JP6833334B2 - Topical skin or cosmetics - Google Patents

Description

The present invention relates to a skin external preparation or cosmetic containing an extract or fruit juice of a pear genus plant, silicone oil, or vegetable oil, and more particularly to a skin external preparation or cosmetic having an excellent exfoliating effect.

Human skin is covered with keratin and functions as a barrier that protects the living body from the invasion of foreign substances and the evaporation of water in the body. This keratin also plays an important role for beautiful skin, but if it is thickened without peeling, it will lead to dullness of the skin and have an unfavorable effect. In order to keep the skin beautiful and clean, it is important to remove dead skin cells, and methods for properly removing dead skin cells have been studied.

Various peels are known as a method for removing keratin, and chemical peels that weaken the adhesion of keratin cells by using α-hydroxy acids such as glycolic acid and lactic acid, or soften the keratin by using salicylic acid. (See, for example, Patent Documents 1 and 2), physical peeling using organic powder, inorganic powder, aqueous gel-forming polymer, etc. and utilizing the frictional action of those powders (see, for example, Patent Documents 3 and 4), papaine and There is peeling using a proteolytic enzyme such as a protease (see, for example, Patent Document 5). Further, as a cosmetic for exfoliating, there is a scrub cosmetic using urea and α-hydroxy acid (see, for example, Patent Document 6).

Japanese Unexamined Patent Publication No. 2004-277294 Japanese Unexamined Patent Publication No. 2005-281134 JP-A-2002-293716 Japanese Unexamined Patent Publication No. 2001-139426 Japanese Unexamined Patent Publication No. 2006-160711 Japanese Unexamined Patent Publication No. 2003-292411

However, the chemical peels using α-hydroxy acids and salicylic acids described in Patent Documents 1, 2 and 6 usually have a low pH of 1.0 to 3.0, and may cause skin irritation or redness. However, if the subsequent skin care is not sufficiently performed, pigmentation may occur due to ultraviolet rays or the like. Further, the physical peeling using the organic powder or the inorganic powder described in Patent Document 3 has strong physical irritation due to the massage and may damage the skin, although it depends on the size of the particles. Physical peeling using the aqueous gel-forming polymer described in Patent Document 4 is sufficient because it takes a long time for gel aggregates to be formed and the amount of gel aggregates varies depending on the condition of the skin. Exfoliation may not be expected. In peeling using the enzyme described in Patent Document 5, there are restrictions on formulation such as being able to be blended only in powder cosmetics due to reasons such as insufficient stabilization of the enzyme, and exfoliation that is not always satisfactory. No effect was obtained. As described above, conventionally, the development of a technique excellent in safety, stability of the active ingredient, and exfoliation has been insufficient.

In view of the above circumstances, the present inventor has found that, as a result of diligent studies, the exfoliating effect is excellent while being excellent in safety and stability by containing an extract or fruit juice of a pear genus plant, silicone oil, and vegetable oil. , The present invention has been completed.

That is, the present invention has the following components (A) to (C);
It provides a skin external preparation or cosmetic containing (A) an extract of a pear plant or fruit juice (B) silicone oil (C) vegetable oil.

Further, it provides the above-mentioned external preparation for skin or cosmetic in which the extract or fruit juice of a pear plant of the component (A) is an extract or fruit juice of a pear.

Further, the present invention provides the above-mentioned external preparation for skin or cosmetic, in which the silicone oil of the component (B) is a volatile silicone oil.

Further, it provides the above-mentioned external preparation for skin or cosmetics in which the vegetable oil of the component (C) is olive oil.

Further, it provides the above-mentioned external preparation for skin or cosmetics for exfoliating.

The present invention is a skin external preparation or cosmetic having an excellent exfoliating effect.

3 is a photomicrograph of the keratin removed when Example 1 and Comparative Example 2 were used.

The pear genus plant extract or fruit juice of the component (A) used in the present invention is an extract or fruit juice obtained from a plant belonging to the Rosaceae pear genus (Pyrus). Examples of plants belonging to the genus Pear include pear (Pyrus communis), pear (Pyrus pyrifolia), pear (Pyrus calllyana), pear (Pyrus nivalis), pear (Pyrus nivalis), and pear (Pyrus nivalis). It is possible, and one or more of these can be used without particular limitation. Of these, pear is preferred.

