JP6735665B2 - 安定性が改善され迅速に発光する親水性高量子収率アクリジニウムエステル - Google Patents

安定性が改善され迅速に発光する親水性高量子収率アクリジニウムエステル Download PDF

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Publication number
JP6735665B2
JP6735665B2 JP2016525393A JP2016525393A JP6735665B2 JP 6735665 B2 JP6735665 B2 JP 6735665B2 JP 2016525393 A JP2016525393 A JP 2016525393A JP 2016525393 A JP2016525393 A JP 2016525393A JP 6735665 B2 JP6735665 B2 JP 6735665B2
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JP
Japan
Prior art keywords
analyte
acridinium ester
group
succinimidyl
ester according
Prior art date
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Active
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JP2016525393A
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English (en)
Japanese (ja)
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JP2016531099A5 (fr
JP2016531099A (ja
Inventor
ナトラヤン、アナンド
シャープ、デイヴィッド
ジアーン、チーンピーン
ウエン、デイヴィッド
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Siemens Healthcare Diagnostics Inc
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Siemens Healthcare Diagnostics Inc
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
    • C09K11/07—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials having chemically interreactive components, e.g. reactive chemiluminescent compositions
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F21—LIGHTING
    • F21K—NON-ELECTRIC LIGHT SOURCES USING LUMINESCENCE; LIGHT SOURCES USING ELECTROCHEMILUMINESCENCE; LIGHT SOURCES USING CHARGES OF COMBUSTIBLE MATERIAL; LIGHT SOURCES USING SEMICONDUCTOR DEVICES AS LIGHT-GENERATING ELEMENTS; LIGHT SOURCES NOT OTHERWISE PROVIDED FOR
    • F21K2/00—Non-electric light sources using luminescence; Light sources using electrochemiluminescence
    • F21K2/06—Non-electric light sources using luminescence; Light sources using electrochemiluminescence using chemiluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Materials Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Electromagnetism (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plasma & Fusion (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
JP2016525393A 2013-07-08 2014-07-04 安定性が改善され迅速に発光する親水性高量子収率アクリジニウムエステル Active JP6735665B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361843528P 2013-07-08 2013-07-08
US61/843,528 2013-07-08
PCT/US2014/045505 WO2015006174A1 (fr) 2013-07-08 2014-07-04 Esters d'acridinium hydrophiles à rendement quantique élevé présentant une meilleure stabilité et une émission lumineuse rapide

Publications (3)

Publication Number Publication Date
JP2016531099A JP2016531099A (ja) 2016-10-06
JP2016531099A5 JP2016531099A5 (fr) 2017-08-17
JP6735665B2 true JP6735665B2 (ja) 2020-08-05

Family

ID=52280476

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016525393A Active JP6735665B2 (ja) 2013-07-08 2014-07-04 安定性が改善され迅速に発光する親水性高量子収率アクリジニウムエステル

Country Status (6)

Country Link
US (3) US20170320830A1 (fr)
EP (1) EP3019575B1 (fr)
JP (1) JP6735665B2 (fr)
CN (2) CN112521335A (fr)
ES (1) ES2716395T3 (fr)
WO (1) WO2015006174A1 (fr)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4918192A (en) 1986-10-06 1990-04-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
US5110932A (en) 1986-10-06 1992-05-05 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
DE3750503T2 (de) 1986-10-22 1995-02-09 Abbott Lab Chemilumineszierende Acridinium- und Phenantridiniumsalze.
US5656426A (en) 1988-08-01 1997-08-12 Chiron Diagnostics Corporation Functionaized hydrophilic acridinium esters
US6664043B2 (en) 2001-07-03 2003-12-16 Bayer Corporation Acridinium ester labels having hydrophilic modifiers
US7309615B2 (en) * 2002-09-27 2007-12-18 Siemens Medical Solutions Diagnostic High quantum yield acridinium compounds and their uses in improving assay sensitivity
JP5503969B2 (ja) * 2006-10-13 2014-05-28 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッド 迅速に発光する安定なアクリジニウムエステル
EP2215063B1 (fr) * 2007-11-20 2013-10-30 Siemens Healthcare Diagnostics Inc. N-alkylation facile de composés d'acridine dans des liquides ioniques
WO2011060228A1 (fr) * 2009-11-16 2011-05-19 Siemens Healthcare Diagnostics Inc. Composés d'acridinium contenant du zwitterion

Also Published As

Publication number Publication date
CN105378029B (zh) 2020-12-18
CN112521335A (zh) 2021-03-19
EP3019575A1 (fr) 2016-05-18
US11332445B2 (en) 2022-05-17
JP2016531099A (ja) 2016-10-06
US20220227711A1 (en) 2022-07-21
US20170320830A1 (en) 2017-11-09
CN105378029A (zh) 2016-03-02
WO2015006174A1 (fr) 2015-01-15
EP3019575A4 (fr) 2016-12-28
ES2716395T3 (es) 2019-06-12
EP3019575B1 (fr) 2018-12-19
US11932603B2 (en) 2024-03-19
US20200190037A1 (en) 2020-06-18

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