NL2007951C2 - A column material and a method for adsorbing mo-99 in a 99mo/99mtc generator. - Google Patents

A column material and a method for adsorbing mo-99 in a 99mo/99mtc generator. Download PDF

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Publication number
NL2007951C2
NL2007951C2 NL2007951A NL2007951A NL2007951C2 NL 2007951 C2 NL2007951 C2 NL 2007951C2 NL 2007951 A NL2007951 A NL 2007951A NL 2007951 A NL2007951 A NL 2007951A NL 2007951 C2 NL2007951 C2 NL 2007951C2
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Prior art keywords
column
mesoporous material
adsorbing
99mtc
mesoporous
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NL2007951A
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Dutch (nl)
Inventor
Peter Bode
Antinia Georgieva Denkova
Olav Maria Steinebach
Baukje Elisabeth Terpstra
Hubert Theodoor Wolterbeek
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Univ Delft Tech
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Priority to NL2007951A priority Critical patent/NL2007951C2/en
Priority to PCT/NL2012/050875 priority patent/WO2013095108A1/en
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Publication of NL2007951C2 publication Critical patent/NL2007951C2/en

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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/06Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group B01J20/04
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/06Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group B01J20/04
    • B01J20/08Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group B01J20/04 comprising aluminium oxide or hydroxide; comprising bauxite
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/10Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
    • B01J20/103Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate comprising silica
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/10Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
    • B01J20/16Alumino-silicates
    • B01J20/18Synthetic zeolitic molecular sieves
    • GPHYSICS
    • G21NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21GCONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/001Recovery of specific isotopes from irradiated targets
    • GPHYSICS
    • G21NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21GCONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G4/00Radioactive sources
    • G21G4/04Radioactive sources other than neutron sources
    • G21G4/06Radioactive sources other than neutron sources characterised by constructional features
    • G21G4/08Radioactive sources other than neutron sources characterised by constructional features specially adapted for medical application
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00Aspects relating to sorbent materials
    • B01J2220/40Aspects relating to the composition of sorbent or filter aid materials
    • B01J2220/42Materials comprising a mixture of inorganic materials
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2220/00Aspects relating to sorbent materials
    • B01J2220/50Aspects relating to the use of sorbent or filter aid materials
    • B01J2220/58Use in a single column
    • GPHYSICS
    • G21NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21GCONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/001Recovery of specific isotopes from irradiated targets
    • G21G2001/0036Molybdenum