The extraction / purification method for obtaining the extract from a pear plant is not particularly limited, but a method of extracting the extract with an appropriate extraction solvent to obtain the extract and further purifying it by column chromatography or the like can be exemplified. it can. Further, it may be the pressed juice of a pear plant itself, or the pressed juice may be concentrated, dried or the like. Extraction may also rely on the method of steam distillation.

The site used to obtain an extract or fruit juice of a pear genus plant is not particularly limited, and examples thereof include whole plants, flowers, fruits, stems or leaves, branches and leaves, rhizomes, root bark, roots and the like. Among the parts of the above, fruits are suitable. Various parts may be used as they are, but they may be subjected to treatments such as shredding, drying, degreasing, decolorization, and fermentation before being extracted or pressed, or these treatments may be performed after extraction or pressing. May be given. Since the concentration of the active ingredient increases, it is preferable to carry out a fermentation treatment. Examples of the fermentation treatment include fermentation with yeast, lactic acid bacteria and the like.

The extraction solvent is not particularly limited, and for example, one or more kinds of water; alcohols; ketones such as acetone; ethers such as ethyl ether; esters such as ethyl acetate can be used. Examples of the alcohols include lower monohydric alcohols such as methanol and ethanol; liquid polyhydric alcohols such as glycerin, propylene glycol and butylene glycol. In the present invention, the lower alcohol refers to a monohydric or polyhydric alcohol having 1 to 4 carbon atoms. Among these, it is preferable to use butylene glycol.

The content of the component (A) used in the present invention is not particularly limited, but is preferably 0.0001 to 1% by mass (hereinafter, mass% is simply abbreviated as "%") from the viewpoint of exfoliating, and is 0. More preferably .001 to 0.5%.

The silicone oil of the component (B) used in the present invention can be used without limitation as long as it is usually used for cosmetics and the like. For example, chain silicone such as dimethylpolysiloxane and methylphenylpolysiloxane, octa. Cyclic silicones such as methylcyclotetrasiloxane and decamethylcyclopentasiloxane, fluorine-modified polysiloxanes, amino-modified polysiloxanes, fatty acid-modified polysiloxanes, modified silicones such as higher alcohol-modified polysiloxanes, and the like can be mentioned. The above can be used. Further, the silicone oil may be either volatile or non-volatile. The volatile silicone oil refers to a silicone oil that volatilizes at 1 atm and 25 ° C.

Among these, when a volatile silicone oil such as low molecular weight chain silicone, octamethylcyclotetrasiloxane, or decamethylcyclopentasiloxane is selected as the component (B), it does not feel sticky or oily. It is preferable because it is possible to obtain a skin external preparation or cosmetic that is more excellent in exfoliating, and decamethylcyclopentasiloxane is most preferable.

The content of the component (B) used in the present invention is not particularly limited, but is preferably 1 to 30%, more preferably 5 to 25%, and 10 from the viewpoint of exfoliating from the viewpoint of usability and exfoliation. ~ 20% is more preferable.

The vegetable oil of the component (C) used in the present invention can be used without limitation as long as it is usually used for cosmetics and the like, and there is no limitation on the origin and type of the plant, the site and method of extraction and squeezing, and the properties. Can be used. Ingredients (C) include, for example, olive oil, coconut oil, rice germ oil, rice bran oil, sunflower oil, macadamian nut oil, avocado oil, safflower oil, sunflower oil, jojoba oil, hemp seed oil, flaxseed oil, Egoma oil, walnut oil, kerosene oil, sardine oil, soybean oil, tobacco seed oil, Japanese sardine oil, sunflower seed oil, grape seed oil, anzu kernel oil, pumpkin seed oil, sesame oil, western thigh oil, corn oil, Examples include vegetable oils such as rapeseed oil, cottonseed oil, lemon oil, teaseed oil, camellia oil, peanut oil, shea butter, coconut oil, palm kernel oil, mokuro, and palm oil, and one or more of these can be used. Of these, olive oil is preferable from the viewpoint of exfoliating.

The content of the component (C) used in the present invention is not particularly limited, but is preferably 0.001 to 10% from the viewpoint of usability and exfoliation, and 0.01 to 1% from the viewpoint of exfoliation. More preferred.

