JP6792745B2 - オピオイド化合物を調製するプロセス - Google Patents

オピオイド化合物を調製するプロセス Download PDF

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Publication number
JP6792745B2
JP6792745B2 JP2016565669A JP2016565669A JP6792745B2 JP 6792745 B2 JP6792745 B2 JP 6792745B2 JP 2016565669 A JP2016565669 A JP 2016565669A JP 2016565669 A JP2016565669 A JP 2016565669A JP 6792745 B2 JP6792745 B2 JP 6792745B2
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formula
compound
hpo
range
amount
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Japanese (ja)
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JP2017514846A5 (cg-RX-API-DMAC7.html
JP2017514846A (ja
Inventor
コンツァ・マッテオ
レレク・ビット
ツィンザー・ハルトムート
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Noramco LLC
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Noramco LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
    • C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
    • C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2016565669A 2014-05-05 2015-04-28 オピオイド化合物を調製するプロセス Active JP6792745B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461988523P 2014-05-05 2014-05-05
US61/988,523 2014-05-05
US14/689,712 2015-04-17
US14/689,712 US9701688B2 (en) 2014-05-05 2015-04-17 Process for the preparation of opioid compounds
PCT/US2015/027912 WO2015171354A2 (en) 2014-05-05 2015-04-28 Process for the preparation of opioid compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020021254A Division JP2020073598A (ja) 2014-05-05 2020-02-12 オピオイド化合物を調製するプロセス

Publications (3)

Publication Number Publication Date
JP2017514846A JP2017514846A (ja) 2017-06-08
JP2017514846A5 JP2017514846A5 (cg-RX-API-DMAC7.html) 2018-06-14
JP6792745B2 true JP6792745B2 (ja) 2020-12-02

Family

ID=54354748

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016565669A Active JP6792745B2 (ja) 2014-05-05 2015-04-28 オピオイド化合物を調製するプロセス
JP2020021254A Pending JP2020073598A (ja) 2014-05-05 2020-02-12 オピオイド化合物を調製するプロセス

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2020021254A Pending JP2020073598A (ja) 2014-05-05 2020-02-12 オピオイド化合物を調製するプロセス

Country Status (9)

Country Link
US (1) US9701688B2 (cg-RX-API-DMAC7.html)
EP (1) EP3140308B8 (cg-RX-API-DMAC7.html)
JP (2) JP6792745B2 (cg-RX-API-DMAC7.html)
CN (1) CN107001381A (cg-RX-API-DMAC7.html)
AU (3) AU2015256416B2 (cg-RX-API-DMAC7.html)
CA (2) CA3208298A1 (cg-RX-API-DMAC7.html)
DK (1) DK3140308T3 (cg-RX-API-DMAC7.html)
ES (1) ES2946177T3 (cg-RX-API-DMAC7.html)
WO (1) WO2015171354A2 (cg-RX-API-DMAC7.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201716830D0 (en) 2017-10-13 2017-11-29 Cambrex Charles City Inc New Process
WO2023102489A1 (en) * 2021-12-03 2023-06-08 Board Of Regents Of The University Of Nebraska Compounds, nanoparticles, and pharmaceutical compositions for the treatment of drug addiction

