JP6781403B2 - ペプチド混合物 - Google Patents

ペプチド混合物 Download PDF

Info

Publication number
JP6781403B2
JP6781403B2 JP2016557194A JP2016557194A JP6781403B2 JP 6781403 B2 JP6781403 B2 JP 6781403B2 JP 2016557194 A JP2016557194 A JP 2016557194A JP 2016557194 A JP2016557194 A JP 2016557194A JP 6781403 B2 JP6781403 B2 JP 6781403B2
Authority
JP
Japan
Prior art keywords
peptide
amino acid
seq
mutation
peptides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016557194A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017502081A (ja
JP2017502081A5 (enExample
Inventor
ジョン アムンド エリクセン
ジョン アムンド エリクセン
Original Assignee
タルゴバックス エーエスエー
タルゴバックス エーエスエー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by タルゴバックス エーエスエー, タルゴバックス エーエスエー filed Critical タルゴバックス エーエスエー
Publication of JP2017502081A publication Critical patent/JP2017502081A/ja
Publication of JP2017502081A5 publication Critical patent/JP2017502081A5/ja
Application granted granted Critical
Publication of JP6781403B2 publication Critical patent/JP6781403B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001154Enzymes
    • A61K39/001164GTPases, e.g. Ras or Rho
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82Translation products from oncogenes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047Cells of the immune system
    • G01N33/505Cells of the immune system involving T-cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515Animal cells
    • A61K2039/5158Antigen-pulsed cells, e.g. T-cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/82Translation products from oncogenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
JP2016557194A 2013-12-09 2014-12-09 ペプチド混合物 Active JP6781403B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13196333.2 2013-12-09
EP13196333 2013-12-09
PCT/EP2014/077033 WO2015086590A2 (en) 2013-12-09 2014-12-09 A peptide mixture

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2019183442A Division JP2020023525A (ja) 2013-12-09 2019-10-04 ペプチド混合物

Publications (3)

Publication Number Publication Date
JP2017502081A JP2017502081A (ja) 2017-01-19
JP2017502081A5 JP2017502081A5 (enExample) 2018-01-25
JP6781403B2 true JP6781403B2 (ja) 2020-11-04

Family

ID=49765823

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2016557194A Active JP6781403B2 (ja) 2013-12-09 2014-12-09 ペプチド混合物
JP2019183442A Pending JP2020023525A (ja) 2013-12-09 2019-10-04 ペプチド混合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2019183442A Pending JP2020023525A (ja) 2013-12-09 2019-10-04 ペプチド混合物

Country Status (24)