Further, in the skin external preparation or cosmetics of the present invention, in addition to the above essential components, water-based components and surfactants are used as components used in ordinary cosmetics and the like within a quantitative and qualitative range that does not impair the effects of the present invention. Activators, oily ingredients, moisturizers, polymers, powders, pigments, UV absorbers, film-forming agents, pH regulators, anti-fading agents, antioxidants, defoamers, beauty ingredients, preservatives, fragrances, etc. Can be appropriately blended in order to impart various effects.

Aqueous components include alcohols such as ethyl alcohol and isopropyl alcohol, glycols such as propylene glycol, polypropylene glycol, 1,3-butylene glycol, dipropylene glycol, 1,2-pentanediol and polyethylene glycol, glycerin and diglycerin. , Glycerols such as polyglycerin, sugar alcohols such as sorbitol, martitol, glucose, green tea, tea, aloe vera, witch hazel, hamamelis, cucumber, lemon, lavender, rose and other plant extracts.

As the surfactant, any surfactant used in ordinary cosmetics and the like can be used, and a nonionic surfactant, an anionic surfactant, a cationic surfactant, and an amphoteric interface can be used. Activators and the like can be mentioned. Specifically, glycerin fatty acid ester and its alkylene glycol adduct, polyglycerin fatty acid ester and its alkylene glycol adduct, sorbitan fatty acid ester and its alkylene glycol adduct, glyceride fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyalkylene. Examples thereof include alkyl co-modified organopolysiloxane, polyether-modified organopolysiloxane, and phospholipids.

The oily component is not particularly limited as long as it is used in ordinary cosmetics, etc., regardless of the properties of solid oils, semi-solid oils, liquid oils, volatile oils, etc. of origin such as animal oils and synthetic oils. Examples thereof include hydrocarbons, oils and fats, waxes, hydrogenated oils, ester oils, fatty acids, higher alcohols, fluorooils, lanolin derivatives, oil-based gelling agents, and oil-soluble resins.

The method for producing an external preparation for skin or cosmetics of the present invention is not particularly limited, and examples thereof include a method for producing an oil-in-water emulsified composition such as ordinary cosmetics, or a water-in-oil composition. it can.

In addition, examples of the external preparation for skin of the present invention include external liquids, external gels, creams, ointments, liniments, lotions, haptics, plasters, sprays, aerosols and the like. Examples of the method of use include a method of using with hands, fingers and cotton, a method of impregnating a non-woven fabric and the like, and a method of spraying. Examples of cosmetics include lotion, milky lotion, cream, beauty liquid, massage cosmetics, pack cosmetics, hand cream, body lotion, body cream, makeup cosmetics, makeup base cosmetics, deodorant, cleansing cosmetics. , Wiping cosmetics and the like can be exemplified. Further, the method of use thereof can be mentioned in the same manner as the above-mentioned external preparation for skin. Among these, it is preferable to use it as a cleansing cosmetic or a wiping cosmetic from the viewpoint of exfoliating. In addition, since the present invention exerts an excellent effect on exfoliating, it is preferably used as an external preparation for skin or cosmetics for exfoliating.

The external preparation for skin or cosmetic of the present invention can be implemented in various forms such as liquid, gel, cream, solid, and mousse, and is stored in a mist-sprayable container to mist. You may use it by spraying it in a shape. The dosage form of the product of the present invention is not particularly limited, such as a solubilized type, an oil-in-water type, a water-in-oil type, an oil-based type, a water-in-oil-in-water type, an oil-in-oil-in-oil type, and a multilayer type.

Hereinafter, the present invention will be described in more detail with reference to examples, but the scope of the present invention is not limited thereto.

Production Example 1: Pear Fruit Extract 10 kg of pear fruit was sliced into round slices, 25 L of 50% by volume 1,3-butylene glucol solution was added thereto, and the mixture was allowed to stand in a cold place for 15 days and then filtered. The filtrate was allowed to stand in a cold place for 10 days for aging, and the precipitate and sediment were removed by filtration, and a 50% by volume 1,3-butylene glucol solution was added to make 25 kg to obtain a pear fruit extract.