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3474101A (en) 1960-09-05 1969-10-21 Reckitt & Sons Ltd Thebaine and oripavine derivatives
CA2674915C (en) 2006-10-17 2015-06-30 Penick Corporation Process for preparing oxymorphone
US20080125592A1 (en) 2006-10-17 2008-05-29 Penick Corporation Process for preparing oxymorphone, naltrexone, and buprenorphine
EP2101773A2 (en) 2006-11-22 2009-09-23 Progenics Pharmaceuticals, Inc. (r)-n-stereoisomers of 7,8-saturated-4,5-epoxy-morphinanium analogs
EP2180000B1 (en) 2007-05-04 2013-03-27 Mallinckrodt LLC Improved process for the preparation of 6-alpha-hydroxy-n-alkylated opiates
US8962841B2 (en) 2007-06-29 2015-02-24 Brock University Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids
CN101861315B (zh) 2007-11-20 2013-01-16 日产化学工业株式会社 2-氮杂金刚烷类的制造方法
AU2009233315B2 (en) * 2008-03-31 2013-08-29 Sun Pharmaceutical Industries Ltd. An improved process for the preparation of morphinane analogues
EP2328900B1 (en) 2008-08-11 2013-08-28 Tasmanian Alkaloids Pty. Ltd. PROCESS FOR MAKING MORPHINAN-6 alpha-OLS
ES2529057T3 (es) 2008-09-30 2015-02-16 Mallinckrodt Inc. Procedimientos para la hidrogenación de derivados de alcaloides opiáceos
ES2477190T3 (es) 2008-09-30 2014-07-16 Mallinckrodt Llc Procedimiento de reciclaje para aumentar el rendimiento de una reacción de Grignard en la preparación de derivados alcaloides opiáceos
AU2009300384B2 (en) 2008-09-30 2014-10-02 SpecGx LLC Processes for increasing the yield of opiate alkaloid derivatives
ES2566559T3 (es) 2008-09-30 2016-04-13 Mallinckrodt Llc Procesos para la alquilación de grupos amino secundarios de derivados de morfinano
WO2010039216A1 (en) 2008-09-30 2010-04-08 Mallinckrodt Inc. Processes for the alkylation of norbuprenorphine with reduced impurity formation
US8431701B2 (en) 2009-02-17 2013-04-30 Mallinckrodt Llc Process for the reductive alkylation of normorphinans
WO2010121369A1 (en) 2009-04-24 2010-10-28 Brock University Processes for the preparation of morphinane and morphinone compounds
US20110269964A1 (en) * 2010-04-29 2011-11-03 Mallinckrodt Inc. N-Alkylation of Opiates
AU2011263416B2 (en) * 2010-06-11 2014-04-10 Rhodes Technologies Process for N-dealkylation of tertiary amines
RS55777B1 (sr) * 2010-11-05 2017-07-31 H Lundbeck As Postupak za proizvodnju naltreksona
WO2012149633A1 (en) * 2011-05-02 2012-11-08 Brock University Processes and intermediates in the preparation of morphine analogs via n-demethylation of n-oxides using cyclodehydration reagents
GB2509659B (en) 2011-10-03 2019-01-09 Johnson Matthey Plc Process for the 3-O-demethylation of morphinan compounds
WO2013113120A1 (en) 2012-02-03 2013-08-08 Tomas Hudlicky Process for the preparation of morphine analogs via the reaction of organometallic reagents with an oxazolidine derived from morphinans
AR090916A1 (es) * 2012-05-03 2014-12-17 Lundbeck & Co As H Metodo para la fabricacion de naltrexona

Also Published As

Publication number Publication date
AU2020201990A1 (en) 2020-04-09
AU2018203948B2 (en) 2019-12-19
CA2947012C (en) 2023-09-26
DK3140308T3 (da) 2023-06-19
AU2015256416A1 (en) 2016-11-24
WO2015171354A2 (en) 2015-11-12
AU2018203948A1 (en) 2018-06-21
EP3140308B1 (en) 2023-05-24
EP3140308B8 (en) 2023-06-28
CA3208298A1 (en) 2015-11-12
WO2015171354A3 (en) 2016-03-17
ES2946177T3 (es) 2023-07-13
CA2947012A1 (en) 2015-11-12
CN107001381A (zh) 2017-08-01
AU2015256416B2 (en) 2018-03-08
JP2017514846A (ja) 2017-06-08
EP3140308A2 (en) 2017-03-15
US20150315205A1 (en) 2015-11-05
JP2020073598A (ja) 2020-05-14
US9701688B2 (en) 2017-07-11

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