JP6771246B2 - それに関連する障害の治療または予防に有用なβ−３アドレナリン受容体調節剤 - Google Patents

それに関連する障害の治療または予防に有用なβ−３アドレナリン受容体調節剤 Download PDF

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Publication number
JP6771246B2
JP6771246B2 JP2019516084A JP2019516084A JP6771246B2 JP 6771246 B2 JP6771246 B2 JP 6771246B2 JP 2019516084 A JP2019516084 A JP 2019516084A JP 2019516084 A JP2019516084 A JP 2019516084A JP 6771246 B2 JP6771246 B2 JP 6771246B2
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compound
oxa
azaspiro
decane
phenoxy
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JP2019518079A5 (enExample
JP2019518079A (ja
Inventor
トゥイ−アン トラン，
トゥイ−アン トラン，
クエン−クエン ドー，
クエン−クエン ドー，
ブレット ウルマン，
ブレット ウルマン，
アンソニー シー． ブラックバーン，
アンソニー シー． ブラックバーン，
麻衣子 名倉
麻衣子 名倉
Original Assignee
アリーナ ファーマシューティカルズ， インコーポレイテッド
アリーナ ファーマシューティカルズ， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4525—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2019516084A 2016-06-06 2017-06-05 それに関連する障害の治療または予防に有用なβ−３アドレナリン受容体調節剤 Active JP6771246B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662346293P 2016-06-06 2016-06-06
US62/346,293 2016-06-06
PCT/US2017/035867 WO2017214002A1 (en) 2016-06-06 2017-06-05 Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto

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JP2020157196A Division JP7083087B2 (ja) 2016-06-06 2020-09-18 それに関連する障害の治療または予防に有用なβ－３アドレナリン受容体調節剤

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JP2019518079A JP2019518079A (ja) 2019-06-27
JP2019518079A5 JP2019518079A5 (enExample) 2020-07-16
JP6771246B2 true JP6771246B2 (ja) 2020-10-21

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JP2019516084A Active JP6771246B2 (ja) 2016-06-06 2017-06-05 それに関連する障害の治療または予防に有用なβ−３アドレナリン受容体調節剤
JP2020157196A Active JP7083087B2 (ja) 2016-06-06 2020-09-18 それに関連する障害の治療または予防に有用なβ－３アドレナリン受容体調節剤
JP2022069821A Active JP7449329B2 (ja) 2016-06-06 2022-04-21 それに関連する障害の治療または予防に有用なβ－３アドレナリン受容体調節剤

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JP2022069821A Active JP7449329B2 (ja) 2016-06-06 2022-04-21 それに関連する障害の治療または予防に有用なβ－３アドレナリン受容体調節剤

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US (5) US20190284200A1 (enExample)
EP (1) EP3464292B8 (enExample)
JP (3) JP6771246B2 (enExample)
KR (2) KR20190026731A (enExample)
CN (1) CN109563103B (enExample)
AR (1) AR108772A1 (enExample)
AU (2) AU2017278102B2 (enExample)
CA (1) CA3026024C (enExample)
CL (1) CL2018003451A1 (enExample)
CO (1) CO2019000041A2 (enExample)
CR (1) CR20180595A (enExample)
DK (1) DK3464292T3 (enExample)
EA (1) EA201892817A1 (enExample)
EC (1) ECSP19001018A (enExample)
ES (1) ES2929737T3 (enExample)
IL (2) IL289378B (enExample)
MA (2) MA44037B1 (enExample)
MX (2) MX387995B (enExample)
MY (1) MY195982A (enExample)
NI (1) NI201800130A (enExample)
NZ (1) NZ749202A (enExample)
PE (1) PE20190445A1 (enExample)
PH (1) PH12018502550B1 (enExample)
PT (1) PT3464292T (enExample)
SG (1) SG11201810788QA (enExample)
TN (1) TN2018000391A1 (enExample)
TW (2) TWI752963B (enExample)
UA (1) UA125120C2 (enExample)
WO (1) WO2017214002A1 (enExample)