Examples 1 to 10 and Comparative Examples 1 to 5: Wiping cosmetics A wiping cosmetic was prepared by the composition shown in Tables 1 and 2 and the following manufacturing method, and the exfoliation was evaluated by the evaluation method and the judgment criteria shown below. The judgment was made and the results are shown in Tables 1 and 2.

(Note 1) PEMULEN TR-1 (manufactured by NOVEON)
(Note 2) Silicon KF-6012 (manufactured by Shin-Etsu Chemical Co., Ltd.)
(Note 3) KF-96-100CS (manufactured by Shin-Etsu Chemical Co., Ltd.)
(Note 4) HYCOAL K-350 (manufactured by Kaneda)
(Note 5) Farmment Pear B (manufactured by Ichimaru Falcos)
(Note 6) Pear fruit extract obtained in Production Example 1 (Note 7) Apple extract BG (manufactured by Maruzen Pharmaceuticals Co., Ltd.)

(Production method)
A. Ingredients 1 to 7 are heated to 60 ° C. and mixed uniformly.
B. Ingredients 8-12 are heated to 60 ° C. and mixed uniformly.
C. After uniformly mixing A and B, it is cooled.
D. Ingredients 13 to 15 were added to C and mixed uniformly to obtain a wiping cosmetic.

(Exfoliation)
For each sample of Examples and Comparative Examples, five cosmetic evaluation panel used on the face. A 0.5 g sample was applied to the cotton and the cheeks were rubbed 5 times with it to dry the cotton. Tape stripping was performed once from the dried cotton, and the tape was fixed with a fixative such as 4% paraformaldehyde fixative (manufactured by Muto Chemical Co., Ltd.), and then washed with PBS solution. Then, it was stained with 1% eosin Y solution (manufactured by Wako Pure Chemical Industries, Ltd.), stained for a certain period of time, and washed with running water. After the washed tape was attached to a slide glass or the like, it was appropriately covered with a cover glass or the like and used for observation. The slide glass sample was observed using an inverted fluorescence microscope manufactured by Olympus Corporation, and a micrograph was taken at a constant magnification. Using micrographs, the stained keratin in one image was counted and evaluated in 5 stages according to the following evaluation criteria, and the average score was judged according to the following criteria. A micrograph of the keratin removed using Example 1 and Comparative Example 2 is shown in FIG.
[Evaluation criteria]
5: Very much stained keratin 4: Many stained keratin 3: Stained keratin 2: Almost no stained keratin 1: No stained keratin [Criteria]
[Average score]: [Judgment]
Over 4.5 points: ◎
Over 3.5 points and below 4.5 points: ○
More than 2 points and less than 3.5 points: △
2 points or less: ×

As is clear from the results in Tables 1 and 2, the wiping cosmetics of Examples 1 to 10 were excellent in exfoliating. On the other hand, Comparative Example 1 which does not contain the component (A) is inferior in exfoliating, and Comparative Example 2 which does not contain the component (B) and Comparative Example 3 which does not contain the component (C) are poor in exfoliating. It was. Further, Comparative Example 4 containing an apple fruit extract instead of an extract of a pear genus plant or fruit juice was inferior in exfoliation, and Comparative Example 5 containing liquid paraffin instead of silicone oil was inferior in exfoliation. there were.

[Example 11: Emulsion]
(Ingredient) (%)
1. 1. Polyoxyethylene monooleate (20) Sorbitan 1.0
2. 2. Sorbitan sesquioleate 0.5
3. 3. Macadamia nut oil 0.5
4. Jojoba oil 0.5
5. Dimethylpolysiloxane (Note 3) 0.5
6. Decamethylcyclopentasiloxane 0.5
7. Residual amount of purified water 8. Disodium edetate 0.1
9. Methylparaben 0.2
10. Phenoxyethanol 0.5
11. Glycerin 5.0
12.1, 3-Butylenglcol 1.0
13. Propylene glycol 2.0
14. Sodium lactate 0.5
15. Xanthan gum 0.05
16. Purified water 10.0
17. Lactic acid bacillus / pear juice fermented liquid (Note 5) 0.15
18. Ethanol 3.0
19. Fragrance 0.01

(Production method)
A: Component 15 is swollen with component 16 heated to 70 ° C.
B: Ingredients 1 to 6 are heated and mixed at 70 ° C.
C: Ingredients 7 to 14 are heated and dissolved at 70 ° C., then added to B for emulsification.
After cooling D: C to room temperature, components 17 to 19 and A were added to obtain a milky lotion.