Description

P95495NL00
Title: A column material and a method for adsorbing Mo-99 in a "Mo/99mTc generator
FIELD OF THE INVENTION
The invention relates to a column material for adsorbing Mo-99 in a "Mo/99mTc generator.
5
The invention still further relates to a column for adsorbing Mo-99 in a "Mo/99mTc generator.
The invention further relates to a method for adsorbing Mo-99 in a 10 "Mo/99mTc generator.
The invention still further relates to use of a mesoporous material.
BACKGROUND OF THE INVENTION 15
An embodiment of a method as is set forth in the opening paragraph is known from US 5, 910, 971. In the known method a molybdenum-99 isotope is generated in the uranyl pulphate nuclear fuel of a homogeneous solution nuclear reactor. The 99-molybdenum isotope is extracted from the fuel by a solid polymer 20 sorbent. The sorbent is composed of a composite ether of a maleic anhydride copolymer and a-benzoin-oxime.
In the known method use is made of the following nuclear reaction for producing the molybdenum-99 isotope: 235U —> 99Mo —>99mTc. It is appreciated that 25 99mrpc js uie isotope which has relevant clinical value for diagnostic purposes.
However, "mTc has a half-life time of about 6 hours which induces logistic problems associated with generation and delivery of "Mo obtained in the nuclear generator.
An embodiment of a column for production of Molybdenum-99 is known 30 from RU 2 296 712. The known column is used in the nuclear aqueous solution reactor 2 wherein molybdenum-99 is being produced. The resulting molybdenum-99 is being sorbed in a column, washed off the sorbent material and subsequently desorbed and cleaned from radio-nuclides and chemical admixtures.
5 It is a disadvantage of the known column that complicated post-processing steps are required after the molybdenum-99 isotope has been adsorbed in the column.
A still further embodiment of a process and a device for producing molybdenum-99 is known from WO 2011/081576. In the known method and the device 10 use is made of a solution reactor wherein fuel comprising uranyl sulfate is used. After the nuclear reactor is brought into power the production of molybdenum-99 commences after which the produced molybdenum-99 is sorbed. For purposes of sorbing, the solution containing molybdenum-99 is being pumped through a column comprising a suitable sorbent after which the nuclear fuel may be conditioned and 15 reused.
It is a disadvantage of the known method that sorbing capacity of molybdenum-99 isotope in the known column is sub-optimal.
20 A still further method of generating "Mo/99mTc isotopes is known from US 4, 782, 231. In the know method use is made of a column comprising a molybdenum target which is subjected to a medium flux neutron irradiation. The resulting isotopes are produced by the following reaction: 98Mo(n, y) —► "Mo/99mTc. The resulting "Mo/99mTc is eluted from the column using an elution solution of 0.9% 25 solution of NaCl by weight.
It is a disadvantage of the known method that at least there is a specific maximum to the Mo loading capacity. In addition, it is a disadvantage of the known method that the release efficiency of "Mo/99mTc may be relatively low.
3
SUMMARY OF THE INVENTION
It is an object of the invention to provide an improved method of "Mo/99mTc generation. In particular, it is an object of the invention to provide an improved 5 method of "Mo/99mTc generation wherein Mo adsorbing processes in a column are optimized followed by an efficient release of produced 99mTc.
To this end in the column material for adsorbing Mo-99 in a "Mo/99mTc generator, according to the invention, said column material comprises a mesoporous 10 material.
It is found that when using a mesoporous material in the column, due to a large surface area of such material, it has a substantially increased capacity than the conventional materials based on Aluminum oxide.
15
Accordingly, much higher amounts of Mo can be loaded (adsorbed) in "Mo/99mTc generators without increasing the volume of the generator. Higher capacity of the generator column allows for the use of 99Mo with much lower specific activity (SA) than compared to the devices known from the art. Accordingly, relaxed 20 constrained on SA means that the production of "Mo from natural molybdenum rather than from the enriched 98Mo using a high neutron flux reactor can successfully replace "Mo obtained by fission of 235U. Accordingly, not only the costs of the "Mo production may be decreased, but also a substantial contribution to the protection of the environment can be made.
25
The technical measure of the invention is based on the following insights. According to the practice as is known from the art, a specific quantity of "Mo radioactivity and a specific associated Mo mass is loaded onto a specific mass of column material, under specific conditions and procedural approaches, for purposes of 30 increasing loading efficiency. In addition, specific and complicated measures are undertaken in the prior art methods to avoid Mo breakthrough, and to achieve an efficient release of produced 99mTc.
4
Accordingly, the known columns used for adsorption of molybdenum isotopes have to be tuned at least for meeting the following desirable criteria: i) a specific maximum to the Mo loading capacity; ii) a specific optimum to the Mo column affinity 5 iii) a minimum to the "Mo specific radioactivity (SA) to be applied; iv) a minimum to the column material mass to be used; v) a limited number of routes to produce "Mo of the required high SA; vi) a limited set of applicable conditions, dictated, for example by column solubility in an elution solution.
