JP6860652B2 - 医薬組成物 - Google Patents

医薬組成物 Download PDF

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Publication number
JP6860652B2
JP6860652B2 JP2019508989A JP2019508989A JP6860652B2 JP 6860652 B2 JP6860652 B2 JP 6860652B2 JP 2019508989 A JP2019508989 A JP 2019508989A JP 2019508989 A JP2019508989 A JP 2019508989A JP 6860652 B2 JP6860652 B2 JP 6860652B2
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Japan
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administration
obinutuzumab
hour
cycle
pharmaceutical composition
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Japanese (ja)
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JP2019528282A (ja
Inventor
マイケル ウェンガー
マイケル ウェンガー
メルダッド モバシャー
メルダッド モバシャー
チン−ウー リン
チン−ウー リン
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エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト
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Application filed by エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト filed Critical エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト
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Priority to JP2021052571A priority Critical patent/JP7370357B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
JP2019508989A 2017-10-19 2018-10-19 医薬組成物 Active JP6860652B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2021052571A JP7370357B2 (ja) 2017-10-19 2021-03-26 医薬組成物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762574297P 2017-10-19 2017-10-19
US62/574,297 2017-10-19
PCT/JP2018/038924 WO2019017499A2 (en) 2017-10-19 2018-10-19 PHARMACEUTICAL COMPOSITION

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021052571A Division JP7370357B2 (ja) 2017-10-19 2021-03-26 医薬組成物

Publications (2)

Publication Number Publication Date
JP2019528282A JP2019528282A (ja) 2019-10-10
JP6860652B2 true JP6860652B2 (ja) 2021-04-21

Family

ID=64362606

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2019508989A Active JP6860652B2 (ja) 2017-10-19 2018-10-19 医薬組成物
JP2021052571A Active JP7370357B2 (ja) 2017-10-19 2021-03-26 医薬組成物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2021052571A Active JP7370357B2 (ja) 2017-10-19 2021-03-26 医薬組成物

Country Status (14)

Country Link
US (2) US12129304B2 (enExample)
EP (2) EP3697818B1 (enExample)
JP (2) JP6860652B2 (enExample)
KR (3) KR102906969B1 (enExample)
CN (2) CN111212854A (enExample)
AU (2) AU2018303836B2 (enExample)
BR (1) BR112020007731A2 (enExample)
CA (1) CA3079374A1 (enExample)
ES (1) ES3005784T3 (enExample)
IL (2) IL321935A (enExample)
MX (2) MX419643B (enExample)
PL (1) PL3697818T3 (enExample)
TW (2) TWI805630B (enExample)
WO (1) WO2019017499A2 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3697818B1 (en) * 2017-10-19 2024-11-27 F. Hoffmann-La Roche AG Treatment of cd20-positive b-cell lymphoma with obinutuzumab
US20240050562A1 (en) * 2019-10-04 2024-02-15 Chugai Seiyaku Kabushiki Kaisha Inhibitor of cell proliferation in obinutuzumab resistant cd20-positive cancer, and medicinal composition, medicine, production, method for inhibiting cell proliferation, therapeutic method, type ii anti-cd20 antibody, compounds, combination of same, enhancer and inducer, each relating thereto
EP4404430A4 (en) 2021-09-17 2025-10-29 Canon Kk POWER TRANSMISSION DEVICE AND POWER RECEPTION DEVICE

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2672640T3 (es) 2003-11-05 2018-06-15 Roche Glycart Ag Moléculas de unión a antígeno con afinidad de unión a receptores Fc y función efectora incrementadas
DK2234600T3 (da) 2007-12-21 2014-09-08 Hoffmann La Roche Antistofformulering
SI3179992T1 (sl) * 2014-08-11 2022-09-30 Acerta Pharma B.V. Terapevtske kombinacije zaviralca BTK, zaviralca PD-1 in/ali zaviralca PD-L1
US11149091B2 (en) * 2015-12-09 2021-10-19 Cedars-Sinai Medical Center Methods for treating nephrotic syndrome
CN108395482B (zh) 2017-02-08 2021-02-05 西比曼生物科技（香港）有限公司 一种靶向cd20抗原嵌合抗原受体的构建及其工程化t细胞的活性鉴定
JP6881583B2 (ja) 2017-07-21 2021-06-02 横浜ゴム株式会社 空気入りタイヤ
EP3697818B1 (en) * 2017-10-19 2024-11-27 F. Hoffmann-La Roche AG Treatment of cd20-positive b-cell lymphoma with obinutuzumab

Also Published As

Publication number Publication date
CN120983618A (zh) 2025-11-21
WO2019017499A2 (en) 2019-01-24
TWI828593B (zh) 2024-01-01
WO2019017499A3 (en) 2019-02-21
CA3079374A1 (en) 2019-01-24
EP3697818B1 (en) 2024-11-27
BR112020007731A2 (pt) 2020-10-20
PL3697818T3 (pl) 2025-03-24
AU2018303836A1 (en) 2020-05-14
US20250026847A1 (en) 2025-01-23
TW202342099A (zh) 2023-11-01
AU2018303836B2 (en) 2025-04-17
IL321935A (en) 2025-09-01
KR102906969B1 (ko) 2026-01-05
IL273909A (en) 2020-05-31
KR20200067196A (ko) 2020-06-11
KR20260011191A (ko) 2026-01-22
KR20240157135A (ko) 2024-10-31
EP3697818A2 (en) 2020-08-26
US12129304B2 (en) 2024-10-29
IL273909B2 (en) 2025-12-01
JP2019528282A (ja) 2019-10-10
IL273909B1 (en) 2025-08-01
TW201922284A (zh) 2019-06-16
AU2025205481A1 (en) 2025-08-07
ES3005784T3 (en) 2025-03-17
MX2024009217A (es) 2024-11-08
EP4520347A3 (en) 2025-06-04
JP7370357B2 (ja) 2023-10-27
TWI805630B (zh) 2023-06-21
EP4520347A2 (en) 2025-03-12
JP2021152002A (ja) 2021-09-30
MX2020003418A (es) 2020-07-20
MX419643B (es) 2025-01-14
KR102766089B1 (ko) 2025-02-13
CN111212854A (zh) 2020-05-29
US20200299398A1 (en) 2020-09-24

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