JP6801846B2 - ３ｄホログラフィックイメージングフローサイトメトリ - Google Patents

３ｄホログラフィックイメージングフローサイトメトリ Download PDF

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JP6801846B2
JP6801846B2 JP2015556256A JP2015556256A JP6801846B2 JP 6801846 B2 JP6801846 B2 JP 6801846B2 JP 2015556256 A JP2015556256 A JP 2015556256A JP 2015556256 A JP2015556256 A JP 2015556256A JP 6801846 B2 JP6801846 B2 JP 6801846B2
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sample
light
detected
flow channel
imaging system
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JP2016511435A5 (enExample
JP2016511435A (ja
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ソン、ヨンジン
ルー、ニヨム
ヤクーブ、ザヒド
ダサリ、ラマチャンドラ
ソ、ピーター、ティー．シー．
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Massachusetts Institute of Technology
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Massachusetts Institute of Technology
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • G01N21/53—Scattering, i.e. diffuse reflection within a body or fluid within a flowing fluid, e.g. smoke
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/04—Processes or apparatus for producing holograms
    • G03H1/0443—Digital holography, i.e. recording holograms with digital recording means
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/04—Processes or apparatus for producing holograms
    • G03H1/08—Synthesising holograms, i.e. holograms synthesized from objects or objects from holograms
    • G03H1/0866—Digital holographic imaging, i.e. synthesizing holobjects from holograms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1434—Optical arrangements
    • G01N2015/144—Imaging characterised by its optical setup
    • G01N2015/1445—Three-dimensional imaging, imaging in different image planes, e.g. under different angles or at different depths, e.g. by a relative motion of sample and detector, for instance by tomography
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/0005—Adaptation of holography to specific applications
    • G03H2001/0033—Adaptation of holography to specific applications in hologrammetry for measuring or analysing
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/0005—Adaptation of holography to specific applications
    • G03H2001/005—Adaptation of holography to specific applications in microscopy, e.g. digital holographic microscope [DHM]
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/04—Processes or apparatus for producing holograms
    • G03H1/0443—Digital holography, i.e. recording holograms with digital recording means
    • G03H2001/0445—Off-axis recording arrangement
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H2210/00—Object characteristics
    • G03H2210/10—Modulation characteristics, e.g. amplitude, phase, polarisation
    • G03H2210/12—Phase modulating object, e.g. living cell

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  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Computing Systems (AREA)
  • Theoretical Computer Science (AREA)
  • Signal Processing (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Microscoopes, Condenser (AREA)
  • Holo Graphy (AREA)
  • Computer Vision & Pattern Recognition (AREA)
JP2015556256A 2013-02-05 2014-02-05 ３ｄホログラフィックイメージングフローサイトメトリ Active JP6801846B2 (ja)

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US201361761079P 2013-02-05 2013-02-05
US61/761,079 2013-02-05
PCT/US2014/014955 WO2014124057A1 (en) 2013-02-05 2014-02-05 3-d holographic imaging flow cytometry

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JP6801846B2 true JP6801846B2 (ja) 2020-12-16

