JP6727127B2 - Ｐｉ３ｋ／ａｋｔシグナル経路阻害剤およびｅｒｋ阻害剤の組み合わせを使用するがん処置 - Google Patents

Ｐｉ３ｋ／ａｋｔシグナル経路阻害剤およびｅｒｋ阻害剤の組み合わせを使用するがん処置 Download PDF

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JP6727127B2
JP6727127B2 JP2016540554A JP2016540554A JP6727127B2 JP 6727127 B2 JP6727127 B2 JP 6727127B2 JP 2016540554 A JP2016540554 A JP 2016540554A JP 2016540554 A JP2016540554 A JP 2016540554A JP 6727127 B2 JP6727127 B2 JP 6727127B2
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cancer
combination
inhibitor
pfizer
gdc
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JP2017502014A (ja
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サウラブ サハ，
サウラブ サハ，
ディーン ウェルシュ，
ディーン ウェルシュ，
ゲイリー デクレッセンゾ，
ゲイリー デクレッセンゾ，
ジェフリー ジェイムズ ロワ，
ジェフリー ジェイムズ ロワ，
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バイオメッド バレー ディスカバリーズ，インコーポレイティド
バイオメッド バレー ディスカバリーズ，インコーポレイティド
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
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    • C12Q2600/00—Oligonucleotides characterized by their use
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016540554A 2013-12-20 2014-12-19 Ｐｉ３ｋ／ａｋｔシグナル経路阻害剤およびｅｒｋ阻害剤の組み合わせを使用するがん処置 Active JP6727127B2 (ja)

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Application Number Priority Date Filing Date Title
US201361919638P 2013-12-20 2013-12-20
US61/919,638 2013-12-20
PCT/US2014/071728 WO2015095829A1 (en) 2013-12-20 2014-12-19 Cancer treatments using combinations of pi3k/akt pathway and erk inhibitors

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JP2017502014A JP2017502014A (ja) 2017-01-19
JP2017502014A5 JP2017502014A5 (enExample) 2018-02-08
JP6727127B2 true JP6727127B2 (ja) 2020-07-29

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US (1) US11007183B2 (enExample)
EP (2) EP3082957B1 (enExample)
JP (1) JP6727127B2 (enExample)
AU (1) AU2014368916B2 (enExample)
ES (2) ES2918375T3 (enExample)
WO (1) WO2015095829A1 (enExample)

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RU2702908C2 (ru) 2012-11-01 2019-10-14 Инфинити Фармасьютикалз, Инк. Лечение злокачественных опухолей с использованием модуляторов изоформ pi3-киназы
EP3099332A4 (en) 2014-01-29 2017-06-21 Madrigal Pharmaceuticals, Inc. Targeted therapeutics
JP6576942B6 (ja) 2014-03-03 2019-11-27 マドリガル ファーマシューティカルズ インコーポレイテッド 標的治療薬
MA39483A (fr) 2014-03-18 2015-09-24 Synta Pharmaceuticals Corp Agents thérapeutiques cibles
WO2015160975A2 (en) 2014-04-16 2015-10-22 Infinity Pharmaceuticals, Inc. Combination therapies
CN106333951B (zh) * 2015-11-24 2018-11-02 中国科学院大连化学物理研究所 一种mTOR激酶抑制剂与MAPK激酶抑制剂的组合物的应用
BR112018012255A2 (pt) * 2015-12-18 2018-12-04 Ignyta Inc método para tratar câncer
EP3791897A1 (en) * 2016-02-29 2021-03-17 Madrigal Pharmaceuticals, Inc. Hsp90 inhibitor drug conjugates
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WO2018213302A1 (en) * 2017-05-16 2018-11-22 Biomed Valley Discoveries, Inc. Compositions and methods for treating cancer with atypical braf mutations
CN110204529A (zh) * 2018-02-28 2019-09-06 朱允涛 一种氘代的三嗪类化合物的制备方法和用途
CN115151532B (zh) * 2020-04-29 2023-06-06 北京泰德制药股份有限公司 喹喔啉二酮衍生物作为kras g12c突变蛋白的不可逆抑制剂
CN113667747B (zh) * 2020-05-14 2025-01-24 长庚大学 治疗口腔癌的方法
WO2025084759A1 (ko) * 2023-10-18 2025-04-24 주식회사 애스톤사이언스 Kras 면역원성 펩타이드
WO2025110738A1 (ko) * 2023-11-24 2025-05-30 주식회사 캐니캐티케어 반려동물의 pik3ca 유전자 돌연변이성 종양 검출용 조성물 및 이를 이용한 반려동물의 pik3ca 유전자 돌연변이성 종양 진단방법

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US20160317517A1 (en) 2016-11-03
ES3059018T3 (en) 2026-03-16
EP3082957B1 (en) 2022-04-06
ES2918375T3 (es) 2022-07-15
EP4062917B1 (en) 2025-12-03
AU2014368916A1 (en) 2016-07-21
US11007183B2 (en) 2021-05-18
EP4062917A1 (en) 2022-09-28
WO2015095829A1 (en) 2015-06-25
JP2017502014A (ja) 2017-01-19
EP3082957A1 (en) 2016-10-26
AU2014368916B2 (en) 2020-04-30
EP3082957A4 (en) 2017-06-21

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