10
It has been found that the limited column Mo capacity (i) requires for a high "Mo SA (iii), the limited column Mo affinity (ii) may lead to Mo breakthrough incidences, and the overall need of large column mass (iv) implies the necessary large mass of radiation shielding to be implemented into the eventual generator lay-outs.
15 Furthermore, the needed high "Mo SA (iii) limits the available possibilities for production of "Mo (v), and experimental approaches and material choices should prevent any column solubility (vi).
Research has indicated that column materials of higher Mo capacity and 20 affinity may permit more Mo to be loaded (i,ii), as well as may permit less column material to be used (iv) with smaller amount of necessary shielding. In addition such column materials may permit "Mo to be used of lower SA (iii), thereby increasing the production-possibilities for "Mo in "Mo-99mTc generators. However, an additional feature of the column material should be that it has limited solubility under the 25 conditions of Mo loading and Tc unloading (vi).
It has been found that a material composed of or comprising a mesoporous material meets all above criteria and is particularly suitable to be used as a column material for generation "Mo/"mTc as is set forth in the foregoing.
In an embodiment of the column material according to the invention a pore size of the mesoporous material is in the range of 1.5 - 50 nm, preferably in the range of 2 — 30 nm.
30 5
It is further found that a material described in US 2006/0052234 is particularly suitable for embodying the column material.
5 In a further embodiment of the column material according to the invention, the mesoporous material is selected from the group consisting of: AI2O3, Ti02, Al203-Si02, Ti02-Si02> MSU-A1, TUD1-A1.
Experimental verification of said column properties is done both in batch 10 approaches, in which column solids and Mo-solutions are mixed for specific mixing time, and in column set-ups, in which "Mo is loaded and capacity assessment is performed by subsequent elution of 0.9 % NaCl pH 7 solutions.
Tracking of column (material) properties towards Mo is done by data 15 interpretation routines on Langmuir, Freundlich and other conventional saturation isotherms, thereby specifically giving insight in column Mo capacity and affinity. Basic equations used are the generalized Langmuir isotherm (Rill et al. Langmuir 25 (4),2294 (2009)): r -i min
(K.cJ
20 °le #max j + ^ Q y (1) with qe as the adsorbed amount of Mo, ce as the Mo concentration in solution, qmax as the saturation (maximum) column Mo loading, K as a constant, to be regarded as the affinity constant, and with m and n as surface heterogeneity parameters. For the 25 Langmuir model, m and n are both equal to 1, thereby giving (KL.ce) <le = ?max . * , 1 + (KL.ce) (2) 6
With Kl as the Langmuir (adsorption equilibrium) constant. The Langmuir -Freundlich (LF) and Tóth models (T) assume that adsorption energy is not equal for all sites, as expressed by deviations of m and n from unit value. The Langmuir -Freundlich model assumes m=n (eq 3), the Tóth model assumes m=l, eq 4) 5 q‘ q“'l + (Klf.cJ (3) or r nl In 10 The Freundlich isotherm (F) is a further (empirical) model, with Kf as the Freundlich affinity constant (see eq 5), which does not limit the adsorption to a monolayer and is often applicable to adsorption on heterogeneous surfaces „ is \ln
Qe ~ ^FCe (5) 15
In addition, an adapted form of the extended Langmuir equation is used (Zhang P., Wang, L. Separation and Purification Technol. 70, 367-371, 2010), as T V 1 nce KTCe c a = a -—— e max -l 6 JL max -t -wy~ L l + KLCe] <6) 20 with ce < Cmax (cmax respresenting e.g. c solubility, for Molybdates reported as ca 65 mg/L at 20 °C), and eq (6) reducing to eq (2) for n=0.
In experimental verification, mostly eqs 5 and 6 were used.
25 7
Column materials, in mixed or un-mixed forms were taken into batch experiments, in which various Mo compounds (e.g such as dissolved (NH4)2Mo04, Na2MoC>4 or M0O3) and were loaded (adsorbed) onto said materials, under variable conditions viz. acidity (e.g. pH 2-8, see Table 2 for various Mo forms depending on 5 acidity), counter ions (e.g. Na+, NH4+), sorption duration, column pre-conditioning approaches (e.g. washing), and set ionic strength (by adding NaCl). Where considered necessary, all further experiments were performed in Na-acetate (0.15 M) buffered solutions.
10 Results on sorption time indicate that 10 min is enough to largely reach equilibrium in batches: accordingly all further batch tests were carried out with the 30 min duration to ensure full steady state. Results on Mo sorption for various sorber materials with varying NaCl concentrations show that Langmuir constants decrease with increasing ionic strength. Accordingly, it is found preferably to select the ionic 15 strengths to about 0.15 M.
In addition, a number of experiments are presented for pH 2-3, one using a large range of Mo concentrations (remaining far below Mo solubility values), to derive the column capacity qm and formation constant Kl (eq 6), and the other one using a 20 Mo range, limited to small Mo concentrations, to derive an expression of affinity Kf (eq 5). The results indicate best performance (regarding both qm and Kl) for MSU-X and TUD1-A1 materials, with high Freundlich outcomes relative to conventional sorbers.
