JP6846429B2 - ヒトβ−２ミクログロブリン遺伝子に見られる認識配列を有する操作されたメガヌクレアーゼ - Google Patents

ヒトβ−２ミクログロブリン遺伝子に見られる認識配列を有する操作されたメガヌクレアーゼ Download PDF

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JP6846429B2
JP6846429B2 JP2018533097A JP2018533097A JP6846429B2 JP 6846429 B2 JP6846429 B2 JP 6846429B2 JP 2018533097 A JP2018533097 A JP 2018533097A JP 2018533097 A JP2018533097 A JP 2018533097A JP 6846429 B2 JP6846429 B2 JP 6846429B2
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meganuclease
cells
sequence
human
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JP2018538000A5 (enExample
JP2018538000A (ja
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バートセビッチ，ビクター
ファム，クリスティーナ
マーティン，アーロン
ジャンツ，デレック
スミス，ジェームス，ジェファーソン
ニコルソン，マイケル，ジー．
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プレシジョン バイオサイエンシズ，インク．
プレシジョン バイオサイエンシズ，インク．
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/42—Cancer antigens
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    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6901—Conjugates being cells, cell fragments, viruses, ghosts, red blood cells or viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
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    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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  • Hematology (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Developmental Biology & Embryology (AREA)
JP2018533097A 2015-12-23 2016-12-22 ヒトβ−２ミクログロブリン遺伝子に見られる認識配列を有する操作されたメガヌクレアーゼ Active JP6846429B2 (ja)

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JP2021031458A JP7203873B2 (ja) 2015-12-23 2021-03-01 ヒトβ－２ミクログロブリン遺伝子に見られる認識配列を有する操作されたメガヌクレアーゼ
JP2022209145A JP2023052095A (ja) 2015-12-23 2022-12-27 ヒトβ－２ミクログロブリン遺伝子に見られる認識配列を有する操作されたメガヌクレアーゼ

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US201562387318P 2015-12-23 2015-12-23
US62/387,318 2015-12-23
US201662416513P 2016-11-02 2016-11-02
US62/416,513 2016-11-02
PCT/US2016/068289 WO2017112859A1 (en) 2015-12-23 2016-12-22 Engineered meganucleases with recognition sequences found in the human beta-2 microglobulin gene

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JP2018538000A JP2018538000A (ja) 2018-12-27
JP2018538000A5 JP2018538000A5 (enExample) 2020-02-06
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JP2021031458A Active JP7203873B2 (ja) 2015-12-23 2021-03-01 ヒトβ－２ミクログロブリン遺伝子に見られる認識配列を有する操作されたメガヌクレアーゼ
JP2022209145A Pending JP2023052095A (ja) 2015-12-23 2022-12-27 ヒトβ－２ミクログロブリン遺伝子に見られる認識配列を有する操作されたメガヌクレアーゼ

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JP2022209145A Pending JP2023052095A (ja) 2015-12-23 2022-12-27 ヒトβ－２ミクログロブリン遺伝子に見られる認識配列を有する操作されたメガヌクレアーゼ

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US (3) US20190017075A1 (enExample)
EP (2) EP3988655A3 (enExample)
JP (3) JP6846429B2 (enExample)
AU (2) AU2016379393B2 (enExample)
CA (1) CA3009637A1 (enExample)
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TW201923073A (zh) * 2017-11-20 2019-06-16 新加坡商泰莎治療私人有限公司 經修飾之k562細胞
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Publication number Priority date Publication date Assignee Title
JP2021101704A (ja) * 2015-12-23 2021-07-15 プレシジョン バイオサイエンシズ，インク． ヒトβ−２ミクログロブリン遺伝子に見られる認識配列を有する操作されたメガヌクレアーゼ
JP7203873B2 (ja) 2015-12-23 2023-01-13 プレシジョン バイオサイエンシズ，インク． ヒトβ－２ミクログロブリン遺伝子に見られる認識配列を有する操作されたメガヌクレアーゼ

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CA3009637A1 (en) 2017-06-29
EP3394253B1 (en) 2021-09-01
EP3988655A2 (en) 2022-04-27
JP2018538000A (ja) 2018-12-27
EP3988655A3 (en) 2022-08-03
EP3394253A1 (en) 2018-10-31
JP7203873B2 (ja) 2023-01-13
US20240052373A1 (en) 2024-02-15
AU2023202035A1 (en) 2023-04-27
WO2017112859A1 (en) 2017-06-29
ES2901000T3 (es) 2022-03-21
US20190017075A1 (en) 2019-01-17
JP2023052095A (ja) 2023-04-11
AU2016379393B2 (en) 2023-01-05
US20210032664A1 (en) 2021-02-04
JP2021101704A (ja) 2021-07-15
AU2016379393A1 (en) 2018-07-12

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