JP6718376B2 - 抗精神病薬物およびｖｍａｔ２阻害剤を含む医薬組成物およびその使用 - Google Patents

抗精神病薬物およびｖｍａｔ２阻害剤を含む医薬組成物およびその使用 Download PDF

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JP6718376B2
JP6718376B2 JP2016549493A JP2016549493A JP6718376B2 JP 6718376 B2 JP6718376 B2 JP 6718376B2 JP 2016549493 A JP2016549493 A JP 2016549493A JP 2016549493 A JP2016549493 A JP 2016549493A JP 6718376 B2 JP6718376 B2 JP 6718376B2
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antipsychotic drug
vmat2 inhibitor
disorder
antipsychotic
administered
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JP2017505316A (ja
JP2017505316A5 (https=
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サミュエル ロジャー ジェシー ホーア，
サミュエル ロジャー ジェシー ホーア，
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ニューロクライン バイオサイエンシーズ，インコーポレイテッド
ニューロクライン バイオサイエンシーズ，インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2016549493A 2014-02-07 2015-02-06 抗精神病薬物およびｖｍａｔ２阻害剤を含む医薬組成物およびその使用 Expired - Fee Related JP6718376B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461937223P 2014-02-07 2014-02-07
US61/937,223 2014-02-07
PCT/US2015/014893 WO2015120317A1 (en) 2014-02-07 2015-02-06 Pharmaceutical compositions comprising an antipsychotic drug and a vmat2 inhibitor and uses thereof

Related Child Applications (1)

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JP2019087459A Division JP2019116515A (ja) 2014-02-07 2019-05-07 抗精神病薬物およびｖｍａｔ２阻害剤を含む医薬組成物およびその使用

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JP2017505316A JP2017505316A (ja) 2017-02-16
JP2017505316A5 JP2017505316A5 (https=) 2018-03-22
JP6718376B2 true JP6718376B2 (ja) 2020-07-08

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JP2016549493A Expired - Fee Related JP6718376B2 (ja) 2014-02-07 2015-02-06 抗精神病薬物およびｖｍａｔ２阻害剤を含む医薬組成物およびその使用
JP2019087459A Withdrawn JP2019116515A (ja) 2014-02-07 2019-05-07 抗精神病薬物およびｖｍａｔ２阻害剤を含む医薬組成物およびその使用
JP2021032320A Pending JP2021080294A (ja) 2014-02-07 2021-03-02 抗精神病薬物およびｖｍａｔ２阻害剤を含む医薬組成物およびその使用
JP2023195803A Pending JP2024003253A (ja) 2014-02-07 2023-11-17 抗精神病薬物およびｖｍａｔ２阻害剤を含む医薬組成物およびその使用

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JP2019087459A Withdrawn JP2019116515A (ja) 2014-02-07 2019-05-07 抗精神病薬物およびｖｍａｔ２阻害剤を含む医薬組成物およびその使用
JP2021032320A Pending JP2021080294A (ja) 2014-02-07 2021-03-02 抗精神病薬物およびｖｍａｔ２阻害剤を含む医薬組成物およびその使用
JP2023195803A Pending JP2024003253A (ja) 2014-02-07 2023-11-17 抗精神病薬物およびｖｍａｔ２阻害剤を含む医薬組成物およびその使用

Country Status (13)

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US (4) US9782398B2 (https=)
EP (2) EP4049681B1 (https=)
JP (4) JP6718376B2 (https=)
KR (1) KR102328058B1 (https=)
CN (3) CN113368110A (https=)
AU (1) AU2015213778B2 (https=)
CA (1) CA2938581C (https=)
ES (1) ES3062021T3 (https=)
IL (1) IL247127B (https=)
MX (1) MX378664B (https=)
NZ (2) NZ760790A (https=)
RU (2) RU2757221C2 (https=)
WO (1) WO2015120317A1 (https=)

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JOP20190239A1 (ar) 2017-04-19 2019-10-09 Neurocrine Biosciences Inc مركبات مثبطة لـ vmat2 وتركيبات منها
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ES3024958T3 (en) 2017-09-21 2025-06-05 Neurocrine Biosciences Inc High dosage valbenazine formulation and compositions, methods, and kits related thereto
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JP2021502959A (ja) 2017-10-10 2021-02-04 ニューロクライン バイオサイエンシーズ，インコーポレイテッド 特定のｖｍａｔ２インヒビターを投与するための方法
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ES3062021T3 (en) 2026-04-08
IL247127A0 (en) 2016-09-29
EP4049681B1 (en) 2026-01-07
KR20160132830A (ko) 2016-11-21
MX2016010071A (es) 2017-04-27
IL247127B (en) 2021-04-29
JP2019116515A (ja) 2019-07-18
JP2021080294A (ja) 2021-05-27
NZ723107A (en) 2022-11-25
RU2021128797A (ru) 2021-11-26
JP2024003253A (ja) 2024-01-11
NZ760790A (en) 2022-11-25
US9782398B2 (en) 2017-10-10
US20200206215A1 (en) 2020-07-02
WO2015120317A1 (en) 2015-08-13
RU2016135930A3 (https=) 2018-10-05
CN113368110A (zh) 2021-09-10
RU2016135930A (ru) 2018-03-15
KR102328058B1 (ko) 2021-11-17
AU2015213778A1 (en) 2016-08-18
MX378664B (es) 2025-03-10
AU2015213778B2 (en) 2020-04-23
CA2938581A1 (en) 2015-08-13
EP4049681C0 (en) 2026-01-07
RU2757221C2 (ru) 2021-10-12
EP3102239A1 (en) 2016-12-14
US20190381029A1 (en) 2019-12-19
CN113413385A (zh) 2021-09-21
JP2017505316A (ja) 2017-02-16
CA2938581C (en) 2023-02-28
CN106061506A (zh) 2016-10-26
US20160339011A1 (en) 2016-11-24
US20180085364A1 (en) 2018-03-29
EP4049681A1 (en) 2022-08-31

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