Country Link
US (4) US9775892B2 (enExample)
EP (5) EP3363458A3 (enExample)
JP (2) JP6781403B2 (enExample)
KR (1) KR20160097290A (enExample)
CN (1) CN105980403A (enExample)
AU (2) AU2014363643B2 (enExample)
BR (1) BR112016013138A2 (enExample)
CA (1) CA2933126A1 (enExample)
CL (4) CL2016001405A1 (enExample)
CY (1) CY1120578T1 (enExample)
DK (1) DK3079715T3 (enExample)
ES (1) ES2682038T3 (enExample)
HR (1) HRP20181213T1 (enExample)
HU (1) HUE039840T2 (enExample)
IL (1) IL246007B2 (enExample)
LT (1) LT3079715T (enExample)
MX (1) MX2016007429A (enExample)
PL (1) PL3079715T3 (enExample)
PT (1) PT3079715T (enExample)
RS (1) RS57623B1 (enExample)
RU (1) RU2016127327A (enExample)
SG (2) SG11201604644QA (enExample)
SI (1) SI3079715T1 (enExample)
WO (1) WO2015086590A2 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3079715T (pt) 2013-12-09 2018-08-02 Targovax Asa Uma mistura de péptidos
KR20170002563A (ko) 2014-05-06 2017-01-06 타르고바스 에이에스에이 돌연변이 ras 펩타이드를 포함하는 펩타이드 백신 및 화학 요법제
EP3576780A1 (en) * 2017-02-01 2019-12-11 Modernatx, Inc. Immunomodulatory therapeutic mrna compositions encoding activating oncogene mutation peptides
EP3641807A4 (en) * 2017-06-22 2021-04-21 The Westmead Institute For Medical Research Adoptive t cell therapy 2
WO2019246286A1 (en) * 2018-06-19 2019-12-26 Neon Therapeutics, Inc. Neoantigens and uses thereof
WO2020002650A1 (en) 2018-06-29 2020-01-02 Targovax Asa A formulation
KR20210049119A (ko) * 2018-08-22 2021-05-04 프레드 헛친슨 켄서 리서치 센터 Kras 또는 her2 항원을 표적으로 하는 면역요법
GB2596461B (en) 2019-02-20 2023-09-27 Fred Hutchinson Cancer Center Binding proteins specific for RAS neoantigens and uses thereof
MX2021012004A (es) * 2019-03-30 2021-11-04 Biontech Us Inc Composiciones y metodos para preparar composiciones de celulas t y usos de las mismas.
WO2021009633A1 (en) * 2019-07-12 2021-01-21 Massey University Synthetic chromatin vaccine
WO2021087840A1 (zh) * 2019-11-07 2021-05-14 武汉华大吉诺因生物科技有限公司 肿瘤免疫治疗多肽及其应用
CN113416241B (zh) * 2020-04-09 2022-04-08 北京臻知医学科技有限责任公司 一种用于诱导肿瘤特异性免疫响应的通用型抗原肽库及试剂盒
US11421015B2 (en) 2020-12-07 2022-08-23 Think Therapeutics, Inc. Method of compact peptide vaccines using residue optimization
US11058751B1 (en) 2020-11-20 2021-07-13 Think Therapeutics, Inc. Compositions for optimized RAS peptide vaccines
CN116710115A (zh) 2020-11-20 2023-09-05 思维疗法股份有限公司 用于优化的肽疫苗的组合物和方法
KR102515083B1 (ko) 2020-12-24 2023-03-29 부산대학교 산학협력단 폴더블 페로브스카이트 태양전지 및 이의 제조 방법
EP4293043A4 (en) * 2021-02-10 2025-09-10 Shanghai Genbase Biotechnology Co Ltd EPITOPE PEPTIDE OF THE RAS G13D MUTANT AND T LYMPHOCYTE RECEPTOR RECOGNIZING THE RAS G13D MUTANT
US11464842B1 (en) 2021-04-28 2022-10-11 Think Therapeutics, Inc. Compositions and method for optimized peptide vaccines using residue optimization
WO2023220434A2 (en) * 2022-05-12 2023-11-16 The Johns Hopkins University Neoantigen vaccines for cancer prevention
EP4622664A1 (en) * 2022-11-22 2025-10-01 Elixirgen Therapeutics, Inc. Antigens for cancer immunotherapy

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9103974D0 (en) 1991-02-26 1991-04-10 Norsk Hydro As Therapeutically useful peptides or peptide fragments
GB2328689A (en) * 1997-08-27 1999-03-03 Norsk Hydro As Peptides based on the p21 ras proto-oncogene protein for the treatment of cancer
NO309798B1 (no) * 1999-04-30 2001-04-02 Targovax As Peptidblanding, samt farmasoytisk sammensetning og kreftvaksine som innbefatter peptidblandingen
KR101241272B1 (ko) 2002-12-16 2013-03-15 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 면역 요법으로서의 효모계 백신
EP1760089B1 (en) 2005-09-05 2009-08-19 Immatics Biotechnologies GmbH Tumor-associated peptides binding to human leukocyte antigen (HLA) class I or II molecules and related anti-cancer vaccine
EP2004666B1 (en) * 2006-03-27 2014-09-03 Globeimmune, Inc. Ras mutation and compositions and methods related thereto
US20140199405A1 (en) 2013-01-11 2014-07-17 Abraxis Bioscience, Llc Method for treating cancer based on mutation status of k-ras
PT3079715T (pt) 2013-12-09 2018-08-02 Targovax Asa Uma mistura de péptidos
KR20170002563A (ko) 2014-05-06 2017-01-06 타르고바스 에이에스에이 돌연변이 ras 펩타이드를 포함하는 펩타이드 백신 및 화학 요법제

