JP6806679B2 - サーチュイン調節因子としての置換架橋尿素類似体 - Google Patents

サーチュイン調節因子としての置換架橋尿素類似体 Download PDF

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Publication number
JP6806679B2
JP6806679B2 JP2017526852A JP2017526852A JP6806679B2 JP 6806679 B2 JP6806679 B2 JP 6806679B2 JP 2017526852 A JP2017526852 A JP 2017526852A JP 2017526852 A JP2017526852 A JP 2017526852A JP 6806679 B2 JP6806679 B2 JP 6806679B2
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branched
sirtuin
heteroaryl
linear
compound
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Japanese (ja)
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JP2017534662A5 (https=
JP2017534662A (ja
Inventor
ジェームズ、ラモンド、エリス
カレン、アンダーソン、エバンス
ライアン、マイケル、フォックス
ウィリアム、ヘンリー、ミラー
マーク、アンドリュー、シーフェルド
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GlaxoSmithKline Intellectual Property No 2 Ltd
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GlaxoSmithKline Intellectual Property No 2 Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2017526852A 2014-11-19 2015-11-19 サーチュイン調節因子としての置換架橋尿素類似体 Expired - Fee Related JP6806679B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462081916P 2014-11-19 2014-11-19
US62/081,916 2014-11-19
PCT/IB2015/058978 WO2016079710A1 (en) 2014-11-19 2015-11-19 Substituted bridged urea analogs as sirtuin modulators

Publications (3)

Publication Number Publication Date
JP2017534662A JP2017534662A (ja) 2017-11-24
JP2017534662A5 JP2017534662A5 (https=) 2019-01-10
JP6806679B2 true JP6806679B2 (ja) 2021-01-06

Family

ID=54705247

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2017526852A Expired - Fee Related JP6806679B2 (ja) 2014-11-19 2015-11-19 サーチュイン調節因子としての置換架橋尿素類似体
JP2017526965A Pending JP2017534665A (ja) 2014-11-19 2015-11-19 サーチュイン調節因子としての置換架橋尿素類似体
JP2017526950A Pending JP2017534664A (ja) 2014-11-19 2015-11-19 サーチュイン調節因子としての置換架橋尿素類似体
JP2017526875A Withdrawn JP2017534663A (ja) 2014-11-19 2015-11-19 サーチュイン調節因子としての置換架橋尿素類似体

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2017526965A Pending JP2017534665A (ja) 2014-11-19 2015-11-19 サーチュイン調節因子としての置換架橋尿素類似体
JP2017526950A Pending JP2017534664A (ja) 2014-11-19 2015-11-19 サーチュイン調節因子としての置換架橋尿素類似体
JP2017526875A Withdrawn JP2017534663A (ja) 2014-11-19 2015-11-19 サーチュイン調節因子としての置換架橋尿素類似体

Country Status (21)

