JP6863901B2 - キナーゼ阻害のためのヘテロアリール化合物 - Google Patents

キナーゼ阻害のためのヘテロアリール化合物 Download PDF

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Publication number
JP6863901B2
JP6863901B2 JP2017558660A JP2017558660A JP6863901B2 JP 6863901 B2 JP6863901 B2 JP 6863901B2 JP 2017558660 A JP2017558660 A JP 2017558660A JP 2017558660 A JP2017558660 A JP 2017558660A JP 6863901 B2 JP6863901 B2 JP 6863901B2
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alkyl
amino
heteroaryl
substituted
refers
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Japanese (ja)
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JP2018515514A5 (cg-RX-API-DMAC7.html
JP2018515514A (ja
Inventor
ティアンジュン ゾウ，
ティアンジュン ゾウ，
ウィルメン ダブリュー． ヤングセイ，
ウィルメン ダブリュー． ヤングセイ，
ウィリアム シー． シェイクスピア，
ウィリアム シー． シェイクスピア，
アレクシー ブイ． イシュチェンコ，
アレクシー ブイ． イシュチェンコ，
ウェイ−シェン フアン，
ウェイ−シェン フアン，
デイビッド シー． ダルガルノ，
デイビッド シー． ダルガルノ，
Original Assignee
アリアド ファーマシューティカルズ， インコーポレイテッド
アリアド ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2017558660A 2015-05-13 2016-05-12 キナーゼ阻害のためのヘテロアリール化合物 Expired - Fee Related JP6863901B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562160989P 2015-05-13 2015-05-13
US62/160,989 2015-05-13
PCT/US2016/031996 WO2016183278A1 (en) 2015-05-13 2016-05-12 Heteroaryl compounds for kinase inhibition

Publications (3)

Publication Number Publication Date
JP2018515514A JP2018515514A (ja) 2018-06-14
JP2018515514A5 JP2018515514A5 (cg-RX-API-DMAC7.html) 2019-06-13
JP6863901B2 true JP6863901B2 (ja) 2021-04-28

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JP2017558660A Expired - Fee Related JP6863901B2 (ja) 2015-05-13 2016-05-12 キナーゼ阻害のためのヘテロアリール化合物

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Country Link
US (1) US20210323976A1 (cg-RX-API-DMAC7.html)
EP (1) EP3294712A4 (cg-RX-API-DMAC7.html)
JP (1) JP6863901B2 (cg-RX-API-DMAC7.html)
HK (1) HK1251567A1 (cg-RX-API-DMAC7.html)
WO (1) WO2016183278A1 (cg-RX-API-DMAC7.html)

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EA201391626A1 (ru) 2011-05-04 2014-03-31 Ариад Фармасьютикалз, Инк. Соединения для ингибирования клеточной пролиферации в egfr-стимулированных типах рака
AU2013204563B2 (en) 2012-05-05 2016-05-19 Takeda Pharmaceutical Company Limited Compounds for inhibiting cell proliferation in EGFR-driven cancers
WO2017120429A1 (en) 2016-01-07 2017-07-13 CS Pharmasciences, Inc. Selective inhibitors of clinically important mutants of the egfr tyrosine kinase
CN108299419B (zh) * 2017-01-11 2022-04-26 南京圣和药业股份有限公司 一种新型egfr激酶抑制剂的几种新晶型及其制备方法
CN109705118B (zh) * 2017-10-25 2021-12-28 南京圣和药业股份有限公司 三环类egfr激酶抑制剂的制备方法
CN109705117A (zh) * 2017-10-25 2019-05-03 南京圣和药业股份有限公司 三环类化合物、其制备方法及用途
CN108191861B (zh) * 2018-03-01 2020-10-02 天津大学 N-[5-(嘧啶-2-氨基)-2,4-二取代苯基]-反式-2,4-戊二烯酰胺
BR112021025764A2 (pt) * 2019-06-20 2022-02-01 Oncobix Co Ltd Derivado de pirimidina que inibe o crescimento de células cancerígenas e uso medicinal do mesmo
CN115052878B (zh) 2020-02-03 2024-07-09 勃林格殷格翰国际有限公司 作为HER2抑制剂的[1,3]二嗪并[5,4-d]嘧啶
WO2021156180A1 (en) 2020-02-03 2021-08-12 Boehringer Ingelheim International Gmbh [1,3]diazino[5,4-d]pyrimidines as her2 inhibitors
US11608343B2 (en) * 2020-04-24 2023-03-21 Boehringer Ingelheim International Gmbh Substituted pyrimido[5,4-d]pyrimidines as HER2 inhibitors
CN112409192A (zh) * 2020-11-26 2021-02-26 启东东岳药业有限公司 一种4-氟-2-甲氧基苯胺的纯化方法
CA3213079A1 (en) 2021-04-13 2022-10-20 Kristin Lynne ANDREWS Amino-substituted heterocycles for treating cancers with egfr mutations

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003000251A1 (en) * 2001-06-21 2003-01-03 Ariad Pharmaceuticals, Inc. Novel idolinones and uses thereof
US7982036B2 (en) * 2007-10-19 2011-07-19 Avila Therapeutics, Inc. 4,6-disubstitued pyrimidines useful as kinase inhibitors
PT2300013T (pt) * 2008-05-21 2017-10-31 Ariad Pharma Inc Derivados de fósforo como inibidores de cinases
US9273077B2 (en) * 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
CA3031835C (en) * 2008-06-27 2021-09-07 Celgene Car Llc Heteroaryl compounds and uses thereof
CN105198862B (zh) * 2011-07-27 2018-01-23 阿斯利康(瑞典)有限公司 取代的n‑(4‑氟‑2‑甲氧基‑5‑硝基苯基)嘧啶‑2‑胺化合物及其盐
EP3057954A2 (en) * 2013-10-18 2016-08-24 Syros Pharmaceuticals, Inc. Heteromaromatic compounds useful for the treatment of proliferative diseases
EP3143015B1 (en) * 2014-05-13 2019-02-20 ARIAD Pharmaceuticals, Inc. Heteroaryl compounds for kinase inhibition
SG11201610517PA (en) * 2014-06-19 2017-01-27 Ariad Pharma Inc Heteroaryl compounds for kinase inhibition
EP3312179B1 (en) * 2015-04-29 2019-07-10 Nanjing Sanhome Pharmaceutical Co., Ltd. Fused-ring or tricyclic aryl pyrimidine compound used as kinase inhibitor

Also Published As

Publication number Publication date
WO2016183278A1 (en) 2016-11-17
EP3294712A4 (en) 2018-11-07
US20210323976A1 (en) 2021-10-21
EP3294712A1 (en) 2018-03-21
JP2018515514A (ja) 2018-06-14
HK1251567A1 (zh) 2019-02-01

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