25 It will be appreciated that MSU-X (wormhole) is a commercially available mesoporous material (SIGMA-Aldrich 517747), with Sbet=364 m2/g, pore size = 3.8 nm average, particle size 5.65 pm on average.
The TUD1-A1 material has Sbet=428 m2/g, pore volume = 0.832 cm3/g, and 30 pore diameter 6.3 nm. It will be appreciated that the TUD1-A1 material is developed and patented by the Applicant, see US 2006/0052234. For the sake of conciseness the disclosure of US 2006/0052234 is not recited here.
8
In addition to batch experiments, also column experiments were performed, in which "Mo was preloaded (pH 2) into a 2 g sorber column (column total volume 8 cm height by 0.8 cm O), after which extended elutions (up to 100 ml, pH 2, 0.9 % NaCl) were used to monitor column capacity. Results indicate 52.6 mg Mo/g 5 column capacity for (acid y-)Al203 and 101.5 mg Mo/g column capacity for mesoporous AI2O3 (MSU-X), thereby fully substantiating the earlier obtained batch results.
Accordingly, it has been demonstrated that a column material composed of or comprising a mesoporous material as is set forth in the foregoing substantially 10 improved adsorption properties of a column used for "Mo/99mTc generation.
The invention further relates to a column comprising the column material as is set forth in the foregoing. Preferably, the column is adapted to form part of an elution system. This embodiment will be discussed in more detail with reference to 15 Figure 1.
The invention method of adsorbing Mo from a solution into a sorber material, wherein for the sorber material a mesoporous material is used. Preferably, the mesoporous material is selected from the group consisting of: AI2O3, Ti02, AI2O3-20 Si02, Ti02-Si02, MSU-A1, TUD 1 -Al.
In a further embodiment according to a further aspect of the invention the solution is acidic having pH in the range of 2 - 3.
25 In a still further embodiment of the method according to the invention an ionic strength of the solution is about 0.15 mol/L.
Use of a mesoporous material according to the invention is effectuated in a column arranged for adsorbing Mo-99 in a "Mo/"mTc generator. Preferably, the 30 mesoporous material having a pore size in the range of 1.5 - 50 nm, preferably in the range of 2 - 30 nm is used. More preferably, the mesoporous material is selected from the group consisting of: AI2O3, Ti02, Al203-Si02, Ti02-Si02> MSU-A1, TUD1-A1.
9
These and other aspects of the invention will be discussed with reference to drawings wherein like reference signs correspond to like elements. It will be appreciated that the drawings are presented for illustrative purposes only and may not be used for limiting the scope of the appended claims.
5
BRIEF DESCRIPTION OF THE DRAWINGS
Figure 1 presents in a schematic way an embodiment of a column provided with a mesoporous material, forming part of an elution system.
10 DETAILED DESCRIPTION OF THE DRAWINGS
Figure 1 presents in a schematic way an embodiment of a column 4 provided with a mesoporous material, forming part of an elution system 10. The column 4 is provided with a mesoporous material used for adsorbing "Mo isotopes. In 15 accordance with the invention, the mesoporous material may be selected from a group consisting of AI2O3, TiÜ2, Al203-Si02, Ti02-Si02, MSU-A1, TUD1-A1. It will be appreciated that MSU-X (wormhole) is a commercially available mesoporous material (SIGMA-Aldrich 517747), with Sbet=364 m2/g, pore size = 3.8 nm average, particle size 5.65 pm average.
20
The TUD1-A1 material has Sbet=428 m2/g, pore volume = 0.832 cm3/g, and pore diameter 6.3 nm. It will be appreciated that the TUD1-A1 material is developed and patented by the Applicant, see US 2006/0052234. For the sake of conciseness the disclosure of US 2006/0052234 incorporated herein by reference is not recited. In 25 particular, paragraphs [0038] - [0061] are incorporated herewith by reference.
In accordance with the present embodiment, "Mo may be loaded in an alumina sorber and provided in the column 4. The elution vial 2 may be used for supplying a suitable elution liquid via the conduit 2a into the column 4. Preferably, 30 the column 4 is suitably shielded against emanating radiation, for example using a lead shield 3.
10
The elution solution may comprise 0.9% NaCl, which may be fed into the column with a flow rate of 1 ml/min. The volume of the column 4 may be as large as 100 ml. The extracted solution may be collected in an extraction vessel 7 using an exit conduit 4a. Preferably, prior to the extraction vessel 7 a suitable filet 6 is arranged.
5
It will be appreciated that the above eluting scheme is exemplary, not limiting. Any other suitable elution scheme as known from the may be used. For example, the elution scheme known from US2011/0250107 may be used.
10 While specific embodiments have been described above, it will be appreciated that the invention may be practiced otherwise than as described. Moreover, specific items discussed with reference to any of the isolated drawings may freely be inter-changed supplementing each outer in any particular way. The descriptions above are intended to be illustrative, not limiting. Thus, it will be 15 apparent to one skilled in the art that modifications may be made to the invention as described in the foregoing without departing from the scope of the claims set out below.

