JP6871168B2 - 方法 - Google Patents

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JP6871168B2
JP6871168B2 JP2017546051A JP2017546051A JP6871168B2 JP 6871168 B2 JP6871168 B2 JP 6871168B2 JP 2017546051 A JP2017546051 A JP 2017546051A JP 2017546051 A JP2017546051 A JP 2017546051A JP 6871168 B2 JP6871168 B2 JP 6871168B2
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protein
binder
library
binding
target
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Japanese (ja)
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JP2017536846A5 (show.php
JP2017536846A (ja
Inventor
ジェニー,チャバ
Original Assignee
ジーンビレッジ コルラートルト フェレレーシェシェーギュー タールシャシャーグ
ジーンビレッジ コルラートルト フェレレーシェシェーギュー タールシャシャーグ
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00Methods of screening libraries
    • C40B30/04Methods of screening libraries by measuring the ability to specifically bind a target molecule, e.g. antibody-antigen binding, receptor-ligand binding
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1037Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00Labels used in chemical analysis of biological material
    • G01N2458/10Oligonucleotides as tagging agents for labelling antibodies
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2017546051A 2014-11-24 2015-11-24 方法 Active JP6871168B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1420852.4A GB201420852D0 (en) 2014-11-24 2014-11-24 Method
GB1420852.4 2014-11-24
PCT/GB2015/053573 WO2016083793A1 (en) 2014-11-24 2015-11-24 Method

Publications (3)

Publication Number Publication Date
JP2017536846A JP2017536846A (ja) 2017-12-14
JP2017536846A5 JP2017536846A5 (show.php) 2018-12-27
JP6871168B2 true JP6871168B2 (ja) 2021-05-12

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Family Applications (1)

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JP2017546051A Active JP6871168B2 (ja) 2014-11-24 2015-11-24 方法

Country Status (10)

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US (3) US10605814B2 (show.php)
EP (1) EP3224360B1 (show.php)
JP (1) JP6871168B2 (show.php)
KR (1) KR102422494B1 (show.php)
CN (1) CN107430130B (show.php)
CA (1) CA2968488C (show.php)
ES (1) ES2763563T3 (show.php)
GB (1) GB201420852D0 (show.php)
SG (2) SG11201703689SA (show.php)
WO (1) WO2016083793A1 (show.php)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017214211A1 (en) * 2016-06-09 2017-12-14 Igc Bio, Inc. Methods for identifying a high affinity antibody
EP3577258B1 (en) * 2017-01-31 2024-11-27 48Hour Discovery Inc. Display of molecules on silently genetically encoded nanoscale carriers for determining synergistic molecular interactions
WO2019085958A1 (zh) * 2017-11-06 2019-05-09 清华大学 检测生物分子间相互作用及其调控因子的成套试剂与应用
EP3827116A4 (en) 2018-07-23 2022-05-11 The Governors of the University of Alberta Genetically-encoded bicyclic peptide libraries
ES3018082T3 (en) 2019-06-25 2025-05-14 Actome Gmbh Method and kit for measuring of analytes in bi-component systems and uses thereof
JP7727628B2 (ja) 2019-12-03 2025-08-21 アラマー バイオサイエンシーズ, インク. 核酸結合免疫サンドイッチアッセイ(nulisa)
US20240209350A1 (en) * 2021-04-26 2024-06-27 European Molecular Biology Laboratory High complexity microcompartment-based interaction screening
EP4242656A1 (en) * 2022-03-10 2023-09-13 Actome GmbH Quantitative detection method and corresponding device
CN119698486A (zh) 2022-06-29 2025-03-25 阿克托姆有限责任公司 检测单细胞中的生物分子
GB202218453D0 (en) 2022-12-08 2023-01-25 Actome Gmbh Assay system

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5837242A (en) 1992-12-04 1998-11-17 Medical Research Council Multivalent and multispecific binding proteins, their manufacture and use
US7306904B2 (en) 2000-02-18 2007-12-11 Olink Ab Methods and kits for proximity probing
GB0422431D0 (en) * 2004-10-08 2004-11-10 Affitech As Method
PT2209893E (pt) * 2007-10-12 2014-02-26 Pronota Nv Uso de aptâmeros em proteómica
GB0903316D0 (en) * 2009-02-26 2009-04-08 Affitech As Method
MX2011012299A (es) 2009-05-20 2012-03-29 Novimmune Sa Librerias de polipeptidos sinteticos y metodos para generar variantes de polipeptido naturalmente diversificadas.
WO2011005221A1 (en) * 2009-07-07 2011-01-13 Agency For Science, Technology And Research Methods of identifying a pair of binding partners
US20130288929A1 (en) * 2010-09-27 2013-10-31 Vipergen Method for Making an Enriched Library
US9209965B2 (en) 2014-01-14 2015-12-08 Microsemi Semiconductor Ulc Network interface with clock recovery module on line card

Also Published As

Publication number Publication date
CA2968488C (en) 2024-09-10
ES2763563T3 (es) 2020-05-29
US20210003585A1 (en) 2021-01-07
WO2016083793A1 (en) 2016-06-02
CN107430130A (zh) 2017-12-01
CN107430130B (zh) 2020-07-24
US20170269098A1 (en) 2017-09-21
SG10202008300RA (en) 2020-10-29
EP3224360A1 (en) 2017-10-04
US10605814B2 (en) 2020-03-31
KR20170086627A (ko) 2017-07-26
CA2968488A1 (en) 2016-06-02
US11421347B2 (en) 2022-08-23
SG11201703689SA (en) 2017-06-29
EP3224360B1 (en) 2019-10-09
KR102422494B1 (ko) 2022-07-19
GB201420852D0 (en) 2015-01-07
US20230175171A1 (en) 2023-06-08
JP2017536846A (ja) 2017-12-14

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