Also Published As

Publication number Publication date
EP3369432A1 (en) 2018-09-05
AU2019201937B2 (en) 2020-05-28
CL2018000238A1 (es) 2018-06-22
JP2020023525A (ja) 2020-02-13
US20160331820A1 (en) 2016-11-17
JP2017502081A (ja) 2017-01-19
IL246007B2 (en) 2023-05-01
MX2016007429A (es) 2016-11-11
US20170326218A1 (en) 2017-11-16
CN105980403A (zh) 2016-09-28
CY1120578T1 (el) 2019-07-10
EP3363458A2 (en) 2018-08-22
CA2933126A1 (en) 2015-06-18
WO2015086590A3 (en) 2015-07-30
RU2016127327A (ru) 2018-01-23
HRP20181213T1 (hr) 2018-10-19
SG10201811172PA (en) 2019-01-30
US10596239B2 (en) 2020-03-24
AU2014363643B2 (en) 2019-01-03
CL2018000226A1 (es) 2018-06-22
CL2016001405A1 (es) 2017-03-24
SG11201604644QA (en) 2016-07-28
PT3079715T (pt) 2018-08-02
LT3079715T (lt) 2018-08-27
AU2014363643A1 (en) 2016-07-14
PL3079715T3 (pl) 2018-11-30
CL2018000232A1 (es) 2018-06-22
US10335473B2 (en) 2019-07-02
SI3079715T1 (en) 2018-08-31
IL246007B1 (en) 2023-01-01
US10456457B2 (en) 2019-10-29
DK3079715T3 (en) 2018-09-17
IL246007A (en) 2016-07-31
AU2019201937A1 (en) 2019-04-11
US20170189515A1 (en) 2017-07-06
ES2682038T3 (es) 2018-09-18
WO2015086590A2 (en) 2015-06-18
EP3079715B1 (en) 2018-06-13
EP3363458A3 (en) 2018-11-07
EP3363457A1 (en) 2018-08-22
RS57623B1 (sr) 2018-11-30
US20180021419A1 (en) 2018-01-25
HUE039840T2 (hu) 2019-02-28
EP3357505A1 (en) 2018-08-08
EP3079715A2 (en) 2016-10-19
US9775892B2 (en) 2017-10-03
BR112016013138A2 (pt) 2018-01-16
KR20160097290A (ko) 2016-08-17

Similar Documents

Publication Publication Date Title
AU2019201937B2 (en) A peptide mixture
US20190374628A1 (en) Mutated fragments of the ras protein
Guo et al. Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity
JP5787752B2 (ja) 抗腫瘍免疫療法
Jung et al. Photodynamic therapy-mediated DC immunotherapy is highly effective for the inhibition of established solid tumors
CN108348586B (zh) 经修饰的酵母-Brachyury免疫治疗组合物
CN116948967A (zh) 一种基因修饰的树突状细胞及其应用
AU2014265873B2 (en) Yeast-based immunotherapy for chordoma
CN103965360A (zh) Ny-eso-1抗原及其在肿瘤免疫治疗中的应用
KR100522526B1 (ko) 면역 치료용 수지상 세포의 제조방법
KR100530576B1 (ko) 수지상세포를 이용한 암 면역 치료방법

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20161107

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20171206

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20171206

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20180911

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181211

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20190604

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20191004

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20191120

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200107

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200407

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200602

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200828

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20200915

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20200929

R150 Certificate of patent or registration of utility model

Ref document number: 6781403

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S531 Written request for registration of change of domicile

Free format text: JAPANESE INTERMEDIATE CODE: R313531

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250