Claims (12)

1. Kolommateriaal voor het adsorberen van Mo-99 in een "Mo/99mTc generator, het kolommateriaal omvattende een mesoporeus materiaal.A column material for adsorbing Mo-99 in a "Mo / 99m Tc generator, the column material comprising a mesoporous material. 2. Kolommateriaal volgens conclusie 1, waarbij een poriegrootte van het mesoporeuze materiaal in het bereik van 1,5 - 50 nm ligt, bij voorkeur in het 5 bereik van 2-30 nm.2. Column material according to claim 1, wherein a pore size of the mesoporous material is in the range of 1.5 - 50 nm, preferably in the range of 2-30 nm. 3. Kolommateriaal volgens conclusie 1 of 2, waarbij het mesoporeuze materiaal is geselecteerd uit een groep bestaande uit: AI2O3, Ti02, AKOa-SiCh, T1O2-Si02, MSU-A1, TUD1-A1.The column material according to claim 1 or 2, wherein the mesoporous material is selected from a group consisting of: Al 2 O 3, TiO 2, AKOa-SiCl 2, TiO 2 -SiO 2, MSU-A1, TUD1-A1. 4. Kolom omvattende het kolommateriaal volgens één van de voorgaande 10 conclusies.4. Column comprising the column material according to one of the preceding claims. 5. Kolom volgens conclusie 1, geschikt om een deel van een elutiesysteem te vormen.The column of claim 1, adapted to form a part of an elution system. 6. Werkwijze voor het in een sorptiemateriaal adsorberen van Mo uit een oplossing, waarbij als sorptiemateriaal een mesoporeus materiaal wordt gebruikt.6. Process for adsorbing Mo in a sorption material from a solution, wherein a mesoporous material is used as the sorption material. 7. Werkwijze volgens conclusie 6, waarbij het mesoporeuze materiaal is geselecteerd uit een groep bestaande uit: AI2O3, Ti02, AkOs-SiCH TiCk-SiCk, MSU-Al, TUD 1-Al.The method of claim 6, wherein the mesoporous material is selected from a group consisting of: Al 2 O 3, TiO 2, AkO 3 -SiCH TiCk-SiCk, MSU-Al, TUD 1-Al. 8. Werkwijze volgens conclusie 6 of 7, waarbij de oplossing zuur is met een pH in het bereik van 2-3.The method of claim 6 or 7, wherein the solution is acidic with a pH in the range of 2-3. 9. Werkwijze volgens conclusie 8, waarbij de ionsterkte van de oplossing rond 0,15 mol/L is.The method of claim 8, wherein the ionic strength of the solution is around 0.15 mol / L. 10. Gebruik van een mesoporeus materiaal in een kolom voor het adsorberen van Mo-99 in een "Mo/99mTc generator.10. Use of a mesoporous material in a column to adsorb Mo-99 in a "Mo / 99mTc generator. 11. Gebruik volgens conclusie 10, waarbij een poriegrootte van het 25 mesoporeuze materiaal in het bereik van 1,5-50 nm ligt, bij voorkeur in het bereik van 2-30 nm.11. Use according to claim 10, wherein a pore size of the mesoporous material is in the range of 1.5-50 nm, preferably in the range of 2-30 nm. 12. Gebruik volgens conclusie 10 of 11, waarbij het mesoporeuze materiaal is geselecteerd uit een groep bestaande uit: AI2O3, TiÜ2, Ah03-Si02, Ti02-Si02, MSU-Al, TUD 1-Al.The use according to claim 10 or 11, wherein the mesoporous material is selected from a group consisting of: Al 2 O 3, TiO 2, Al 2 O 3 -SiO 2, TiO 2 -SiO 2, MSU-Al, TUD 1-Al.
NL2007951A 2011-12-12 2011-12-12 A column material and a method for adsorbing mo-99 in a 99mo/99mtc generator. NL2007951C2 (en)

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PCT/NL2012/050875 WO2013095108A1 (en) 2011-12-12 2012-12-11 A column material and a method for adsorbing mo-99 in a 99mo/99mtc generator

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US9842664B2 (en) 2013-09-26 2017-12-12 Los Alamos National Security, Llc Recovering and recycling uranium used for production of molybdenum-99
US9793023B2 (en) 2013-09-26 2017-10-17 Los Alamos National Security, Llc Recovery of uranium from an irradiated solid target after removal of molybdenum-99 produced from the irradiated target
JP6211639B2 (en) * 2016-02-08 2017-10-11 株式会社化研 99mTC formulation and 99mTC generator production method, 99mTC formulation and 99mTC generator production apparatus, and 99mTC generator column from low specific activity 99Mo using uranium as a raw material
JP6819954B2 (en) * 2016-09-05 2021-01-27 国立研究開発法人日本原子力研究開発機構 Molybdenum adsorbent of biasite alumina and 99Mo / 99mTc generator using it
JP6890311B2 (en) * 2016-09-05 2021-06-18 国立研究開発法人日本原子力研究開発機構 Pseudo-boehmite alumina molybdenum adsorbent and 99Mo / 99mTc generator using it
AU2022218237A1 (en) * 2021-02-02 2023-08-24 Australian Nuclear Science And Technology Organisation Method and Target for Mo-99 Manufacture
CN117095848A (en) * 2023-09-07 2023-11-21 北京四维宇新科技有限公司 99 Mo- 99m Tc color layer generator 99m Preparation method of Tc isotope

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