JP6781403B2 - ペプチド混合物 - Google Patents

ペプチド混合物 Download PDF

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Publication number
JP6781403B2
JP6781403B2 JP2016557194A JP2016557194A JP6781403B2 JP 6781403 B2 JP6781403 B2 JP 6781403B2 JP 2016557194 A JP2016557194 A JP 2016557194A JP 2016557194 A JP2016557194 A JP 2016557194A JP 6781403 B2 JP6781403 B2 JP 6781403B2
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peptide
amino acid
seq
mutation
peptides
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JP2017502081A (ja
JP2017502081A5 (enExample
Inventor
ジョン アムンド エリクセン
ジョン アムンド エリクセン
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タルゴバックス エーエスエー
タルゴバックス エーエスエー
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001154Enzymes
    • A61K39/001164GTPases, e.g. Ras or Rho
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82Translation products from oncogenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047Cells of the immune system
    • G01N33/505Cells of the immune system involving T-cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5158Antigen-pulsed cells, e.g. T-cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/82Translation products from oncogenes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
JP2016557194A 2013-12-09 2014-12-09 ペプチド混合物 Active JP6781403B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13196333 2013-12-09
EP13196333.2 2013-12-09
PCT/EP2014/077033 WO2015086590A2 (en) 2013-12-09 2014-12-09 A peptide mixture

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019183442A Division JP2020023525A (ja) 2013-12-09 2019-10-04 ペプチド混合物

Publications (3)

Publication Number Publication Date
JP2017502081A JP2017502081A (ja) 2017-01-19
JP2017502081A5 JP2017502081A5 (enExample) 2018-01-25
JP6781403B2 true JP6781403B2 (ja) 2020-11-04

Family

ID=49765823

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016557194A Active JP6781403B2 (ja) 2013-12-09 2014-12-09 ペプチド混合物
JP2019183442A Pending JP2020023525A (ja) 2013-12-09 2019-10-04 ペプチド混合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019183442A Pending JP2020023525A (ja) 2013-12-09 2019-10-04 ペプチド混合物

Country Status (24)

Country Link
US (4) US9775892B2 (enExample)
EP (5) EP3363458A3 (enExample)
JP (2) JP6781403B2 (enExample)
KR (1) KR20160097290A (enExample)
CN (1) CN105980403A (enExample)
AU (2) AU2014363643B2 (enExample)
BR (1) BR112016013138A2 (enExample)
CA (1) CA2933126A1 (enExample)
CL (4) CL2016001405A1 (enExample)
CY (1) CY1120578T1 (enExample)
DK (1) DK3079715T3 (enExample)
ES (1) ES2682038T3 (enExample)
HR (1) HRP20181213T1 (enExample)
HU (1) HUE039840T2 (enExample)
IL (1) IL246007B2 (enExample)
LT (1) LT3079715T (enExample)
MX (1) MX2016007429A (enExample)
PL (1) PL3079715T3 (enExample)
PT (1) PT3079715T (enExample)
RS (1) RS57623B1 (enExample)
RU (1) RU2016127327A (enExample)
SG (2) SG10201811172PA (enExample)
SI (1) SI3079715T1 (enExample)
WO (1) WO2015086590A2 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9775892B2 (en) 2013-12-09 2017-10-03 Targovax Asa Peptide mixture
CN106414493A (zh) 2014-05-06 2017-02-15 塔格瓦克斯公司 包含突变的ras肽和化疗剂的肽疫苗
EP3576780A1 (en) 2017-02-01 2019-12-11 Modernatx, Inc. Immunomodulatory therapeutic mrna compositions encoding activating oncogene mutation peptides
AU2018288386A1 (en) * 2017-06-22 2020-02-06 New South Wales Health Pathology Adoptive T cell therapy 2
CA3103983A1 (en) * 2018-06-19 2019-12-26 Biontech Us Inc. Neoantigens and uses thereof
WO2020002650A1 (en) 2018-06-29 2020-01-02 Targovax Asa A formulation
JP2021534752A (ja) * 2018-08-22 2021-12-16 フレッド ハッチンソン キャンサー リサーチ センター Kras抗原またはher2抗原を標的とする免疫療法
GB2596461B (en) 2019-02-20 2023-09-27 Fred Hutchinson Cancer Center Binding proteins specific for RAS neoantigens and uses thereof
WO2021009633A1 (en) * 2019-07-12 2021-01-21 Massey University Synthetic chromatin vaccine
US12453774B2 (en) 2019-11-07 2025-10-28 Genoimmune Therapeutics Co., Ltd. Tumor immunotherapy polypeptide and application thereof
CN113416241B (zh) * 2020-04-09 2022-04-08 北京臻知医学科技有限责任公司 一种用于诱导肿瘤特异性免疫响应的通用型抗原肽库及试剂盒
CN116710115A (zh) 2020-11-20 2023-09-05 思维疗法股份有限公司 用于优化的肽疫苗的组合物和方法
US11058751B1 (en) 2020-11-20 2021-07-13 Think Therapeutics, Inc. Compositions for optimized RAS peptide vaccines
US11421015B2 (en) 2020-12-07 2022-08-23 Think Therapeutics, Inc. Method of compact peptide vaccines using residue optimization
KR102515083B1 (ko) 2020-12-24 2023-03-29 부산대학교 산학협력단 폴더블 페로브스카이트 태양전지 및 이의 제조 방법
EP4293043A4 (en) * 2021-02-10 2025-09-10 Shanghai Genbase Biotechnology Co Ltd EPITOPE PEPTIDE OF THE RAS G13D MUTANT AND T LYMPHOCYTE RECEPTOR RECOGNIZING THE RAS G13D MUTANT
US11464842B1 (en) 2021-04-28 2022-10-11 Think Therapeutics, Inc. Compositions and method for optimized peptide vaccines using residue optimization
EP4522192A2 (en) * 2022-05-12 2025-03-19 The Johns Hopkins University Neoantigen vaccines for cancer prevention
JP2025538524A (ja) * 2022-11-22 2025-11-28 エリクサージェン セラピューティクス,インコーポレイティド 癌免疫療法のための抗原

