JP6722598B2 - 関節リウマチ治療のための間葉系間質細胞 - Google Patents

関節リウマチ治療のための間葉系間質細胞 Download PDF

Info

Publication number
JP6722598B2
JP6722598B2 JP2016575898A JP2016575898A JP6722598B2 JP 6722598 B2 JP6722598 B2 JP 6722598B2 JP 2016575898 A JP2016575898 A JP 2016575898A JP 2016575898 A JP2016575898 A JP 2016575898A JP 6722598 B2 JP6722598 B2 JP 6722598B2
Authority
JP
Japan
Prior art keywords
cells
mscs
msc
treatment
subject
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2016575898A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017520582A5 (enExample
JP2017520582A (ja
Inventor
ダレマンズ，ウィルフリード
ロムバード，エレウテリオ
デッカー，ロバート
Original Assignee
ティジェニクス エス．エー．ユー．
ティジェニクス エス．エー．ユー．
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ティジェニクス エス．エー．ユー．, ティジェニクス エス．エー．ユー． filed Critical ティジェニクス エス．エー．ユー．
Publication of JP2017520582A publication Critical patent/JP2017520582A/ja
Publication of JP2017520582A5 publication Critical patent/JP2017520582A5/ja
Application granted granted Critical
Publication of JP6722598B2 publication Critical patent/JP6722598B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2016575898A 2014-06-30 2015-06-30 関節リウマチ治療のための間葉系間質細胞 Active JP6722598B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14175096 2014-06-30
EP14175096.8 2014-06-30
PCT/IB2015/054922 WO2016001845A1 (en) 2014-06-30 2015-06-30 Mesenchymal stromal cells for treating rheumatoid arthritis

Publications (3)

Publication Number Publication Date
JP2017520582A JP2017520582A (ja) 2017-07-27
JP2017520582A5 JP2017520582A5 (enExample) 2018-08-09
JP6722598B2 true JP6722598B2 (ja) 2020-07-15

Family

ID=51033024

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016575898A Active JP6722598B2 (ja) 2014-06-30 2015-06-30 関節リウマチ治療のための間葉系間質細胞

Country Status (4)

Country Link
US (1) US20170136065A1 (enExample)
EP (1) EP3160480B1 (enExample)
JP (1) JP6722598B2 (enExample)
WO (1) WO2016001845A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3464563B1 (en) * 2016-06-06 2021-07-28 Pluristem Ltd. Altered adherent stromal cells and methods of producing and using same
KR101969229B1 (ko) * 2016-09-27 2019-04-15 가톨릭대학교 산학협력단 통증이 경감되는 골관절염 치료용 키트
RU2659204C1 (ru) * 2017-02-03 2018-06-28 Федеральное государственное автономное образовательное учреждение высшего образования "Балтийский федеральный университет имени Иммануила Канта" (БФУ им. И. Канта) Биотрансплантат для лечения дисплазии суставов и способ его получения
US20230346842A1 (en) * 2020-05-07 2023-11-02 Primegen Biotech, Llc Methods and Compositions For Reducing Joint Inflammation Using Mesenchymal Stem Cells
WO2024110591A1 (en) 2022-11-23 2024-05-30 DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH Biomarkers predictive of immunomodulatory mesenchymal stromal cells

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT71914A (en) 1992-12-02 1996-02-28 Shell Int Research Azoxycyanobenzene-derivatives, process for their preparation, fungicidal compositions containing them
WO1995002698A1 (en) 1993-07-12 1995-01-26 Life Technologies, Inc. Composition and methods for transfecting eukaryotic cells
US6051429A (en) 1995-06-07 2000-04-18 Life Technologies, Inc. Peptide-enhanced cationic lipid transfections
DE69634084T2 (de) 1995-06-07 2005-12-08 Inex Pharmaceuticals Corp. Herstellung von lipid-nukleinsäure partikeln duch ein hydrophobische lipid-nukleinsäuree komplexe zwischenprodukt und zur verwendung in der gentransfer
US5744335A (en) 1995-09-19 1998-04-28 Mirus Corporation Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein
US5705308A (en) 1996-09-30 1998-01-06 Eastman Kodak Company Infrared-sensitive, negative-working diazonaphthoquinone imaging composition and element
US6777231B1 (en) 1999-03-10 2004-08-17 The Regents Of The University Of California Adipose-derived stem cells and lattices
SG165418A1 (en) 2005-09-23 2010-10-28 Cellerix Sl Cell populations having immunoregulatory activity, method for isolation and uses
WO2011047345A2 (en) * 2009-10-15 2011-04-21 Tai June Yoo Methods of treating diseases of conditions using mesenchymal stem cells
JP2014508527A (ja) * 2011-03-11 2014-04-10 ティゲニクス、エセ、ア、ウ 免疫調節活性を有する細胞集団、単離方法および使用
EP3013943B1 (en) * 2013-06-25 2019-04-10 TiGenix, S.A.U. Cell populations having immunoregulatory activity, methods for the preparation and uses thereof

Also Published As

Publication number Publication date
US20170136065A1 (en) 2017-05-18
EP3160480A1 (en) 2017-05-03
WO2016001845A1 (en) 2016-01-07
EP3160480B1 (en) 2020-09-09
JP2017520582A (ja) 2017-07-27

Similar Documents

Publication Publication Date Title
JP6764912B2 (ja) 免疫調節活性を有する細胞集団、その調製方法および使用
JP6755850B2 (ja) 間葉系幹細胞の使用
JP6722599B2 (ja) 全身性炎症反応症候群の治療のための間葉系間質細胞
US8900573B2 (en) Immune privileged and modulatory progenitor cells
JP6722598B2 (ja) 関節リウマチ治療のための間葉系間質細胞
US20230149523A1 (en) Treatment of autoimmunity and transplant rejection through establishment and/or promotion of tolerogenic processes by fibroblast-mediated reprogramming of antigen presenting cells
HK1224333B (en) Cell populations having immunoregulatory activity, methods for the preparation and uses thereof

Legal Events

Date Code Title Description
RD01 Notification of change of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7426

Effective date: 20170825

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20170825

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20180629

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20180629

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190618

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20190904

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20200526

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20200622

R150 Certificate of patent or registration of utility model

Ref document number: 6722598

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: R3D02

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250