JP6793657B2 - 置換三環式ヘテロ環式化合物 - Google Patents

置換三環式ヘテロ環式化合物 Download PDF

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Publication number
JP6793657B2
JP6793657B2 JP2017549092A JP2017549092A JP6793657B2 JP 6793657 B2 JP6793657 B2 JP 6793657B2 JP 2017549092 A JP2017549092 A JP 2017549092A JP 2017549092 A JP2017549092 A JP 2017549092A JP 6793657 B2 JP6793657 B2 JP 6793657B2
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phenyl
dihydro
pyrrolo
imidazo
pyridine
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Japanese (ja)
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JP2018508553A5 (OSRAM
JP2018508553A (ja
Inventor
ハイ−ユン・シャオ
ティ・ジー・ムラリ・ダール
ジンウー・ドワン
ビン・ジアン
アンドリュー・ジェイ・テベン
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Bristol Myers Squibb Co
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Bristol Myers Squibb Co
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
JP2017549092A 2015-03-18 2016-03-17 置換三環式ヘテロ環式化合物 Active JP6793657B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562134769P 2015-03-18 2015-03-18
US62/134,769 2015-03-18
PCT/US2016/022737 WO2016149436A1 (en) 2015-03-18 2016-03-17 Substituted tricyclic heterocyclic compounds

Publications (3)

Publication Number Publication Date
JP2018508553A JP2018508553A (ja) 2018-03-29
JP2018508553A5 JP2018508553A5 (OSRAM) 2019-04-25
JP6793657B2 true JP6793657B2 (ja) 2020-12-02

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ID=55640932

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JP2017549092A Active JP6793657B2 (ja) 2015-03-18 2016-03-17 置換三環式ヘテロ環式化合物

Country Status (14)

Country Link
US (1) US10189840B2 (OSRAM)
EP (1) EP3271360B1 (OSRAM)
JP (1) JP6793657B2 (OSRAM)
KR (1) KR102654709B1 (OSRAM)
CN (1) CN107635993B (OSRAM)
AU (1) AU2016233288A1 (OSRAM)
BR (1) BR112017019773A2 (OSRAM)
CA (1) CA2980159A1 (OSRAM)
EA (1) EA032315B1 (OSRAM)
ES (1) ES2797805T3 (OSRAM)
IL (1) IL254424A0 (OSRAM)
MX (1) MX2017011434A (OSRAM)
SG (1) SG11201707469WA (OSRAM)
WO (1) WO2016149436A1 (OSRAM)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
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WO2016149439A1 (en) 2015-03-18 2016-09-22 Bristol-Myers Squibb Company Heterocyclic compounds useful as inhibitors of tnf
CA2982446A1 (en) 2015-03-18 2016-09-22 Bristol-Myers Squibb Company Tricyclic heterocyclic compounds useful as inhibitors of tnf
EP3294726A1 (en) 2015-04-17 2018-03-21 AbbVie Inc. Indazolones as modulators of tnf signaling
WO2016168641A1 (en) 2015-04-17 2016-10-20 Abbvie Inc. Tricyclic modulators of tnf signaling
AR104293A1 (es) 2015-04-17 2017-07-12 Abbvie Inc Indazolonas como moduladores de la señalización de tnf
GB201510758D0 (en) 2015-06-18 2015-08-05 Ucb Biopharma Sprl Novel TNFa structure for use in therapy
EP3331889B1 (en) 2015-08-03 2020-09-23 Bristol-Myers Squibb Company Cyclic compounds useful as modulators of tnf alpha
GB201621907D0 (en) 2016-12-21 2017-02-01 Ucb Biopharma Sprl And Sanofi Antibody epitope
WO2018167176A1 (en) 2017-03-15 2018-09-20 Ucb Biopharma Sprl Fused pentacyclic imidazole derivatives as modulators of tnf activity

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AU741772B2 (en) 1997-02-25 2001-12-06 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Substituted benzimidazoles as non-nucleoside inhibitors of reverse transcriptase
EP1224185B1 (en) * 1999-10-27 2005-11-30 Novartis AG Thiazole and imidazo[4,5-b]pyridine compounds and their pharmaceutical use
US7601846B2 (en) 2001-06-26 2009-10-13 The Regents Of The University Of California Compounds having activity as inhibitors of apoptosis
EP1479681A4 (en) 2002-01-31 2006-05-10 Daiichi Seiyaku Co IMIDAZO (1,2-a) pyridine
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US20050124638A1 (en) 2003-12-08 2005-06-09 Swayze Eric E. Benzimidazoles and analogs thereof as antivirals
EP2173747B1 (en) * 2007-06-26 2011-12-21 Sanofi A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles
FR2919610B1 (fr) * 2007-08-02 2009-10-16 Sanofi Aventis Sa Derives de n-heteroaryl-carboxamides tricycliques,leur preparation et leur application en therapeutique
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JP2009227599A (ja) 2008-03-21 2009-10-08 Daiichi Sankyo Co Ltd イミダゾピリダジン誘導体
CN101717397B (zh) 2008-10-09 2012-11-28 中国科学院上海药物研究所 一类取代吡啶并[2',1':2,3]咪唑并[4,5-c]异喹啉酮类化合物及其合成方法和用途,以及包含该类化合物的药物组合物
JP5487214B2 (ja) * 2008-12-19 2014-05-07 ブリストル−マイヤーズ スクイブ カンパニー キナーゼ阻害剤として有用なカルバゾールカルボキシアミド化合物
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GB201321744D0 (en) 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
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CA2982446A1 (en) 2015-03-18 2016-09-22 Bristol-Myers Squibb Company Tricyclic heterocyclic compounds useful as inhibitors of tnf

Also Published As

Publication number Publication date
EP3271360A1 (en) 2018-01-24
IL254424A0 (en) 2017-11-30
US10189840B2 (en) 2019-01-29
JP2018508553A (ja) 2018-03-29
EA032315B1 (ru) 2019-05-31
CA2980159A1 (en) 2016-09-22
EA201792034A1 (ru) 2018-03-30
CN107635993B (zh) 2020-05-22
SG11201707469WA (en) 2017-10-30
ES2797805T3 (es) 2020-12-03
KR102654709B1 (ko) 2024-04-03
AU2016233288A1 (en) 2017-11-09
KR20170129810A (ko) 2017-11-27
US20180111936A1 (en) 2018-04-26
EP3271360B1 (en) 2020-04-22
BR112017019773A2 (pt) 2018-05-15
CN107635993A (zh) 2018-01-26
WO2016149436A1 (en) 2016-09-22
MX2017011434A (es) 2018-01-25

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