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US (1) US10670510B2 (enExample)
EP (1) EP2954309B1 (enExample)
JP (2) JP6801846B2 (enExample)
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Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014079478A1 (en) 2012-11-20 2014-05-30 Light In Light Srl High speed laser processing of transparent materials
EP2754524B1 (de) * 2013-01-15 2015-11-25 Corning Laser Technologies GmbH Verfahren und Vorrichtung zum laserbasierten Bearbeiten von flächigen Substraten, d.h. Wafer oder Glaselement, unter Verwendung einer Laserstrahlbrennlinie
EP2781296B1 (de) 2013-03-21 2020-10-21 Corning Laser Technologies GmbH Vorrichtung und verfahren zum ausschneiden von konturen aus flächigen substraten mittels laser
US9815730B2 (en) 2013-12-17 2017-11-14 Corning Incorporated Processing 3D shaped transparent brittle substrate
US11556039B2 (en) 2013-12-17 2023-01-17 Corning Incorporated Electrochromic coated glass articles and methods for laser processing the same
US9676167B2 (en) 2013-12-17 2017-06-13 Corning Incorporated Laser processing of sapphire substrate and related applications
US9701563B2 (en) 2013-12-17 2017-07-11 Corning Incorporated Laser cut composite glass article and method of cutting
US9850160B2 (en) 2013-12-17 2017-12-26 Corning Incorporated Laser cutting of display glass compositions
US20150165560A1 (en) 2013-12-17 2015-06-18 Corning Incorporated Laser processing of slots and holes
US9517963B2 (en) 2013-12-17 2016-12-13 Corning Incorporated Method for rapid laser drilling of holes in glass and products made therefrom
US10442719B2 (en) 2013-12-17 2019-10-15 Corning Incorporated Edge chamfering methods
TWI730945B (zh) 2014-07-08 2021-06-21 美商康寧公司 用於雷射處理材料的方法與設備
WO2016010991A1 (en) 2014-07-14 2016-01-21 Corning Incorporated Interface block; system for and method of cutting a substrate being transparent within a range of wavelengths using such interface block
US10611667B2 (en) 2014-07-14 2020-04-07 Corning Incorporated Method and system for forming perforations
JP2017530867A (ja) * 2014-07-14 2017-10-19 コーニング インコーポレイテッド 長さおよび直径の調節可能なレーザビーム焦線を用いて透明材料を加工するためのシステムおよび方法
US10335902B2 (en) 2014-07-14 2019-07-02 Corning Incorporated Method and system for arresting crack propagation
US10047001B2 (en) 2014-12-04 2018-08-14 Corning Incorporated Glass cutting systems and methods using non-diffracting laser beams
FR3030749B1 (fr) * 2014-12-19 2020-01-03 Commissariat A L'energie Atomique Et Aux Energies Alternatives Methode d'identification de particules biologiques par piles d'images holographiques defocalisees
WO2016115017A1 (en) 2015-01-12 2016-07-21 Corning Incorporated Laser cutting of thermally tempered substrates using the multi photon absorption method
WO2016154284A1 (en) 2015-03-24 2016-09-29 Corning Incorporated Laser cutting and processing of display glass compositions
JP2018516215A (ja) 2015-03-27 2018-06-21 コーニング インコーポレイテッド 気体透過性窓、および、その製造方法
KR102499697B1 (ko) 2015-07-10 2023-02-14 코닝 인코포레이티드 유연한 기판 시트에서의 홀의 연속 제조 방법 및 이에 관한 물품
LT6428B (lt) 2015-10-02 2017-07-25 Uab "Altechna R&D" Skaidrių medžiagų lazerinis apdirbimo būdas ir įrenginys
ES2944957T3 (es) 2016-03-16 2023-06-27 Siemens Healthcare Gmbh Diferencial de 5 partes de alta exactitud con microscopía holográfica digital y leucocitos intactos de sangre periférica
WO2017192896A1 (en) 2016-05-06 2017-11-09 Uwm Research Foundation, Inc. Snapshot optical tomography system and method of acquiring an image with the system
JP6938543B2 (ja) 2016-05-06 2021-09-22 コーニング インコーポレイテッド 透明基板からの、輪郭設定された形状のレーザ切断及び取り外し
US10410883B2 (en) 2016-06-01 2019-09-10 Corning Incorporated Articles and methods of forming vias in substrates
KR101865624B1 (ko) * 2016-06-10 2018-06-11 주식회사 토모큐브 파면 제어기를 이용한 초고속 3차원 굴절률 영상 촬영 및 형광 구조화 조도 현미경 시스템 및 이를 이용한 방법
US10794679B2 (en) 2016-06-29 2020-10-06 Corning Incorporated Method and system for measuring geometric parameters of through holes
WO2018022476A1 (en) 2016-07-29 2018-02-01 Corning Incorporated Apparatuses and methods for laser processing
US10522963B2 (en) 2016-08-30 2019-12-31 Corning Incorporated Laser cutting of materials with intensity mapping optical system
US10730783B2 (en) 2016-09-30 2020-08-04 Corning Incorporated Apparatuses and methods for laser processing transparent workpieces using non-axisymmetric beam spots
EP3848333B1 (en) 2016-10-24 2025-12-03 Corning Incorporated Substrate processing station for laser-based machining of sheet-like glass substrates
US10752534B2 (en) 2016-11-01 2020-08-25 Corning Incorporated Apparatuses and methods for laser processing laminate workpiece stacks
US10688599B2 (en) 2017-02-09 2020-06-23 Corning Incorporated Apparatus and methods for laser processing transparent workpieces using phase shifted focal lines
US10983209B2 (en) * 2017-04-12 2021-04-20 Ellumen, Inc. Accurate signal compensations for UWB radar imaging in dispersive medium
US11078112B2 (en) 2017-05-25 2021-08-03 Corning Incorporated Silica-containing substrates with vias having an axially variable sidewall taper and methods for forming the same
US10580725B2 (en) 2017-05-25 2020-03-03 Corning Incorporated Articles having vias with geometry attributes and methods for fabricating the same
EP3413033B1 (en) * 2017-06-09 2020-09-23 Roche Diagnostics GmbH Method and apparatus for determining properties of a laboratory sample contained in a laboratory sample container
US10626040B2 (en) 2017-06-15 2020-04-21 Corning Incorporated Articles capable of individual singulation
CN110799829B (zh) * 2017-07-06 2023-01-03 特拉维夫大学拉莫特有限公司 用于在环境室中的生物细胞样品的三维无标记光学成像的系统和方法
CN107271421A (zh) * 2017-07-27 2017-10-20 深圳中科芯海智能科技有限公司 一种液体样品中的微粒荧光检测装置
KR20200049800A (ko) * 2017-08-25 2020-05-08 코닝 인코포레이티드 어포컬 빔 조정 조립체를 사용하여 투명 가공물을 레이저 가공하는 장치 및 방법
EP3462170B1 (en) 2017-09-29 2020-09-16 Siemens Healthcare GmbH Specific malaria detection with digital optical microscopy
EP3697533A1 (en) * 2017-10-16 2020-08-26 Scherr, Steven Systems and methods for particulate encapsulation in microdroplets
US12180108B2 (en) 2017-12-19 2024-12-31 Corning Incorporated Methods for etching vias in glass-based articles employing positive charge organic molecules
US11554984B2 (en) 2018-02-22 2023-01-17 Corning Incorporated Alkali-free borosilicate glasses with low post-HF etch roughness
WO2020014858A1 (zh) * 2018-07-17 2020-01-23 深圳大学 一种基于光纤马赫-曾德尔干涉仪的生物传感器及其制作方法
WO2020261826A1 (ja) 2019-06-28 2020-12-30 富士フイルム株式会社 画像処理装置、評価システム、画像処理プログラム及び画像処理方法
WO2021240512A1 (en) * 2020-05-25 2021-12-02 Ramot At Tel-Aviv University Ltd. A tomography system and a method for analysis of biological cells
JP7495301B2 (ja) 2020-08-28 2024-06-04 浜松ホトニクス株式会社 学習モデル生成方法、識別方法、学習モデル生成システム、識別システム、学習モデル生成プログラム、識別プログラム及び記録媒体
RU2770567C1 (ru) * 2021-06-26 2022-04-18 федеральное государственное бюджетное образовательное учреждение высшего образования «Донской государственный технический университет», (ДГТУ) Способ голографического анализа взвешенных частиц
JP2024022034A (ja) * 2022-08-05 2024-02-16 浜松ホトニクス株式会社 プログラムされた細胞死を起こした細胞の領域を決定する方法、決定部を備える装置及び決定ステップを含む情報処理プログラム
CN116540212A (zh) * 2023-07-06 2023-08-04 中国空气动力研究与发展中心超高速空气动力研究所 一种三维成像装置及方法
EP4592637A1 (en) * 2024-01-29 2025-07-30 Mitutoyo Corporation Method for determining a surface map and imaging system for same
WO2025168660A1 (de) * 2024-02-06 2025-08-14 Leibniz-Institut Für Naturstoff-Forschung Und Infektionsbiologie E. V. - Hans-Knöll-Institut (Hki) Optische messvorrichtung, messverfahren und auswerteverfahren
CN119470168B (zh) * 2024-11-04 2025-07-25 上海健康医学院 一种纳米制剂与细胞相互作用评测方法、装置及设备