When the emulsion of Example 11 was applied to cotton and used on the face, it was excellent in exfoliating.

[Example 12: Cream]
(Ingredient) (%)
1. 1. Polyoxyethylene (40 mol) sorbitan monostearate 2.0
2. 2. Self-emulsifying glyceryl monostearate 5.0
3. 3. Stearic acid 5.0
4. Behenyl alcohol 0.5
5. Decamethylcyclopentasiloxane 25.0
6. Coconut oil 5.0
7. Tocopherol acetate 0.1
8. Methylparaben 0.1
9. Lactobacillus / Pear juice fermented liquid (Note 5) 0.2
10. Xanthan gum (2% aqueous solution) 7.0
11.1,3-butylene glycol 5.0
12. Residual amount of purified water 13. Fragrance 0.05

(Production method)
A. Ingredients 8-12 are heated and mixed and kept at 70 ° C.
B. Ingredients 1 to 7 are heated and mixed and kept at 70 ° C.
C. B is added to A, mixed and uniformly emulsified.
D. After cooling C, component 13 was added and mixed uniformly to obtain a cream.

When the cream of Example 12 was applied to cotton and used on the face, it was excellent in exfoliating.

Example 13: Wiping cleansing (ingredient) (%)
1. 1. Phospholipid (Note 8) 0.1
2. 2. Polyoxyethylene fatty acid monoethanolamide (Note 9) 0.5
3. 3. Rice bran oil 0.1
4. Decamethylcyclopentasiloxane 0.2
5. Poly (oxyethylene / oxypropylene) methylpolysiloxane copolymer (Note 2) 0.3
6. Polyoxyethylene / methylpolysiloxane copolymer (Note 10) 0.2
7. Dimethylpolysiloxane (Note 11) 0.1
8. Polyoxypropylene methylglucoside (Note 12) 0.5
9. Glycerin 1.0
10.1,3-butylene glycol 5.0
11. Residual amount of purified water 12. Xanthan gum 0.1
13. Carboxyvinyl polymer (Note 13) 0.1
14. Alkylation-modified carboxyvinyl polymer (Note 1) 0.1
15. Ethanol 10.0
16. PPG-6 decyltetradeceth-20 1.0
17. Methyl paraoxybenzoate 0.1
18. Fragrance 0.1
19. Lactic acid bacillus / pear juice fermented liquid (Note 5) 0.05
(Note 8) Resinol S-10 (manufactured by Nikko Chemicals Co., Ltd.)
(Note 9) Amizet 5C (manufactured by Kawaken Fine Chemicals)
(Note 10) Silicon KF-6017 (manufactured by Shin-Etsu Chemical Co., Ltd.)
(Note 11) SH200C FLUID 6CS (manufactured by Toray Dow Corning)
(Note 12) GLUCAM P-10 (manufactured by LUBRIZOL ADVANCED MATERIALS)
(Note 13) CARBOPOL 980 (manufactured by LUBRIZOL ADVANCED MATERIALS)

(Production method)
A: Ingredients 1 to 7 are uniformly dissolved and mixed at 70 ° C.
B: Ingredients 8 to 14 are uniformly mixed at 70 ° C.
C: A is added to B and emulsified at 70 ° C. D: C was cooled to 40 ° C., components 15 to 19 were added and mixed uniformly to obtain wiping cleansing.

When the wiping cleansing of Example 13 was applied to cotton and used on the face, it was excellent in exfoliating.

Claims (3)

The following components (A) to (C);
(A) Extract of pear fruit or fruit juice 0.0001 to 1%
(B) Volatile silicone oil 5-25%
(C) External skin preparation or cosmetic containing olive oil (excluding those for physical peeling). The skin external preparation or cosmetic according to claim 1, which is for exfoliating. The following components (A) to (C);
(A) Extract of pear fruit or fruit juice 0.0001 to 1%
(B) Volatile silicone oil 5-25%
(C) A skin external preparation or cosmetic for chemical peeling containing olive oil.