JP6819954B2 - バイヤライト系アルミナのモリブデン吸着剤及びそれを用いた99Mo/99mTcジェネレータ - Google Patents
バイヤライト系アルミナのモリブデン吸着剤及びそれを用いた99Mo/99mTcジェネレータ Download PDFInfo
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- JP6819954B2 JP6819954B2 JP2016172616A JP2016172616A JP6819954B2 JP 6819954 B2 JP6819954 B2 JP 6819954B2 JP 2016172616 A JP2016172616 A JP 2016172616A JP 2016172616 A JP2016172616 A JP 2016172616A JP 6819954 B2 JP6819954 B2 JP 6819954B2
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- alumina
- molybdenum
- biasite
- generator
- adsorption
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- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 title claims description 80
- 229910052750 molybdenum Inorganic materials 0.000 title claims description 24
- 239000011733 molybdenum Substances 0.000 title claims description 24
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 title claims description 23
- 239000003463 adsorbent Substances 0.000 title claims description 16
- ZOKXTWBITQBERF-AKLPVKDBSA-N Molybdenum Mo-99 Chemical compound [99Mo] ZOKXTWBITQBERF-AKLPVKDBSA-N 0.000 title claims description 5
- 229950009740 molybdenum mo-99 Drugs 0.000 title claims description 5
- 238000001179 sorption measurement Methods 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 20
- 239000013078 crystal Substances 0.000 claims description 13
- 229910001680 bayerite Inorganic materials 0.000 claims description 8
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 239000000243 solution Substances 0.000 description 15
- 238000010828 elution Methods 0.000 description 13
- 238000010304 firing Methods 0.000 description 12
- 238000004519 manufacturing process Methods 0.000 description 11
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000002504 physiological saline solution Substances 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 230000007423 decrease Effects 0.000 description 5
- 239000008213 purified water Substances 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- 238000001095 inductively coupled plasma mass spectrometry Methods 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 230000008859 change Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000004992 fission Effects 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 229910052770 Uranium Inorganic materials 0.000 description 2
- 238000002441 X-ray diffraction Methods 0.000 description 2
- 239000012670 alkaline solution Substances 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 229910001593 boehmite Inorganic materials 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000000032 diagnostic agent Substances 0.000 description 2
- 229940039227 diagnostic agent Drugs 0.000 description 2
- FAHBNUUHRFUEAI-UHFFFAOYSA-M hydroxidooxidoaluminium Chemical compound O[Al]=O FAHBNUUHRFUEAI-UHFFFAOYSA-M 0.000 description 2
- 238000009616 inductively coupled plasma Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- JCCNYMKQOSZNPW-UHFFFAOYSA-N loratadine Chemical compound C1CN(C(=O)OCC)CCC1=C1C2=NC=CC=C2CCC2=CC(Cl)=CC=C21 JCCNYMKQOSZNPW-UHFFFAOYSA-N 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000005245 sintering Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- JFALSRSLKYAFGM-UHFFFAOYSA-N uranium(0) Chemical compound [U] JFALSRSLKYAFGM-UHFFFAOYSA-N 0.000 description 2
- 238000004438 BET method Methods 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- KJZYNXUDTRRSPN-UHFFFAOYSA-N holmium atom Chemical compound [Ho] KJZYNXUDTRRSPN-UHFFFAOYSA-N 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 150000002751 molybdenum Chemical class 0.000 description 1
- VLAPMBHFAWRUQP-UHFFFAOYSA-L molybdic acid Chemical compound O[Mo](O)(=O)=O VLAPMBHFAWRUQP-UHFFFAOYSA-L 0.000 description 1
- 238000009206 nuclear medicine Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002901 radioactive waste Substances 0.000 description 1
- 239000012217 radiopharmaceutical Substances 0.000 description 1
- 229940121896 radiopharmaceutical Drugs 0.000 description 1
- 230000002799 radiopharmaceutical effect Effects 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 239000011684 sodium molybdate Substances 0.000 description 1
- 235000015393 sodium molybdate Nutrition 0.000 description 1
- TVXXNOYZHKPKGW-UHFFFAOYSA-N sodium molybdate (anhydrous) Chemical compound [Na+].[Na+].[O-][Mo]([O-])(=O)=O TVXXNOYZHKPKGW-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 238000005979 thermal decomposition reaction Methods 0.000 description 1
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- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
Description
(1)アルミナの製造方法
2.アルミナの製造と特性評価
a) バイヤライト(Bayerite)→ η(Eta) → θ(Theta)
b) ベーマイト(Boehmite) → γ(Gamma) → δ(Delta)
と構造変化する系列が混在していると推定される。
3.アルミナのMo吸着試験及びMo溶離試験
(1)モリブデン(Mo)吸着試験
(2)モリブデン(Mo)溶離試験
4.モリブデン(Mo)回収試験
1)放射化法((n,γ)法)により製造した比放射能の低い99Moでも使用可能である。
2)現行医療用アルミナと同等の高純度99mTc溶液を得ることが可能である。
3)高価な98Mo濃縮原料をアルミナから回収し、98Mo濃縮モリブデン原料は再利用が可能である。
4)安価で大量製造が可能である。
Claims (4)
- モリブデン(Mo)の比表面積換算吸着量が、0.194 mg/m2から0.290 mg/m2の範囲にあり、少なくとも「η」の結晶構造を含むことを特徴とするバイヤライト系アルミナから成るモリブデン吸着剤。
- 請求項1に記載のモリブデン吸着剤において、前記バイヤライト系アルミナがさらに「γ」の結晶構造を持つことを特徴とするモリブデン吸着剤。
- 天然同位体もしくは98Mo濃縮Moから(n,γ)法を利用して99mTcを得る99Mo/99mTcジェネレータにおいて、モリブデン(Mo)の比表面積換算吸着量が、0.194 mg/m 2 から0.290 mg/m 2 の範囲にあり、少なくとも「η」の結晶構造を含むことを特徴とするバイヤライト系アルミナから成るモリブデン吸着剤を用いた99Mo/99mTcジェネレータ。
- 請求項3に記載の99Mo/99mTcジェネレータにおいて、前記バイヤライト系アルミナがさらに「γ」の結晶構造を持つことを特徴とする99Mo/99mTcジェネレータ。
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JP2016172616A JP6819954B2 (ja) | 2016-09-05 | 2016-09-05 | バイヤライト系アルミナのモリブデン吸着剤及びそれを用いた99Mo/99mTcジェネレータ |
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JP2016172616A JP6819954B2 (ja) | 2016-09-05 | 2016-09-05 | バイヤライト系アルミナのモリブデン吸着剤及びそれを用いた99Mo/99mTcジェネレータ |
Publications (2)
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JP2018038935A JP2018038935A (ja) | 2018-03-15 |
JP6819954B2 true JP6819954B2 (ja) | 2021-01-27 |
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Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3469285B2 (ja) * | 1993-11-08 | 2003-11-25 | 水澤化学工業株式会社 | 粒状アルミナの製造方法及び球状アルミナ粒子 |
JP3922818B2 (ja) * | 1998-09-17 | 2007-05-30 | 水澤化学工業株式会社 | 酸性活性アルミナの製法 |
KR100755933B1 (ko) * | 2006-11-08 | 2007-09-06 | 한국원자력연구원 | 진단용 및 치료용 방사성 동위원소 흡착제 및 이의제조방법 |
NL2007951C2 (en) * | 2011-12-12 | 2013-06-13 | Univ Delft Tech | A column material and a method for adsorbing mo-99 in a 99mo/99mtc generator. |
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