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9103974D0 (en) 1991-02-26 1991-04-10 Norsk Hydro As Therapeutically useful peptides or peptide fragments
GB2328689A (en) * 1997-08-27 1999-03-03 Norsk Hydro As Peptides based on the p21 ras proto-oncogene protein for the treatment of cancer
NO309798B1 (no) * 1999-04-30 2001-04-02 Targovax As Peptidblanding, samt farmasoytisk sammensetning og kreftvaksine som innbefatter peptidblandingen
AU2003301021C1 (en) 2002-12-16 2010-02-18 Globelmmune, Inc. Yeast-based vaccines as immunotherapy
PL1760089T3 (pl) 2005-09-05 2010-03-31 Immatics Biotechnologies Gmbh Peptydy towarzyszące nowotworom, wiążące się z cząsteczkami klasy I i II antygenów ludzkich leukocytów (HLA) i związana z nimi szczepionka przeciwnowotworowa
CN101448848B (zh) * 2006-03-27 2013-12-04 全球免疫股份有限公司 Ras突变及其相关组合物和方法
US20140199405A1 (en) 2013-01-11 2014-07-17 Abraxis Bioscience, Llc Method for treating cancer based on mutation status of k-ras
US9775892B2 (en) 2013-12-09 2017-10-03 Targovax Asa Peptide mixture
CN106414493A (zh) 2014-05-06 2017-02-15 塔格瓦克斯公司 包含突变的ras肽和化疗剂的肽疫苗

Also Published As

Publication number Publication date
BR112016013138A2 (pt) 2018-01-16
US10335473B2 (en) 2019-07-02
HRP20181213T1 (hr) 2018-10-19
JP2020023525A (ja) 2020-02-13
CL2018000226A1 (es) 2018-06-22
PT3079715T (pt) 2018-08-02
US20170189515A1 (en) 2017-07-06
EP3079715B1 (en) 2018-06-13
AU2014363643A1 (en) 2016-07-14
AU2014363643B2 (en) 2019-01-03
KR20160097290A (ko) 2016-08-17
US20180021419A1 (en) 2018-01-25
LT3079715T (lt) 2018-08-27
RS57623B1 (sr) 2018-11-30
EP3363458A2 (en) 2018-08-22
EP3363457A1 (en) 2018-08-22
US10456457B2 (en) 2019-10-29
IL246007B1 (en) 2023-01-01
CY1120578T1 (el) 2019-07-10
CN105980403A (zh) 2016-09-28
SG10201811172PA (en) 2019-01-30
WO2015086590A2 (en) 2015-06-18
WO2015086590A3 (en) 2015-07-30
US10596239B2 (en) 2020-03-24
MX2016007429A (es) 2016-11-11
CL2018000238A1 (es) 2018-06-22
HUE039840T2 (hu) 2019-02-28
JP2017502081A (ja) 2017-01-19
US20160331820A1 (en) 2016-11-17
EP3369432A1 (en) 2018-09-05
AU2019201937A1 (en) 2019-04-11
SI3079715T1 (en) 2018-08-31
CA2933126A1 (en) 2015-06-18
SG11201604644QA (en) 2016-07-28
PL3079715T3 (pl) 2018-11-30
EP3079715A2 (en) 2016-10-19
CL2018000232A1 (es) 2018-06-22
IL246007A (en) 2016-07-31
RU2016127327A (ru) 2018-01-23
AU2019201937B2 (en) 2020-05-28
EP3363458A3 (en) 2018-11-07
CL2016001405A1 (es) 2017-03-24
US9775892B2 (en) 2017-10-03
ES2682038T3 (es) 2018-09-18
EP3357505A1 (en) 2018-08-08
US20170326218A1 (en) 2017-11-16
DK3079715T3 (en) 2018-09-17
IL246007B2 (en) 2023-05-01

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