B (es) | Heterociclos bicíclicos como inhibidores de receptor del factor de crecimiento de fibroblastos (fgfr4). | |
| MX380777B (es) | Compuestos y composiciones como agonistas del receptor tipo toll 7. | |
| MX380669B (es) | Heteroarilhidroxipirimidinonas como agonistas del receptor de apelina (apj). | |
| MX376824B (es) | 2,4-dihidroxi-nicotinamidas como agonistas del recepor de apelina (apj). | |
| BR112017002001A2 (pt) | compostos e composição farmacêutica | |
| BR112018008416A2 (pt) | antagonistas do receptor cgrp | |
| MX381160B (es) | Agonistas del receptor de apelina y metodos de uso. | |
| JOP20190175A1 (ar) | مركبات تعمل كمعدِّل لمستقبل هيدروكربون الأريل (AhR) | |
| BR112016022855A2 (pt) | composições e métodos para modular a expressão de pkk | |
| MX2020001236A (es) | Compuestos aza biciclicos como agonistas del receptor muscarinico m1. | |
| MX378998B (es) | Agonistas de receptor de apelina (apj) de 4-hidroxi-3-(heteroaril) piridin-2-ona como para uso en el tratamiento de trastornos cardiovasculares. | |
| WO2016100157A3 (en) | 6,5-bicyclic octahydropyrrolopyridine orexin receptor antagonists | |
| EA201592005A1 (ru) | Бициклические гетероциклы в качестве ингибиторов fgfr | |
| BR112017003054A2 (pt) | compostos de aminopirimidinila como inibidores de jak | |
| MX376056B (es) | Pirimidinonas como inhibidores del factor xia. | |
| WO2016100162A3 (en) | 5,5-bicyclic oxazole orexin receptor antagonists | |
| MX2016011072A (es) | Derivado de pirazol amida. | |
| MX370689B (es) | Polipeptidos apelina. | |
| BR112018008423A2 (pt) | antagonistas do receptor cgrp | |
| BR112018003776A2 (pt) | compostos heterocíclicos fundidos como moduladores s1p | |
| MX2019006893A (es) | Inhibidores heterociclicos de mct4. | |
| EA201692008A1 (ru) | Замещенные сконденсированные гетероциклы в качестве модуляторов gpr119 для лечения диабета, ожирения, дислипидемии и связанных нарушений | |
| MX2019008993A (es) | Compuestos moduladores del receptor de hidrocarburos de arilo (ahr). | |
| TW201613896A (en) | Novel 2,5-substituted pyrimidines | |
| BR112018008419A2 (pt) | antagonistas do receptor cgrp |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |