JP6802263B2 - Tyk2阻害剤およびその使用 - Google Patents

Tyk2阻害剤およびその使用 Download PDF

Info

Publication number
JP6802263B2
JP6802263B2 JP2018512319A JP2018512319A JP6802263B2 JP 6802263 B2 JP6802263 B2 JP 6802263B2 JP 2018512319 A JP2018512319 A JP 2018512319A JP 2018512319 A JP2018512319 A JP 2018512319A JP 6802263 B2 JP6802263 B2 JP 6802263B2
Authority
JP
Japan
Prior art keywords
compound
disorder
vii
nitrogen
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2018512319A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018532706A5 (https=
JP2018532706A (ja
Inventor
クレッグ イー. マッセ,
クレッグ イー. マッセ,
ジェレミー ロバート グリーンウッド,
ジェレミー ロバート グリーンウッド,
ドナ エル. ロメロ,
ドナ エル. ロメロ,
ジェラルディン シー. ハリマン,
ジェラルディン シー. ハリマン,
ロナルド ティー. ウェスター,
ロナルド ティー. ウェスター,
ミー シェリー,
ミー シェリー,
ジョシュア ジャフミル ケネディー−スミス,
ジョシュア ジャフミル ケネディー−スミス,
マルクス ダールグレン,
マルクス ダールグレン,
サヤン モンデール,
サヤン モンデール,
Original Assignee
ニンバス ラクシュミ, インコーポレイテッド
ニンバス ラクシュミ, インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ニンバス ラクシュミ, インコーポレイテッド, ニンバス ラクシュミ, インコーポレイテッド filed Critical ニンバス ラクシュミ, インコーポレイテッド
Publication of JP2018532706A publication Critical patent/JP2018532706A/ja
Publication of JP2018532706A5 publication Critical patent/JP2018532706A5/ja
Application granted granted Critical
Publication of JP6802263B2 publication Critical patent/JP6802263B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018512319A 2015-09-02 2016-09-01 Tyk2阻害剤およびその使用 Active JP6802263B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562213475P 2015-09-02 2015-09-02
US62/213,475 2015-09-02
US201562214018P 2015-09-03 2015-09-03
US62/214,018 2015-09-03
PCT/US2016/049852 WO2017040757A1 (en) 2015-09-02 2016-09-01 Tyk2 inhibitors and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019109248A Division JP2019172690A (ja) 2015-09-02 2019-06-12 Tyk2阻害剤およびその使用

Publications (3)

Publication Number Publication Date
JP2018532706A JP2018532706A (ja) 2018-11-08
JP2018532706A5 JP2018532706A5 (https=) 2019-07-18
JP6802263B2 true JP6802263B2 (ja) 2020-12-16

Family

ID=58188382

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2018512319A Active JP6802263B2 (ja) 2015-09-02 2016-09-01 Tyk2阻害剤およびその使用
JP2019109248A Withdrawn JP2019172690A (ja) 2015-09-02 2019-06-12 Tyk2阻害剤およびその使用
JP2021093678A Pending JP2021130712A (ja) 2015-09-02 2021-06-03 Tyk2阻害剤およびその使用

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2019109248A Withdrawn JP2019172690A (ja) 2015-09-02 2019-06-12 Tyk2阻害剤およびその使用
JP2021093678A Pending JP2021130712A (ja) 2015-09-02 2021-06-03 Tyk2阻害剤およびその使用

Country Status (5)

Country Link
US (4) US10023571B2 (https=)
EP (2) EP3344624B8 (https=)
JP (3) JP6802263B2 (https=)
TW (1) TWI707852B (https=)
WO (1) WO2017040757A1 (https=)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI788655B (zh) 2015-02-27 2023-01-01 美商林伯士拉克許米公司 酪胺酸蛋白質激酶2(tyk2)抑制劑及其用途
TWI707852B (zh) 2015-09-02 2020-10-21 美商林伯士拉克許米公司 Tyk2 抑制劑及其用途
EP3528816A4 (en) * 2016-10-21 2020-04-08 Nimbus Lakshmi, Inc. TYK2 INHIBITORS AND USES THEREOF
EP3532466A1 (en) 2016-10-26 2019-09-04 E-Therapeutics plc Modulators of hedgehog (hh) signalling pathway
US20180153922A1 (en) 2016-12-06 2018-06-07 New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Inhibition of expansion and function of pathogenic age-associated b cells and use for the prevention and treatment of autoimmune disease
TW202515876A (zh) 2017-03-08 2025-04-16 日商武田藥品工業股份有限公司 Tyk2抑制劑及其用途
CN107235982B (zh) * 2017-06-29 2019-03-26 武汉药明康德新药开发有限公司 叔丁基7-羟基-7,8-二氢-4h-吡唑并二氮杂卓5(6h)羧酸酯的合成方法
SI3658557T1 (sl) 2017-07-28 2024-10-30 Takeda Pharmaceutical Company Limited Zaviralci TYK2 in njihova uporaba
AR117398A1 (es) * 2018-03-12 2021-08-04 Abbvie Inc Inhibidores de la señalización mediada por tirosina cinasa 2
CN113271940A (zh) 2018-10-15 2021-08-17 林伯士拉克许米公司 Tyk2抑制剂和其用途
AR117189A1 (es) 2018-11-02 2021-07-21 Aicuris Gmbh & Co Kg Derivados de 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activos contra el virus de la hepatitis b (vhb)
US12479816B2 (en) * 2019-02-08 2025-11-25 University of Pittsburgh—of the Commonwealth System of Higher Education 20-HETE formation inhibitors
SG11202112043PA (en) 2019-04-30 2021-11-29 Celgene Corp Combination therapies comprising apremilast and tyk2 inhibitors
CN111116456B (zh) * 2019-12-26 2022-01-28 南通华祥医药科技有限公司 一种4,4-二氟哌啶盐酸盐的制备方法
CN111053761B (zh) * 2020-01-16 2022-05-03 杭州旦承医药科技有限公司 一种吸入用双膦酸类药物及其制备方法及其在慢性阻塞性肺疾病的用途
JP7804941B2 (ja) * 2020-03-24 2026-01-23 国立大学法人東海国立大学機構 遺伝性対側性色素異常症治療用医薬組成物、遺伝性対側性色素異常症モデルマウス、および、遺伝性対側性色素異常症治療用化合物のスクリーニング方法
EP4178958A4 (en) * 2020-07-10 2024-12-11 Blossomhill Therapeutics, Inc. MACROCYCLES AND THEIR USE
US20230339977A1 (en) * 2020-08-13 2023-10-26 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compound, and composition and application thereof
CN114075220A (zh) * 2020-08-13 2022-02-22 广东东阳光药业有限公司 取代的杂芳基化合物及其组合物和用途
US20240390369A1 (en) 2021-09-30 2024-11-28 Bristol-Myers Squibb Company Methods for determining responsiveness to tyk2 inhibitors
EP4423086A1 (en) 2021-10-25 2024-09-04 Kymera Therapeutics, Inc. Tyk2 degraders and uses thereof
US20250051360A1 (en) * 2021-12-23 2025-02-13 Sunshine Lake Pharma Co., Ltd. Substituted heteroaryl compound, and composition and use thereof
AU2023204770A1 (en) * 2022-01-05 2024-07-18 Blossomhill Therapeutics, Inc. Macrocyclic compounds and use as kinase inhibitors
CN114674813B (zh) * 2022-03-21 2025-02-07 同济大学 一种利用芳基丙酸类药物半定量检测硫酸根自由基的方法
CN117886669A (zh) * 2024-01-10 2024-04-16 中国农业大学 一种将酰氯还原氘化为氘代醇的方法
CN118955546A (zh) * 2024-07-31 2024-11-15 上海毕得医药科技股份有限公司 一种化合物1-异丙基吡唑-3-硼酸频哪醇酯的合成方法

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516931A (en) 1982-02-01 1996-05-14 Northeastern University Release tag compounds producing ketone signal groups
US5650270A (en) 1982-02-01 1997-07-22 Northeastern University Molecular analytical release tags and their use in chemical analysis
US4709016A (en) 1982-02-01 1987-11-24 Northeastern University Molecular analytical release tags and their use in chemical analysis
US4650750A (en) 1982-02-01 1987-03-17 Giese Roger W Method of chemical analysis employing molecular release tag compounds
JPS63107966A (ja) * 1986-05-22 1988-05-12 Fujisawa Pharmaceut Co Ltd ピリミジン誘導体
DE4430639A1 (de) * 1994-08-29 1996-03-07 Bayer Ag Verwendung von 5-substituierten Pyridin- und Hexahydrochinolin-3-carbonsäurederivaten
DE60037345T2 (de) 1999-12-10 2008-11-13 Pfizer Products Inc., Groton Pyrrolo(2,3-d)pyrimidin-Verbindungen
PE20020354A1 (es) 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
DE60217322T2 (de) 2001-04-27 2007-10-04 Zenyaku Kogyo K.K. Heterocyclische verbindung und antitumormittel, das diese als wirkstoff enthält
TWI329105B (en) 2002-02-01 2010-08-21 Rigel Pharmaceuticals Inc 2,4-pyrimidinediamine compounds and their uses
PT1536827E (pt) 2002-08-14 2009-03-20 Silence Therapeutics Ag Utilização de proteína cinase n beta
AU2004228668B2 (en) 2003-04-03 2011-10-27 Park Funding, Llc PI-3 kinase inhibitor prodrugs
ES2382377T3 (es) 2003-05-30 2012-06-07 Gemin X Pharmaceuticals Canada Inc. Compuestos triheterocíclicos, composiciones, y métodos para tratar cáncer
EP1692153A4 (en) 2003-07-03 2007-03-21 Univ Pennsylvania INHIBITION OF EXPRESSION OF SYK-KINASE
WO2005025504A2 (en) * 2003-09-12 2005-03-24 Kemia, Inc. Modulators of calcitonin and amylin activity
WO2005113556A1 (en) 2004-05-13 2005-12-01 Icos Corporation Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta
AU2006206458B2 (en) 2005-01-19 2012-10-25 Rigel Pharmaceuticals, Inc. Prodrugs of 2,4-pyrimidinediamine compounds and their uses
PL1888550T3 (pl) 2005-05-12 2014-12-31 Abbvie Bahamas Ltd Promotory apoptozy
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
US7521557B2 (en) * 2005-05-20 2009-04-21 Bristol-Myers Squibb Company Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods
US7402325B2 (en) 2005-07-28 2008-07-22 Phoenix Biotechnology, Inc. Supercritical carbon dioxide extract of pharmacologically active components from Nerium oleander
US7989622B2 (en) 2005-10-07 2011-08-02 Exelixis, Inc. Phosphatidylinositol 3-kinase inhibitors and methods of their use
JP5191391B2 (ja) 2005-11-01 2013-05-08 ターゲジェン インコーポレーティッド キナーゼのビ−アリールメタ−ピリミジン阻害剤
SG10202003901UA (en) 2005-12-13 2020-05-28 Incyte Holdings Corp Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
WO2007129161A2 (en) 2006-04-26 2007-11-15 F. Hoffmann-La Roche Ag Thieno [3, 2-d] pyrimidine derivative useful as pi3k inhibitor
DK2526933T3 (en) 2006-09-22 2015-05-18 Pharmacyclics Inc Inhibitors of Bruton's tyrosine kinase
JPWO2008047831A1 (ja) * 2006-10-17 2010-02-25 協和発酵キリン株式会社 Jak阻害剤
KR101566840B1 (ko) 2007-03-12 2015-11-06 와이엠 바이오사이언시즈 오스트레일리아 피티와이 엘티디 페닐 아미노 피리미딘 화합물 및 이의 용도
WO2008118802A1 (en) 2007-03-23 2008-10-02 Regents Of The University Of Minnesota Therapeutic compounds
PE20090717A1 (es) 2007-05-18 2009-07-18 Smithkline Beecham Corp Derivados de quinolina como inhibidores de la pi3 quinasa
EP2211620B1 (en) * 2007-10-25 2013-12-25 Merck Sharp & Dohme Corp. 3-PYRAZIN SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AS JANUS KINASE INHIBITORS FOR THE TREATMENT OF CANCER DISEASES
HUE029767T2 (en) 2008-03-11 2017-04-28 Incyte Holdings Corp JAK inhibitor azetidine and cyclobutane derivatives
EP2299816B1 (en) * 2008-06-18 2013-11-13 Merck Sharp & Dohme Corp. Inhibitors of janus kinases
US8338439B2 (en) 2008-06-27 2012-12-25 Celgene Avilomics Research, Inc. 2,4-disubstituted pyrimidines useful as kinase inhibitors
NZ601267A (en) * 2009-12-23 2014-03-28 Takeda Pharmaceutical Fused heteroaromatic pyrrolidinones as syk inhibitors
AU2014308991B2 (en) * 2013-08-21 2019-02-14 Janssen Biopharma, Inc. Antiviral compounds
WO2015131080A1 (en) 2014-02-28 2015-09-03 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof
TWI788655B (zh) 2015-02-27 2023-01-01 美商林伯士拉克許米公司 酪胺酸蛋白質激酶2(tyk2)抑制劑及其用途
TWI707852B (zh) 2015-09-02 2020-10-21 美商林伯士拉克許米公司 Tyk2 抑制劑及其用途
US10323036B2 (en) 2016-10-14 2019-06-18 Nimbus Lakshmi, Inc. TYK2 inhibitors and uses thereof
EP3528816A4 (en) 2016-10-21 2020-04-08 Nimbus Lakshmi, Inc. TYK2 INHIBITORS AND USES THEREOF
TW202515876A (zh) 2017-03-08 2025-04-16 日商武田藥品工業股份有限公司 Tyk2抑制劑及其用途
SI3658557T1 (sl) 2017-07-28 2024-10-30 Takeda Pharmaceutical Company Limited Zaviralci TYK2 in njihova uporaba
CN113271940A (zh) 2018-10-15 2021-08-17 林伯士拉克许米公司 Tyk2抑制剂和其用途
CA3120866A1 (en) 2018-11-30 2020-06-04 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof
CN113348021B (zh) 2019-01-23 2025-07-11 武田药品工业株式会社 Tyk2抑制剂和其用途

Also Published As

Publication number Publication date
TWI707852B (zh) 2020-10-21
HK1256997A1 (en) 2019-10-11
EP3344624A1 (en) 2018-07-11
US11434240B2 (en) 2022-09-06
EP4327809A2 (en) 2024-02-28
EP3344624B8 (en) 2023-11-29
US20210047319A1 (en) 2021-02-18
EP4327809A3 (en) 2024-04-17
WO2017040757A1 (en) 2017-03-09
EP3344624B1 (en) 2023-10-25
TW201718576A (zh) 2017-06-01
US10781204B2 (en) 2020-09-22
JP2019172690A (ja) 2019-10-10
EP3344624A4 (en) 2019-01-16
US10023571B2 (en) 2018-07-17
JP2018532706A (ja) 2018-11-08
US20180354949A1 (en) 2018-12-13
US20170066763A1 (en) 2017-03-09
US20230074228A1 (en) 2023-03-09
JP2021130712A (ja) 2021-09-09

Similar Documents

Publication Publication Date Title
JP6802263B2 (ja) Tyk2阻害剤およびその使用
JP7498200B2 (ja) Tyk2阻害剤およびその使用
JP6526065B2 (ja) Tyk2阻害剤およびその使用
TWI744225B (zh) 酪胺酸蛋白質激酶2(tyk2)抑制劑及其用途
JP2023546996A (ja) Ctps1阻害剤およびその使用
JP2022509260A (ja) Tyk2阻害剤およびその使用
US20250034147A1 (en) Mdm2 degraders and uses thereof
US20250270200A1 (en) Ctps1 inhibitors and uses thereof
US20260092057A1 (en) Bcl-xl/bcl-2 degraders and uses thereof
HK40106718A (en) Tyk2 inhibitors and uses thereof
HK1256997B (en) Tyk2 inhibitors and uses thereof

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20190612

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20190612

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20200423

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200515

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200817

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20201109

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20201126

R150 Certificate of patent or registration of utility model

Ref document number: 6802263

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250