JP6847044B2 - 肥満及び2型糖尿病(t2d)の治療のための膵内分泌前駆細胞療法 - Google Patents
肥満及び2型糖尿病(t2d)の治療のための膵内分泌前駆細胞療法 Download PDFInfo
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- JP6847044B2 JP6847044B2 JP2017547514A JP2017547514A JP6847044B2 JP 6847044 B2 JP6847044 B2 JP 6847044B2 JP 2017547514 A JP2017547514 A JP 2017547514A JP 2017547514 A JP2017547514 A JP 2017547514A JP 6847044 B2 JP6847044 B2 JP 6847044B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/37—Digestive system
- A61K35/39—Pancreas; Islets of Langerhans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0676—Pancreatic cells
- C12N5/0677—Three-dimensional culture, tissue culture or organ culture; Encapsulated cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Virology (AREA)
- Physiology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nutrition Science (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562131540P | 2015-03-11 | 2015-03-11 | |
| US62/131,540 | 2015-03-11 | ||
| PCT/CA2016/000072 WO2016141460A1 (en) | 2015-03-11 | 2016-03-11 | Pancreatic endocrine progenitor cell therapies for the treatment of obesity and type 2 diabetes (t2d) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018507889A JP2018507889A (ja) | 2018-03-22 |
| JP2018507889A5 JP2018507889A5 (OSRAM) | 2019-04-18 |
| JP6847044B2 true JP6847044B2 (ja) | 2021-03-24 |
Family
ID=56879832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017547514A Active JP6847044B2 (ja) | 2015-03-11 | 2016-03-11 | 肥満及び2型糖尿病(t2d)の治療のための膵内分泌前駆細胞療法 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10772917B2 (OSRAM) |
| EP (1) | EP3268016B1 (OSRAM) |
| JP (1) | JP6847044B2 (OSRAM) |
| CN (1) | CN107530379A (OSRAM) |
| AU (1) | AU2016228894B2 (OSRAM) |
| CA (1) | CA2979293C (OSRAM) |
| WO (1) | WO2016141460A1 (OSRAM) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019118641A1 (en) | 2017-12-12 | 2019-06-20 | The Regents Of The University Of California | Preservation of pancreatic islet grafts in the extrahepatic space |
| KR20200110338A (ko) | 2018-01-18 | 2020-09-23 | 다이이찌 산쿄 가부시키가이샤 | 디하이드로인돌리지논 유도체 |
| BR112021022682A2 (pt) | 2019-05-14 | 2022-02-22 | Provention Bio Inc | Métodos e composições para prevenir diabetes do tipo 1 |
| US12435315B2 (en) | 2019-05-22 | 2025-10-07 | The Cleveland Clinic Foundation | Generating dorsal foregut, and anterior domain, endoderm cells |
| CN110585242A (zh) * | 2019-10-15 | 2019-12-20 | 南通大学 | 多系分化持续应激细胞的应用、治疗糖尿病的药物及其制备方法 |
| CN111411072B (zh) * | 2020-03-09 | 2022-10-11 | 同济大学 | SLC30A8基因表达下调的抗糖尿病胰岛β细胞及其应用 |
| CA3182445A1 (en) | 2020-06-11 | 2021-12-16 | Francisco Leon | Methods and compositions for preventing type 1 diabetes |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6703017B1 (en) * | 1994-04-28 | 2004-03-09 | Ixion Biotechnology, Inc. | Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| WO2003039489A2 (en) * | 2001-11-09 | 2003-05-15 | Artecel Sciences, Inc. | Endocrine pancreas differentiation of adipose tissue-derived stromal cells and uses thereof |
| IL165242A0 (en) * | 2002-05-24 | 2005-12-18 | Waratah Pharmaceuticals Inc | Treatment for diabetes |
| EP1539928A4 (en) * | 2002-09-06 | 2006-09-06 | Amcyte Inc | POSIOTIVE PANCREATIC ENDOCRINE PROGENITOR CELLS CD56 IN ADULT HUMAN BEINGS |
| AU2004252566B2 (en) | 2003-06-27 | 2011-09-15 | Ethicon, Incorporated | Postpartum cells derived from placental tissue, and methods of making and using the same |
| CN1589904A (zh) * | 2003-09-01 | 2005-03-09 | 北京大学 | 造血干细胞动员剂制备治疗糖尿病药物的用途 |
| JP2006149380A (ja) * | 2004-10-27 | 2006-06-15 | Kobe Univ | 遺伝子改変動物の新規用途 |
| AU2006202209B2 (en) | 2005-05-27 | 2011-04-14 | Lifescan, Inc. | Amniotic fluid derived cells |
| CN102016582A (zh) * | 2006-10-31 | 2011-04-13 | 国家干细胞控股公司 | 鉴别、分离和利用来自成人胰腺的内分泌祖细胞的方法 |
| KR20190042766A (ko) * | 2006-11-09 | 2019-04-24 | 오렉시젠 세러퓨틱스 인크. | 신속하게 용해되는 중간층을 포함하는 층상의 약제학적 제형 |
| MX2010005805A (es) | 2007-11-27 | 2010-06-09 | Lifescan Inc | Diferenciacion de celulas madre embrionarias humanas. |
| US20090280096A1 (en) * | 2008-05-09 | 2009-11-12 | Atsushi Kubo | Pancreatic endocrine progenitor cells derived from pluripotent stem cells |
| CN117547538A (zh) * | 2009-02-13 | 2024-02-13 | 勃林格殷格翰国际有限公司 | 包含dpp-4抑制剂(利格列汀)任选地组合其它抗糖尿病药的抗糖尿病药物 |
| WO2011059725A2 (en) | 2009-10-29 | 2011-05-19 | Centocor Ortho Biotech Inc. | Pluripotent stem cells |
| WO2011160066A1 (en) * | 2010-06-17 | 2011-12-22 | Regents Of The University Of Minnesota | Production of insulin producing cells |
| CN103052393B (zh) * | 2010-08-12 | 2017-11-14 | 詹森生物科技公司 | 用胰腺内分泌前体细胞治疗糖尿病 |
| US8859286B2 (en) | 2013-03-14 | 2014-10-14 | Viacyte, Inc. | In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells |
-
2016
- 2016-03-11 CN CN201680024439.5A patent/CN107530379A/zh active Pending
- 2016-03-11 WO PCT/CA2016/000072 patent/WO2016141460A1/en not_active Ceased
- 2016-03-11 US US15/556,907 patent/US10772917B2/en active Active
- 2016-03-11 CA CA2979293A patent/CA2979293C/en active Active
- 2016-03-11 JP JP2017547514A patent/JP6847044B2/ja active Active
- 2016-03-11 EP EP16760957.7A patent/EP3268016B1/en active Active
- 2016-03-11 AU AU2016228894A patent/AU2016228894B2/en active Active
-
2020
- 2020-08-03 US US16/983,810 patent/US20210015872A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016141460A1 (en) | 2016-09-15 |
| CA2979293C (en) | 2022-01-04 |
| EP3268016B1 (en) | 2021-04-28 |
| CA2979293A1 (en) | 2016-09-15 |
| CN107530379A (zh) | 2018-01-02 |
| JP2018507889A (ja) | 2018-03-22 |
| US20180055890A1 (en) | 2018-03-01 |
| US10772917B2 (en) | 2020-09-15 |
| EP3268016A1 (en) | 2018-01-17 |
| US20210015872A1 (en) | 2021-01-21 |
| AU2016228894A1 (en) | 2017-11-02 |
| EP3268016A4 (en) | 2018-12-12 |
| AU2016228894B2 (en) | 2021-03-04 |
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