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ES2953576T3 (es) * 2017-12-06 2023-11-14 Arena Pharm Inc Moduladores del receptor beta-3 adrenérgico útiles para el tratamiento o la prevención de la insuficiencia cardíaca y los trastornos relacionados con la misma
JP7450610B2 (ja) 2018-09-19 2024-03-15 ノヴォ・ノルディスク・ヘルス・ケア・アーゲー ピルビン酸キナーゼｒの活性化
WO2020061378A1 (en) 2018-09-19 2020-03-26 Forma Therapeutics, Inc. Treating sickle cell disease with a pyruvate kinase r activating compound
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JP2023024954A (ja) * 2021-08-09 2023-02-21 アリーナ ファーマシューティカルズ， インコーポレイテッド ベータ－３アドレナリン作動性受容体に関連する障害の処置または予防に有用なベータ－３アドレナリン作動性受容体のモジュレーター
WO2023026185A1 (en) * 2021-08-26 2023-03-02 Arena Pharmaceuticals, Inc. Modulators of the beta-3 adrenergic receptor for the treatment or prevention of renal cystic disease and cardiorenal syndrome
US20240409548A1 (en) * 2021-10-06 2024-12-12 Arena Pharmaceuticals, Inc. Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of disorders related thereto
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CN114539103B (zh) * 2022-03-21 2023-04-07 佳木斯黑龙农药有限公司 2-二氟乙氧基-6-三氟甲基苯磺酰氯的合成方法
CN116178220A (zh) * 2022-12-13 2023-05-30 爱斯特（成都）生物制药股份有限公司 一种制备(2s)-2-[[3-(甲基磺酰基l)苯氧基]甲基]环氧乙烷的方法

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US20200270264A1 (en) 2020-08-27
CA3026024C (en) 2024-07-02
CN109563103A (zh) 2019-04-02
KR20190026731A (ko) 2019-03-13
IL289378A (en) 2022-02-01
EP3464292B8 (en) 2022-10-26
ES2929737T3 (es) 2022-12-01
NZ749202A (en) 2022-07-01
ECSP19001018A (es) 2019-02-28
TW202237619A (zh) 2022-10-01
US20190389875A1 (en) 2019-12-26
AU2021206809B2 (en) 2023-01-05
JP2019518079A (ja) 2019-06-27
TN2018000391A1 (en) 2020-06-15
CN109563103B (zh) 2022-05-27
KR20220025128A (ko) 2022-03-03
US10927123B2 (en) 2021-02-23
US20190284200A1 (en) 2019-09-19
AR108772A1 (es) 2018-09-26
TWI784840B (zh) 2022-11-21
JP7449329B2 (ja) 2024-03-13
UA125120C2 (uk) 2022-01-12
MX2021014043A (es) 2022-02-21
AU2021206809A1 (en) 2021-08-12
MA45150A (fr) 2021-05-05
PE20190445A1 (es) 2019-03-29
TWI752963B (zh) 2022-01-21
EP3464292A1 (en) 2019-04-10
US20210340154A1 (en) 2021-11-04
CL2018003451A1 (es) 2019-02-22
NI201800130A (es) 2019-06-13
KR102408272B1 (ko) 2022-06-10
MX2018015124A (es) 2019-09-09
JP2020203945A (ja) 2020-12-24
DK3464292T3 (da) 2022-10-31
CA3026024A1 (en) 2017-12-14
JP7083087B2 (ja) 2022-06-10
IL289378B (en) 2022-09-01
US10662200B2 (en) 2020-05-26
TW201803877A (zh) 2018-02-01
MA44037B1 (fr) 2020-03-31
EP3464292B1 (en) 2022-09-21
IL263148B (en) 2022-02-01
PH12018502550A1 (en) 2019-11-04
US20190292196A1 (en) 2019-09-26
SG11201810788QA (en) 2018-12-28
JP2022089984A (ja) 2022-06-16
CR20180595A (es) 2019-04-09
CO2019000041A2 (es) 2019-04-30
MX387995B (es) 2025-03-19
WO2017214002A1 (en) 2017-12-14
AU2017278102A1 (en) 2019-01-17
PH12018502550B1 (en) 2023-01-27
IL263148A (en) 2018-12-31
BR112018075201A2 (pt) 2019-03-19
US10479797B2 (en) 2019-11-19
PT3464292T (pt) 2022-11-15
MY195982A (en) 2023-02-27
US11560386B2 (en) 2023-01-24
MA44037A1 (fr) 2019-05-31
AU2017278102B2 (en) 2021-04-29
EA201892817A1 (ru) 2019-06-28

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