Country Link
US (4) US10072011B2 (https=)
EP (4) EP3221317B1 (https=)
JP (4) JP6806679B2 (https=)
KR (4) KR20170083134A (https=)
CN (4) CN107207521A (https=)
AU (4) AU2015348941A1 (https=)
BR (4) BR112017010595A2 (https=)
CA (4) CA2968029A1 (https=)
CL (1) CL2017001275A1 (https=)
CO (1) CO2017004994A2 (https=)
CR (1) CR20170209A (https=)
DO (1) DOP2017000123A (https=)
EA (1) EA201791074A1 (https=)
ES (1) ES2823748T3 (https=)
IL (1) IL252252A0 (https=)
MX (1) MX2017006658A (https=)
PE (1) PE20171257A1 (https=)
PH (1) PH12017500913A1 (https=)
RU (3) RU2017120858A (https=)
SG (1) SG11201703824QA (https=)
WO (4) WO2016079709A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016086088A2 (en) 2014-11-25 2016-06-02 Northwestern University Wound healing through sirt1 overexpression
CN108329388A (zh) * 2018-01-18 2018-07-27 天津市湖滨盘古基因科学发展有限公司 一种人的沉默配型信息调节蛋白突变蛋白及其应用
CN108395436B (zh) * 2018-05-14 2021-01-12 鹤壁市人民医院 一种咪唑并吡嗪医药中间体的制备方法
CN108707150B (zh) * 2018-05-14 2021-04-16 江苏惠利生物科技有限公司 一种咪唑并吡嗪医药中间体的制备方法
CN110478339A (zh) * 2019-08-12 2019-11-22 昆明理工大学 紫铆因在制备靶向恢复突变p53构象药物中的应用
KR20220056223A (ko) 2019-09-02 2022-05-04 메르크 파텐트 게엠베하 유기 전계발광 디바이스용 재료
WO2021100059A1 (en) * 2019-11-19 2021-05-27 Lupin Limited Process for preparing chroman compounds
PT4090654T (pt) * 2020-01-17 2025-10-07 Lupin Ltd Métodos, processos e intermediários para a preparação de compostos de cromano
CN114890955A (zh) * 2022-06-23 2022-08-12 江西瑞威尔生物科技有限公司 一种n取代吗啉类有机化合物的制备工艺
WO2025194094A1 (en) * 2024-03-15 2025-09-18 The Regents Of The University Of Michigan Small molecule modulators of sirt5 and uses thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727064A (en) 1984-04-25 1988-02-23 The United States Of America As Represented By The Department Of Health And Human Services Pharmaceutical preparations containing cyclodextrin derivatives
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
WO2006094210A2 (en) * 2005-03-03 2006-09-08 Sirtris Pharmaceuticals, Inc. Tetrahydroquinoxalinone sirtuin modulators
UA108596C2 (xx) 2007-11-09 2015-05-25 Інгібітори пептиддеформілази
US9556201B2 (en) * 2009-10-29 2017-01-31 Glaxosmithkline Llc Bicyclic pyridines and analogs as sirtuin modulators
AU2012352442A1 (en) * 2011-12-12 2014-07-03 Smb Innovation Aps Novel heterocyclic compounds useful in sirtuin binding and modulation
CN105392788B (zh) * 2013-05-13 2018-10-23 葛兰素史密斯克莱有限责任公司 用作沉默调节蛋白调节剂的取代的桥连脲类似物

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Publication number Publication date
JP2017534665A (ja) 2017-11-24
IL252252A0 (en) 2017-07-31
JP2017534663A (ja) 2017-11-24
JP2017534664A (ja) 2017-11-24
EP3220918A1 (en) 2017-09-27
CA2968029A1 (en) 2016-05-26
CR20170209A (es) 2017-07-17
WO2016079709A1 (en) 2016-05-26
US10072011B2 (en) 2018-09-11
PE20171257A1 (es) 2017-08-28
CN107108627A (zh) 2017-08-29
AU2015348943A1 (en) 2017-06-01
ES2823748T3 (es) 2021-05-10
CL2017001275A1 (es) 2017-12-15
CN107207520A (zh) 2017-09-26
RU2017120858A (ru) 2018-12-19
CA2968027A1 (en) 2016-05-26
JP2017534662A (ja) 2017-11-24
BR112017010601A2 (pt) 2017-12-26
KR20170083134A (ko) 2017-07-17
AU2015348942A1 (en) 2017-06-01
PH12017500913A1 (en) 2017-12-04
CO2017004994A2 (es) 2017-09-20
EP3221317A1 (en) 2017-09-27
AU2015348942B2 (en) 2018-07-05
KR20170087907A (ko) 2017-07-31
EP3221322A1 (en) 2017-09-27
DOP2017000123A (es) 2017-08-15
KR20170083133A (ko) 2017-07-17
CN107207509A (zh) 2017-09-26
AU2015348941A1 (en) 2017-06-01
KR20170083135A (ko) 2017-07-17
BR112017010595A2 (pt) 2018-01-02
AU2015348944A1 (en) 2017-06-01
CN107207521A (zh) 2017-09-26
US20170355705A1 (en) 2017-12-14
BR112017010599A2 (pt) 2017-12-26
WO2016079711A1 (en) 2016-05-26
US20180319810A1 (en) 2018-11-08
RU2017120855A (ru) 2018-12-19
CA2968030A1 (en) 2016-05-26
WO2016079710A1 (en) 2016-05-26
WO2016079712A1 (en) 2016-05-26
EP3221317B1 (en) 2020-07-22
CN107207509B (zh) 2020-04-21
CA2968032A1 (en) 2016-05-26
US20190048016A1 (en) 2019-02-14
BR112017010602A2 (pt) 2017-12-26
MX2017006658A (es) 2018-01-15
EP3221316A1 (en) 2017-09-27
EA201791074A1 (ru) 2017-10-31
SG11201703824QA (en) 2017-06-29
US20170362234A1 (en) 2017-12-21
RU2017120857A (ru) 2018-12-19

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