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4293221A (en) * 1979-04-17 1981-10-06 Research Corporation Multidimensional slit-scan flow system
US5633714A (en) 1994-12-19 1997-05-27 International Business Machines Corporation Preprocessing of image amplitude and phase data for CD and OL measurement
US6744038B2 (en) 2000-11-13 2004-06-01 Genoptix, Inc. Methods of separating particles using an optical gradient
CA2432210A1 (en) * 2000-12-29 2002-08-01 Chromagen, Inc. Scanning spectrophotometer for high throughput fluorescence detection
US7365858B2 (en) 2001-12-18 2008-04-29 Massachusetts Institute Of Technology Systems and methods for phase measurements
DE10254139A1 (de) 2002-11-15 2004-05-27 Carl Zeiss Jena Gmbh Verfahren und Anordnung zur tiefenaufgelösten optischen Erfassung einer Probe
WO2006010253A1 (en) 2004-07-30 2006-02-02 University Of Victoria Innovation And Development Corporation Confocal scanning holography microscope
EP1864112B1 (en) 2005-03-25 2015-05-06 Massachusetts Institute of Technology Device and method for hilbert phase imaging
WO2007019548A2 (en) 2005-08-08 2007-02-15 Zetetic Institute Apparatus and methods for reduction and compensation of effects of vibrations and of environmental effects in wavefront interferometry
EP2010885B1 (en) 2006-04-07 2020-06-03 Ecole Polytechnique Fédérale de Lausanne Method and apparatus to measure and compute the amplitude point spread function and associated parameters of a coherent optical imaging system
US7633631B2 (en) 2007-04-04 2009-12-15 Nikon Corporation Three-dimensional microscope and method for obtaining three-dimensional image
US8848199B2 (en) * 2007-07-10 2014-09-30 Massachusetts Institute Of Technology Tomographic phase microscopy
CA2756045A1 (en) 2009-03-20 2010-09-23 Biorad Laboratories, Inc. Serial-line-scan-encoded multi-color fluorescence microscopy and imaging flow cytometry
CN103238120B (zh) * 2010-11-12 2016-08-10 布鲁塞尔大学 用于表征透明颗粒的光学方法
US8896840B2 (en) 2012-04-25 2014-11-25 Canon Kabushiki Kaisha Interferometric method and digital holographic microscope

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Publication number Publication date
EP2954309A1 (en) 2015-12-16
JP6958964B2 (ja) 2021-11-02
JP2016511435A (ja) 2016-04-14
EP2954309B1 (en) 2019-08-28
US20140333929A1 (en) 2014-11-13
JP2019148798A (ja) 2019-09-05
US10670510B2 (en) 2020-06-02
WO2014124057A1 (en) 2014-08-14

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